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Sacubitril/valsartan (LCZ696) reduces myocardial injury following myocardial infarction by inhibiting NLRP3‑induced pyroptosis via the TAK1/JNK signaling pathway

  • Authors:
    • Jianfen Shen
    • Zhongbao Fan
    • Guang Sun
    • Guoxian Qi
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Hepatobiliary Surgery, People's Hospital of China Medical University, Liaoning Provincial People's Hospital, Shenyang, Liaoning 110016, P.R. China, Department of Geriatric Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
    Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 676
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    Published online on: July 23, 2021
       https://doi.org/10.3892/mmr.2021.12315
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Abstract

The present study aimed to investigate the protective effects of sacubitril/valsartan (LCZ696) on ventricular remodeling in myocardial infarction (MI) and the effects of the inflammasome‑mediated inflammatory response. First, a rat model was established. Animals were then treated with LCZ696 so that the histopathological changes associated with ventricular remodeling could be investigated. The serum levels of the inflammatory factors IL‑18 and IL‑1β were also determined by ELISA. Immunofluorescence was used to investigate the ratio of pyroptosis following MI modelling. Western blotting and reverse transcription‑quantitative PCR were used to detect the relative expression levels of proteins and mRNAs in the transforming growth factor β‑activated kinase‑1 (TAK1)/JNK pathway and those associated with the NLR pyrin family domain containing 3 (NLRP3) inflammasome, respectively. The present study also investigated the regulatory mechanisms and associations between the TAK1 and JNK pathways, NOD‑, leucine‑rich repeat‑ and the NLRP3 inflammasome, in H9C2 cells and myocardial cells from the rat model of MI. LCZ696 improved MI‑induced myocardial fibrosis, rescued myocardial injury and suppressed the release of inflammatory factors. With regards to myocardial cell damage, pyroptosis in cardiomyocytes was observed. The in vitro experiments demonstrated that the overexpression of TAK1 promoted lysis of the N‑terminal of GSDMD, thereby activating the NLRP3 inflammasome and promoting the conversion of pro‑IL‑1β and pro‑IL‑18 into mature IL‑1β and IL‑18, respectively. In contrast, the silencing of TAK1 inhibited the expression levels of the NLRP3 inflammasome. In summary, LCZ696 reduced the expression levels of the NLRP3 inflammasome, suppressed inflammatory responses, improved the ventricular remodeling and exhibited protective effects in the MI heart by inhibiting the TAK1/JNK signaling pathway.
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View References

1 

Konstantinidis K, Whelan RS and Kitsis RN: Mechanisms of cell death in heart disease. Arterioscler Thromb Vasc Biol. 32:1552–1562. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Elmore S: Apoptosis: A review of programmed cell death. Toxicol Pathol. 35:495–516. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Cahill TJ and Kharbanda RK: Heart failure after myocardial infarction in the era of primary percutaneous coronary intervention: Mechanisms, incidence and identification of patients at risk. World J Cardiol. 9:407–415. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Bergsbaken T, Fink SL and Cookson BT: Pyroptosis: Host cell death and inflammation. Nat Rev Microbiol. 7:99–109. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Wree A, Eguchi A, McGeough MD, Pena CA, Johnson CD, Canbay A, Hoffman HM and Feldstein AE: NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology. 59:898–910. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Man SM, Karki R and Kanneganti TD: Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases. Immunol Rev. 277:61–75. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Azevedo PS, Polegato BF, Minicucci MF, Paiva SAR and Zornoff LAM: Cardiac remodeling: Concepts, clinical impact, pathophysiological mechanisms and pharmacologic treatment. Arq Bras Cardiol. 106:62–69. 2016.PubMed/NCBI

8 

Chen G, Li J, Song M, Wu Z, Zhang W, Wang Z, Gao J, Yang Z and Ou C: A mixed component supramolecular hydrogel to improve mice cardiac function and alleviate ventricular remodeling after acute myocardial infarction. Adv Funct Materials. 27:17017982017.https://doi.org/10.1002/adfm.201701798 View Article : Google Scholar : PubMed/NCBI

