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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October-2021 Volume 24 Issue 4

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

miR‑101a‑3p overexpression prevents acetylcholine‑CaCl2‑induced atrial fibrillation in rats via reduction of atrial tissue fibrosis, involving inhibition of EZH2

Jing Zhu, Ning Zhu, Jian Xu
Article Number: 740
Published online on: 20 August 2021

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Article Open Access

Assessing the protective effects of cryptotanshinone on CoCl2‑induced hypoxia in RPE cells

Yu Gu, Weiming Liu, Gaoqin Liu, Xin Li, Peirong Lu
Article Number: 739
Published online on: 20 August 2021

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Article Open Access

Role of the CXCR3‑mediated TLRs/MyD88 signaling pathway in promoting the development of hepatitis B into cirrhosis and liver cancer

Gang Yuan, Bin Chen, Yina Meng, Jialin Lu, Xiaojun Shi, Airong Hu, Yaoren Hu, Donghui Wang
Article Number: 738
Published online on: 20 August 2021

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Article Open Access

Porcine pancreas mesenchymal cell characterization and functional differentiation into insulin‑producing cells in vitro

Shang Zhang, Qi Wang, Hongbing Ji, Huidi Lu, Qin Yang, Jiahui Yin, Weijun Guan
Article Number: 737
Published online on: 17 August 2021

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Article Open Access

Polyherbal formulation Anoac‑H suppresses the expression of RANTES and VEGF for the management of bleeding hemorrhoids and fistula

Ashwin Porwal, Gopal C. Kundu, Gajanan Bhagwat, Ramesh Butti
Article Number: 736
Published online on: 16 August 2021

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Article Open Access

hsa‑miR‑15a‑5p inhibits colon cell carcinoma via targeting CCND1

Zhipeng Li, Zeyu Zhu, Yanjun Wang, Ying Wang, Weibing Li, Zhigang Wang, Xinyuan Zhou, Yuhua Bao
Article Number: 735
Published online on: 16 August 2021

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Review Open Access

Roles of α‑synuclein in gastrointestinal microbiome dysbiosis‑related Parkinson's disease progression (Review)

Qingchun Lei, Tingting Wu, Jin Wu, Xiaogang Hu, Yingxia Guan, Ying Wang, Jinyuan Yan, Guolin Shi
Article Number: 734
Published online on: 16 August 2021

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Article

Intermedin1‑47 inhibits high phosphate‑induced vascular smooth muscle cell calcification by regulating Wnt/β‑catenin signaling

Yin Zhang, Naiwang Tang, Jinjie Zhou
Article Number: 733
Published online on: 16 August 2021

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Review Open Access

Theories behind the effect of starch‑ and sucrose‑reduced diets on gastrointestinal symptoms in irritable bowel syndrome (Review)

Bodil Ohlsson
Article Number: 732
Published online on: 16 August 2021

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Article Open Access

A microRNA‑17‑5p/homeobox B13 axis participates in the phenotypic modulation of vascular smooth muscle cells

Tianchi Yu, Tao Wang, Shifang Kuang, Guoping Zhao, Kun Zhou, Hui Zhang
Article Number: 731
Published online on: 16 August 2021

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Article Open Access

Ulinastatin protects against sepsis‑induced myocardial injury by inhibiting NLRP3 inflammasome activation

Juanjuan Qiu, Xiaoguang Xiao, Xue Gao, Yongli Zhang
Article Number: 730
Published online on: 16 August 2021

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Article Open Access

Reactive oxygen species induced by uric acid promote NRK‑52E cell apoptosis through the NEK7‑NLRP3 signaling pathway

Dongdong Li, Luobing Wang, Jiaoying Ou, Chuanxu Wang, Jiabao Zhou, Lili Lu, Yanshneg Wu, Jiandong Gao
Article Number: 729
Published online on: 13 August 2021

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Article Open Access

Circular RNA OMA1 regulates the progression of breast cancer via modulation of the miR‑1276/SIRT4 axis

Lingli Xu, Ke Xu, Lijun Xiang, Jiamei Yan
Article Number: 728
Published online on: 13 August 2021

