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Dendrobium mixture attenuates renal damage in rats with diabetic nephropathy by inhibiting the PI3K/Akt/mTOR pathway

  • Authors:
    • Yong Chen
    • Yan Fang Zheng
    • Xiao Hui Lin
    • Jie Ping Zhang
    • Fan Lin
    • Hong Shi
  • View Affiliations / Copyright

    Affiliations: School of Integrated Traditional Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China, School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 590
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    Published online on: June 17, 2021
       https://doi.org/10.3892/mmr.2021.12229
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Abstract

Dendrobium mixture (DMix) is a Traditional Chinese Medicine widely used for preventing and treating diabetic nephropathy (DN). Autophagy contributes to DN development and progression. The present study aimed to investigate the mechanism underlying the protective effects of DMix on the kidneys of rats with DN and to determine whether this involves autophagy. Herein, a high‑sugar and high‑fat diet, combined with the intra‑abdominal injection of low‑dose streptozocin, was used to induce DN in 40 Sprague‑Dawley male rats. In total, 10 additional rats were used as controls. The rats with DN were then randomly divided into three groups and treated with DMix, gliquidone or saline via gastric administration for 8 weeks. Body weight, kidney weight, kidney index, fasting blood glucose (FBG), blood lipid, hemoglobin A1c (HbA1c), insulin, blood urea nitrogen and serum creatinine levels, as well as the 24‑h urinary albumin excretion rate (UAER) were measured. H&E, Periodic Acid‑Schiff and Masson staining were used to examine the renal pathology. The mRNA and protein expression levels of LC3 and Beclin‑1 in renal tissues were measured using reverse transcription‑quantitative PCR and immunohistochemistry, respectively. Western blotting was conducted to measure the protein expression levels of PI3K, phosphorylated (p)‑PI3K, Akt, p‑Akt, mTOR, p‑mTOR, LC3 and Beclin‑1 in renal tissues. It was found that DMix significantly reduced the FBG, blood lipids, HbA1c and insulin levels, kidney weight, kidney index and UAER in rats with DN, as well as improved renal function. Rats with DN showed notable glomerular hypertrophy, an increase in mesangial matrix content and renal interstitial fibrosis. Moreover, DMix notably reduced kidney damage. The results demonstrated that DMix inhibited the phosphorylation of PI3K, Akt and mTOR in the kidney tissues of rats with DN, and increased the protein and mRNA expression levels of LC3 and Beclin‑1. Therefore, it was suggested that DMix has protective effects on the kidney of rats with DN, which may be associated with the inhibition of the PI3K/Akt/mTOR signaling pathway and activation of renal autophagy by this traditional medicine.
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View References

1 

Li X, Wang L and Ma H: Betaine alleviates high glucose-induced mesangial cell proliferation by inhibiting cell proliferation and extracellular matrix deposition via the AKT/ERK1/2/p38 MAPK pathway. Mol Med Rep. 20:1754–1760. 2019.PubMed/NCBI

2 

Hsieh AR, Huang YC, Yang YF, Lin HJ, Lin JM, Chang YW, Wu CM, Liao WL and Tsai FJ: Lack of association of genetic variants for diabetic retinopathy in Taiwanese patients with diabetic nephropathy. BMJ Open Diabetes Res Care. 8:e0007272020. View Article : Google Scholar : PubMed/NCBI

3 

Perkovic V, Jardine MJ, Neal B, Bompoint S, Heerspink HJL, Charytan DM, Edwards R, Agarwal R, Bakris G, Bull S, et al: Canagliflozin and renal outcomes in type 2 diabetes and nephropathy. N Engl J Med. 380:2295–2306. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Zhang Q, Yang M, Xiao Y, Han Y, Yang S and Sun L: Towards better drug repositioning: Targeted immunoinflammatory therapy for diabetic nephropathy. Curr Med Chem. 8:1003–1024. 2021. View Article : Google Scholar : PubMed/NCBI

5 

Oraby MA, El-Yamany MF, Safar MM, Assaf N and Ghoneim HA: Amelioration of early markers of diabetic nephropathy by linagliptin in fructose-streptozotocin-induced type 2 diabetic rats. Nephron. 141:273–286. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Li X, Zhu Q, Zheng R, Yan J, Wei M, Fan Y, Deng Y and Zhong Y: Puerarin attenuates diabetic nephropathy by promoting autophagy in podocytes. Front Physiol. 11:732020. View Article : Google Scholar : PubMed/NCBI

7 

Yang C, Chen XC, Li ZH, Wu HL, Jing KP, Huang XR, Ye L, Wei B, Lan HY and Liu HF: SMAD3 promotes autophagy dysregulation by triggering lysosome depletion in tubular epithelial cells in diabetic nephropathy. Autophagy. 10:1–20. 2020. View Article : Google Scholar

