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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October-2021 Volume 24 Issue 4

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

miR‑101a‑3p overexpression prevents acetylcholine‑CaCl2‑induced atrial fibrillation in rats via reduction of atrial tissue fibrosis, involving inhibition of EZH2

Jing Zhu, Ning Zhu, Jian Xu
Article Number: 740
Published online on: 20 August 2021

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Article Open Access

Assessing the protective effects of cryptotanshinone on CoCl2‑induced hypoxia in RPE cells

Yu Gu, Weiming Liu, Gaoqin Liu, Xin Li, Peirong Lu
Article Number: 739
Published online on: 20 August 2021

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Article Open Access

Role of the CXCR3‑mediated TLRs/MyD88 signaling pathway in promoting the development of hepatitis B into cirrhosis and liver cancer

Gang Yuan, Bin Chen, Yina Meng, Jialin Lu, Xiaojun Shi, Airong Hu, Yaoren Hu, Donghui Wang
Article Number: 738
Published online on: 20 August 2021

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Article Open Access

Porcine pancreas mesenchymal cell characterization and functional differentiation into insulin‑producing cells in vitro

Shang Zhang, Qi Wang, Hongbing Ji, Huidi Lu, Qin Yang, Jiahui Yin, Weijun Guan
Article Number: 737
Published online on: 17 August 2021

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Article Open Access

Polyherbal formulation Anoac‑H suppresses the expression of RANTES and VEGF for the management of bleeding hemorrhoids and fistula

Ashwin Porwal, Gopal C. Kundu, Gajanan Bhagwat, Ramesh Butti
Article Number: 736
Published online on: 16 August 2021

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Article Open Access

hsa‑miR‑15a‑5p inhibits colon cell carcinoma via targeting CCND1

Zhipeng Li, Zeyu Zhu, Yanjun Wang, Ying Wang, Weibing Li, Zhigang Wang, Xinyuan Zhou, Yuhua Bao
Article Number: 735
Published online on: 16 August 2021

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Review Open Access

Roles of α‑synuclein in gastrointestinal microbiome dysbiosis‑related Parkinson's disease progression (Review)

Qingchun Lei, Tingting Wu, Jin Wu, Xiaogang Hu, Yingxia Guan, Ying Wang, Jinyuan Yan, Guolin Shi
Article Number: 734
Published online on: 16 August 2021

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Article

Intermedin1‑47 inhibits high phosphate‑induced vascular smooth muscle cell calcification by regulating Wnt/β‑catenin signaling

Yin Zhang, Naiwang Tang, Jinjie Zhou
Article Number: 733
Published online on: 16 August 2021

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Review Open Access

Theories behind the effect of starch‑ and sucrose‑reduced diets on gastrointestinal symptoms in irritable bowel syndrome (Review)

Bodil Ohlsson
Article Number: 732
Published online on: 16 August 2021

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Article Open Access

A microRNA‑17‑5p/homeobox B13 axis participates in the phenotypic modulation of vascular smooth muscle cells

Tianchi Yu, Tao Wang, Shifang Kuang, Guoping Zhao, Kun Zhou, Hui Zhang
Article Number: 731
Published online on: 16 August 2021

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Article Open Access

Ulinastatin protects against sepsis‑induced myocardial injury by inhibiting NLRP3 inflammasome activation

Juanjuan Qiu, Xiaoguang Xiao, Xue Gao, Yongli Zhang
Article Number: 730
Published online on: 16 August 2021

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Article Open Access

Reactive oxygen species induced by uric acid promote NRK‑52E cell apoptosis through the NEK7‑NLRP3 signaling pathway

Dongdong Li, Luobing Wang, Jiaoying Ou, Chuanxu Wang, Jiabao Zhou, Lili Lu, Yanshneg Wu, Jiandong Gao
Article Number: 729
Published online on: 13 August 2021

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Article Open Access

Circular RNA OMA1 regulates the progression of breast cancer via modulation of the miR‑1276/SIRT4 axis

Lingli Xu, Ke Xu, Lijun Xiang, Jiamei Yan
Article Number: 728
Published online on: 13 August 2021

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Retraction Open Access

[Retracted] Upregulation of microRNA‑27b contributes to the migration and invasion of gastric cancer cells via the inhibition of sprouty2‑mediated ERK signaling

Juan Jiang, Bo Yi, Chunxiang Qin, Siqing Ding, Wei Cao
Article Number: 727
Published online on: 13 August 2021

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Retraction Open Access

[Retracted] MicroRNA‑145 inhibits migration and invasion via inhibition of fascin 1 protein expression in non‑small‑cell lung cancer cells

