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Article

Effect of intestinal microbiota imbalance associated with chronic hepatitis B virus infection on the expression of microRNA‑192 and GLP‑1

  • Authors:
    • Yinghui Liu
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    Affiliations: Department of Infectious Disease, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China
  • Article Number: 662
    |
    Published online on: July 19, 2021
       https://doi.org/10.3892/mmr.2021.12301
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Abstract

It has been reported that hepatitis B virus (HBV) infection has an impact on intestinal microbiota imbalance to induce diabetes mellitus (DM), but the underlying mechanisms still remain to be explored. The present study aimed to investigate the regulatory role of microRNA‑192 (miR‑192‑5p) and glucagon‑like peptide‑1 (GLP‑1) in intestinal microbiota imbalance by recruiting patients with DM infected with HBV. In the present study, patients with HBV infection and different levels of alanine transaminase (ALT) were recruited and divided into three groups. Intestinal microbiota analysis was performed to evaluate the fecal bacterial composition of patients in various groups. Quantitative PCR was performed to explore the differential expression of miR‑192‑5p and GLP‑1 in the feces, peripheral blood and intestinal mucosal tissue samples of each patient. Immunohistochemistry was used to assess the expression of GLP‑1 protein in the intestinal mucosal tissue samples. Luciferase assays were performed by cell transfection of miR‑192‑5p mimics/precursors/inhibitors to study the inhibitory effect of miR‑192‑5p on GLP‑1 expression. Intestinal microbiota imbalance was observed in hepatitis B surface antigen (HBsAg)‑positive patients with high ALT. The expression of miR‑192‑5p was significantly elevated in the feces, peripheral blood and intestinal mucosal tissue samples of HBsAg‑positive patients with high ALT along with decreased GLP‑1 mRNA and protein expression. Luciferase activity of GLP‑1 vector was inhibited by miR‑192‑5p mimics and promoted by miR‑192‑5p inhibitors. Transfection of miR‑192‑5p precursors resulted in upregulation of miR‑192‑5p and downregulation of GLP‑1, while miR‑192‑5p inhibitors remarkably suppressed the expression of miR‑192‑5p and notably induced the expression of GLP‑1. These results showed a regulatory network involving HBV infection, intestinal microbiota imbalance, and miR‑192‑5p and GLP‑1 expression.
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View References

1 

Beasley RP: Rocks along the road to the control of HBV and HCC. Ann Epidemiol. 19:231–234. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Cho EJ, Kim SE, Suk KT, An J, Jeong SW, Chung WJ and Kim YJ: Current status and strategies for hepatitis B control in Korea. Clin Mol Hepatol. 23:205–211. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Younossi Z, Kochems K, de Ridder M, Curran D, Bunge EM and de Moerlooze L: Should adults with diabetes mellitus be vaccinated against hepatitis B virus? A systematic review of diabetes mellitus and the progression of hepatitis B disease. Hum Vaccin Immunother. 13:2695–2706. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Szabo G and Bala S: Alcoholic liver disease and the gut-liver axis. World J Gastroenterol. 16:1321–1329. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Zhang D, Hao X, Xu L, Cui J, Xue L and Tian Z: Intestinal flora imbalance promotes alcohol-induced liver fibrosis by the TGFβ/smad signaling pathway in mice. Oncol Lett. 14:4511–4516. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Mou H, Yang F, Zhou J and Bao C: Correlation of liver function with intestinal flora, vitamin deficiency and IL-17A in patients with liver cirrhosis. Exp Ther Med. 16:4082–4088. 2018.PubMed/NCBI

7 

Macfarlane LA and Murphy PR: MicroRNA: Biogenesis, function and role in cancer. Curr Genomics. 11:537–561. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Fisher K and Lin J: MicroRNA in inflammatory bowel disease: Translational research and clinical implication. World J Gastroenterol. 21:12274–12282. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Peck BC, Weiser M, Lee SE, Gipson GR, Iyer VB, Sartor RB, Herfarth HH, Long MD, Hansen JJ, Isaacs KL, et al: MicroRNAs classify different disease behavior phenotypes of crohn's disease and may have prognostic utility. Inflamm Bowel Dis. 21:2178–2187. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Chiang Y, Song Y, Wang Z, Liu Z, Gao P, Liang J, Zhu J, Xing C and Xu H: microRNA-192, −194 and −215 are frequently downregulated in colorectal cancer. Exp Ther Med. 3:560–566. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Jones MF, Hara T, Francis P, Li XL, Bilke S, Zhu Y, Pineda M, Subramanian M, Bodmer WF and Lal A: The CDX1-microRNA-215 axis regulates colorectal cancer stem cell differentiation. Proc Natl Acad Sci USA. 112:E1550–E1558. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Fischer J, Walker LC, Robinson BA, Frizelle FA, Church JM and Eglinton TW: Clinical implications of the genetics of sporadic colorectal cancer. ANZ J Surg. 89:1224–1229. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Moloney GM, Viola MF, Hoban AE, Dinan TG and Cryan JF: Faecal microRNAs: Indicators of imbalance at the host-microbe interface? Benef Microbes. 9:175–183. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Dalmasso G, Nguyen HT, Yan Y, Laroui H, Charania MA, Ayyadurai S, Sitaraman SV and Merlin D: Microbiota modulate host gene expression via microRNAs. PLoS One. 6:e192932011. View Article : Google Scholar : PubMed/NCBI