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Retraction Open Access

[Retracted] Upregulation of microRNA‑27b contributes to the migration and invasion of gastric cancer cells via the inhibition of sprouty2‑mediated ERK signaling

Juan Jiang, Bo Yi, Chunxiang Qin, Siqing Ding, Wei Cao
Article Number: 727
Published online on: 13 August 2021

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Retraction Open Access

[Retracted] MicroRNA‑145 inhibits migration and invasion via inhibition of fascin 1 protein expression in non‑small‑cell lung cancer cells

Yingying Zhang, Xucheng Yang, Haijun Wu, Weibin Zhou, Zhenzhen Liu
Article Number: 726
Published online on: 12 August 2021

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Article Open Access

Alcohol inhibits alveolar fluid clearance through the epithelial sodium channel via the A2 adenosine receptor in acute lung injury

Wang Deng, Jing He, Xu-Mao Tang, Chang-Yi Li, Jin Tong, Di Qi, Dao-Xin Wang
Article Number: 725
Published online on: 11 August 2021

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Article

MicroRNA‑25 protects nucleus pulposus cells against apoptosis via targeting SUMO2 in intervertebral disc degeneration Retraction in /10.3892/mmr.2024.13212

Changbin Lei, Jian Li, Guang Tang, Jiong Wang
Article Number: 724
Published online on: 11 August 2021

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Article Open Access

miR‑4306 inhibits the malignant behaviors of colorectal cancer by regulating lncRNA FoxD2‑AS1 Retraction in /10.3892/mmr.2024.13299

Jinjun Ye, Jidong Liu, Tao Tang, Le Xin, Xing Bao, Yukuang Yan
Article Number: 723
Published online on: 11 August 2021

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Article Open Access

HOXB13 suppresses proliferation, migration and invasion, and promotes apoptosis of gastric cancer cells through transcriptional activation of VGLL4 to inhibit the involvement of TEAD4 in the Hippo signaling pathway

Hui Geng, Guangli Liu, Jiandong Hu, Jianchao Li, Dong Wang, Shenshan Zou, Xintao Xu
Article Number: 722
Published online on: 11 August 2021

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Article Open Access

Chemosensitivity analysis and study of gene resistance on tumors and cancer stem cell isolates from patients with colorectal cancer

Elsa N. Garza‑Treviño, Herminia G. Martínez‑Rodríguez, Paulina Delgado‑González, Orlando Solís‑Coronado, Rocio Ortíz‑Lopez, Adolfo Soto‑Domínguez, Víctor M. Treviño, Gerardo R. Padilla‑Rivas, Jose F. Islas‑Cisneros, Adriana G. Quiroz‑Reyes, Salvador L. Said‑Fernández
Article Number: 721
Published online on: 11 August 2021

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Correction Open Access

[Corrigendum] Hsa‑circRNA‑G004213 promotes cisplatin sensitivity by regulating miR‑513b‑5p/PRPF39 in liver cancer

Ling Qin, Zibo Zan, Chunxue Wei, Xuemei Li, Tongqin Zhang, Jun Li
Article Number: 720
Published online on: 11 August 2021

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Article Open Access

Adiponectin inhibits D‑gal‑induced cardiomyocyte senescence via AdipoR1/APPL1

Ruiying Liu, Jing Meng, Danfei Lou
Article Number: 719
Published online on: 10 August 2021

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Article Open Access

Phylogenetic analysis of combined lobular and ductal carcinoma of the breast

Hiroko Kobayashi, Tokiko Nakai, Yoko Nakanishi, Mariko Esumi, Shinobu Masuda
Article Number: 718
Published online on: 10 August 2021

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Article

Inhibition of the p‑SPAK/p‑NKCC1 signaling pathway protects the blood‑brain barrier and reduces neuronal apoptosis in a rat model of surgical brain injury

Yating Gong, Muyao Wu, Fan Gao, Mengying Shi, Haiping Gu, Rong Gao, Bao-Qi Dang, Gang Chen
Article Number: 717
Published online on: 10 August 2021

