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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
September-2021 Volume 24 Issue 3

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Distinct effects of different doses of kaempferol on D‑GalN/LPS‑induced ALF depend on the autophagy pathway

Yuan Tian, Feng Ren, Ling Xu, Xiangying Zhang
Article Number: 682
Published online on: 27 July 2021

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Article

Senescent RAW264.7 cells exhibit increased production of nitric oxide and release inducible nitric oxide synthase in exosomes

Hirokazu Hattori, Kazuki Takaoka, Miho Ueta, Masayuki Oshitani, Joji Tamaoka, Kazuma Noguchi, Hiromitsu Kishimoto
Article Number: 681
Published online on: 27 July 2021

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Review

Effects of calcium‑permeable ion channels on various digestive diseases in the regulation of autophagy (Review)

Jun Lou, Xiaoxu Yang, Weixi Shan, Zhe Jin, Jianhong Ding, Yanxia Hu, Qiushi Liao, Qian Du, Rui Xie, Jingyu Xu
Article Number: 680
Published online on: 26 July 2021

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Retraction Open Access

[Retracted] Talen‑mediated girdin knockout downregulates cell proliferation, migration and invasion in human esophageal carcinoma ECA109 cells

Ke Cao, Wenting Jiang, Peiguo Cao, Qiong Zou, Sheng Xiao, Jianda Zhou, Chenghui Huang
Article Number: 679
Published online on: 23 July 2021

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Article

Preliminary results of targeted sequencing of BRCA1 and BRCA2 in a cohort of breast cancer families: New insight into pathogenic variants in patients and at‑risk relatives

Marwa H. Saied, Dalal Elkaffash, Reham Fadl, Reham Abdel Haleem, Amal Refeat, Inas Ibrahim, Mona Tahoun, Alyaa Elkayal, Eman Tayae
Article Number: 678
Published online on: 23 July 2021

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Review Open Access

Claudin 6: Therapeutic prospects for tumours, and mechanisms of expression and regulation (Review)

Huan Du, Xiyue Yang, Jinjia Fan, Xiaobo Du
Article Number: 677
Published online on: 23 July 2021

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Article Open Access

Sacubitril/valsartan (LCZ696) reduces myocardial injury following myocardial infarction by inhibiting NLRP3‑induced pyroptosis via the TAK1/JNK signaling pathway

Jianfen Shen, Zhongbao Fan, Guang Sun, Guoxian Qi
Article Number: 676
Published online on: 23 July 2021

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Article Open Access

miR‑140‑5p alleviates mouse liver ischemia/reperfusion injury by targeting CAPN1

Qiwen Yu, Sanyang Chen, Hongwei Tang, Han Yang, Jiakai Zhang, Xiaoyi Shi, Jie Li, Wenzhi Guo, Shuijun Zhang
Article Number: 675
Published online on: 22 July 2021

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Article Open Access

Salusin‑β participates in high glucose‑induced HK‑2 cell ferroptosis in a Nrf‑2‑dependent manner

Wen-Juan Wang, Xia Jiang, Chang-Chun Gao, Zhi-Wei Chen
Article Number: 674
Published online on: 22 July 2021

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Correction Open Access

[Corrigendum] miR‑592 acts as an oncogene and promotes medullary thyroid cancer tumorigenesis by targeting cyclin‑dependent kinase 8

Ting Liu, Jingjing Meng, Yu Zhang
Article Number: 673
Published online on: 22 July 2021

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Article Open Access

Dimethyl itaconate inhibits LPS‑induced microglia inflammation and inflammasome‑mediated pyroptosis via inducing autophagy and regulating the Nrf‑2/HO‑1 signaling pathway

Su Yang, Xingxing Zhang, Hengli Zhang, Xiangxiang Lin, Xijun Chen, Ying Zhang, Xiao Lin, Lijie Huang, Qichuan Zhuge
Article Number: 672
Published online on: 21 July 2021

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Article Open Access

SOD2 overexpression in bone marrow‑derived mesenchymal stem cells ameliorates hepatic ischemia/reperfusion injury

Qiuyun Li, Wei Zhang, Enhua Xiao
Article Number: 671
Published online on: 21 July 2021

