Chloride intracellular channels as novel biomarkers for digestive system tumors (Review)

  • Authors:
    • Hui Wang
    • Jiaxing An
    • Suyu He
    • Chengcheng Liao
    • Juan Wang
    • Biguang Tuo
  • View Affiliations

  • Published online on: July 5, 2021     https://doi.org/10.3892/mmr.2021.12269
  • Article Number: 630
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Abstract

Digestive system malignant tumors are common tumors, and the traditional treatment methods for these tumors include surgical resection, radiotherapy, chemotherapy, and molecularly targeted drugs. However, diagnosis remains challenging, and the early detection of postoperative recurrence is complicated. Therefore, it is necessary to explore novel biomarkers to facilitate clinical diagnosis and treatment. Accumulating evidence supports the crucial role of chloride channels in the development of multiple types of cancers. Given that chloride channels are widely expressed and involved in cell proliferation, apoptosis and cell cycle, among other processes, they may serve as a promising diagnostic and therapeutic target. Chloride intracellular channels (CLICs) are a class of chloride channels that are upregulated or downregulated in certain types of cancer. Furthermore, in certain cases, during cell cycle progression, the localization and function of the cytosolic form of the transmembrane proteins of CLICs are also altered, which may provide a key target for cancer therapy. The aim of the present review was to focus on CLICs as biomarkers for digestive system tumors.
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September-2021
Volume 24 Issue 3

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Online ISSN:1791-3004

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Spandidos Publications style
Wang H, An J, He S, Liao C, Wang J and Tuo B: Chloride intracellular channels as novel biomarkers for digestive system tumors (Review). Mol Med Rep 24: 630, 2021
APA
Wang, H., An, J., He, S., Liao, C., Wang, J., & Tuo, B. (2021). Chloride intracellular channels as novel biomarkers for digestive system tumors (Review). Molecular Medicine Reports, 24, 630. https://doi.org/10.3892/mmr.2021.12269
MLA
Wang, H., An, J., He, S., Liao, C., Wang, J., Tuo, B."Chloride intracellular channels as novel biomarkers for digestive system tumors (Review)". Molecular Medicine Reports 24.3 (2021): 630.
Chicago
Wang, H., An, J., He, S., Liao, C., Wang, J., Tuo, B."Chloride intracellular channels as novel biomarkers for digestive system tumors (Review)". Molecular Medicine Reports 24, no. 3 (2021): 630. https://doi.org/10.3892/mmr.2021.12269