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Atractylenolide‑1 alleviates gastroparesis in diabetic rats by activating the stem cell factor/c‑kit signaling pathway

  • Authors:
    • Hui Li
    • Wen Cao
    • Xun-Bin Zhang
    • Xi-Xia Zhang
    • Chao Gu
    • Li-Mei Gu
    • Cheng-Yu Pan
    • Yao-Zhou Tian
    • Min Lu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, P.R. China, Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, P.R. China, Department of Gastroenterology, Nanjing Lishui District Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu 211200, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 691
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    Published online on: August 1, 2021
       https://doi.org/10.3892/mmr.2021.12331
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Abstract

Diabetic gastroparesis (DGP), also known as delayed gastric emptying, is a common complication of diabetes mellitus. There are numerous clinical symptoms associated with DGP, as well as high treatment costs and markedly reduced patient quality of life. However, the pathogenesis of DGP is not clear, thus effective treatment methods are yet to be established. In the present study, a DGP rat model was established in Sprague‑Dawley rats by the intraperitoneal injection of streptozotocin (STZ). DGP model rats were treated with different doses of atractylenolide‑1 to detect alterations in gastrointestinal function, including gastroparesis, gastric emptying, gastric motility, gastric peristalsis and gastric blood flow. Compared with the DGP group, atractylenolide‑1 treatment significantly reduced glycaemia and the level of glycated hemoglobin, as well as restoring gastrointestinal function. Gastroparesis, gastric emptying, gastric motility, gastric peristalsis and gastric blood flow were significantly impaired in the STZ‑induced group compared with the vehicle control group. Moreover, the STZ‑induced group displayed downregulated expression levels of the DGP indicator KIT proto‑oncogene, receptor tyrosine kinase (c‑kit), as investigated by immunohistochemistry, and stem cell factor (SCF) protein, as assessed using ELISA, significantly enhanced rat interstitial cells of Cajal (ICC) apoptosis, and significantly altered levels of oxidative stress‑related markers (malondialdehyde and superoxide dismutase) in the serum and gastric tissues compared with the vehicle control group. By contrast, treatment with atractylenolide‑1 significantly counteracted the effects of DGP on peristalsis, inhibited apoptosis and suppressed oxidative stress by regulating the expression of heme oxygenase 1 in STZ‑induced DGP model rats. Further research indicated that atractylenolide‑1 regulated oxidative stress reactions and improved gastric function by activating the SCF/c‑kit signaling pathway. Collectively, the results of the present study suggested that atractylenolide‑1 promoted ICC survival and preserved the structure of the gastric tissue network in a DGP rat model via the SCF/c‑kit signaling pathway, providing novel insights for the treatment of DGP.
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1 

Jung HK: The incidence, prevalence, and survival of gastroparesis in olmsted county, Minnesota, 1996–2006 (gastroenterology 2009;136:1225-1233). J Neurogastroenterol Motil. 16:99–100. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Vinik AI and Ziegler D: Diabetic cardiovascular autonomic neuropathy. Circulation. 115:387–397. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Choung RS, Locke GR III, Schleck CD, Zinsmeister AR, Melton LJ III and Talley NJ: Risk of gastroparesis in subjects with type 1 and 2 diabetes in the general population. Am J Gastroenterol. 107:82–88. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Camilleri M: Advances in diabetic gastroparesis. Rev Gastroenterol Disord. 2:47–56. 2002.PubMed/NCBI

5 

Camilleri M, Parkman HP, Shafi MA, Abell TL and Gerson L; American College of Gastroenterology, : Clinical guideline: Management of gastroparesis. Am J Gastroenterol. 108:18–37; quiz 38. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Wang CP, Kao CH, Chen WK, Lo WY and Hsieh CL: A single-blinded, randomized pilot study evaluating effects of electroacupuncture in diabetic patients with symptoms suggestive of gastroparesis. J Altern Complement Med. 14:833–839. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Thazhath SS, Jones KL, Horowitz M and Rayner CK: Diabetic gastroparesis: Recent insights into pathophysiology and implications for management. Expert Rev Gastroenterol Hepatol. 7:127–139. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Talley NJ, Young L, Bytzer P, Hammer J, Leemon M, Jones M and Horowitz M: Impact of chronic gastrointestinal symptoms in diabetes mellitus on health-related quality of life. Am J Gastroenterol. 96:71–76. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Abell TL, Bernstein RK, Cutts T, Farrugia G, Forster J, Hasler WL, McCallum RW, Olden KW, Parkman HP, Parrish CR, et al: Treatment of gastroparesis: A multidisciplinary clinical review. Neurogastroenterol Motil. 18:263–283. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Syed AA, Rattansingh A and Furtado SD: Current perspectives on the management of gastroparesis. J Postgrad Med. 51:54–60. 2005.PubMed/NCBI

