Effects of calcium‑permeable ion channels on various digestive diseases in the regulation of autophagy (Review)

  • Authors:
    • Jun Lou
    • Xiaoxu Yang
    • Weixi Shan
    • Zhe Jin
    • Jianhong Ding
    • Yanxia Hu
    • Qiushi Liao
    • Qian Du
    • Rui Xie
    • Jingyu Xu
  • View Affiliations

  • Published online on: July 26, 2021     https://doi.org/10.3892/mmr.2021.12319
  • Article Number: 680
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Abstract

Autophagy is a process of degradation and catabolism in cells. By removing damaged or dysfunctional organelles, autophagy interacts with the ubiquitin‑proteasome degradation system to jointly regulate cell function and energy homeostasis. Since autophagy plays a key role in physiology, disorders of the autophagy mechanism are associated with various diseases. Therefore, thorough understanding of the autophagy regulatory mechanism are crucially important in the diagnosis and treatment of diseases. To date, ion channels may affect the development and treatment of diseases by regulating autophagy, especially calcium‑permeable ion channels, in the process of digestive system diseases. However, the mechanism by which calcium ions and their channels regulate autophagy is still poorly understood, thus emphasizing the need for further research in this field. The present review intends to discuss the association, mechanism and application of calcium ions, their channels and autophagy in the occurrence and development of digestive system diseases.
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September-2021
Volume 24 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Lou J, Yang X, Shan W, Jin Z, Ding J, Hu Y, Liao Q, Du Q, Xie R, Xu J, Xu J, et al: Effects of calcium‑permeable ion channels on various digestive diseases in the regulation of autophagy (Review). Mol Med Rep 24: 680, 2021
APA
Lou, J., Yang, X., Shan, W., Jin, Z., Ding, J., Hu, Y. ... Xu, J. (2021). Effects of calcium‑permeable ion channels on various digestive diseases in the regulation of autophagy (Review). Molecular Medicine Reports, 24, 680. https://doi.org/10.3892/mmr.2021.12319
MLA
Lou, J., Yang, X., Shan, W., Jin, Z., Ding, J., Hu, Y., Liao, Q., Du, Q., Xie, R., Xu, J."Effects of calcium‑permeable ion channels on various digestive diseases in the regulation of autophagy (Review)". Molecular Medicine Reports 24.3 (2021): 680.
Chicago
Lou, J., Yang, X., Shan, W., Jin, Z., Ding, J., Hu, Y., Liao, Q., Du, Q., Xie, R., Xu, J."Effects of calcium‑permeable ion channels on various digestive diseases in the regulation of autophagy (Review)". Molecular Medicine Reports 24, no. 3 (2021): 680. https://doi.org/10.3892/mmr.2021.12319