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Article

CXCL16 may be a predisposing factor to atherosclerosis: An animal study

Junbi Zhao, Menglin Yang, Jie Wu
Article Number: 716
Published online on: 10 August 2021

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Article Open Access

Methylation profile of hepatitis B virus is not influenced by interferon α in human liver cancer cells

In Young Moon, Jin-Wook Kim
Article Number: 715
Published online on: 10 August 2021

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Review

Functional role of miR‑155 in physiological and pathological processes of liver injury (Review)

Xiao Feng, Jiaying Bao, Chunxia Song, Ling Xie, Xu Tan, Jiaqi Li, Huimin Jia, Miaomiao Tian, Jianni Qi, Chengyong Qin, Hongjun Bian
Article Number: 714
Published online on: 10 August 2021

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Article Open Access

Erastin‑induced ferroptosis causes physiological and pathological changes in healthy tissues of mice

Jing Zhao, Ben Xu, Qingqing Xiong, Yunfei Feng, Huahua Du
Article Number: 713
Published online on: 10 August 2021

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Article Open Access

Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4 Corrigendum in /10.3892/mmr.2025.13752

Yan Shi, Shu-Ai Hou
Article Number: 712
Published online on: 10 August 2021

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Article

lncRNA GAS5 regulates angiogenesis by targeting miR‑10a‑3p/VEGFA in osteoporosis

Wen Wu, Qiang Li, Yi-Feng Liu, Yong Li
Article Number: 711
Published online on: 09 August 2021

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Article Open Access

Cucurbitacin B enhances apoptosis in gefitinib resistant non‑small cell lung cancer by modulating the miR‑17‑5p/STAT3 axis

Baodan Yu, Lixia Zheng, Huiqin Tang, Weixin Wang, Yongping Lin
Article Number: 710
Published online on: 09 August 2021

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Article Open Access

Metformin inhibits cholesterol‑induced adhesion molecule expression via activating the AMPK signaling pathway in vascular smooth muscle cells

Qi Liu, Mengyue Yang, Lu Zhang, Ruoxi Zhang, Xingtao Huang, Xuedong Wang, Wenjuan Du, Jingbo Hou
Article Number: 709
Published online on: 09 August 2021

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Article Open Access

miR‑125a‑5p and miR‑7 inhibits the proliferation, migration and invasion of vascular smooth muscle cell by targeting EGFR

Hualan Zhou, Sen Lin, Youdong Hu, Dianxuan Guo, Yun Wang, Xia Li
Article Number: 708
Published online on: 09 August 2021

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Retraction Open Access

[Retracted] Effects of cyclooxygenase‑2 gene silencing on the biological behavior of SKOV3 ovarian cancer cells

Feng-Jun Guo, Jing-Yan Tian, Yue-Mei Jin, Ling Wang, Rui-Qi Yang, Man-Hua Cui
Article Number: 707
Published online on: 08 August 2021

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Review Open Access

Functional study of SCCD pathogenic gene UBIAD1 (Review)

Jumin Xie, Lingxing Li
Article Number: 706
Published online on: 06 August 2021

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Retraction Open Access

[Retracted] MicroRNA‑144 acts as a tumor suppressor by targeting Rho‑associated coiled‑coil containing protein kinase 1 in osteosarcoma cells

Jianjun Huang, Ying Shi, Hui Li, Meisongzhu Yang, Guohong Liu
Article Number: 705
Published online on: 05 August 2021

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Retraction Open Access

[Retracted] MicroRNA‑7 inhibits the malignant phenotypes of non‑small cell lung cancer in vitro by targeting Pax6

Jiashun Luo, Hui Li, Chunfang Zhang
Article Number: 704
Published online on: 05 August 2021

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Article

Canagliflozin is a potential cardioprotective drug but exerts no significant effects on pirarubicin‑induced cardiotoxicity in rats

Hongwei Shi, Qingfu Zeng, Yunjie Wei, Hong Yang, Heng Tang, Dan Wang, Peng Pu, Rui Feng
Article Number: 703
Published online on: 05 August 2021

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Article Open Access

Study of the pathology and the underlying molecular mechanism of tissue injury around hematoma following intracerebral hemorrhage