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Retraction Open Access

[Retracted] Small interfering RNA‑induced silencing of galectin‑3 inhibits the malignant phenotypes of osteosarcoma in vitro

Pengfei Lei, Hongbo He, Yihe Hu, Zhan Liao
Article Number: 670
Published online on: 21 July 2021

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Correction Open Access

[Corrigendum] Novel markers of human ovarian granulosa cell differentiation toward osteoblast lineage: A microarray approach

Maciej Brązert, Wiesława Kranc, Piotr Celichowski, Katarzyna Ożegowska, Joanna Budna‑Tukan, Michal Jeseta, Leszek Pawelczyk, Małgorzata Bruska, Maciej Zabel, Michał Nowicki, Bartosz Kempisty
Article Number: 669
Published online on: 21 July 2021

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Article Open Access

Transcriptional activation of ENPP2 by FoxO4 protects cardiomyocytes from doxorubicin‑induced toxicity

Ling He, Yuting Yang, Juan Chen, Pengtao Zou, Juxiang Li
Article Number: 668
Published online on: 20 July 2021

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Article Open Access

Upregulation of miR‑128 inhibits neuronal cell apoptosis following spinal cord injury via FasL downregulation by repressing ULK1

Ruixuan Liu, Zhibin Peng, Yubo Zhang, Rui Li, Yansong Wang
Article Number: 667
Published online on: 20 July 2021

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Article Open Access

MicroRNA‑93 inhibits the apoptosis and inflammatory response of tubular epithelial cells via the PTEN/AKT/mTOR pathway in acute kidney injury

Yaping Zhan, Minxia Zhu, Shang Liu, Jiayue Lu, Zhaohui Ni, Hong Cai, Weiming Zhang
Article Number: 666
Published online on: 20 July 2021

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Article

Protein tyrosine phosphatase 1B inhibition improves endoplasmic reticulum stress‑impaired endothelial cell angiogenic response: A critical role for cell survival

Shahenda S. Abdelsalam, Mazhar Pasha, Heba El‑Gamal, Maram Hasan, Mohamed A. Elrayess, Asad Zeidan, Hesham M. Korashy, Abdelali Agouni
Article Number: 665
Published online on: 20 July 2021

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Article

miR‑34a increases inflammation and oxidative stress levels in patients with necrotizing enterocolitis by downregulating SIRT1 expression

Hui Zhu, Yan Lin, Yongle Liu
Article Number: 664
Published online on: 20 July 2021

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Review Open Access

Ghrelin and its role in gastrointestinal tract tumors (Review)

Irene Alexandra Spiridon, Delia Gabriela Apostol Ciobanu, Simona Eliza Giușcă, Irina Draga Căruntu
Article Number: 663
Published online on: 19 July 2021

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Article

Effect of intestinal microbiota imbalance associated with chronic hepatitis B virus infection on the expression of microRNA‑192 and GLP‑1

Yinghui Liu
Article Number: 662
Published online on: 19 July 2021

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Article Open Access

Dexmedetomidine alleviates early brain injury following traumatic brain injury by inhibiting autophagy and neuroinflammation through the ROS/Nrf2 signaling pathway

Xiaoyan Feng, Weiwei Ma, Jie Zhu, Wei Jiao, Yuhai Wang
Article Number: 661
Published online on: 18 July 2021

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Retraction Open Access

[Retracted] PAX6, a novel target of miR-335, inhibits cell proliferation and invasion in glioma cells

Quan Cheng, Hui Cao, Zigui Chen, Zhiming Ma, Xin Wan, Renjun Peng, Bing Jiang
Article Number: 660
Published online on: 16 July 2021

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Retraction Open Access

[Retracted] MicroRNA‑148a inhibits migration and invasion of ovarian cancer cells via targeting sphingosine‑1‑phosphate receptor 1

Zhengfang Wen, Shuzhen Zhao, Shanshan Liu, Ying Liu, Xiaorui Li, Shaoru Li
Article Number: 659
Published online on: 15 July 2021

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Article

Tacrolimus inhibits insulin release and promotes apoptosis of Min6 cells through the inhibition of the PI3K/Akt/mTOR pathway

