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Identification of differentially expressed proteins involved in fetal scarless wound healing using a rat model of cleft lip

  • Authors:
    • Yu Yan
    • Hong Liu
    • Jiarong Yi
    • Zizi Chen
    • Jia Chen
    • Jianfei Zhang
    • Kewa Gao
    • Siqi He
    • Aijun Wang
    • Ping Jin
    • Feng Hu
    • Jianda Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China, Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China, Department of Plastic and Reconstructive Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China, Department of Burns and Plastic Surgery, The Second Hospital of South China University, Hengyang, Hunan 421000, P.R. China, Department of Surgery, Surgical Bioengineering Laboratory, University of California Davis, Sacramento, CA 95817, USA, Department of Dermatology, Hunan People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410000, P.R. China
    Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 596
    |
    Published online on: June 22, 2021
       https://doi.org/10.3892/mmr.2021.12235
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Abstract

In early pregnancy, fetal skin wounds can heal quickly and undergo a transition period from scarless healing to scar formation. The aim of the present study was to identify potential biomarkers associated with scarless repair of cleft lips, in order to determine the intrinsic factors leading to scar formation in embryonic tissue. A stable model of cleft lip was established using microsurgery by constructing a wedge‑shaped cleft lip‑like defect in fetal rats at gestational age (GA) 16.5 and GA18.5. The GA16.5 and GA18.5 groups were used to model scarless healing and scar formation, respectively. The fetuses were returned to the uterus following surgery, then removed 72 h after the procedure. Macroscopic observation of the cleft defect and histological examination were carried out. Reverse transcription‑quantitative (RT‑q) PCR and parallel reaction monitoring (PRM) were used to detect mRNA and protein expression levels, respectively. The upper‑left lip completely healed 72 h after surgery in the GA16.5 group of fetal rats. However, this was not the case in the GA18.5 group. Histological examination indicated new follicles visible under the epidermis of the scarless group (GA16.5). Scarring was visible on the upper‑left cleft lip wound of the fetal rats in the GA18.5 group. The expression of some growth and pro‑inflammatory factors, including TNF‑α, were also different between two groups. Label‑free quantification was used to identified differentially expressed proteins and five differentially expressed proteins (Smad4, Fabp5, S100a4, S100a8 and S100a9) were identified. The relative expression of these molecules at the mRNA and protein levels were measured using RT‑qPCR and PRM. These molecules may represent potential biomarkers for the scarless repair of fetal rat cleft lip wounds.
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View References

1 

VanKoevering KK, Morrison RJ, Prabhu SP, Torres MF, Mychaliska GB, Treadwell MC, Hollister SJ and Green GE: Antenatal three-dimensional printing of aberrant facial anatomy. Pediatrics. 136:e1382–e1385. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Burrington JD: Wound healing in the fetal lamb. J Pediatr Surg. 6:523–528. 1971. View Article : Google Scholar : PubMed/NCBI

3 

Beanes SR, Hu FY, Soo C, Dang CM, Urata M, Ting K, Atkinson JB, Benhaim P, Hedrick MH and Lorenz HP: Confocal microscopic analysis of scarless repair in the fetal rat: Defining the transition. Plast Reconstr Surg. 109:160–170. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Walmsley GG, Hu MS, Hong WX, Maan ZN, Lorenz HP and Longaker MT: A mouse fetal skin model of scarless wound repair. J Vis Exp. 16:522972015.

5 

Dang CM, Beanes SR, Lee H, Zhang X, Soo C and Ting K: Scarless fetal wounds are associated with an increased matrix metalloproteinase-to-tissue-derived inhibitor of metalloproteinase ratio. Plast Reconstr Surg. 111:2273–2285. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Longaker MT, Whitby DJ, Adzick NS, Crombleholme TM, Langer JC, Duncan BW, Bradley SM, Stern R, Ferguson MW and Harrison MR: Studies in fetal wound healing, VI. Second and early third trimester fetal wounds demonstrate rapid collagen deposition without scar formation. J Pediatr Surg. 25:63–69. 1990. View Article : Google Scholar : PubMed/NCBI