Jinglei Wang, Ying Chen, Jingjing Liang, Maosheng Cao, Jiabing Shen, Kaifu Ke
Article Number: 702
Published online on: 05 August 2021

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Article

Isoalantolactone alleviates ovalbumin‑induced asthmatic inflammation by reducing alternatively activated macrophage and STAT6/PPAR‑γ/KLF4 signals

Yunduan Song, Xiaozong Li, Fangfang Liu, Hongbo Zhu, Yao Shen
Article Number: 701
Published online on: 05 August 2021

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Article Open Access

Glutamate receptor, ionotropic, N‑methyl D‑aspartate‑associated protein 1 promotes colorectal cancer cell proliferation and metastasis, and is negatively regulated by miR‑296‑3p

Zaihua Yan, Peidong Li, Yuan Xue, Hongpeng Tian, Tong Zhou, Guangjun Zhang
Article Number: 700
Published online on: 04 August 2021

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Article Open Access

circCD151 promotes GLI2 expression by regulating miR‑30d‑5p and enhancing proliferation, invasion and stemness of lung cancer

Lihong Zhao, Hong Zheng, Ping Jiang
Article Number: 699
Published online on: 04 August 2021

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Article Open Access

Ginsenoside Re exhibits neuroprotective effects by inhibiting neuroinflammation via CAMK/MAPK/NF‑κB signaling in microglia

Iskander Madhi, Ji-Hee Kim, Ji Eun Shin, Younghee Kim
Article Number: 698
Published online on: 03 August 2021

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Article Open Access

Comparative analysis of the autism‑related variants between different autistic children in a family pedigree

Luxi Shen, Panyuan Li, Tianjin Zheng, Meichen Luo, Shao Zhang, Yuting Huang, Yongwu Hu, Hongzhi Li
Article Number: 697
Published online on: 03 August 2021

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Review Open Access

Protective effect of hydrogen sulfide on the kidney (Review)

Hu Zhang, Haitian Zhao, Nannan Guo
Article Number: 696
Published online on: 03 August 2021

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Retraction Open Access

[Retracted] MicroRNA‑214 promotes proliferation and inhibits apoptosis via targeting Bax in nasopharyngeal carcinoma cells

Jian He, Yaoyun Tang, Yongquan Tian
Article Number: 695
Published online on: 02 August 2021

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Retraction Open Access

[Retracted] MicroRNA‑101 induces apoptosis in cisplatin‑resistant gastric cancer cells by targeting VEGF‑C

Guangyan Li, Fang Yang, Shiyu Gu, Zhenjuan Li, Minghui Xue
Article Number: 694
Published online on: 02 August 2021

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Correction Open Access

[Corrigendum] Synergic effect between 5‑fluorouracil and celecoxib on hypoxic gastric cancer cells

Xiao-Qian Zhang, Xiu-E Sun, Wen-Dong Liu, Yu-Guang Feng, Hong-Mei Zhang, Li-Hong Shi, Xiu-Ning Sun, Yan-Qing Li, Zhi-Xing Gao
Article Number: 693
Published online on: 02 August 2021

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Article Open Access

Salidroside inhibits endothelial‑mesenchymal transition via the KLF4/eNOS signaling pathway

Yongpan Huang, Xiaodong Han, Jiayu Tang, Xian Long, Xiaoye Wang
Article Number: 692
Published online on: 01 August 2021

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Article Open Access

Atractylenolide‑1 alleviates gastroparesis in diabetic rats by activating the stem cell factor/c‑kit signaling pathway

Hui Li, Wen Cao, Xun-Bin Zhang, Xi-Xia Zhang, Chao Gu, Li-Mei Gu, Cheng-Yu Pan, Yao-Zhou Tian, Min Lu
Article Number: 691
Published online on: 01 August 2021

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Article Open Access

Heat shock protein 70 attenuates hypoxia‑induced apoptosis of pulmonary microvascular endothelial cells isolated from neonatal rats

Jing Cao, Lingjie Yang, Le Wang, Qian Zhao, Dian Wu, Mingxia Li, Yuming Mu
Article Number: 690
Published online on: 30 July 2021