Ling Tong, Weiliang Li, Ying Zhang, Fan Zhou, Yan Zhao, Linlin Zhao, Jing Liu, Zhirui Song, Mengchen Yu, Chengrui Zhou, Airong Yu
Article Number: 658
Published online on: 15 July 2021

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Article Open Access

Blockage of Drp1 phosphorylation at Ser579 protects neurons against Aβ1‑42‑induced degeneration

Dan Xu, Ping Yang, Zhang-Jian Yang, Qiu-Gen Li, Ye-Tong Ouyang, Ting Yu, Jian-Hui Shangguan, Yu-Ying Wan, Li-Ping Jiang, Xin-Hui Qu, Xiao-Jian Han
Article Number: 657
Published online on: 15 July 2021

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Correction Open Access

[Corrigendum] Integrated transcriptomic and epigenetic data analysis identifies aberrant expression of genes in acute myeloid leukemia with MLL‑AF9 translocation

Fangce Wang, Zheng Li, Guangming Wang, Xiaoxue Tian, Jie Zhou, Wenlei Yu, Zhuoyi Fan, Lin Dong, Jinyuan Lu, Jun Xu, Wenjun Zhang, Aibin Liang
Article Number: 656
Published online on: 15 July 2021

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Retraction Open Access

[Retracted] MicroRNA‑148a inhibits the proliferation and promotes the paclitaxel‑induced apoptosis of ovarian cancer cells by targeting PDIA3

Shuzhen Zhao, Zhengfang Wen, Shanshan Liu, Ying Liu, Xiaorui Li, Yanna Ge, Shaoru Li
Article Number: 655
Published online on: 14 July 2021

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Article Open Access

hsa_circ_0101119 facilitates the progression of cervical cancer via an interaction with EIF4A3 to inhibit TCEAL6 expression

Xuezuo Sui, Yanchun Wang, Hui Liu
Article Number: 654
Published online on: 14 July 2021

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Article Open Access

Protective effect of taurine on sepsis‑induced lung injury via inhibiting the p38/MAPK signaling pathway

Jiao Chen, Xiang Xue, Jianqin Cai, Ling Jia, Baodi Sun, Wei Zhao
Article Number: 653
Published online on: 14 July 2021

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Article Open Access

Psoralen inhibits the inflammatory response and mucus production in allergic rhinitis by inhibiting the activator protein 1 pathway and the downstream expression of cystatin‑SN

Wenying Gao, Zhenglong Jin, Yanxia Zheng, Youjia Xu
Article Number: 652
Published online on: 14 July 2021

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Article Open Access

FOXG1 improves mitochondrial function and promotes the progression of nasopharyngeal carcinoma

Huajun Xi, Zhengxiang He, Cao Lv
Article Number: 651
Published online on: 14 July 2021

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Article Open Access

Identification and validation of EPHX2 as a prognostic biomarker in hepatocellular carcinoma

Ke Zhan, Yang Bai, Shengtao Liao, Hongyu Chen, Lili Kuang, Qingqing Luo, Lin Lv, Liewang Qiu, Zhechuan Mei
Article Number: 650
Published online on: 13 July 2021

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Article

Long non‑coding RNA DANCR represses the viability, migration and invasion of multiple myeloma cells by sponging miR‑135b‑5p to target KLF9

Linlin Wu, Liang Xia, Huimin Jiang, Yue Hu, Lingling Li, Li Xu, Ruixiang Xia
Article Number: 649
Published online on: 13 July 2021

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Review Open Access

Regulation of pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway (Review)

Qingtao Zhang, Jian Yu, Qiuqiu Chen, Honghai Yan, Hongjiang Du, Wenjing Luo
Article Number: 648
Published online on: 13 July 2021

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Article Open Access

FBXL19‑AS1 promotes the progression of nasopharyngeal carcinoma by acting as a competing endogenous RNA to sponge miR‑431 and upregulate PBOV1

Hongjun Dong, Chao Huang, Jingjing Huang
Article Number: 647
Published online on: 12 July 2021

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Article Open Access

Map of dimorphic switching‑related signaling pathways in Sporothrix schenckii based on its transcriptome

