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SOD2 overexpression in bone marrow‑derived mesenchymal stem cells ameliorates hepatic ischemia/reperfusion injury

  • Authors:
    • Qiuyun Li
    • Wei Zhang
    • Enhua Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China, Department of Radiology, The Second People's Hospital of Hunan Province, Changsha, Hunan 410007, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 671
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    Published online on: July 21, 2021
       https://doi.org/10.3892/mmr.2021.12310
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Abstract

Hepatic ischemia/reperfusion injury (HIRI) is a complex pathophysiological process that may develop after liver transplantation and resection surgery, as well as in uncontrolled clinical conditions. Bone marrow‑derived mesenchymal stem cells (BM‑MSCs) are potential targets for liver diseases. Thus, the present study aimed to investigate the effects of superoxide dismutase 2 (SOD2) overexpression in BM‑MSCs on HIRI by constructing a HIRI rat model. The adenoviral vector containing SOD2 and the corresponding control vector were designed and constructed, and SOD2‑overexpressing BM‑MSCs were injected into the tail vein of the rats. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, as well as pathological changes and the remnant liver regeneration rate were determined. The activities of SOD and glutathione peroxidase (GSH‑Px), and malondialdehyde (MDA) content were measured. Reactive oxygen species (ROS) were determined with 2',7'‑­dichlorofluorescein diacetate and measured via fluorescence microscopy. Cell apoptosis was assessed using TUNEL staining. Moreover, the expression levels of Bax, Bcl‑2 and caspase‑3 were detected via western blotting. SOD2‑overexpressing BM‑MSCs significantly reduced the elevation of serum AST and ALT levels. Furthermore, SOD2‑overexpressing BM‑MSCs enhanced SOD and GSH‑Px activities, and suppressed the production of MDA and ROS. Histopathological findings revealed that SOD2‑overexpressing BM‑MSCs decreased the number of TUNEL‑positive cells in the liver. It was also found that SOD2‑overexpressing BM‑MSCs promoted Bcl‑2 expression, but inhibited Bax and caspase‑3 expression in HIRI. Collectively, these findings suggest that SOD2‑overexpressing BM‑MSCs may provide therapeutic support in HIRI by inhibiting oxidative stress and hepatocyte apoptosis.
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View References

1 

Huang Y, Gao F, Zhang Y, Chen Y, Wang B, Zheng Y and Shi G: N-n-Butyl haloperidol iodide inhibits the augmented Na+/Ca2+ exchanger currents and L-type Ca2+ current induced by hypoxia/reoxygenation or H2O2 in cardiomyocytes. Biochem Biophys Res Commun. 421:86–90. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Cannistrà M, Ruggiero M, Zullo A, Gallelli G, Serafini S, Maria M, Naso A, Grande R, Serra R and Nardo B: Hepatic ischemia reperfusion injury: A systematic review of literature and the role of current drugs and biomarkers. Int J Surg. 33 (Suppl 1):S57–S70. 2016. View Article : Google Scholar

3 

Hirakawa Y, Tsuchishima M, Fukumura A, Kinoshita K, Hayashi N, Saito T, George J, Toshikuni N, Ueda Y and Tsutsumi M: Recombinant thrombomodulin prevented hepatic ischemia-reperfusion injury by inhibiting high-mobility group box 1 in rats. Eur J Pharmacol. 863:1726812019. View Article : Google Scholar : PubMed/NCBI

4 

Li J, Li RJ, Lv GY and Liu HQ: The mechanisms and strategies to protect from hepatic ischemia-reperfusion injury. Eur Rev Med Pharmacol Sci. 19:2036–2047. 2015.PubMed/NCBI

5 

Chao YH, Lin CW, Pan HH, Yang SF, Weng TF, Peng CT and Wu KH: Increased apoptosis and peripheral blood mononuclear cell suppression of bone marrow mesenchymal stem cells in severe aplastic anemia. Pediatr Blood Cancer. 65:e272472018. View Article : Google Scholar : PubMed/NCBI