Yingying Zhang, Xucheng Yang, Haijun Wu, Weibin Zhou, Zhenzhen Liu
Article Number: 726
Published online on: 12 August 2021

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Article Open Access

Alcohol inhibits alveolar fluid clearance through the epithelial sodium channel via the A2 adenosine receptor in acute lung injury

Wang Deng, Jing He, Xu-Mao Tang, Chang-Yi Li, Jin Tong, Di Qi, Dao-Xin Wang
Article Number: 725
Published online on: 11 August 2021

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Article

MicroRNA‑25 protects nucleus pulposus cells against apoptosis via targeting SUMO2 in intervertebral disc degeneration Retraction in /10.3892/mmr.2024.13212

Changbin Lei, Jian Li, Guang Tang, Jiong Wang
Article Number: 724
Published online on: 11 August 2021

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Article Open Access

miR‑4306 inhibits the malignant behaviors of colorectal cancer by regulating lncRNA FoxD2‑AS1 Retraction in /10.3892/mmr.2024.13299

Jinjun Ye, Jidong Liu, Tao Tang, Le Xin, Xing Bao, Yukuang Yan
Article Number: 723
Published online on: 11 August 2021

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Article Open Access

HOXB13 suppresses proliferation, migration and invasion, and promotes apoptosis of gastric cancer cells through transcriptional activation of VGLL4 to inhibit the involvement of TEAD4 in the Hippo signaling pathway

Hui Geng, Guangli Liu, Jiandong Hu, Jianchao Li, Dong Wang, Shenshan Zou, Xintao Xu
Article Number: 722
Published online on: 11 August 2021

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Article Open Access

Chemosensitivity analysis and study of gene resistance on tumors and cancer stem cell isolates from patients with colorectal cancer

Elsa N. Garza‑Treviño, Herminia G. Martínez‑Rodríguez, Paulina Delgado‑González, Orlando Solís‑Coronado, Rocio Ortíz‑Lopez, Adolfo Soto‑Domínguez, Víctor M. Treviño, Gerardo R. Padilla‑Rivas, Jose F. Islas‑Cisneros, Adriana G. Quiroz‑Reyes, Salvador L. Said‑Fernández
Article Number: 721
Published online on: 11 August 2021

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Correction Open Access

[Corrigendum] Hsa‑circRNA‑G004213 promotes cisplatin sensitivity by regulating miR‑513b‑5p/PRPF39 in liver cancer

Ling Qin, Zibo Zan, Chunxue Wei, Xuemei Li, Tongqin Zhang, Jun Li
Article Number: 720
Published online on: 11 August 2021

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Article Open Access

Adiponectin inhibits D‑gal‑induced cardiomyocyte senescence via AdipoR1/APPL1

Ruiying Liu, Jing Meng, Danfei Lou
Article Number: 719
Published online on: 10 August 2021

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Article Open Access

Phylogenetic analysis of combined lobular and ductal carcinoma of the breast

Hiroko Kobayashi, Tokiko Nakai, Yoko Nakanishi, Mariko Esumi, Shinobu Masuda
Article Number: 718
Published online on: 10 August 2021

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Article

Inhibition of the p‑SPAK/p‑NKCC1 signaling pathway protects the blood‑brain barrier and reduces neuronal apoptosis in a rat model of surgical brain injury

Yating Gong, Muyao Wu, Fan Gao, Mengying Shi, Haiping Gu, Rong Gao, Bao-Qi Dang, Gang Chen
Article Number: 717
Published online on: 10 August 2021

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Article

CXCL16 may be a predisposing factor to atherosclerosis: An animal study

Junbi Zhao, Menglin Yang, Jie Wu
Article Number: 716
Published online on: 10 August 2021

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Article Open Access

Methylation profile of hepatitis B virus is not influenced by interferon α in human liver cancer cells

In Young Moon, Jin-Wook Kim
Article Number: 715
Published online on: 10 August 2021

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Review

Functional role of miR‑155 in physiological and pathological processes of liver injury (Review)

Xiao Feng, Jiaying Bao, Chunxia Song, Ling Xie, Xu Tan, Jiaqi Li, Huimin Jia, Miaomiao Tian, Jianni Qi, Chengyong Qin, Hongjun Bian
Article Number: 714
Published online on: 10 August 2021

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Article Open Access

Erastin‑induced ferroptosis causes physiological and pathological changes in healthy tissues of mice

Jing Zhao, Ben Xu, Qingqing Xiong, Yunfei Feng, Huahua Du
Article Number: 713
Published online on: 10 August 2021

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Article Open Access

Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4 Corrigendum in /10.3892/mmr.2025.13752