Fangliang Zheng, Wei Gao, Ying Wang, Qingyan Chen, Qiuling Zhang, Xiuyan Jiang, Binbin Hou, Zhenying Zhang
Article Number: 646
Published online on: 12 July 2021

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Article

Asiaticoside reduces autophagy and improves memory in a rat model of dementia through mTOR signaling pathway regulation

Min Guo, Jianmeng Xu, Shiwei Wang, Baohua Dong
Article Number: 645
Published online on: 12 July 2021

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Correction Open Access

[Corrigendum] Cryptotanshinone inhibits IgE‑mediated degranulation through inhibition of spleen tyrosine kinase and tyrosine‑protein kinase phosphorylation in mast cells

Sumiyasuren Buyanravjikh, Sora Han, Sunyi Lee, Ae Lee Jeong, Hye In Ka, Ji Young Park, Ariundavaa Boldbaatar, Jong-Seok Lim, Myeong-Sok Lee, Young Yang
Article Number: 644
Published online on: 12 July 2021

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Article

Lycium barbarum polysaccharides attenuate cardiovascular oxidative stress injury by enhancing the Keap1/Nrf2 signaling pathway in exhaustive exercise rats

Xiaohui Hu, Le Mu, Lingqin Zhu, Xiaoyu Chang, Lihong Nie, Li Wang, Guanghua Li
Article Number: 643
Published online on: 11 July 2021

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Article Open Access

Expression of TCF3 in Wilms' tumor and its regulatory role in kidney tumor cell viability, migration and apoptosis in vitro

Nian Zhou, Bing Yan, Jing Ma, Hongchao Jiang, Li Li, Haoyu Tang, Fengming Ji, Zhigang Yao
Article Number: 642
Published online on: 11 July 2021

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Retraction Open Access

[Retracted] miR‑22 inhibits proliferation and invasion in estrogen receptor α‑positive endometrial endometrioid carcinomas cells

Shaoru Li, Ruili Hu, Chuanhong Wang, Fang Guo, Xiaoli Li, Shijin Wang
Article Number: 641
Published online on: 09 July 2021

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Retraction Open Access

[Retracted] microRNA‑206 overexpression inhibits cellular proliferation and invasion of estrogen receptor α‑positive ovarian cancer cells

Shaoru Li, Yan Li, Zhengfang Wen, Fanjing Kong, Xinlei Guan, Wenhui Liu
Article Number: 640
Published online on: 09 July 2021

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Retraction Open Access

[Retracted] microRNA‑335 inhibits proliferation, cell‑cycle progression, colony formation, and invasion via targeting PAX6 in breast cancer cells

Yuanbiao Meng, Quanqing Zou, Tianqi Liu, Xiaoyong Cai, Yubin Huang, Jinfei Pan
Article Number: 639
Published online on: 09 July 2021

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Article Open Access

Cinnamaldehyde inhibits psoriasis‑like inflammation by suppressing proliferation and inflammatory response of keratinocytes via inhibition of NF‑κB and JNK signaling pathways

Zhenzhen Ding, Jingjing Liu, Huangjing Qian, Lingjian Wu, Mingfen Lv
Article Number: 638
Published online on: 07 July 2021

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Article Open Access

Hypoxia‑induced lactate dehydrogenase A protects cells from apoptosis in endometriosis

Jinyan Zheng, Yongdong Dai, Xiang Lin, Qianmeng Huang, Libing Shi, Xiaoying Jin, Na Liu, Feng Zhou, Songying Zhang
Article Number: 637
Published online on: 06 July 2021

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Article Open Access

Interactions between the ERK1/2 signaling pathway and PCAF play a key role in PE‑induced cardiomyocyte hypertrophy

Qian Mao, Shuqi Wu, Chang Peng, Bohui Peng, Xiaomei Luo, Lixin Huang, Huanting Zhang
Article Number: 636
Published online on: 06 July 2021

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Article Open Access

Chemokine CCL20 promotes the paclitaxel resistance of CD44+CD117+ cells via the Notch1 signaling pathway in ovarian cancer

Min Chen, Juan Su, Chunmei Feng, Ying Liu, Li Zhao, Yongjie Tian
Article Number: 635
Published online on: 06 July 2021