9 

Kale P and Afzal A: Stage B heart failure: To strain or not to strain. JACC Cardiovasc Imaging. 11:1401–1404. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Bujak M and Frangogiannis NG: The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc Res. 74:184–195. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Dobaczewski MW, Chen W and Frangogiannis NG: Transforming growth factor (TGF)-β signaling in cardiac remodeling. J Mol Cell Cardiol. 51:600–606. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Frangogiannis NG: The role of transforming growth factor (TGF)-β in the infarcted myocardium. J Thorac Dis. 9 (Suppl 1):S52–S63. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Monzen K, Hiroi Y, Kudoh S, Akazawa H, Oka T, Takimoto E, Hayashi D, Hosoda T, Kawabata M, Miyazono K, et al: Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation. J Cell Biol. 153:687–698. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Mihaly SR, Ninomiya-Tsuji J and Morioka S: TAK1 control of cell death. Cell Death Differ. 21:1667–1676. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Okada M, Matsuzawa A, Yoshimura A and Ichijo H: The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation. J Biol Chem. 289:32926–3236. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Toldo S, Mezzaroma E, Mauro AG, Salloum F, Van Tassell BW and Abbate A: The inflammasome in myocardial injury and cardiac remodeling. Antioxid Redox Signal. 22:1146–1161. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Zhaolin Z, Guohua L, Shiyuan W and Zuo W: Role of pyroptosis in cardiovascular disease. Cell Prolif. 52:e125632019. View Article : Google Scholar : PubMed/NCBI

18 

Mezzaroma E, Toldo S, Farkas D, Seropian IM, Van Tassell BW, Salloum FN, Kannan HR, Menna AC, Voelkel NF and Abbate A: The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse. Proc Natl Acad Sci USA. 108:19725–19730. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Liu D, Zeng X, Li X, Mehta JL and Wang X: Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases. Basic Res Cardiol. 113:52018. View Article : Google Scholar : PubMed/NCBI

20 

Ferrini A, Stevens MM, Sattler S and Rosenthal N: Toward regeneration of the heart: Bioengineering strategies for immunomodulation. Front Cardiovasc Med. 6:262019. View Article : Google Scholar : PubMed/NCBI

21 

McKenzie BA, Mamik MK, Saito LB, Boghozian R, Monaco MC, Major EO, Lu JQ, Branton WG and Power C: Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis. Proc Natl Acad Sci USA. 115:E6065–E6074. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Sharma B, McLeland CB, Potter TM, Stern ST and Adiseshaiah PP: Assessing NLRP3 inflammasome activation by nanoparticles. Methods Mol Biol. 1682:135–147. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Fann DY, Santro T, Manzanero S, Widiapradja A, Cheng YL, Lee SY, Chunduri P, Jo DG, Stranahan AM, Mattson MP and Arumugam TV: Intermittent fasting attenuates inflammasome activity in ischemic stroke. Exp Neurol. 257:114–119. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Zhu ZD, Ye JY, Niu H, Ma YM, Fu XM, Xia ZH and Zhang X: Effects of microRNA-292-5p on myocardial ischemia-reperfusion injury through the peroxisome proliferator-activated receptor-α/-γ signaling pathway. Gene Ther. 25:234–248. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Volpe M, Carnovali M and Mastromarino V: The natriuretic peptides system in the pathophysiology of heart failure: From molecular basis to treatment. Clin Sci (Lond). 130:57–77. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Zablocki D and Sadoshima J: Angiotensin II and oxidative stress in the failing heart. Antioxid Redox Signal. 19:1095–1109. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Jones ES, Vinh A, McCarthy CA, Gaspari TA and Widdop RE: AT2 receptors: Functional relevance in cardiovascular disease. Pharmacol Ther. 120:292–316. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Michel MC, Brunner HR, Foster C and Huo Y: Angiotensin II type 1 receptor antagonists in animal models of vascular, cardiac, metabolic and renal disease. Pharmacol Ther. 164:1–81. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Kompa AR, Lu J, Weller TJ, Kelly DJ, Krum H, von Lueder TG and Wang BH: Angiotensin receptor neprilysin inhibition provides superior cardioprotection compared to angiotensin converting enzyme inhibition after experimental myocardial infarction. Int J Cardiol. 258:192–198. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Shirley M and McCormack PL: Perindopril/amlodipine (Prestalia®): A review in hypertension. Am J Cardiovasc Drugs. 15:363–370. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Campbell DJ: A review of perindopril in the reduction of cardiovascular events. Vasc Health Risk Manag. 2:117–124. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Ishii M, Kaikita K, Sato K, Sueta D, Fujisue K, Arima Y, Oimatsu Y, Mitsuse T, Onoue Y, Araki S, et al: Cardioprotective effects of LCZ696 (Sacubitril/Valsartan) after experimental acute myocardial infarction. JACC Basic Transl Sci. 2:655–668. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Chang PC, Lin SF, Chu Y, Wo HT, Lee HL, Huang YC, Wen MS and Chou CC: LCZ696 therapy reduces ventricular tachyarrhythmia inducibility in a myocardial infarction-induced heart failure rat model. Cardiovasc Ther. 2019:60326312019. View Article : Google Scholar : PubMed/NCBI