6 

Rong Y, Liu W, Wang J, Fan J, Luo Y, Li L, Kong F, Chen J, Tang P and Cai W: Neural stem cell-derived small extracellular vesicles attenuate apoptosis and neuroinflammation after traumatic spinal cord injury by activating autophagy. Cell Death Dis. 10:3402019. View Article : Google Scholar : PubMed/NCBI

7 

Zha JM, Li HS, Lin Q, Kuo WT, Jiang ZH, Tsai PY, Ding N, Wu J, Xu SF, Wang YT, et al: Interleukin 22 expands transit-amplifying cells while depleting Lgr5+ stem cells via inhibition of wnt and notch signaling. Cell Mol Gastroenterol Hepatol. 7:255–274. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Sun X, Luo L and Li J: LncRNA MALAT1 facilitates BM-MSCs differentiation into endothelial cells via targeting miR-206/VEGFA axis. Cell Cycle. 19:3018–3028. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Zuo R, Liu M, Wang Y, Li J, Wang W, Wu J, Sun C, Li B, Wang Z, Lan W, et al: BM-MSC-derived exosomes alleviate radiation-induced bone loss by restoring the function of recipient BM-MSCs and activating Wnt/β-catenin signaling. Stem Cell Res Ther. 10:302019. View Article : Google Scholar : PubMed/NCBI

10 

Tan YF, Tang L, OuYang WX, Jiang T, Zhang H and Li SJ: β-catenin-coordinated lncRNA MALAT1 up-regulation of ZEB-1 could enhance the telomerase activity in HGF-mediated differentiation of bone marrow mesenchymal stem cells into hepatocytes. Pathol Res Pract. 215:546–554. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Shay JW, Homma N, Zhou R, Naseer MI, Chaudhary AG, Al-Qahtan M, Hirokawa N, Goudarzi M, Fornace AJ Jr, Baeesa S, et al: Abstracts from the 3rd international genomic medicine conference (3rd IGMC 2015): Jeddah, kingdom of Saudi Arabia. 30 November-3 December 2015. BMC Genomics. 17 (Suppl 6):S4872016. View Article : Google Scholar

12 

Wang X, Wang S, Zhou Y, Obulkasim H, Zhang ZH, Dai B, Zhu W and Shi XL: BM-MSCs protect against liver ischemia/reperfusion injury via HO-1 mediated autophagy. Mol Med Rep. 18:2253–2262. 2018.PubMed/NCBI

13 

Yang B, Duan W, Wei L, Zhao Y, Han Z, Wang J, Wang M, Dai C, Zhang B, Chen D and Chen Z: Bone Marrow mesenchymal stem cell-derived hepatocyte-like cell exosomes reduce hepatic ischemia/reperfusion injury by enhancing autophagy. Stem Cells Dev. 29:372–379. 2020. View Article : Google Scholar : PubMed/NCBI

14 

Zare MA, Zare A, Azarpira N and Pakbaz S: The protective effect of bone marrow-derived mesenchymal stem cells in liver ischemia/reperfusion injury via down-regulation of miR-370. Iran J Basic Med Sci. 22:683–689. 2019.PubMed/NCBI

15 

Zheng J, Chen L, Lu T, Zhang Y, Sui X, Li Y, Huang X, He L, Cai J, Zhou C, et al: MSCs ameliorate hepatocellular apoptosis mediated by PINK1-dependent mitophagy in liver ischemia/reperfusion injury through AMPKα activation. Cell Death Dis. 11:2562020. View Article : Google Scholar : PubMed/NCBI

16 

Jin G, Qiu G, Wu D, Hu Y, Qiao P, Fan C and Gao F: Allogeneic bone marrow-derived mesenchymal stem cells attenuate hepatic ischemia-reperfusion injury by suppressing oxidative stress and inhibiting apoptosis in rats. Int J Mol Med. 31:1395–1401. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Chen P, Cui L, Chen G, You T, Li W, Zuo J, Wang C, Zhang W and Jiang C: The application of BMP-12-overexpressing mesenchymal stem cells loaded 3D-printed PLGA scaffolds in rabbit rotator cuff repair. Int J Biol Macromol. 138:79–88. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Shi X, Bai Y, Zhang G, Liu Y, Xiao H, Liu X and Zhang W: Effects of over-expression of SOD2 in bone marrow-derived mesenchymal stem cells on traumatic brain injury. Cell Tissue Res. 372:67–75. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Lee M, Song BR, Kim DH, Ha J, Lee M, Choi SJ, Oh W, Um S and Jin HJ: Up-regulation of superoxide dismutase 2 in 3D spheroid formation promotes therapeutic potency of human umbilical cord blood-derived mesenchymal stem cells. Antioxidants (Basel). 9:662020. View Article : Google Scholar : PubMed/NCBI