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Article Open Access

Sirt3 promotes the autophagy of HK‑2 human proximal tubular epithelial cells via the inhibition of Notch‑1/Hes‑1 signaling

Ying Wang, Jiang Chang, Zi-Qiang Wang, Ying Li
Article Number: 634
Published online on: 06 July 2021

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Article Open Access

miR‑3613‑3p/MAP3K2/p38/caspase‑3 pathway regulates the heat‑stress‑induced apoptosis of endothelial cells

Jie Liu, Siya Xu, Shixin Liu, Bingguan Chen
Article Number: 633
Published online on: 06 July 2021

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Article Open Access

ZIC2 upregulates lncRNA SNHG12 expression to promote endometrial cancer cell proliferation and migration by activating the Notch signaling pathway

Pengyu Cai, Gaijuan Li, Mingxiu Wu, Bin Zhang, Hong Bai
Article Number: 632
Published online on: 05 July 2021

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Article Open Access

Whole‑genome identification and systematic analysis of lncRNA‑mRNA co‑expression profiles in patients with cutaneous basal cell carcinoma

Jiaan Zhang, Xuyue Zhou, Chenpu Zhu, Yu Hu, Rong Li, Shuang Jin, Dan Huang, Mei Ju, Kun Chen, Chao Luan
Article Number: 631
Published online on: 05 July 2021

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Review

Chloride intracellular channels as novel biomarkers for digestive system tumors (Review)

Hui Wang, Jiaxing An, Suyu He, Chengcheng Liao, Juan Wang, Biguang Tuo
Article Number: 630
Published online on: 05 July 2021

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Article Open Access

Oxaliplatin promotes siMAD2L2‑induced apoptosis in colon cancer cells

Lu Ma, Xin Li, Xiaopeng Zhao, Haotong Sun, Feifei Kong, Yuanjie Li, Yu Sui, Fang Xu
Article Number: 629
Published online on: 05 July 2021

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Correction Open Access

[Corrigendum] Lentivirus‑mediated RNA interference of clusterin enhances the chemosensitivity of EJ bladder cancer cells to epirubicin in vitro

Jian Lu, Jun-Hang Luo, Jian Pang, Jia-Zheng Cao, Rong-Hai Wu, Zhu-Ting Tong, Wei Chen, Dan Xie
Article Number: 628
Published online on: 01 July 2021

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Article Open Access

MicroRNA‑199a‑5p regulates FOXC2 to control human vascular smooth muscle cell phenotypic switch

Yushi Cao, Zhongwen Cao, Weitie Wang, Xiangyu Jie, Lei Li
Article Number: 627
Published online on: 01 July 2021

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Correction Open Access

[Erratum] Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review)

Ying Li, Jinming Wang, Weiliang Zhong
Article Number: 626
Published online on: 30 June 2021

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Article Open Access

Differences in TNF‑α and TNF‑R1 expression in damaged neurons and activated astrocytes of the hippocampal CA1 region between young and adult gerbils following transient forebrain ischemia

Choong Hyun Lee, Ji Hyeon Ahn, Bai Hui Chen, Dae Won Kim, Hyejin Sim, Tae-Kyeong Lee, Joon Ha Park, Moo-Ho Won, Soo Young Choi
Article Number: 625
Published online on: 30 June 2021

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Article Open Access

Effect of Tongfu Xingshen capsule on the endogenous neural stem cells of experimental rats with intracerebral hemorrhage

Zhizhong Cui, Shanshan Liu, Lingbo Hou, Yifan Sun, Haoxuan Chen, Hui Mao, Yuanqi Zhao, Lijun Qiao
Article Number: 624
Published online on: 30 June 2021

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Article Open Access

Inhibitory effect of gefitinib derivative LPY‑9 on human glioma

Yuchen Sun, Liangzhao Chu, Huijuan Wang, Han Peng, Jian Liu
Article Number: 623
Published online on: 30 June 2021

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Article Open Access

Interference with KCNJ2 inhibits proliferation, migration and EMT progression of apillary thyroid carcinoma cells by upregulating GNG2 expression