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Article Open Access

miR‑351‑5p aggravates lipopolysaccharide‑induced acute lung injury via inhibiting AMPK

Fen Hu, Xianfeng Dong, Weixin Li, Jianfa Lv, Feng Lin, Gan Song, Guoqiang Hou, Ruiyun Li
Article Number: 689
Published online on: 30 July 2021

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Article Open Access

Urantide prevents CCl4‑induced acute liver injury in rats by regulating the MAPK signalling pathway

Ying Li, Zheming Guo, Haipeng Cui, Tu Wang, Yuhang Xu, Juan Zhao
Article Number: 688
Published online on: 30 July 2021

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Article

Prevention of streptozotocin‑induced Neuro‑2a cell death by C8‑B4 microglia transformed with repetitive low‑dose lipopolysaccharide

Haruka Mizobuchi, Kazushi Yamamoto, Masashi Yamashita, Hiroyuki Inagawa, Chie Kohchi, Gen-Ichiro Soma
Article Number: 687
Published online on: 30 July 2021

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Article Open Access

Liquiritigenin attenuates isoprenaline‑induced myocardial fibrosis in mice through the TGF‑β1/Smad2 and AKT/ERK signaling pathways

Li Li, Hui Fang, Yong-Hong Yu, Shan-Xin Liu, Zhi-Qiang Yang
Article Number: 686
Published online on: 30 July 2021

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Article Open Access

Galectin‑3 blockade suppresses the growth of cetuximab‑resistant human oral squamous cell carcinoma Retraction in /10.3892/mmr.2024.13275

Peng Yin, Shuanlong Cui, Xiangling Liao, Xiaoguang Yao
Article Number: 685
Published online on: 29 July 2021

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Article Open Access

Knockdown of circ‑PVT1 inhibits the progression of lung adenocarcinoma and enhances the sensitivity to cisplatin via the miR‑429/FOXK1 signaling axis

Limin Cao, Xuefeng Zhou, Xi Ding, Dongyun Gao
Article Number: 684
Published online on: 29 July 2021

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Article Open Access

miR‑214 ameliorates sepsis‑induced acute kidney injury via PTEN/AKT/mTOR‑regulated autophagy

Zhenzhen Sang, Shimin Dong, Pu Zhang, Yunxia Wei
Article Number: 683
Published online on: 29 July 2021

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Journal Cover
November-2026 Volume 34 Issue 5

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Research on the role and mechanism of SLC7A5 in idiopathic pulmonary fibrosis

Menghan Wang, Yao Yu, Zhaoyu Liu, Dandan Xu, Yupeng Li, Xing Zou, Ning Shan, Xining Liu, Ce Shi, Hong Chen
Article Number: 323
Published online on: 01 October 2026

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Review Open Access

Electroencephalography research in neuropathic pain (Review)

Lanling Zhou, Nianshun Liao, Hongmei Wang, Jiaxi Zhao, Haijun Jiang, Shihua Dang, Sixun Yu, Haifeng Shu, Xin Chen
Article Number: 322
Published online on: 25 September 2026

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BMAL1 in cardiovascular diseases: Molecular mechanisms, circadian regulation and translational perspectives (Review)

Yu Liang, Tingjin Chen, Xuemei Wen, Dan Liu, Zhongjian Zhang, Weiqing Li, Hengdi Zhang
Article Number: 321
Published online on: 24 September 2026

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Review Open Access

Progress on quinoline‑based antitumour agents: Mechanistic insights and optimization strategies (Review)

Yuwen Zeng, Yutong Yan, Shiye Wu, Wanshan Wu, Ke Chen, Youyi Lai, Qing Ye, Nan Zhang, Yuanyuan Zhou
Article Number: 320
Published online on: 23 September 2026

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Review Open Access

Lactylation in gastric cancer: From mechanisms to clinical applications (Review)

Yuliang Fang, Peng Chen, Yuhong Gao, Yanpiao Li, Xue Li
Article Number: 319
Published online on: 23 September 2026

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Sleep deprivation exacerbates lens‑induced myopia in association with ERK/NF‑κB pathway activation