20 

Mohr BJ, Fakoya FA, Hau J, Souilem O and Anestidou L: The Governance of Animal Care and Use for Scientific Purposes in Africa and the Middle East. ILAR J. 57:333–346. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Krüger-Haag A, Lehmann C, Schmidt E, Sonntag F, Hörer M and Kochanek S: Evaluation of life cycle defective adenovirus mutants for production of adeno-associated virus vectors. J Gene Med. 21:e30942019. View Article : Google Scholar

22 

Kronenburg A, Bulder MMM, Bokkers RPH, Hartkamp NS, Hendrikse J, Vonken EJ, Kappelle LJ, van der Zwan A, Klijn CJM and Braun KPJ: Cerebrovascular reactivity measured with ASL perfusion MRI, Ivy sign, and regional tissue vascularization in moyamoya. World Neurosurg. 125:e639–e650. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Lv FJ, Tuan RS, Cheung KM and Leung VY: Concise review: The surface markers and identity of human mesenchymal stem cells. Stem Cells. 32:1408–1419. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Xu L, Yu Y, Sang R, Li J, Ge B and Zhang X: Protective effects of taraxasterol against ethanol-induced liver injury by regulating CYP2E1/Nrf2/HO-1 and NF-kappaB signaling pathways in mice. Oxid Med Cell Longev. 2018:82841072018. View Article : Google Scholar : PubMed/NCBI

26 

Yuan R, Tao X, Liang S, Pan Y, He L, Sun J, Wenbo J, Li X, Chen J and Wang C: Protective effect of acidic polysaccharide from Schisandra chinensis on acute ethanol-induced liver injury through reducing CYP2E1-dependent oxidative stress. Biomed Pharmacother. 99:537–542. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Zhang M, Yang D, Gong X, Ge P, Dai J, Lin L and Zhang L: Protective benefits of AMP-activated protein kinase in hepatic ischemia-reperfusion injury. Am J Transl Res. 9:823–829. 2017.PubMed/NCBI

28 

Peralta C, Rull R, Rimola A, Deulofeu R, Roselló-Catafau J, Gelpí E and Rodés J: Endogenous nitric oxide and exogenous nitric oxide supplementation in hepatic ischemia-reperfusion injury in the rat. Transplantation. 71:529–536. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Hataji K, Watanabe T, Oowada S, Nagaya M, Kamibayashi M, Murakami E, Kawakami H, Ishiuchi A, Kumai T, Nakano H, et al: Effects of a calcium-channel blocker (CV159) on hepatic ischemia/reperfusion injury in rats: Evaluation with selective NO/pO2 electrodes and an electron paramagnetic resonance spin-trapping method. Biol Pharm Bull. 33:77–83. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Charbord P: Bone marrow mesenchymal stem cells: Historical overview and concepts. Hum Gene Ther. 21:1045–1056. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Zhou W, Lin J, Zhao K, Jin K, He Q, Hu Y, Feng G, Cai Y, Xia C, Liu H, et al: Single-cell profiles and clinically useful properties of human mesenchymal stem cells of adipose and bone marrow origin. Am J Sports Med. 47:1722–1733. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Kassis I, Vaknin-Dembinsky A and Karussis D: Bone marrow mesenchymal stem cells: Agents of immunomodulation and neuroprotection. Curr Stem Cell Res Ther. 6:63–68. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Miao C, Lei M, Hu W, Han S and Wang Q: A brief review: The therapeutic potential of bone marrow mesenchymal stem cells in myocardial infarction. Stem Cell Res Ther. 8:2422017. View Article : Google Scholar : PubMed/NCBI