7 

Lorenz HP, Whitby DJ, Longaker MT and Adzick NS: Fetal wound healing. The ontogeny of scar formation in the non-human primate. Ann Surg. 217:391–396. 1993. View Article : Google Scholar : PubMed/NCBI

8 

Cass D, Bullard KM, Sylvester KG, Yang EY, Longaker MT and Adzick NS: Wound size and gestational age modulate scar formation in fetal wound repair. J Pediatr Surg. 32:411–415. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Longaker MT and Adzick NS: The biology of fetal wound healing: A review. Plast Reconstr Surg. 87:788–798. 1991. View Article : Google Scholar : PubMed/NCBI

10 

Armstrong JR and Ferguson MW: Ontogeny of the skin and the transition from scar-free to scarring phenotype during wound healing in the pouch young of a marsupial, Monodelphis domestica. Dev Biol. 169:242–260. 1995. View Article : Google Scholar : PubMed/NCBI

11 

Stern M, Dodson TB, Longaker MT, Lorenz HP, Harrison MR and Kaban LB: Fetal cleft lip repair in lambs: Histologic characteristics of the healing wound. Int J Oral Maxillofac Surg. 22:371–374. 1993. View Article : Google Scholar : PubMed/NCBI

12 

Longaker MT, Dodson TB and Kaban LB: A rabbit model for fetal cleft lip repair. J Oral Maxillofac Surg. 48:714–719. 1990. View Article : Google Scholar : PubMed/NCBI

13 

Oberg KC, Evans ML, Nguyen T, Peckham NH, Kirsch WM and Hardesty RA: Intrauterine repair of surgically created defects in mice (lip incision model) with a microclip: Preamble to endoscopic intrauterine surgery. Cleft Palate Craniofac J. 32:129–137. 1995. View Article : Google Scholar : PubMed/NCBI

14 

Hu F, Yan Y, Wang CW, Liu Y, Wang JJ, Zhou F, Zeng QH, Zhou X, Chen J, Wang AJ and Zhou JD: Article effect and mechanism of ganoderma lucidum polysaccharides on human fibroblasts and skin wound healing in mice. Chin J Integr Med. 25:203–209. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Xue YN, Yan Y, Chen ZZ, Chen J, Tang FJ, Xie HQ, Tang SJ, Cao K, Zhou X, Wang AJ and Zhou JD: LncRNA TUG1 regulates FGF1 to enhance endothelial differentiation of adipose-derived stem cells by sponging miR-143. J Cell Biochem. 120:19087–19097. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Guo H, Chen T, Liang Z, Fan L, Shen Y and Zhou D: iTRAQ and PRM-based comparative proteomic profiling in gills of white shrimp Litopenaeus vannamei under copper stress. Chemosphere. 263:1282702021. View Article : Google Scholar : PubMed/NCBI

17 

Chen PS, Li YP and Ni HF: Morphology and evaluation of renal fibrosis. Adv Exp Med Biol. 1165:17–36. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Luo Y, Yan Y, Zhang S and Li Z: Computational approach to investigating key GO terms and KEGG pathways associated with CNV. Biomed Res Int. 2018:84068572018. View Article : Google Scholar : PubMed/NCBI

19 

Dong X, Landford WN, Hart J, Risolino M, Kaymakcalan O, Jin J, Toyoda Y, Ferretti E, Selleri L and Spector JA: Toward microsurgical correction of cleft lip ex utero through restoration of craniofacial developmental programs. Plast Reconstr Surg. 140:75–85. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Stelnicki EJ, Lee S, Hoffman W, Lopoo J, Foster R, Harrison MR and Longaker MT: A long-term, controlled-outcome analysis of in utero versus neonatal cleft lip repair using an ovine model. Plast Reconstr Surg. 104:607–615. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Harling TR, Stelnicki EJ, Hedrick MH and Longaker MT: In utero models of craniofacial surgery. World J Surg. 27:108–116. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Mast BA, Haynes JH, Krummel TM, Diegelmann RF and Cohen IK: In vivo degradation of fetal wound hyaluronic acid results in increased fibroplasia, collagen deposition, and neovascularization. Plast Reconstr Surg. 89:503–509. 1992. View Article : Google Scholar : PubMed/NCBI