8 

Kim JH, Kim KM, Jeong JU, Shin JH, Shin JM and Bang KT: Nrf2-Heme oxygenase-1 modulates autophagy and inhibits apoptosis triggered by elevated glucose levels in renal tubule cells. Kidney Res Clin Pract. 38:318–325. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Cao T, Xu R, Xu Y, Liu Y, Qi D and Wan Q: The protective effect of cordycepin on diabetic nephropathy through autophagy induction in vivo and in vitro. Int Urol Nephrol. 51:1883–1892. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Dai H, Liu Q and Liu B: Research progress on mechanism of podocyte depletion in diabetic nephropathy. J Diabetes Res. 2017:26152862017. View Article : Google Scholar : PubMed/NCBI

11 

Chen Y, Liu Q, Shan Z, Mi W, Zhao Y, Li M, Wang B, Zheng X and Feng W: Catalpol ameliorates podocyte injury by stabilizing cytoskeleton and enhancing autophagy in diabetic nephropathy. Front Pharmacol. 10:14772019. View Article : Google Scholar : PubMed/NCBI

12 

Zhang MZ, Jang H and Nussinov R: The structural basis for ras activation of PI3Kα lipid kinase. Phys Chem Chem Phys. 21:12021–12028. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Zhang X, Wang D, Liu B, Jin X, Wang X, Pan J, Tu W and Shao Y: IMP3 accelerates the progression of prostate cancer through inhibiting PTEN expression in a SMURF1-dependent way. J Exp Clin Cancer Res. 39:1902020. View Article : Google Scholar : PubMed/NCBI

14 

Clement E, Inuzuka H, Nihira NT, Wei W and Toker A: Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors. Sci Signal. 11:eaao38102018. View Article : Google Scholar : PubMed/NCBI

15 

Chen XB, Sun Y, Wang BR and Wang HH: Prognostic significance of autophagy-related genes beclin1 and LC3 in ovarian cancer: A meta-analysis. J Int Med Res. 48:3000605209682992020. View Article : Google Scholar : PubMed/NCBI

16 

Yu H, Shao J, Huang R, Guan Y, Li G, Chen S, Zhou F, Yao Q and Shen J: Targeting PTEN to regulate autophagy and promote the repair of injured neurons. Brain Res Bull. 165:161–168. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Jung G, Roh J, Lee H, Gil M, Yoon DH, Suh C, Jang S, Park CJ, Huh J and Park CS: Autophagic markers beclin1 and LC3 are associated with prognosis of multiple myeloma. Acta Haematol. 134:17–24. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Ebrahim N, Ahmed IA, Hussien NI, Dessouky AA, Farid AS, Elshazly AM, Mostafa O, Gazzar WBE, Sorour SM, Seleem Y, et al: Mesenchymal stem cell-derived exosomes ameliorated diabetic nephropathy by autophagy induction through the mTOR signaling pathway. Cells. 7:2262018. View Article : Google Scholar : PubMed/NCBI

19 

Fu L, Wu W, Sun X and Zhang P: Glucocorticoids enhanced osteoclast autophagy through the PI3K/Akt/mTOR signaling pathway. Calcif Tissue Int. 107:60–71. 2020. View Article : Google Scholar : PubMed/NCBI

20 

Vurusaner B, Gargiulo S, Testa G, Gamba P, Leonarduzzi G, Poli G and Basaga H: The role of autophagy in survival response induced by 27-hydroxycholesterol in human promonocytic cells. Redox Biol. 17:400–410. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Xu Q, Liu Y, Cong YB, Zheng YY, Zhang JP and Shi H: Gene expression and microarray investigation of dendrobium mixture as progressive therapy for the treatment of type 2 diabetes mellitus. Trop J Pharmaceutical Res. 12:195–201. 2013.

22 

Lin X, Shi H, Cui Y, Wang X, Zhang J, Yu W and Wei M: Dendrobium mixture regulates hepatic gluconeogenesis in diabetic rats via the phosphoinositide-3-kinase/protein kinase B signaling pathway. Exp Ther Med. 16:204–212. 2018.PubMed/NCBI

23 

Nitulescu GM, Margina D, Juzenas P, Peng Q, Olaru OT, Saloustros E, Fenga C, Spandidos DA, Libra M and Tsatsakis AM: Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use. Int J Oncol. 48:869–885. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Nitulescu GM, Van De Venter M, Nitulescu G, Ungurianu A, Juzenas P, Peng Q, Olaru OT, Grădinaru D, Tsatsakis A, Tsoukalas D, et al: The Akt pathway in oncology therapy and beyond. Int J Oncol. 53:2319–2331. 2018.PubMed/NCBI