34 

Yang W and Ma B: A mini-review: The therapeutic potential of bone marrow mesenchymal stem cells and relevant signaling cascades. Curr Stem Cell Res Ther. 14:214–218. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Yang C, Yang HJ, Deng SP and Zhang Y: Current status of ex-vivo liver resection and autologous liver transplantation for end-stage hepatic alveolar echinococcosis. Ann Palliat Med. 9:2271–2278. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Konishi T and Lentsch AB: Hepatic Ischemia/reperfusion: Mechanisms of tissue injury, repair, and regeneration. Gene Expr. 17:277–287. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Mohamed HE, Elswefy SE, Rashed LA, Younis NN, Shaheen MA and Ghanim AM: Bone marrow-derived mesenchymal stem cells effectively regenerate fibrotic liver in bile duct ligation rat model. Exp Biol Med (Maywood). 241:581–591. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Souza MC, Silva JD, Pádua TA, Torres ND, Antunes MA, Xisto DG, Abreu TP, Capelozzi VL, Morales MM, Sá Pinheiro AA, et al: Mesenchymal stromal cell therapy attenuated lung and kidney injury but not brain damage in experimental cerebral malaria. Stem Cell Res Ther. 6:1022015. View Article : Google Scholar : PubMed/NCBI

39 

Jain R, Dey B, Khera A, Srivastav P, Gupta UD, Katoch VM, Ramanathan VD and Tyagi AK: Over-expression of superoxide dismutase obliterates the protective effect of BCG against tuberculosis by modulating innate and adaptive immune responses. Vaccine. 29:8118–8125. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Du Y, Qian B, Gao L, Tan P, Chen H, Wang A, Zheng T, Pu S, Xia X and Fu W: Aloin preconditioning attenuates hepatic ischemia/reperfusion injury via inhibiting TLR4/MyD88/NF-κB signal pathway in vivo and in vitro. Oxid Med Cell Longev. 2019:37658982019. View Article : Google Scholar : PubMed/NCBI

41 

Marampon F, Codenotti S, Megiorni F, Del Fattore A, Camero S, Gravina GL, Festuccia C, Musio D, De Felice F, Nardone V, et al: NRF2 orchestrates the redox regulation induced by radiation therapy, sustaining embryonal and alveolar rhabdomyosarcoma cells radioresistance. J Cancer Res Clin Oncol. 145:881–893. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Zelko IN, Mariani TJ and Folz RJ: Superoxide dismutase multigene family: A comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radical Biol Med. 33:337–349. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Katwal G, Baral D, Fan X, Weiyang H, Zhang X, Ling L, Xiong Y, Ye Q and Wang Y: SIRT3 a major player in attenuation of hepatic ischemia-reperfusion injury by reducing ROS via its downstream mediators: SOD2, CYP-D, and HIF-1α. Oxid Med Cell Longev. 2018:29769572018. View Article : Google Scholar : PubMed/NCBI

44 

Miyauchi T, Uchida Y, Kadono K, Hirao H, Kawasoe J, Watanabe T, Ueda S, Jobara K, Kaido T, Okajima H, et al: Preventive effect of antioxidative nutrient-rich enteral diet against liver ischemia and reperfusion injury. JPEN J Parenter Enteral Nutr. 43:133–144. 2019. View Article : Google Scholar : PubMed/NCBI

45 

Elias-Miró M, Mendes-Braz M, Cereijo R, Villarroya F, Jiménez-Castro MB, Gracia-Sancho J, Guixé-Muntet S, Massip-Salcedo M, Domingo JC, Bermudo R, et al: Resistin and visfatin in steatotic and non-steatotic livers in the setting of partial hepatectomy under ischemia-reperfusion. J Hepatol. 60:87–95. 2014. View Article : Google Scholar

46 

Katwal G, Baral D, Fan X, Weiyang H, Zhang X, Ling L, Xiong Y, Ye Q and Wang Y: SIRT3 a major player in attenuation of hepatic ischemia-reperfusion injury by reducing ROS via its downstream mediators: SOD2, CYP-D, and HIF-1α. Oxid Med Cell Longev. 2018:29769572018. View Article : Google Scholar : PubMed/NCBI