Siyuan Chen, Miaoming Huang, Xiarong Hu
Article Number: 622
Published online on: 30 June 2021

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Article Open Access

Protective effects of the knockdown of lncRNA AK139328 against oxygen glucose deprivation/reoxygenation-induced injury in PC12 cells

Liyan Liu, Bin Zheng, Zhaoxia Wang
Article Number: 621
Published online on: 30 June 2021

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Correction Open Access

[Corrigendum] 20(s)‑ginseonside‑Rg3 modulation of AMPK/FoxO3 signaling to attenuate mitochondrial dysfunction in a dexamethasone‑injured C2C12 myotube‑based model of skeletal atrophy in vitro

Manying Wang, Rui Jiang, Jianzeng Liu, Xiaohao Xu, Guang Sun, Daqing Zhao, Liwei Sun
Article Number: 620
Published online on: 30 June 2021

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Long non‑coding RNA HOTTIP enhances the fibrosis of lung tissues by regulating the miR‑744‑5p/PTBP1 signaling axis

Jing Li, Wenshu Chai, Zhuo Zhao, Yan Zhou, Qi Wu
Article Number: 619
Published online on: 30 June 2021

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February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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ISX promotes tumor migration and invasion in lung cancer by upregulating COL1A1 in vitro

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Article Number: 77
Published online on: 31 December 2025

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Role and mechanism of miR‑222‑5p in endothelial cell apoptosis

Shimeng Wang, Boxin Zhao, Ying Cui, Lin Gui, Jingyao Fan, Lijuan Huang
Article Number: 76
Published online on: 31 December 2025

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[Expression of Concern] MicroRNA-29c inhibits proliferation and promotes apoptosis in non-small cell lung cancer cells by targeting VEGFA

Shijuan Zhan, Chunfeng Wang, Fangqing Yin
Article Number: 75
Published online on: 22 December 2025

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Melatonin induces autophagy in neuroblastoma by alleviating Pak2‑mediated endoplasmic reticulum stress

Qian-Qi Qiu, Na Zhang, Ying-Yi Xu, Jing-Wen Qin, Gao-Feng Yu, Xing-Rong Song
Article Number: 74
Published online on: 22 December 2025

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ST3Gal1 modulates intestinal barrier function and impacts human ulcerative colitis

Yin Tian, Yun Liu, Yangyang Shang, Lijian Ran, Li Liu, Rongquan Wang, Jun Ye
Article Number: 73
Published online on: 18 December 2025

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Mechanistic study of miR‑369‑3p in regulating the Wnt/β‑catenin signaling pathway via targeting SPTBN1 in inflammatory response and bone destruction of rheumatoid arthritis

Aihong Wu, Yuan Wang, Feifei Liu, Zhoufang Cao, Shuhui Du, Mengyu Sun
Article Number: 72
Published online on: 18 December 2025

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CACNB1 alleviates mepivacaine‑induced myocardial ischemia/reperfusion injury by promoting Nrf2 nuclear translocation

Qingbo Shao, Ji Zhang, Huaying Wang
Article Number: 71
Published online on: 17 December 2025

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[Expression of Concern] Effects of cullin 4B on the proliferation and invasion of human gastric cancer cells

Feng He, Xiu-Mei Cheng, Wen-Long Gu
Article Number: 70
Published online on: 17 December 2025

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Aggravated effects of human parvovirus B19 NS1 protein on bleomycin‑induced pulmonary fibrosis

Tsai-Ching Hsu, Chih-Chen Tzang, Chia-Wei Kuo, Zhi-Han Wen, Der-Yuan Chen, Bor-Show Tzang
Article Number: 69
Published online on: 16 December 2025

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Advances regarding the mechanism of endoplasmic reticulum stress in diabetic kidney disease and pharmacological interventions (Review)

Pai Zhang, Yabin Cui, Chunyan Liu, Chengji Cui, Shoulin Zhang, Yue Zhang, Fan Li
Article Number: 68
Published online on: 16 December 2025

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[Retracted] N‑Myc downstream‑regulated gene 2 suppresses the proliferation of T24 human bladder cancer cells via induction of oncosis