15 

Liu S, da Cunha AP, Rezende RM, Cialic R, Wei Z, Bry L, Comstock LE, Gandhi R and Weiner HL: The host shapes the gut Microbiota via fecal MicroRNA. Cell Host Microbe. 19:32–43. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Pan W, Zhang Y, Zeng C, Xu F, Yan J and Weng J: miR-192 is upregulated in T1DM, regulates pancreatic β-cell development and inhibits insulin secretion through suppressing GLP-1 expression. Exp Ther Med. 16:2717–2724. 2018.PubMed/NCBI

17 

Yun Y, Chang Y, Kim HN, Ryu S, Kwon MJ, Cho YK, Kim HL, Cheong HS and Joo EJ: Alterations of the gut microbiome in chronic hepatitis B virus infection associated with alanine aminotransferase level. J Clin Med. 8:1732019. View Article : Google Scholar : PubMed/NCBI

18 

Lin PY, Chen SC, Lo TC and Kuo HW: Dual infection with hepatitis B virus and hepatitis C virus correlated with type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes. 128:38–42. 2020. View Article : Google Scholar : PubMed/NCBI

19 

Xie QH, He XX, Chang Y, Jiang X and Lin JS: HBx gene down-regulates miR-192 expression and inhibits apoptosis of human hepatoma cell line HepG2. Zhonghua Gan Zang Bing Za Zhi. 19:857–860. 2011.(In Chinese). PubMed/NCBI

20 

Yuan X, Ni H, Chen X, Feng X, Wu Q and Chen J: Identification of therapeutic effect of glucagon-like peptide 1 in the treatment of STZ-induced diabetes mellitus in rats by restoring the balance of intestinal flora. J Cell Biochem. 119:10067–10074. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Shin EC, Sung PS and Park SH: Immune responses and immunopathology in acute and chronic viral hepatitis. Nat Rev Immunol. 16:509–523. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Ou JH: Molecular biology of hepatitis B virus e antigen. J Gastroenterol Hepatol. 12:S178–S187. 1997. View Article : Google Scholar : PubMed/NCBI

23 

Ben Q, Li Z, Liu C, Cai Q, Yuan Y, Wang K, Xiao L, Gao J and Zhang H: Hepatitis B virus status and risk of pancreatic ductal adenocarcinoma: A case-control study from China. Pancreas. 41:435–440. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Li YT, Wang L, Chen Y, Chen YB, Wang HY, Wu ZW and Li LJ: Effects of gut microflora on hepatic damage after acute liver injury in rats. J Trauma. 68:76–83. 2010.PubMed/NCBI

25 

Neelam K, Goenadi CJ, Lun K, Yip CC and Au Eong KG: Putative protective role of lutein and zeaxanthin in diabetic retinopathy. Br J Ophthalmol. 101:551–558. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Boni V, Bitarte N, Cristobal I, Zarate R, Rodriguez J, Maiello E, Garcia-Foncillas J and Bandres E: miR-192/miR-215 influence 5-fluorouracil resistance through cell cycle-mediated mechanisms complementary to its post-transcriptional thymidilate synthase regulation. Mol Cancer Ther. 9:2265–2275. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Hu F, Meng X, Tong Q, Liang L, Xiang R, Zhu T and Yang S: BMP-6 inhibits cell proliferation by targeting microRNA-192 in breast cancer. Biochim Biophys Acta. 1832:2379–2390. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Agarwal V, Bell GW, Nam JW and Bartel DP: Predicting effective microRNA target sites in mammalian mRNAs. Elife. 4:e050052015. View Article : Google Scholar : PubMed/NCBI

30 

Hutin YJ, Bulterys M and Hirnschall GO: How far are we from viral hepatitis elimination service coverage targets? J Int AIDS Soc. 21 (Suppl 2):e250502018. View Article : Google Scholar : PubMed/NCBI