11 

Santhanam P, Marashdeh W and Solnes L: Functional imaging of evaluation of diabetic gastroparesis. Curr Diabetes Rev. 14:222–226. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Vinik AI, Erbas T and Casellini CM: Diabetic cardiac autonomic neuropathy, inflammation and cardiovascular disease. J Diabetes Investig. 4:4–18. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Moraveji S, Bashashati M, Elhanafi S, Sunny J, Sarosiek I, Davis B, Torabi A and McCallum RW: Depleted interstitial cells of Cajal and fibrosis in the pylorus: Novel features of gastroparesis. Neurogastroenterol Motil. 28:1048–1054. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Thuneberg L: Interstitial cells of Cajal: Intestinal pacemaker cells? Adv Anat Embryol Cell Biol. 71:1–130. 1982. View Article : Google Scholar : PubMed/NCBI

15 

Rich A, Miller SM, Gibbons SJ, Malysz J, Szurszewski JH and Farrugia G: Local presentation of Steel factor increases expression of c-kit immunoreactive interstitial cells of Cajal in culture. Am J Physiol Gastrointest Liver Physiol. 284:G313–G320. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Faussone Pellegrini MS, Cortesini C and Romagnoli P: Ultrastructure of the tunica muscularis of the cardial portion of the human esophagus and stomach, with special reference to the so-called Cajal's interstitial cells. Arch Ital Anat Embriol. 82:157–177. 1977.(In Italian). PubMed/NCBI

17 

Forster J, Damjanov I, Lin Z, Sarosiek I, Wetzel P and McCallum RW: Absence of the interstitial cells of Cajal in patients with gastroparesis and correlation with clinical findings. J Gastrointest Surg. 9:102–108. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Iwasaki H, Kajimura M, Osawa S, Kanaoka S, Furuta T, Ikuma M and Hishida A: A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus. J Gastroenterol. 41:1076–1087. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Choi KM, Gibbons SJ, Nguyen TV, Stoltz GJ, Lurken MS, Ordog T, Szurszewski JH and Farrugia G: Heme oxygenase-1 protects interstitial cells of Cajal from oxidative stress and reverses diabetic gastroparesis. Gastroenterology. 135:2055–2064, 2064 e1-2. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Jin QH, Shen HX, Wang H, Shou QY and Liu Q: Curcumin improves expression of SCF/c-kit through attenuating oxidative stress and NF-κB activation in gastric tissues of diabetic gastroparesis rats. Diabetol Metab Syndr. 5:122013. View Article : Google Scholar : PubMed/NCBI

21 

Feng J, Gao J, Zhou S, Liu Y, Zhong Y, Shu Y, Meng MS, Yan J, Sun D, Fang Q, et al: Role of stem cell factor in the regulation of ICC proliferation and detrusor contraction in rats with an underactive bladder. Mol Med Rep. 16:1516–1522. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Song HP, Li RL, Zhou C, Cai X and Huang HY: Atractylodes macrocephala Koidz stimulates intestinal epithelial cell migration through a polyamine dependent mechanism. J Ethnopharmacol. 159:23–35. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Hossen MJ, Chou JY, Li SM, Fu XQ, Yin C, Guo H, Amin A, Chou GX and Yu ZL: An ethanol extract of the rhizome of Atractylodes chinensis exerts anti-gastritis activities and inhibits Akt/NF-κB signaling. J Ethnopharmacol. 228:18–25. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Hossen MJ, Amin A, Fu XQ, Chou JY, Wu JY, Wang XQ, Chen YJ, Wu Y, Li J, Yin CL, et al: The anti-inflammatory effects of an ethanolic extract of the rhizome of Atractylodes lancea, involves Akt/NF-κB signaling pathway inhibition. J Ethnopharmacol. 277:1141832021. View Article : Google Scholar : PubMed/NCBI

25 

Zhu B, Zhang QL, Hua JW, Cheng WL and Qin LP: The traditional uses, phytochemistry, and pharmacology of Atractylodes macrocephala Koidz.: A review. J Ethnopharmacol. 226:143–167. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Wang C, Duan H and He L: Inhibitory effect of atractylenolide I on angiogenesis in chronic inflammation in vivo and in vitro. Eur J Pharmacol. 612:143–152. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Guide for the Care and Use of Laboratory Animals. National Academies Press; Washington, DC: 1996

28 

Olfert ED, Cross BM and McWilliam AA: Guide to the Care and Use of Experimental Animals. 1. 2nd edition. Ottawa, ON, Canada: 1993

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Al-Awar A, Kupai K, Veszelka M, Szűcs G, Attieh Z, Murlasits Z, Török S, Pósa A and Varga C: Experimental diabetes mellitus in different animal models. J Diabetes Res. 2016:90514262016. View Article : Google Scholar : PubMed/NCBI