34 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Li W, Li Y, Chu Y, Wu W, Yu Q, Zhu X and Wang Q: PLCE1 promotes myocardial ischemia-reperfusion injury in H/R H9c2 cells and I/R rats by promoting inflammation. Biosci Rep. 39:BSR201816132019. View Article : Google Scholar : PubMed/NCBI

36 

Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, Zhuang Y, Cai T, Wang F and Shao F: Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 526:660–665. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H and Lieberman J: Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature. 535:153–158. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Malireddi R, Kesavardhana S and Kanneganti TD: ZBP1 and TAK1: Master regulators of NLRP3 inflammasome/pyroptosis, apoptosis, and necroptosis (PAN-optosis). Front Cell Infect Microbiol. 9:4062019. View Article : Google Scholar : PubMed/NCBI

39 

Orning P, Weng D, Starheim K, Ratner D, Best Z, Lee B, Brooks A, Xia S, Wu H, Kelliher MA, et al: Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death. Science. 362:1064–1069. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Bhatt AS, Ambrosy AP and Velazquez EJ: Adverse remodeling and reverse remodeling after myocardial infarction. Curr Cardiol Rep. 19:712017. View Article : Google Scholar : PubMed/NCBI

41 

Li J, Cai SX, He Q, Zhang H, Friedberg D, Wang F and Redington AN: Intravenous miR-144 reduces left ventricular remodeling after myocardial infarction. Basic Res Cardiol. 113:362018. View Article : Google Scholar : PubMed/NCBI

42 

Caporizzo MA, Chen CY, Bedi K, Margulies KB and Prosser BL: Microtubules increase diastolic stiffness in failing human cardiomyocytes and myocardium. Circulation. 141:902–915. 2020. View Article : Google Scholar : PubMed/NCBI

43 

Tang YS, Zhao YH, Zhong Y, Li XZ, Pu JX, Luo YC and Zhou QL: Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis via regulation of ROS/NLRP3/caspase-1 signaling pathway. Inflamm Res. 68:727–738. 2019. View Article : Google Scholar : PubMed/NCBI

44 

Gao R, Shi H, Chang S, Gao Y, Li X, Lv C, Yang H, Xiang H, Yang J, Xu L and Tang Y: The selective NLRP3-inflammasome inhibitor MCC950 reduces myocardial fibrosis and improves cardiac remodeling in a mouse model of myocardial infarction. Int Immunopharmacol. 74:1055752019. View Article : Google Scholar : PubMed/NCBI

45 

Takahashi M: Role of NLRP3 inflammasome in cardiac inflammation and remodeling after myocardial infarction. Biol Pharm Bull. 42:518–523. 2019. View Article : Google Scholar : PubMed/NCBI

46 

Bai Y, Sun X, Chu Q, Li A, Qin Y, Li Y, Yue E, Wang H, Li G, Zahra SM, et al: Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β. Biosci Rep. 38:BSR201714382018. View Article : Google Scholar : PubMed/NCBI