Xueli Yang, Zhou Zhang, Chengbai Zhu, Jianbo Li, Wenting Gong, Ruirui Yang, Lipeng Guan
Article Number: 318
Published online on: 22 September 2026

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Advances in biomarkers of benzene exposure and toxicity: From mechanistic insights to occupational health applications (Review)

Yuanshe Huang, Zhenjun Xi, Jingxin Mao, Xiaobing Li
Article Number: 317
Published online on: 21 September 2026

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Retraction Open Access

[Retracted] CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells

Long-Qiao Cao, Ya-Nan Wang, Ming Liang, Mei-Zhou Pan
Article Number: 316
Published online on: 21 September 2026

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Artemisinin and its derivatives for metabolic syndrome: From multi‑target mechanisms to translational opportunities (Review)

Shuo Cao, Mo Yang, Siyu Qu, Jinsong Wu, Jiaheng Li, Ying Zhao
Article Number: 315
Published online on: 17 September 2026

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Demethylase FTO attenuates atherosclerotic plaque via upregulating ABCA1 and ABCG1 expression by targeting ATG5

Fengxia Guo, Mei He, Yaonan Li, Kangning Zhu, Bing Hu
Article Number: 314
Published online on: 16 September 2026

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Correction Open Access

[Corrigendum] Bcl11b regulates enamel matrix protein expression and dental epithelial cell differentiation during rat tooth development

Ziyue Li, Guoqing Chen, Yaling Yang, Weihua Guo, Weidong Tian
Article Number: 313
Published online on: 16 September 2026

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Review Open Access

Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review)

Changshun Chen, Xingxi Hu, Sixing Wei, Yongcheng Deng, Qinggang Zhao, Ge Chen, Zhong Cheng, Jianhua Ji, Jinyi Gu
Article Number: 312
Published online on: 15 September 2026

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Therapeutic effects of exosome‑based hyperin delivery in a cyclophosphamide‑induced mouse model of diminished ovarian reserve

Yi Ying, Yue Wu, Ji Zhou, Yaming Wang, Hongtao Yin, Gang Lu, Ruolang Pan, Liangzhong Lv
Article Number: 311
Published online on: 15 September 2026

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Arginine metabolism, polyamine homeostasis and ferroptosis in cancer: Molecular links and therapeutic opportunities (Review)

Xin Dong, Yongkun Hou, Jingjing Shao, Haixia Zhu, Jibin Liu
Article Number: 310
Published online on: 15 September 2026

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Mitochondria‑associated endoplasmic reticulum membranes in degenerative musculoskeletal disorders: Mechanistic evidence and therapeutic perspectives (Review)

Shilong Meng, Xinlei Fu, Yawei Xu, Zhiliang Peng, Xu Zhang, Yanguang Cao, Binbin Tang, Xiaolin Shi, Kang Liu
Article Number: 309
Published online on: 15 September 2026

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High‑fat diet exacerbates hepatic and adipose insulin signaling impairment and ovarian lesions in a rat model of letrozole‑induced polycystic ovary syndrome

Sunju So, Sujin Kwon, La Yoon Choi, Dae Yong Kim, Mi Hye Kim
Article Number: 308
Published online on: 15 September 2026

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Retraction Open Access

[Retracted] RNAi‑mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non‑small lung cancer in vitro and in vivo

Liang Chang, Fangchao Gong, Youbin Cui
Article Number: 307
Published online on: 14 September 2026

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A four‑gene signature identifies TKI‑induced persister cells and uncovers a ZLN005‑induced pyroptotic vulnerability via the GSDME pathway in EGFR‑mutant lung cancer

Wenwen Chang, Jiaxin Yuan, Huilin Zhang, Ying Yu, Yan Ma, Mingyue Li, Wenjing Li, Hongxia Yan, Chongran Sun, Peng Zhang, Yang Tian, Feng Guo, Pan Li, Yang Sun
Article Number: 306
Published online on: 11 September 2026

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Review Open Access

Research advances in the microbiota‑gut‑brain axis and Parkinson's disease (Review)

