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Cinnamaldehyde inhibits psoriasis‑like inflammation by suppressing proliferation and inflammatory response of keratinocytes via inhibition of NF‑κB and JNK signaling pathways

  • Authors:
    • Zhenzhen Ding
    • Jingjing Liu
    • Huangjing Qian
    • Lingjian Wu
    • Mingfen Lv
  • View Affiliations / Copyright

    Affiliations: Department of Dermatovenereology, Yuyao People's Hospital of Zhejiang Province, Yuyao, Zhejiang 315400, P.R. China, Department of Dermatovenereology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Operating Room, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
    Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 638
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    Published online on: July 7, 2021
       https://doi.org/10.3892/mmr.2021.12277
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Abstract

Psoriasis is a systemic immune‑mediated inflammatory disease characterized by uncontrolled keratinocyte proliferation and poor differentiation. Cinnamaldehyde (CIN) has been shown to inhibit the proliferation and inflammatory response of primary and immortalized immune cells. However, to the best of our knowledge, the role of CIN in the progression of psoriasis remains unclear. Therefore, the present study aimed to investigate the biological role of CIN in psoriasis. To mimic abnormal proliferation and differentiation in keratinocytes in vitro, normal human epidermal keratinocytes (NHEKs) were stimulated with M5 (IL‑1α, IL‑17A, IL‑22, oncostatin M and TNF‑α). The viability and proliferation of NHEKs were analyzed using Cell Counting Kit‑8 and 5‑Ethynyl‑2'‑deoxyuridine assays, respectively. Western blotting was used to analyze the expression levels of keratin 1, filaggrin and loricrin in NHEKs. The results of the present study revealed that CIN significantly inhibited the proliferation and cell cycle progression, and promoted the differentiation of M5‑stimulated NHEKs. CIN also markedly attenuated the extent of oxidative stress‑induced damage in M5‑stimulated NHEKs. Moreover, CIN ameliorated M5‑induced inflammatory injury in NHEKs, as evidenced by the decreased levels of multiple inflammatory factors. Furthermore, CIN notably downregulated the expression levels of phosphorylated (p)‑inhibitor of NF‑κB, p‑p65 and p‑JNK in M5‑stimulated NHEKs. In conclusion, the present data suggested that CIN may protect NHEKs against M5‑induced hyperproliferation and inflammatory injury via inhibition of NF‑κB and JNK signaling pathways. These results provide a novel insight on the role of CIN in psoriasis.
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View References

1 

Schleicher SM: Psoriasis: Pathogenesis, assessment, and therapeutic update. Clin Podiatr Med Surg. 33:355–366. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Nakajima K and Sano S: Mouse models of psoriasis and their relevance. J Dermatol. 45:252–263. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Lee J, Song K, Hiebert P, Werner S, Kim TG and Kim YS: Tussilagonone ameliorates psoriatic features in keratinocytes and imiquimod-induced psoriasis-like lesions in mice via NRF2 activation. J Invest Dermatol. 140:1223–1232.e4. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Girolomoni G, Strohal R, Puig L, Bachelez H, Barker J, Boehncke WH and Prinz JC: The role of IL-23 and the IL-23/T(H) 17 immune axis in the pathogenesis and treatment of psoriasis. J Eur Acad Dermatol Venereol. 31:1616–1626. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Madden SK, Flanagan KL and Jones G: How lifestyle factors and their associated pathogenetic mechanisms impact psoriasis. Clin Nutr. 39:1026–1040. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Rabeony H, Petit-Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, Jegou JF, Guillet G, Huguier V, Lecron JC, et al: Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1α, TNFα and oncostatin M. PLoS One. 9:e1019372014. View Article : Google Scholar : PubMed/NCBI

7 

Niyonsaba F, Ushio H, Nakano N, Ng W, Sayama K, Hashimoto K, Nagaoka I, Okumura K and Ogawa H: Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J Invest Dermatol. 127:594–604. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Zhang D, Wang Y, Xia Y, Huo J, Zhang Y, Yang P, Zhang Y and Wang X: Repression of miR-142-3p alleviates psoriasis-like inflammation by repressing proliferation and promoting apoptosis of keratinocytes via targeting Sema3A. Mol Cell Probes. 52:1015732020. View Article : Google Scholar : PubMed/NCBI

9 

Nguyen LTH, Ahn SH, Nguyen UT and Yang IJ: Dang-Gui-Liu-Huang Tang a traditional herbal formula, ameliorates imiquimod-induced psoriasis-like skin inflammation in mice by inhibiting IL-22 production. Phytomedicine. 47:48–57. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Hoesel B and Schmid JA: The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer. 12:862013. View Article : Google Scholar : PubMed/NCBI