31 

Da Silva LM, da Silva RCMVAF, Maria-Ferreira D, Beltrame OC, da Silva-Santos JE and Werner MFP: Vitamin C improves gastroparesis in diabetic rats: Effects on gastric contractile responses and oxidative stress. Dig Dis Sci. 62:2338–2347. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Li J, Tang HL, Chen Y, Fan Q, Shao YT, Jia M, Wang JC and Yang CM: Malondialdehyde and SOD-induced changes of gastric tissues in acute gastric mucosal injury under positive acceleration. Genet Mol Res. 14:4361–4368. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Bharucha AE, Batey-Schaefer B, Cleary PA, Murray JA, Cowie C, Lorenzi G, Driscoll M, Harth J, Larkin M, Christofi M, et al: Diabetes control and complications trial-epidemiology of diabetes interventions and complications research Group: delayed gastric emptying is associated with early and long-term hyperglycemia in type 1 diabetes mellitus. Gastroenterology. 149:330–339. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Yamamoto T, Watabe K, Nakahara M, Ogiyama H, Kiyohara T, Tsutsui S, Tamura S, Shinomura Y and Hayashi N: Disturbed gastrointestinal motility and decreased interstitial cells of Cajal in diabetic db/db mice. J Gastroenterol Hepatol. 23:660–667. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Chen W, Jiang C, Jin X, Shen W, Song B and Li L: Roles of stem cell factor on loss of interstitial cells of Cajal in bladder of diabetic rats. Urology. 78:1443.e1–1443.e6. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Yu Y, Cai Q and Jia TZ: Study on variation of gastroprotective effect of Atractylodes lancea Rhizome before and after processing. Zhong Yao Cai. 39:760–763. 2016.(In Chinese). PubMed/NCBI

37 

Giacco F and Brownlee M: Oxidative stress and diabetic complications. Circ Res. 107:1058–1070. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Xu L, Li Z and Guo F: Curcumin improves expression of ghrelin through attenuating oxidative stress in gastric tissues of streptozotocin-induced diabetic gastroparesis rats. Eur J Pharmacol. 718:219–225. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li H, Cao W, Zhang X, Zhang X, Gu C, Gu L, Pan C, Tian Y and Lu M: Atractylenolide‑1 alleviates gastroparesis in diabetic rats by activating the stem cell factor/c‑kit signaling pathway. Mol Med Rep 24: 691, 2021.
APA
Li, H., Cao, W., Zhang, X., Zhang, X., Gu, C., Gu, L. ... Lu, M. (2021). Atractylenolide‑1 alleviates gastroparesis in diabetic rats by activating the stem cell factor/c‑kit signaling pathway. Molecular Medicine Reports, 24, 691. https://doi.org/10.3892/mmr.2021.12331
MLA
Li, H., Cao, W., Zhang, X., Zhang, X., Gu, C., Gu, L., Pan, C., Tian, Y., Lu, M."Atractylenolide‑1 alleviates gastroparesis in diabetic rats by activating the stem cell factor/c‑kit signaling pathway". Molecular Medicine Reports 24.4 (2021): 691.
Chicago
Li, H., Cao, W., Zhang, X., Zhang, X., Gu, C., Gu, L., Pan, C., Tian, Y., Lu, M."Atractylenolide‑1 alleviates gastroparesis in diabetic rats by activating the stem cell factor/c‑kit signaling pathway". Molecular Medicine Reports 24, no. 4 (2021): 691. https://doi.org/10.3892/mmr.2021.12331
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Cao W, Zhang X, Zhang X, Gu C, Gu L, Pan C, Tian Y and Lu M: Atractylenolide‑1 alleviates gastroparesis in diabetic rats by activating the stem cell factor/c‑kit signaling pathway. Mol Med Rep 24: 691, 2021.
APA
Li, H., Cao, W., Zhang, X., Zhang, X., Gu, C., Gu, L. ... Lu, M. (2021). Atractylenolide‑1 alleviates gastroparesis in diabetic rats by activating the stem cell factor/c‑kit signaling pathway. Molecular Medicine Reports, 24, 691. https://doi.org/10.3892/mmr.2021.12331
MLA
Li, H., Cao, W., Zhang, X., Zhang, X., Gu, C., Gu, L., Pan, C., Tian, Y., Lu, M."Atractylenolide‑1 alleviates gastroparesis in diabetic rats by activating the stem cell factor/c‑kit signaling pathway". Molecular Medicine Reports 24.4 (2021): 691.
Chicago
Li, H., Cao, W., Zhang, X., Zhang, X., Gu, C., Gu, L., Pan, C., Tian, Y., Lu, M."Atractylenolide‑1 alleviates gastroparesis in diabetic rats by activating the stem cell factor/c‑kit signaling pathway". Molecular Medicine Reports 24, no. 4 (2021): 691. https://doi.org/10.3892/mmr.2021.12331
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