23 

Frantz FW, Diegelmann RF, Mast BA and Cohen IK: Biology of fetal wound healing: Collagen biosynthesis during dermal repair. J Pediatr Surg. 27:945–949. 1992. View Article : Google Scholar : PubMed/NCBI

24 

Wilgus TA: Regenerative healing in fetal skin: A review of the literature. Ostomy Wound Manage. 53:16–33. 2007.PubMed/NCBI

25 

Hu HH, Chen DQ, Wang YN, Feng YL, Cao G, Vaziri ND and Zhao YY: New insights into TGF-beta/Smad signaling in tissue fibrosis. Chem Biol Interac. 292:76–83. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Honardoust D, Ding J, Varkey M, Shankowsky HA and Tredget EE: Deep dermal fibroblasts refractory to migration and decorin-induced apoptosis contribute to hypertrophic scarring. J Burn Care Res. 33:668–677. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Wu C, Jiang J, Boye A, Jiang Y and Yang Y: Compound Astragalus and Salvia miltiorrhiza extract suppresses rabbits' hypertrophic scar by modulating the TGF-β/Smad signal. Dermatology. 229:363–368. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Furuhashi M, Ogura M, Matsumoto M, Yuda S, Muranaka A, Kawamukai M, Omori A, Tanaka M, Moniwa N, Ohnishi H, et al: Serum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages. Sci Rep. 7:2172017. View Article : Google Scholar : PubMed/NCBI

29 

Yeung DC, Wang Y, Xu A, Cheung SC, Wat NM, Fong DY, Fong CH, Chau MT, Sham PC and Lam KS: Epidermal fatty-acid-binding protein: A new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis. Eur Heart J. 29:2156–2163. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Song J, Zhang H, Wang Z, Xu W, Zhong L, Cao J, Yang J, Tian Y, Yu D, Ji J, et al: The role of FABP5 in radiation-induced human skin fibrosis. Radiat Res. 189:177–186. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Fei F, Qu J, Li C, Wang X, Li Y and Zhang S: Role of metastasis-induced protein S100A4 in human non-tumor pathophysiologies. Cell Biosci. 7:642017. View Article : Google Scholar : PubMed/NCBI

32 

Grotterød I, Maelandsmo GM and Boye K: Signal transduction mechanisms involved in S100A4-induced activation of the transcription factor NF-kappaB. BMC Cancer. 10:2412010. View Article : Google Scholar

33 

Schneider M, Kostin S, Strøm CC, Aplin M, Lyngbaek S, Theilade J, Grigorian M, Andersen CB, Lukanidin E, Lerche Hansen J and Sheikh SP: S100A4 is upregulated in injured myocardium and promotes growth and survival of cardiac myocytes. Cardiovasc Res. 75:40–50. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Tomcik M, Palumbo-Zerr K, Zerr P, Avouac J, Dees C, Sumova B, Distler A, Beyer C, Cerezo LA, Becvar R, et al: S100A4 amplifies TGF-β-induced fibroblast activation in systemic sclerosis. Ann Rheum Dis. 74:1748–1755. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Zhao YX, Ho CK, Xie Y, Chen YH, Li HZ, Zhang GY and Li QF: Calcimycin suppresses S100A4 expression and inhibits the stimulatory effect of transforming growth factor β1 on Keloid fibroblasts. Ann Plast Surg. 81:163–169. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Donato R: Intracellular and extracellular roles of S100 proteins. Microsc Res Tech. 60:540–551. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Lin H, Andersen GR and Yatime L: Crystal structure of human S100A8 in complex with zinc and calcium. BMC Struct Biol. 16:82016. View Article : Google Scholar : PubMed/NCBI

38 

Bouzidi F and Doussiere J: Binding of arachidonic acid to myeloid-related proteins (S100A8/A9) enhances phagocytic NADPH oxidase activation. Biochem Biophys Res Commun. 325:1060–1065. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Gebhardt C, Németh J, Angel P and Hess J: S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol. 72:1622–1631. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Basso D, Bozzato D, Padoan A, Moz S, Zambon CF, Fogar P, Greco E, Scorzeto M, Simonato F, Navaglia F, et al: Inflammation and pancreatic cancer: Molecular and functional interactions between S100A8, S100A9, NT-S100A8 and TGFβ1. Cell Commun Signal. 26:12–20. 2014.PubMed/NCBI