47 

Cohn JN, Ferrari R and Sharpe N: Cardiac remodeling-concepts and clinical implications: A consensus paper from an international forum on cardiac remodeling. Behalf of an international forum on cardiac remodeling. J Am Coll Cardiol. 35:569–582. 2000. View Article : Google Scholar : PubMed/NCBI

48 

Schnee JM and Hsueh WA: Angiotensin II, adhesion, and cardiac fibrosis. Cardiovasc Res. 46:264–268. 2000. View Article : Google Scholar : PubMed/NCBI

49 

Yamazaki T, Komuro I, Shiojima I and Yazaki Y: The renin-angiotensin system and cardiac hypertrophy. Heart. 76 (Suppl 3):S33–S35. 1996. View Article : Google Scholar : PubMed/NCBI

50 

Brand T and Schneider MD: Transforming growth factor-beta signal transduction. Circ Res. 78:173–179. 1996. View Article : Google Scholar : PubMed/NCBI

51 

da Silva PM and Aguiar C: Sacubitril/valsartan: An important piece in the therapeutic puzzle of heart failure. Rev Port Cardiol. 36:655–668. 2017.(In English, Portuguese). PubMed/NCBI

52 

Forte M, Madonna M, Schiavon S, Valenti V, Versaci F, Zoccai GB, Frati G and Sciarretta S: Cardiovascular pleiotropic effects of natriuretic peptides. Int J Mol Sci. 20:38742019. View Article : Google Scholar : PubMed/NCBI

53 

Lee NS and Daniels LB: Current understanding of the compensatory actions of cardiac natriuretic peptides in cardiac failure: A clinical perspective. Card Fail Rev. 2:14–19. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Ni J, Li Y, Xu Y and Guo R: Salidroside protects against cardiomyocyte apoptosis and ventricular remodeling by AKT/HO-1 signaling pathways in a diabetic cardiomyopathy mouse model. Phytomedicine. 82:1534062021. View Article : Google Scholar : PubMed/NCBI

55 

Xia P, Liu Y and Cheng Z: Signaling pathways in cardiac myocyte apoptosis. Biomed Res Int. 2016:95832682016. View Article : Google Scholar : PubMed/NCBI

56 

Jia C, Chen H, Zhang J, Zhou K, Zhuge Y, Niu C, Qiu J, Rong X, Shi Z, Xiao J, et al: Role of pyroptosis in cardiovascular diseases. Int Immunopharmacol. 67:311–318. 2019. View Article : Google Scholar : PubMed/NCBI

57 

Wu J, Lin S, Wan B, Velani B and Zhu Y: Pyroptosis in liver disease: New insights into disease mechanisms. Aging Dis. 10:1094–1108. 2019. View Article : Google Scholar : PubMed/NCBI

58 

Guo H, Xie M, Zhou C and Zheng M: The relevance of pyroptosis in the pathogenesis of liver diseases. Life Sci. 223:69–73. 2019. View Article : Google Scholar : PubMed/NCBI

59 

Zheng Z and Li G: Mechanisms and therapeutic regulation of pyroptosis in inflammatory diseases and cancer. Int J Mol Sci. 21:14562020. View Article : Google Scholar : PubMed/NCBI

60 

Teng JF, Mei QB, Zhou XG, Tang Y, Xiong R, Qiu WQ, Pan R, Law BYK, Wong VKW, Yu CL, et al: Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer. Cancers (Basel). 12:1932020. View Article : Google Scholar : PubMed/NCBI

61 

Li A, Yu Y, Ding X, Qin Y, Jiang Y, Wang X, Liu G, Chen X, Yue E, Sun X, et al: MiR-135b protects cardiomyocytes from infarction through restraining the NLRP3/caspase-1/IL-1β pathway. Int J Cardiol. 307:137–145. 2020. View Article : Google Scholar : PubMed/NCBI

62 

Tan M, Tan L, Jiang T, Zhu XC, Wang HF, Jia CD and Yu JT: Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer's disease. Cell Death Dis. 5:e1382. 2014. View Article : Google Scholar : PubMed/NCBI