25 

Brown MJ, Symonowicz C, Medina LV, Bratcher NA, Buckmaster CA, Klein H and Anderson LC: Culture of care: Organizational responsibilities. Management of Animal Care and Use Programs in Research, Education, and Testing. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2018, PubMed/NCBI

26 

Tesch GH and Allen TJ: Rodent models of streptozotocin-induced diabetic nephropathy. Nephrology (Carlton). 12:261–266. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Liu K, Yang Y, Zhou F, Xiao Y and Shi L: Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy and relieves hyperalgesia in diabetic rats. Neuroreport. 31:644–649. 2020. View Article : Google Scholar : PubMed/NCBI

28 

Zeng LF, Xiao Y and Sun L: A glimpse of the mechanisms related to renal fibrosis in diabetic nephropathy. Adv Exp Med Biol. 1165:49–79. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Qi C, Mao X, Zhang Z and Wu H: Classification and differential diagnosis of diabetic nephropathy. J Diabetes Res. 2017:86371382017. View Article : Google Scholar : PubMed/NCBI

30 

Dong Z, Sun Y, Wei G, Li S and Zhao Z: Ergosterol ameliorates diabetic nephropathy by attenuating mesangial cell proliferation and extracellular matrix deposition via the TGF-β1/smad2 signaling pathway. Nutrients. 11:4832019. View Article : Google Scholar : PubMed/NCBI

31 

Park CH, Hiratani K, Natazuka T and Yokozawa T: Therapeutic effect of Chinese prescription Kangen-Karyu in patients with diabetic nephropathy. Drug Discov Ther. 14:84–88. 2020. View Article : Google Scholar : PubMed/NCBI

32 

Wang J, Ma Q, Li Y, Li P, Wang M, Wang T, Wang C, Wang T and Zhao B: Research progress on Traditional Chinese Medicine syndromes of diabetes mellitus. Biomed Pharmacother. 121:1095652020. View Article : Google Scholar : PubMed/NCBI

33 

Cheng T, Ye J, Li H, Dong H, Xie N, Mi N, Zhang Z, Zou J, Jin H and Zhang W: Hybrid multidimensional data acquisition and data processing strategy for comprehensive characterization of known, unknown and isomeric compounds from the compound dan zhi tablet by UPLC-TWIMS-QTOFMS. Rsc Advances. 9:8714–8727. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Shen H, Qu Z, Harata-Lee Y, Aung TN, Cui J, Wang W, Kortschak RD and Adelson DL: Understanding the mechanistic contribution of herbal extracts in compound kushen injection with transcriptome analysis. Front Oncol. 9:6322019. View Article : Google Scholar : PubMed/NCBI

35 

Tian HY, Yang JB, Xie ZC and Liu JL: Gliquidone alleviates diabetic nephropathy by inhibiting notch/snail signaling pathway. Cell Physiol Biochem. 51:2085–2097. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Kim H, Dusabimana T, Kim SR, Je J, Jeong K, Kang MC, Cho KM, Kim HJ and Park SW: Supplementation of abelmoschus manihot ameliorates diabetic nephropathy and hepatic steatosis by activating autophagy in mice. Nutrients. 10:17032018. View Article : Google Scholar : PubMed/NCBI

37 

Liu WJ, Huang WF, Ye L, Chen RH, Yang C, Wu HL, Pan QJ and Liu HF: The activity and role of autophagy in the pathogenesis of diabetic nephropathy. Eur Rev Med Pharmacol Sci. 22:3182–3189. 2018.PubMed/NCBI

38 

Tu Q, Li Y, Jin J, Jiang X, Ren Y and He Q: Curcumin alleviates diabetic nephropathy via inhibiting podocyte mesenchymal transdifferentiation and inducing autophagy in rats and MPC5 cells. Pharm Biol. 57:778–786. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Jiang Y, Zhao Y, Zhu X, Liu Y, Wu B, Guo Y, Liu B and Zhang X: Effects of autophagy on macrophage adhesion and migration in diabetic nephropathy. Ren Fail. 41:682–690. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Wu W, Zhang M, Liu Q, Xue L, Li Y and Ou S: Piwil 2 gene transfection changes the autophagy status in a rat model of diabetic nephropathy. Int J Clin Exp Pathol. 8:10734–10742. 2015.PubMed/NCBI

