Expression levels of specific microRNAs are increased after exercise and are associated with cognitive improvement in Parkinson's disease

Da Silva,Franciele Cascaes; Da Silva,Franciele Cascaes; Da Silva,Franciele Cascaes; Rode,Michele Patrícia; Rode,Michele Patrícia; Rode,Michele Patrícia; Vietta,Giovanna Grunewald; Vietta,Giovanna Grunewald; Vietta,Giovanna Grunewald; Iop,Rodrigo Da Rosa; Iop,Rodrigo Da Rosa; Iop,Rodrigo Da Rosa; Creczynski‑Pasa,Tânia Beatriz; Creczynski‑Pasa,Tânia Beatriz; Creczynski‑Pasa,Tânia Beatriz; Martin,Alessandra Swarowsky; Martin,Alessandra Swarowsky; Martin,Alessandra Swarowsky; Da Silva,Rudney; Da Silva,Rudney; Da Silva,Rudney

doi:10.3892/mmr.2021.12257

Expression levels of specific microRNAs are increased after exercise and are associated with cognitive improvement in Parkinson's disease

Authors:
- Franciele Cascaes Da Silva
- Michele Patrícia Rode
- Giovanna Grunewald Vietta
- Rodrigo Da Rosa Iop
- Tânia Beatriz Creczynski‑Pasa
- Alessandra Swarowsky Martin
- Rudney Da Silva
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Affiliations: Center for Health Sciences and Sports, Adapted Physical Activity Laboratory, Santa Catarina State University, Florianópolis, Santa Catarina 88080‑350, Brazil, Pharmaceutical Sciences Department, Federal University of Santa Catarina, Florianópolis, Santa Catarina 88010‑970, Brazil, Nucleus of Epidemiology, University of Southern Santa Catarina, Palhoça, Santa Catarina 88137‑270, Brazil, Center for Health and Sport Sciences, Physical Therapy Department, Santa Catarina State University, Florianópolis, Santa Catarina 88080‑350, Brazil
Published online on: June 29, 2021 https://doi.org/10.3892/mmr.2021.12257
Article Number: 618
Copyright: © Da Silva et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

There is a consensus regarding the efficacy of physical exercise in maintaining or improving human health; however, there are few studies examining the effect of physical exercise on the expression levels of microRNAs (miRNA/miRs) in Parkinson's disease (PD). The aim of the present study was to investigate the effects of an interval training program on a cycle ergometer on the expression levels of miR‑106a‑5p, miR‑103a‑3p and miR‑29a‑3p in serum samples from men with PD. This was a quasi‑experimental study with pre‑ and post‑testing and with a non‑equivalent group design. The participants were selected based on the eligibility criteria and subsequently classified into two groups: Experimental group and control group. The evaluations were performed at the beginning of the study (week 0) and after 8 weeks of the intervention program (week 9). The interval training program was performed on a cycle ergometer for 30 min, three times a week during an 8‑week period. The expression levels of miR‑106a‑5p, miR‑103a‑3p and miR‑29a‑3p in the experimental group were increased after physical exercise and were associated with cognitive improvement in men with PD. However, further studies are required to clarify the potential use of these circulating miRNAs as markers of adaptation to physical exercise. Collectively, the present results indicated that these three miRNAs may be associated with the exercise response and cognitive improvement in men with PD.

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