Jie Huang, Zhou Wu, Guangxiu Wang, Yingxian Cai, Minshan Cai, Yaozhang Li
Article Number: 67
Published online on: 15 December 2025

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Deciphering epigenetic regulation in cardiac developmental toxicity: Mechanisms and implications (Review)

Ziling Qin, Ranran Chen, Dianrong Song
Article Number: 66
Published online on: 11 December 2025

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Gut microbiota as a multifaceted modulator of prostate cancer: Mechanistic insights, therapeutic opportunities and clinical challenges (Review)

Zhenming Hao, Yongqiang Xie, Ru Zhang, Hui Sang, Luxi Li, Yulin Liu, Jinbo Hu, Jijun Wang, Keqiang Chai, Qiang Zhao
Article Number: 65
Published online on: 11 December 2025

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[Expression of Concern] lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis

Yi Han, Xiaoyan Wang, Enqiang Mao, Boyong Shen, Liang Huang
Article Number: 64
Published online on: 10 December 2025

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Influence and treatment of insulin receptor substrate/PI3K/Akt‑mediated insulin resistance in diabetes mellitus (Review)

Weikang Tang, Huixia Liu, Xuan Li, Siyao Deng, Changyu Gao
Article Number: 63
Published online on: 09 December 2025

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[Retracted] Long non‑coding RNA ANRIL knockdown suppresses apoptosis and pro‑inflammatory cytokines while enhancing neurite outgrowth via binding microRNA‑125a in a cellular model of Alzheimer’s disease

Bingling Zhou, Lijuan Li, Xin Qiu, Jiashun Wu, Lei Xu, Wei Shao
Article Number: 62
Published online on: 08 December 2025

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Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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Article

MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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March-2026 Volume 33 Issue 3

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Advances in the mechanisms of the NLRP3 inflammasome in sepsis‑induced cardiomyopathy and targeted therapeutic studies 
(Review)

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Article Number: 98
Published online on: 22 January 2026

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HMGN2 induces pyroptosis in tumour cells by modulating the STT3B/PD‑L1/caspase‑1/GSDMD axis

Wenwen Han, Hongli Chen, Bomiao Cui, Jiao Chen, Ping Zhang, Yun Feng
Article Number: 97
Published online on: 22 January 2026

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Naringin ameliorates intestinal injury in ulcerative colitis model mice by modulating the JAK2/STAT3 signaling pathway

Miaomiao Wu, Yating An, Yongmin Li, Wei He, Ying Wang, Yaqi Wang, Caixia Wu
Article Number: 96
Published online on: 22 January 2026

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PDX1 in human cancers: Molecular mechanisms, dual roles and clinical implications (Review)

Chen Zhou, Yifei Wang, Jie Zhao, Yantao Yang, Yuhang Yuan, Xiaochen Hou, Yu Tang, Lianhua Ye
Article Number: 95
Published online on: 22 January 2026

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[Retracted] Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species

Uddin Md Nazim, Honghua Yin, Sang-Youel Park
Article Number: 94
Published online on: 19 January 2026

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Converting ‘cold’ to ‘hot’ hepatocellular carcinoma for improved immunotherapy (Review)

Ching-Hua Hsieh, Pei-Chin Chuang
Article Number: 93
Published online on: 15 January 2026

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Pathological mechanism of ferroptosis in a rat model of α‑naphthyl isothiocyanate‑induced chronic cholestasis

Zhen Guo, Jiaxuan Wang, Yiwen Wang, Xinzhu Liu, Yubing Xia, Ping Liu, Li Qi, Jia Liu, Xiaoning Wang
Article Number: 92
Published online on: 14 January 2026

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[Corrigendum] Role of hypoxia‑inducible factor‑1α and CD146 in epidermal growth factor receptor‑mediated angiogenesis in salivary gland adenoid cystic carcinom

Wei-Ming Wang, Zhi-Li Zhao, Wen-Feng Zhang, Yi-Fang Zhao, Lu Zhang, Zhi-Jun Sun
Article Number: 91
Published online on: 13 January 2026

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Klebsiella pneumoniae and pyogenic liver abscess: Emerging clinical threats, virulence mechanisms and therapeutic strategies (Review)