47 

Wheeler MD, Katuna M, Smutney OM, Froh M, Dikalova A, Mason RP, Samulski RJ and Thurman RG: Comparison of the effect of adenoviral delivery of three superoxide dismutase genes against hepatic ischemia-reperfusion injury. Hum Gene Ther. 12:2167–2177. 2001. View Article : Google Scholar : PubMed/NCBI

48 

Wheeler MD, Nakagami M, Bradford BU, Uesugi T, Mason RP, Connor HD, Dikalova A, Kadiiska M and Thurman RG: Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat. J Biol Chem. 276:36664–36672. 2001. View Article : Google Scholar : PubMed/NCBI

49 

Rodríguez-Reynoso S, Leal-Cortés C, Portilla-de Buen E and López-De la Torre SP: Ischemic preconditioning preserves liver energy charge and function on hepatic ischemia/reperfusion injury in rats. Arch Med Res. 49:373–380. 2018. View Article : Google Scholar

50 

Wang X, Wang S, Zhou Y, Obulkasim H, Zhang ZH, Dai B, Zhu W and Shi XL: BM-MSCs protect against liver ischemia/reperfusion injury via HO-1 mediated autophagy. Mol Med Rep. 18:2253–2262. 2018.PubMed/NCBI

51 

Li DP, Chen YL, Jiang HY, Chen Y, Zeng XQ, Xu LL, Ye Y, Ke CQ, Lin G, Wang JY and Gao H: Phosphocreatine attenuates Gynura segetum-induced hepatocyte apoptosis via a SIRT3-SOD2-mitochondrial reactive oxygen species pathway. Drug Des Devel Ther. 13:2081–2096. 2019. View Article : Google Scholar : PubMed/NCBI

52 

Wang Q, Wei S, Li L, Qiu J, Zhou S, Shi C, Shi Y, Zhou H and Lu L: TGR5 deficiency aggravates hepatic ischemic/reperfusion injury via inhibiting SIRT3/FOXO3/HIF-1 pathway. Cell Death Discov. 6:1162020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Q, Zhang W and Xiao E: SOD2 overexpression in bone marrow‑derived mesenchymal stem cells ameliorates hepatic ischemia/reperfusion injury. Mol Med Rep 24: 671, 2021.
APA
Li, Q., Zhang, W., & Xiao, E. (2021). SOD2 overexpression in bone marrow‑derived mesenchymal stem cells ameliorates hepatic ischemia/reperfusion injury. Molecular Medicine Reports, 24, 671. https://doi.org/10.3892/mmr.2021.12310
MLA
Li, Q., Zhang, W., Xiao, E."SOD2 overexpression in bone marrow‑derived mesenchymal stem cells ameliorates hepatic ischemia/reperfusion injury". Molecular Medicine Reports 24.3 (2021): 671.
Chicago
Li, Q., Zhang, W., Xiao, E."SOD2 overexpression in bone marrow‑derived mesenchymal stem cells ameliorates hepatic ischemia/reperfusion injury". Molecular Medicine Reports 24, no. 3 (2021): 671. https://doi.org/10.3892/mmr.2021.12310
Copy and paste a formatted citation
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Spandidos Publications style
Li Q, Zhang W and Xiao E: SOD2 overexpression in bone marrow‑derived mesenchymal stem cells ameliorates hepatic ischemia/reperfusion injury. Mol Med Rep 24: 671, 2021.
APA
Li, Q., Zhang, W., & Xiao, E. (2021). SOD2 overexpression in bone marrow‑derived mesenchymal stem cells ameliorates hepatic ischemia/reperfusion injury. Molecular Medicine Reports, 24, 671. https://doi.org/10.3892/mmr.2021.12310
MLA
Li, Q., Zhang, W., Xiao, E."SOD2 overexpression in bone marrow‑derived mesenchymal stem cells ameliorates hepatic ischemia/reperfusion injury". Molecular Medicine Reports 24.3 (2021): 671.
Chicago
Li, Q., Zhang, W., Xiao, E."SOD2 overexpression in bone marrow‑derived mesenchymal stem cells ameliorates hepatic ischemia/reperfusion injury". Molecular Medicine Reports 24, no. 3 (2021): 671. https://doi.org/10.3892/mmr.2021.12310
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