Yangping Meng, Qian Liu, Hao Zou, Xingyu Zhu, Xinxin Mi, Sitong Li, Yutian Xia, Yucheng Ma, Qianyu Yang, Jiaxin Peng, Junrui Li, Xingliang Liu, Junli Chen
Article Number: 305
Published online on: 10 September 2026

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Ameliorative effects of Paulownia tomentosa flower absolute on atopic dermatitis‑related responses in mast cells and keratinocytes and its chemical composition

Da Yeon Yoo, Kyung Jong Won, Do Yoon Kim, Yoon Yi Kim, Ji Hye Bae, Ji Seong Yun, Hwan Myung Lee
Article Number: 304
Published online on: 10 September 2026

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Retraction Open Access

[Retracted] PYGB siRNA inhibits the cell proliferation of human osteosarcoma cell lines

Shuwei Zhang, Yichi Zhou, Yuanyu Zha, Yang Yang, Linlong Wang, Jingfeng Li, Wei Jin
Article Number: 303
Published online on: 10 September 2026

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Article Open Access

KIF4A drives esophageal squamous cell carcinoma via Wnt/β‑catenin signaling and predicts poor prognosis

Jialong Chen, Tong Wang, Da Wang, Weiguo Liu, Chunlai Liu, Yang Yang, Xiangfu Sun, Lei Zhou
Article Number: 302
Published online on: 08 September 2026

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Review Open Access

Research progress of aptamers in the diagnosis and treatment of colorectal cancer (Review)

Yiwen Li, Penghui Yan, Ji Zhang, Binghui Wu, Min Li, Baoliang Bao
Article Number: 301
Published online on: 08 September 2026

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Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review)

Mary-Lyn Eichhorn, Anna M. Dmitrieva, Lydia Meder
Article Number: 300
Published online on: 08 September 2026

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Expression of Concern Open Access

[Expression of Concern] Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway

Xiaohui Zhao, Dayu Zhou, Yunen Liu, Chun Li, Xiaoguang Zhao, Ying Li, Wei Li
Article Number: 299
Published online on: 07 September 2026

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Multi‑omics approaches to decipher the molecular mechanisms of exercise‑mediated bone protection: From mechanistic insights to personalized exercise prescription (Review)

Bin Tian, Xuesong Chen, Xin Kang
Article Number: 298
Published online on: 03 September 2026

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Retraction Open Access

[Retracted] MicroRNA‑27a promotes tumorigenesis via targeting AKT in triple negative breast cancer

Jing Wu, Zhihui Sun, Huijie Sun, Yanhua Li
Article Number: 297
Published online on: 03 September 2026

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December-2026 Volume 34 Issue 6

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Research progress in neural regulatory mechanisms and targeted therapy of obesity (Review)

Dejie Kang, Xia Li, Yaoyou Zhang, Yihan Sun, Yuhan Li, Zhiyan Yao, Youlei Li
Article Number: 341
Published online on: 22 October 2026

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Mechanisms of the interaction between aging of the male reproductive system and obesity, and clinical management strategies (Review)

Dandan Luo, Lulu Zhang, Xiangyu Qi, Qiangbo Guan, Feng Xu, Peng Lu, Chunxiao Yu
Article Number: 340
Published online on: 22 October 2026

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Erythropoietin beyond red blood cells: Systemic and oncological functions (Review)

Kristína Danková, Zuzana Solárová, Pavol Harvanik, Martina Šemeláková, Peter Solár
Article Number: 339
Published online on: 22 October 2026

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Liquid‑liquid phase separation and post‑transcriptional regulation intersection: A new paradigm of RNA‑binding protein condensates in hepatocellular carcinoma malignant phenotypes (Review)

Xiao Liu, Yunyi Huang
Article Number: 338
Published online on: 21 October 2026

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Research advances in the interplay between ferroptosis and T cells in the tumor microenvironment (Review)

Shihan Tang, Wenbo Xu, Yichen Li, Chuwei Liu, Weitao Liu, Ruihan Liang, Qianhui Liao, Han Sun, Zhuoyan Wang, Lingchang Shi, Qiying Liu, Huiping Liu
Article Number: 337
Published online on: 21 October 2026