41 

Ribback S, Cigliano A, Kroeger N, Pilo MG, Terracciano L, Burchardt M, Bannasch P, Calvisi DF and Dombrowski F: PI3K/AKT/mTOR pathway plays a major pathogenetic role in glycogen accumulation and tumor development in renal distal tubules of rats and men. Oncotarget. 6:13036–13048. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Huang C, Lin MZ, Cheng D, Braet F, Pollock CA and Chen XM: KCa3.1 mediates dysfunction of tubular autophagy in diabetic kidneys via PI3k/Akt/mTOR signaling pathways. Sci Rep. 6:238842016. View Article : Google Scholar : PubMed/NCBI

43 

Yang F, Qu Q, Zhao C, Liu X, Yang P, Li Z, Han L and Shi X: Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice. Biomed Pharmacother. 129:1104792020. View Article : Google Scholar : PubMed/NCBI

44 

Zhang Q, Wang X, Cao S, Sun Y, He X, Jiang B, Yu Y, Duan J, Qiu F and Kang N: Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and akt signaling pathways. Biomed Pharmacother. 128:1102452020. View Article : Google Scholar : PubMed/NCBI

45 

Li D, Lu Z, Xu Z, Ji J, Zheng Z, Lin S and Yan T: Spironolactone promotes autophagy via inhibiting PI3K/AKT/mTOR signalling pathway and reduce adhesive capacity damage in podocytes under mechanical stress. Biosci Rep. 36:e003552016. View Article : Google Scholar : PubMed/NCBI

46 

Yang P, Tian YM, Deng WX, Cai X, Liu WH, Li L and Huang HY: Sijunzi decoction may decrease apoptosis via stabilization of the extracellular matrix following cerebral ischaemia-reperfusion in rats. Exp Ther Med. 18:2805–2812. 2019.PubMed/NCBI

47 

Lee D, Lee SH, Lee M, Lee SH, Shin YJ, Lee JY, Kim H, Kim YS and Song J: Effects of Siwu decoction on chondrocyte proliferation of growth plate in adolescent rats. J Ethnopharmacol. 236:108–113. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen Y, Zheng YF, Lin XH, Zhang JP, Lin F and Shi H: <em>Dendrobium</em> mixture attenuates renal damage in rats with diabetic nephropathy by inhibiting the PI3K/Akt/mTOR pathway. Mol Med Rep 24: 590, 2021.
APA
Chen, Y., Zheng, Y.F., Lin, X.H., Zhang, J.P., Lin, F., & Shi, H. (2021). <em>Dendrobium</em> mixture attenuates renal damage in rats with diabetic nephropathy by inhibiting the PI3K/Akt/mTOR pathway. Molecular Medicine Reports, 24, 590. https://doi.org/10.3892/mmr.2021.12229
MLA
Chen, Y., Zheng, Y. F., Lin, X. H., Zhang, J. P., Lin, F., Shi, H."<em>Dendrobium</em> mixture attenuates renal damage in rats with diabetic nephropathy by inhibiting the PI3K/Akt/mTOR pathway". Molecular Medicine Reports 24.2 (2021): 590.
Chicago
Chen, Y., Zheng, Y. F., Lin, X. H., Zhang, J. P., Lin, F., Shi, H."<em>Dendrobium</em> mixture attenuates renal damage in rats with diabetic nephropathy by inhibiting the PI3K/Akt/mTOR pathway". Molecular Medicine Reports 24, no. 2 (2021): 590. https://doi.org/10.3892/mmr.2021.12229
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Y, Zheng YF, Lin XH, Zhang JP, Lin F and Shi H: <em>Dendrobium</em> mixture attenuates renal damage in rats with diabetic nephropathy by inhibiting the PI3K/Akt/mTOR pathway. Mol Med Rep 24: 590, 2021.
APA
Chen, Y., Zheng, Y.F., Lin, X.H., Zhang, J.P., Lin, F., & Shi, H. (2021). <em>Dendrobium</em> mixture attenuates renal damage in rats with diabetic nephropathy by inhibiting the PI3K/Akt/mTOR pathway. Molecular Medicine Reports, 24, 590. https://doi.org/10.3892/mmr.2021.12229
MLA
Chen, Y., Zheng, Y. F., Lin, X. H., Zhang, J. P., Lin, F., Shi, H."<em>Dendrobium</em> mixture attenuates renal damage in rats with diabetic nephropathy by inhibiting the PI3K/Akt/mTOR pathway". Molecular Medicine Reports 24.2 (2021): 590.
Chicago
Chen, Y., Zheng, Y. F., Lin, X. H., Zhang, J. P., Lin, F., Shi, H."<em>Dendrobium</em> mixture attenuates renal damage in rats with diabetic nephropathy by inhibiting the PI3K/Akt/mTOR pathway". Molecular Medicine Reports 24, no. 2 (2021): 590. https://doi.org/10.3892/mmr.2021.12229
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