31 

Milich D and Liang TJ: Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection. Hepatology. 38:1075–1086. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Khella HW, Bakhet M, Allo G, Jewett MA, Girgis AH, Latif A, Girgis H, Von Both I, Bjarnason GA and Yousef GM: miR-192, miR-194 and miR-215: A convergent microRNA network suppressing tumor progression in renal cell carcinoma. Carcinogenesis. 34:2231–2239. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Zhang L, Zhou W, Velculescu VE, Kern SE, Hruban RH, Hamilton SR, Vogelstein B and Kinzler KW: Gene expression profiles in normal and cancer cells. Science. 276:1268–1272. 1997. View Article : Google Scholar : PubMed/NCBI

34 

Rashid H, Hossain B, Siddiqua T, Kabir M, Noor Z, Ahmed M and Haque R: Fecal microRNAs as potential biomarkers for screening and diagnosis of intestinal diseases. Front Mol Biosci. 7:1812020. View Article : Google Scholar : PubMed/NCBI

35 

Sarshar M, Scribano D, Ambrosi C, Palamara AT and Masotti A: Fecal microRNAs as innovative biomarkers of intestinal diseases and effective players in host-microbiome interactions. Cancers (Basel). 12:21742020. View Article : Google Scholar : PubMed/NCBI

36 

Honda K and Littman DR: The microbiome in infectious disease and inflammation. Annu Rev Immunol. 30:759–795. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Kim M and Zhang X: The profiling and role of miRNAs in diabetes mellitus. J Diabetes Clin Res. 1:5–23. 2019.PubMed/NCBI

38 

Holst JJ, Vilsboll T and Deacon CF: The incretin system and its role in type 2 diabetes mellitus. Mol Cell Endocrinol. 297:127–136. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Kieffer TJ and Habener JF: The glucagon-like peptides. Endocr Rev. 20:876–913. 1999. View Article : Google Scholar : PubMed/NCBI

40 

Flint A, Raben A, Astrup A and Holst JJ: Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J Clin Invest. 101:515–520. 1998. View Article : Google Scholar : PubMed/NCBI

41 

Verdich C, Flint A, Gutzwiller JP, Näslund E, Beglinger C, Hellström PM, Long SJ, Morgan LM, Holst JJ and Astrup A: A meta-analysis of the effect of glucagon-like peptide-1 (7–36) amide on ad libitum energy intake in humans. J Clin Endocrinol Metab. 86:4382–4389. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Dickson SL, Shirazi RH, Hansson C, Bergquist F, Nissbrandt H and Skibicka KP: The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: A new role for mesolimbic GLP-1 receptors. J Neurosci. 32:4812–4820. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Meeran K, O'Shea D, Edwards CM, Turton MD, Heath MM, Gunn I, Abusnana S, Rossi M, Small CJ, Goldstone AP, et al: Repeated intracerebroventricular administration of glucagon-like peptide-1-(7–36) amide or exendin-(9–39) alters body weight in the rat. Endocrinology. 140:244–250. 1999. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu Y: Effect of intestinal microbiota imbalance associated with chronic hepatitis B virus infection on the expression of microRNA‑192 and GLP‑1. Mol Med Rep 24: 662, 2021.
APA
Liu, Y. (2021). Effect of intestinal microbiota imbalance associated with chronic hepatitis B virus infection on the expression of microRNA‑192 and GLP‑1. Molecular Medicine Reports, 24, 662. https://doi.org/10.3892/mmr.2021.12301
MLA
Liu, Y."Effect of intestinal microbiota imbalance associated with chronic hepatitis B virus infection on the expression of microRNA‑192 and GLP‑1". Molecular Medicine Reports 24.3 (2021): 662.
Chicago
Liu, Y."Effect of intestinal microbiota imbalance associated with chronic hepatitis B virus infection on the expression of microRNA‑192 and GLP‑1". Molecular Medicine Reports 24, no. 3 (2021): 662. https://doi.org/10.3892/mmr.2021.12301
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y: Effect of intestinal microbiota imbalance associated with chronic hepatitis B virus infection on the expression of microRNA‑192 and GLP‑1. Mol Med Rep 24: 662, 2021.
APA
Liu, Y. (2021). Effect of intestinal microbiota imbalance associated with chronic hepatitis B virus infection on the expression of microRNA‑192 and GLP‑1. Molecular Medicine Reports, 24, 662. https://doi.org/10.3892/mmr.2021.12301
MLA
Liu, Y."Effect of intestinal microbiota imbalance associated with chronic hepatitis B virus infection on the expression of microRNA‑192 and GLP‑1". Molecular Medicine Reports 24.3 (2021): 662.
Chicago
Liu, Y."Effect of intestinal microbiota imbalance associated with chronic hepatitis B virus infection on the expression of microRNA‑192 and GLP‑1". Molecular Medicine Reports 24, no. 3 (2021): 662. https://doi.org/10.3892/mmr.2021.12301
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