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Gut‑kidney axis in chronic kidney disease: Dysbiosis, uremic metabolites and therapeutic opportunities (Review) 

Yinding Wang, Hanyu Zeng, Na Liu, Dong Yang
Article Number: 336
Published online on: 16 October 2026

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Glycyrrhizic acid attenuates corneal inflammation and pathological angiogenesis through FAK/PI3K/AKT signaling

Jinjin Yu, Huiheng Qu, Yinming Fang, Weicheng Xu, Nannan Ding, Jie Ji, Nan Wang, Wei Shi
Article Number: 335
Published online on: 15 October 2026

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Erbin deficiency exacerbates sepsis‑induced liver injury through mitochondrial ROS/NLRP3‑mediated inflammatory responses

Jing Zuo, Xing Wang, Guoqing Jing, Xiaojing Wu, Xuemin Song
Article Number: 334
Published online on: 15 October 2026

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Gut microbiota in patients receiving dialysis: Mechanisms, complications and the road to personalized microbiome‑based care (Review)

Chenxia Jin, Yanping Wang
Article Number: 333
Published online on: 15 October 2026

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Epigallocatechin gallate and thermal cycling‑stimulation synergistically promote apoptosis in A549 cells via endoplasmic reticulum stress‑induced calcium ion dysregulation and oxidative stress

Fang-Tzu Hsu, Hsu-Hsiang Liu, Yi Kung, Chieh-Jou Lin, Chih-Yu Chao
Article Number: 332
Published online on: 15 October 2026

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Piezo1 knockdown alleviates high‑altitude cerebral edema by improving brain microvascular endothelial cell tight junctions via blocking the calcium influx‑mediated Calpain‑1 activity

Taijian Cao, Zhicheng Xiang, Yangyang Zhao, Drolma Gomchok, Haifeng Ma, Shiwang Li, Dahai Cao, Chunqing Yang, Qiang Zhang
Article Number: 331
Published online on: 13 October 2026

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Navigating the landscape of targeted therapies for renal cell carcinoma in the era of precision medicine (Review)

Hongguo Cui, Jingheng Song, Peisen Yang, Zhengchao Zhang, Yuanyuan Liu, Gang Zhang, Aimin Tian, Jizhong Che, Yangyang Liu, Hui Sun, Yankai Xu
Article Number: 330
Published online on: 13 October 2026

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ΔNp63α‑mediated regulation of tumor‑associated genes and pathways in hepatocellular carcinoma progression

Xiaowen Lin, Anghui Peng, Min Zhang, Xinyang Yu
Article Number: 329
Published online on: 13 October 2026

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 Leptin promotes obesity‑related osteoarthritis progression via CD44/JAK2/STAT3 axis‑mediated chondrocyte apoptosis

Hao Qiu, Chao Zeng, Cheng Chen, Xin Zhou, Yongjun Zhu, Zhongliang Deng
Article Number: 328
Published online on: 09 October 2026

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Review Open Access

Mechanical‑immune feedback regulation in distraction osteogenesis: From mechanotransduction to immune microenvironment remodeling (Review)

Xian Wang, Yuetong Wang, Shixi He, Cheng Ma, Zhengzhong He, Xuanping Huang
Article Number: 327
Published online on: 08 October 2026

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Research progress in synergistic multimechanism of nanomaterial-mediated neuroinflammatory therapy (Review)

Heng Wang, Pei Yang, Wantao Liu
Article Number: 326
Published online on: 07 October 2026

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Retraction Open Access

[Retracted] (‑)‑Epicatechin protects against myocardial ischemia‑induced cardiac injury via activation of the PTEN/PI3K/AKT pathway

Jia-Wen Li, Xiao-Yun Wang, Xin Zhang, Lei Gao, Li-Feng Wang, Xin-Hua Yin
Article Number: 325
Published online on: 05 October 2026

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Review Open Access

Lactylation and exercise: A molecular link to disease alleviation (Review)

Jian Wang, Lei Wu
Article Number: 324
Published online on: 02 October 2026

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