11 

Matulewicz N and Karczewska-Kupczewska M: Insulin resistance and chronic inflammation. Postepy Hig Med Dosw (Online). 70:1245–1258. 2016.PubMed/NCBI

12 

Xu F, Xu J, Xiong X and Deng Y: Salidroside inhibits MAPK, NF-κB, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation. Redox Rep. 24:70–74. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Sun L, Liu LN, Li JC, Lv YZ, Zong SB, Zhou J, Wang ZZ, Kou JP and Xiao W: The essential oil from the twigs of Cinnamomum cassia Presl inhibits oxytocin-induced uterine contraction in vitro and in vivo. J Ethnopharmacol. 206:107–114. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Klibanov AM and Giannousis PP: Geometric specificity of alcohol dehydrogenases and its potential for separation of trans and cis isomers of unsaturated aldehydes. Proc Natl Acad Sci USA. 79:3462–3465. 1982. View Article : Google Scholar : PubMed/NCBI

15 

Kim ME, Na JY and Lee JS: Anti-inflammatory effects of trans-cinnamaldehyde on lipopolysaccharide-stimulated macrophage activation via MAPKs pathway regulation. Immunopharmacol Immunotoxicol. 40:219–224. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Yan L, Song F, Li H, Li Y, Li J, He QY, Zhang D, Wang F, Zhang M, Zhao H, et al: Submicron emulsion of cinnamaldehyde ameliorates bleomycin-induced idiopathic pulmonary fibrosis via inhibition of inflammation, oxidative stress and epithelial-mesenchymal transition. Biomed Pharmacother. 102:765–771. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Ye F, Zhang J, Zhang Q, Zhang J and Chen C: Preliminary study on the mechanism of long noncoding RNA SENCR regulating the proliferation and migration of vascular smooth muscle cells. J Cell Physiol. 235:9635–9643. 2020. View Article : Google Scholar : PubMed/NCBI

18 

Zhu J, Liu B, Wang Z, Wang D, Ni H, Zhang L and Wang Y: Exosomes from nicotine-stimulated macrophages accelerate atherosclerosis through miR-21-3p/PTEN-mediated VSMC migration and proliferation. Theranostics. 9:6901–6919. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Farahzadi R, Fathi E and Vietor I: Mesenchymal stem cells could be considered as a candidate for further studies in cell-based therapy of alzheimer's disease via targeting the signaling pathways. ACS Chem Neurosci. 11:1424–1435. 2020. View Article : Google Scholar : PubMed/NCBI

20 

Fathi E and Vietor I: Mesenchymal stem cells promote caspase expression in Molt-4 leukemia cells via GSK-3α/Β and ERK1/2 signaling pathways as a therapeutic strategy. Curr Gene Ther. 21:81–88. 2021. View Article : Google Scholar : PubMed/NCBI

21 

Fathi E, Farahzadi R, Javanmardi S and Vietor I: L-carnitine extends the telomere length of the cardiac differentiated CD117+−expressing stem cells. Tissue Cell. 67:1014292020. View Article : Google Scholar : PubMed/NCBI

22 

Wang J, Li XM, Bai Z, Chi BX, Wei Y and Chen X: Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/GSK3β/cyclin D1 pathway. J Ethnopharmacol. 210:1–9. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Fathi E, Valipour B, Sanaat Z, Nozad Charoudeh H and Farahzadi R: Interleukin-6, −8, and TGF-β secreted from mesenchymal stem cells show functional role in reduction of telomerase activity of leukemia cell Via Wnt5a/β-catenin and p53 pathways. Adv Pharm Bull. 10:307–314. 2020. View Article : Google Scholar : PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Yang BY, Cheng YG, Liu Y, Liu Y, Tan JY, Guan W, Guo S and Kuang HX: Datura Metel L. Ameliorates imiquimod-induced psoriasis-like dermatitis and inhibits inflammatory cytokines production through TLR7/8-MyD88-NF-κB-NLRP3 Inflammasome Pathway. Molecules. 24:21572019. View Article : Google Scholar : PubMed/NCBI

26 

Hotamisligil GS and Davis RJ: Cell signaling and stress responses. Cold Spring Harb Perspect Biol. 8:a0060722016. View Article : Google Scholar : PubMed/NCBI