41 

Shabani F, Farasat A, Mahdavi M and Gheibi N: Calprotectin (S100A8/S100A9): A key protein between inflammation and cancer. Inflamm Res. 67:801–812. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Yaundong L, Dongyan W, Lijun H and Zhibo X: Effects of downregulation of S100A8 protein expression on cell cycle and apoptosis of fibroblasts derived from hypertrophic scars. Aesthet Surg J. 34:160–167. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Hessian PA, Edgeworth J and Hogg N: MRP-8 and MRP-14, two abundant Ca (2+)-binding proteins of neutrophils and monocytes. J Leukoc Biol. 53:197–204. 1993. View Article : Google Scholar : PubMed/NCBI

44 

Markowitz J and Carson WE III: Review of S100A9 biology and its role in cancer. Biochim Biophys Acta. 1835:100–109. 2013.PubMed/NCBI

45 

Zhong A, Xu W, Zhao J, Xie P, Jia S, Sun J, Galiano RD, Mustoe TA and Hong SJ: S100A8 and S100A9 are induced by decreased hydration in the epidermis and promote fibroblast activation and fibrosis in the dermis. Am J Pathol. 186:109–122. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yan Y, Liu H, Yi J, Chen Z, Chen J, Zhang J, Gao K, He S, Wang A, Jin P, Jin P, et al: Identification of differentially expressed proteins involved in fetal scarless wound healing using a rat model of cleft lip. Mol Med Rep 24: 596, 2021.
APA
Yan, Y., Liu, H., Yi, J., Chen, Z., Chen, J., Zhang, J. ... Zhou, J. (2021). Identification of differentially expressed proteins involved in fetal scarless wound healing using a rat model of cleft lip. Molecular Medicine Reports, 24, 596. https://doi.org/10.3892/mmr.2021.12235
MLA
Yan, Y., Liu, H., Yi, J., Chen, Z., Chen, J., Zhang, J., Gao, K., He, S., Wang, A., Jin, P., Hu, F., Zhou, J."Identification of differentially expressed proteins involved in fetal scarless wound healing using a rat model of cleft lip". Molecular Medicine Reports 24.2 (2021): 596.
Chicago
Yan, Y., Liu, H., Yi, J., Chen, Z., Chen, J., Zhang, J., Gao, K., He, S., Wang, A., Jin, P., Hu, F., Zhou, J."Identification of differentially expressed proteins involved in fetal scarless wound healing using a rat model of cleft lip". Molecular Medicine Reports 24, no. 2 (2021): 596. https://doi.org/10.3892/mmr.2021.12235
Copy and paste a formatted citation
x
Spandidos Publications style
Yan Y, Liu H, Yi J, Chen Z, Chen J, Zhang J, Gao K, He S, Wang A, Jin P, Jin P, et al: Identification of differentially expressed proteins involved in fetal scarless wound healing using a rat model of cleft lip. Mol Med Rep 24: 596, 2021.
APA
Yan, Y., Liu, H., Yi, J., Chen, Z., Chen, J., Zhang, J. ... Zhou, J. (2021). Identification of differentially expressed proteins involved in fetal scarless wound healing using a rat model of cleft lip. Molecular Medicine Reports, 24, 596. https://doi.org/10.3892/mmr.2021.12235
MLA
Yan, Y., Liu, H., Yi, J., Chen, Z., Chen, J., Zhang, J., Gao, K., He, S., Wang, A., Jin, P., Hu, F., Zhou, J."Identification of differentially expressed proteins involved in fetal scarless wound healing using a rat model of cleft lip". Molecular Medicine Reports 24.2 (2021): 596.
Chicago
Yan, Y., Liu, H., Yi, J., Chen, Z., Chen, J., Zhang, J., Gao, K., He, S., Wang, A., Jin, P., Hu, F., Zhou, J."Identification of differentially expressed proteins involved in fetal scarless wound healing using a rat model of cleft lip". Molecular Medicine Reports 24, no. 2 (2021): 596. https://doi.org/10.3892/mmr.2021.12235
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