63 

Burdette D, Haskett A, Presser L, McRae S, Iqbal J and Waris G: Hepatitis C virus activates interleukin-1beta via caspase-1-inflammasome complex. J Gen Virol. 93:235–246. 2012. View Article : Google Scholar : PubMed/NCBI

64 

Theofani E, Semitekolou M, Morianos I, Samitas K and Xanthou G: Targeting NLRP3 inflammasome activation in severe asthma. J Clin Med. 8:16152019. View Article : Google Scholar : PubMed/NCBI

65 

Malireddi RS, Gurung P, Mavuluri J, Dasari TK, Klco JM, Chi H and Kanneganti TD: TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation. J Exp Med. 215:1023–1034. 2018. View Article : Google Scholar : PubMed/NCBI

66 

Malireddi R, Gurung P, Kesavardhana S, Samir P, Burton A, Mummareddy H, Vogel P, Pelletier S, Burgula S and Kanneganti TD: Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity-independent pyroptosis, apoptosis, necroptosis, and inflammatory disease. J Exp Med. 217:201916442020. View Article : Google Scholar

67 

Yang Y, Wang, Kouadir M, Song H and Shi F: Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors. Cell Death Dis. 10:1282019. View Article : Google Scholar : PubMed/NCBI

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Shen J, Fan Z, Sun G and Qi G: Sacubitril/valsartan (LCZ696) reduces myocardial injury following myocardial infarction by inhibiting NLRP3‑induced pyroptosis via the TAK1/JNK signaling pathway. Mol Med Rep 24: 676, 2021.
APA
Shen, J., Fan, Z., Sun, G., & Qi, G. (2021). Sacubitril/valsartan (LCZ696) reduces myocardial injury following myocardial infarction by inhibiting NLRP3‑induced pyroptosis via the TAK1/JNK signaling pathway. Molecular Medicine Reports, 24, 676. https://doi.org/10.3892/mmr.2021.12315
MLA
Shen, J., Fan, Z., Sun, G., Qi, G."Sacubitril/valsartan (LCZ696) reduces myocardial injury following myocardial infarction by inhibiting NLRP3‑induced pyroptosis via the TAK1/JNK signaling pathway". Molecular Medicine Reports 24.3 (2021): 676.
Chicago
Shen, J., Fan, Z., Sun, G., Qi, G."Sacubitril/valsartan (LCZ696) reduces myocardial injury following myocardial infarction by inhibiting NLRP3‑induced pyroptosis via the TAK1/JNK signaling pathway". Molecular Medicine Reports 24, no. 3 (2021): 676. https://doi.org/10.3892/mmr.2021.12315
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Spandidos Publications style
Shen J, Fan Z, Sun G and Qi G: Sacubitril/valsartan (LCZ696) reduces myocardial injury following myocardial infarction by inhibiting NLRP3‑induced pyroptosis via the TAK1/JNK signaling pathway. Mol Med Rep 24: 676, 2021.
APA
Shen, J., Fan, Z., Sun, G., & Qi, G. (2021). Sacubitril/valsartan (LCZ696) reduces myocardial injury following myocardial infarction by inhibiting NLRP3‑induced pyroptosis via the TAK1/JNK signaling pathway. Molecular Medicine Reports, 24, 676. https://doi.org/10.3892/mmr.2021.12315
MLA
Shen, J., Fan, Z., Sun, G., Qi, G."Sacubitril/valsartan (LCZ696) reduces myocardial injury following myocardial infarction by inhibiting NLRP3‑induced pyroptosis via the TAK1/JNK signaling pathway". Molecular Medicine Reports 24.3 (2021): 676.
Chicago
Shen, J., Fan, Z., Sun, G., Qi, G."Sacubitril/valsartan (LCZ696) reduces myocardial injury following myocardial infarction by inhibiting NLRP3‑induced pyroptosis via the TAK1/JNK signaling pathway". Molecular Medicine Reports 24, no. 3 (2021): 676. https://doi.org/10.3892/mmr.2021.12315
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