27 

Deng Y, Chang C and Lu Q: The inflammatory response in psoriasis: A comprehensive review. Clin Rev Allergy Immunol. 50:377–389. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Gooderham MJ, Papp KA and Lynde CW: Shifting the focus - the primary role of IL-23 in psoriasis and other inflammatory disorders. J Eur Acad Dermatol Venereol. 32:1111–1119. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Oliveira Mde F, Rocha Bde O and Duarte GV: Psoriasis: Classical and emerging comorbidities. An Bras Dermatol. 90:9–20. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Lin W, Yu Q, Qin Y, Dai L, Xiao J, Jiao L, Liu S, Ye S, Zhang J and Chen M: To explore the clinical efficacy of Traditional Chinese Medicine bath in the treatment of psoriasis vulgaris with blood-heat syndrome and its effect on related cytokines based on different temperature and different concentration. Medicine. 99:e201722020. View Article : Google Scholar : PubMed/NCBI

31 

Liu A, Zhao W, Zhang B, Tu Y, Wang Q and Li J: Cimifugin ameliorates imiquimod-induced psoriasis by inhibiting oxidative stress and inflammation via NF-κB/MAPK pathway. Biosci Rep. 40:BSR202004712020. View Article : Google Scholar : PubMed/NCBI

32 

He Q, Zhang B, Hu F, Long J, Shi Q, Pi X, Chen H and Li J: Triptolide inhibits the proliferation of HaCaT cells induced by IL22 via upregulating miR-181b-5p. Drug Des Devel Ther. 14:2927–2935. 2020. View Article : Google Scholar : PubMed/NCBI

33 

Wu S, Zhao M, Sun Y, Xie M, Le K, Xu M and Huang C: The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model. Life Sci. 241:1171152020. View Article : Google Scholar : PubMed/NCBI

34 

Hammouda MB, Ford AE, Liu Y and Zhang JY: The JNK signaling pathway in inflammatory Skin disorders and cancer. Cells. 9:8572020. View Article : Google Scholar : PubMed/NCBI

35 

Wang C, Zong J, Li Y, Wang X, Du W and Li L: miR-744-3p regulates keratinocyte proliferation and differentiation via targeting KLLN in psoriasis. Exp Dermatol. 28:283–291. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ding Z, Liu J, Qian H, Wu L and Lv M: Cinnamaldehyde inhibits psoriasis‑like inflammation by suppressing proliferation and inflammatory response of keratinocytes via inhibition of NF‑κB and JNK signaling pathways. Mol Med Rep 24: 638, 2021.
APA
Ding, Z., Liu, J., Qian, H., Wu, L., & Lv, M. (2021). Cinnamaldehyde inhibits psoriasis‑like inflammation by suppressing proliferation and inflammatory response of keratinocytes via inhibition of NF‑κB and JNK signaling pathways. Molecular Medicine Reports, 24, 638. https://doi.org/10.3892/mmr.2021.12277
MLA
Ding, Z., Liu, J., Qian, H., Wu, L., Lv, M."Cinnamaldehyde inhibits psoriasis‑like inflammation by suppressing proliferation and inflammatory response of keratinocytes via inhibition of NF‑κB and JNK signaling pathways". Molecular Medicine Reports 24.3 (2021): 638.
Chicago
Ding, Z., Liu, J., Qian, H., Wu, L., Lv, M."Cinnamaldehyde inhibits psoriasis‑like inflammation by suppressing proliferation and inflammatory response of keratinocytes via inhibition of NF‑κB and JNK signaling pathways". Molecular Medicine Reports 24, no. 3 (2021): 638. https://doi.org/10.3892/mmr.2021.12277
Copy and paste a formatted citation
x
Spandidos Publications style
Ding Z, Liu J, Qian H, Wu L and Lv M: Cinnamaldehyde inhibits psoriasis‑like inflammation by suppressing proliferation and inflammatory response of keratinocytes via inhibition of NF‑κB and JNK signaling pathways. Mol Med Rep 24: 638, 2021.
APA
Ding, Z., Liu, J., Qian, H., Wu, L., & Lv, M. (2021). Cinnamaldehyde inhibits psoriasis‑like inflammation by suppressing proliferation and inflammatory response of keratinocytes via inhibition of NF‑κB and JNK signaling pathways. Molecular Medicine Reports, 24, 638. https://doi.org/10.3892/mmr.2021.12277
MLA
Ding, Z., Liu, J., Qian, H., Wu, L., Lv, M."Cinnamaldehyde inhibits psoriasis‑like inflammation by suppressing proliferation and inflammatory response of keratinocytes via inhibition of NF‑κB and JNK signaling pathways". Molecular Medicine Reports 24.3 (2021): 638.
Chicago
Ding, Z., Liu, J., Qian, H., Wu, L., Lv, M."Cinnamaldehyde inhibits psoriasis‑like inflammation by suppressing proliferation and inflammatory response of keratinocytes via inhibition of NF‑κB and JNK signaling pathways". Molecular Medicine Reports 24, no. 3 (2021): 638. https://doi.org/10.3892/mmr.2021.12277
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