Gulam Mustafa Hasan, Taj Mohammad, Sobia Zaidi, Anas Shamsi, Sukhwinder Singh Sohal, Md. Imtaiyaz Hassan
Article Number: 90
Published online on: 13 January 2026

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Collagen III regulates the termination of liver regeneration by suppressing hepatocyte proliferation and promoting functional recovery

Haiyang Peng, Zhiyong Chen, Qiwei Zhang, Yuezhou Zhang, Peng Yang, Jianping Gong, Andong Zhao
Article Number: 89
Published online on: 13 January 2026

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Application of extracellular vesicles in the diagnosis and treatment of chronic obstructive pulmonary disease (Review)

Yixin Zhang, Tong Ren, Jianbo Xue, Yan Yu, Xianqiang Zhou, Xiaoyi Hu, Wenyi Yu, Zhancheng Gao, Cuiling Feng
Article Number: 88
Published online on: 13 January 2026

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Cigarette smoke combined with Klebsiella pneumoniae induce damage to the air‑blood barrier in chronic obstructive pulmonary disease rats via the MAPK/NF‑κB/IκBα pathway

Yange Tian, Kexin Xu, Ruilong Lu, Kangchen Li, Xuejie Shao, Yixi Liao, Yakun Zhao, Zhiguang Qiu, Haoran Dong, Xuefang Liu
Article Number: 87
Published online on: 12 January 2026

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[Retracted] 8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells

Qing Ding, Yi Chen, Qing Zhang, Yanling Guo, Zhi Huang, Liqing Dai, Sudan Cao
Article Number: 86
Published online on: 12 January 2026

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Anxiety‑induced overactive bladder: The role of oxidative stress and NF‑κB signaling pathway with Hsp90 as a potential biomarker

Zhipeng Zhou, Lina Xu, Han Wu, Huaishan Hong
Article Number: 85
Published online on: 12 January 2026

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Echinacoside alleviates asthenozoospermia by upregulating Sox5‑mediated transcriptional activation of the CatSper gene

Zi-Run Jin, Yong-Wei Huo, Bo-Heng Liu, Hong Tian, Shuo Yuan, Yue Tian, Ke Xi, Jie Cai, Hui Jiang, Yong Jiang, Guo-Gang Xing
Article Number: 84
Published online on: 12 January 2026

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Artemisiae Scopariae Herba (Yinchen) suppresses ferroptosis in mice with osteoporosis via the Nrf2/Slc7a11/Gpx4 pathway

Pei Li, Xinyu Wan, Wenjie Li, Ding Cheng, Ying Yang, Yuhan Wang, Ruyuan Zhu, Yanjing Chen, Haixia Liu, Zhiguo Zhang
Article Number: 83
Published online on: 12 January 2026

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Prolyl hydroxylase domain proteins: Localization, regulation, function and their role in erythropoiesis (Review)

Yan Hou, Zhao-Hua Zhang, Wen-Qian Li, Guo-Xiong Han, Kuo Shen, You-Bang Xie
Article Number: 82
Published online on: 12 January 2026

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Therapeutic potential of saponins for allergic rhinitis: Molecular mechanisms and clinical perspectives (Review)

Bing-Yu Liang, Zi-Yue Fu, Fen-Fen Li, Ping-Ting Zhou, Zi-Hui Xie, Ke Han, Yan-Xun Han, Shan-Wen Chen, Yi Zhao, Hai-Feng Pan, Ye-Hai Liu, Yu-Chen Liu
Article Number: 81
Published online on: 07 January 2026

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Interleukin‑6 and ischemic stroke: From mechanisms to clinical prospects (Review)

Xinyue Wang, Xiaohang Zhang, Jianing Lin, Ping Lin
Article Number: 80
Published online on: 05 January 2026

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Preliminary exploration of the putative function of SF3A2 in clear cell renal cell carcinoma

Ru Chen, Jie Xu
Article Number: 79
Published online on: 05 January 2026

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[Retracted] TIPE‑2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3‑kinase/AKT signaling pathway

Lin Wang, Chen Chen, Shuzhi Feng, Jianli Tian
Article Number: 78
Published online on: 05 January 2026

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