Yan Shi, Shu-Ai Hou
Article Number: 712
Published online on: 10 August 2021

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Article

lncRNA GAS5 regulates angiogenesis by targeting miR‑10a‑3p/VEGFA in osteoporosis

Wen Wu, Qiang Li, Yi-Feng Liu, Yong Li
Article Number: 711
Published online on: 09 August 2021

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Article Open Access

Cucurbitacin B enhances apoptosis in gefitinib resistant non‑small cell lung cancer by modulating the miR‑17‑5p/STAT3 axis

Baodan Yu, Lixia Zheng, Huiqin Tang, Weixin Wang, Yongping Lin
Article Number: 710
Published online on: 09 August 2021

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Article Open Access

Metformin inhibits cholesterol‑induced adhesion molecule expression via activating the AMPK signaling pathway in vascular smooth muscle cells

Qi Liu, Mengyue Yang, Lu Zhang, Ruoxi Zhang, Xingtao Huang, Xuedong Wang, Wenjuan Du, Jingbo Hou
Article Number: 709
Published online on: 09 August 2021

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Article Open Access

miR‑125a‑5p and miR‑7 inhibits the proliferation, migration and invasion of vascular smooth muscle cell by targeting EGFR

Hualan Zhou, Sen Lin, Youdong Hu, Dianxuan Guo, Yun Wang, Xia Li
Article Number: 708
Published online on: 09 August 2021

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Retraction Open Access

[Retracted] Effects of cyclooxygenase‑2 gene silencing on the biological behavior of SKOV3 ovarian cancer cells

Feng-Jun Guo, Jing-Yan Tian, Yue-Mei Jin, Ling Wang, Rui-Qi Yang, Man-Hua Cui
Article Number: 707
Published online on: 08 August 2021

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Review Open Access

Functional study of SCCD pathogenic gene UBIAD1 (Review)

Jumin Xie, Lingxing Li
Article Number: 706
Published online on: 06 August 2021

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Retraction Open Access

[Retracted] MicroRNA‑144 acts as a tumor suppressor by targeting Rho‑associated coiled‑coil containing protein kinase 1 in osteosarcoma cells

Jianjun Huang, Ying Shi, Hui Li, Meisongzhu Yang, Guohong Liu
Article Number: 705
Published online on: 05 August 2021

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Retraction Open Access

[Retracted] MicroRNA‑7 inhibits the malignant phenotypes of non‑small cell lung cancer in vitro by targeting Pax6

Jiashun Luo, Hui Li, Chunfang Zhang
Article Number: 704
Published online on: 05 August 2021

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Article

Canagliflozin is a potential cardioprotective drug but exerts no significant effects on pirarubicin‑induced cardiotoxicity in rats

Hongwei Shi, Qingfu Zeng, Yunjie Wei, Hong Yang, Heng Tang, Dan Wang, Peng Pu, Rui Feng
Article Number: 703
Published online on: 05 August 2021

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Article Open Access

Study of the pathology and the underlying molecular mechanism of tissue injury around hematoma following intracerebral hemorrhage

Jinglei Wang, Ying Chen, Jingjing Liang, Maosheng Cao, Jiabing Shen, Kaifu Ke
Article Number: 702
Published online on: 05 August 2021

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Article

Isoalantolactone alleviates ovalbumin‑induced asthmatic inflammation by reducing alternatively activated macrophage and STAT6/PPAR‑γ/KLF4 signals

Yunduan Song, Xiaozong Li, Fangfang Liu, Hongbo Zhu, Yao Shen
Article Number: 701
Published online on: 05 August 2021

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Article Open Access

Glutamate receptor, ionotropic, N‑methyl D‑aspartate‑associated protein 1 promotes colorectal cancer cell proliferation and metastasis, and is negatively regulated by miR‑296‑3p

Zaihua Yan, Peidong Li, Yuan Xue, Hongpeng Tian, Tong Zhou, Guangjun Zhang
Article Number: 700
Published online on: 04 August 2021

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Article Open Access

circCD151 promotes GLI2 expression by regulating miR‑30d‑5p and enhancing proliferation, invasion and stemness of lung cancer

Lihong Zhao, Hong Zheng, Ping Jiang
Article Number: 699
Published online on: 04 August 2021

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Article Open Access

Ginsenoside Re exhibits neuroprotective effects by inhibiting neuroinflammation via CAMK/MAPK/NF‑κB signaling in microglia

Iskander Madhi, Ji-Hee Kim, Ji Eun Shin, Younghee Kim
Article Number: 698
Published online on: 03 August 2021

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Article Open Access

Comparative analysis of the autism‑related variants between different autistic children in a family pedigree

Luxi Shen, Panyuan Li, Tianjin Zheng, Meichen Luo, Shao Zhang, Yuting Huang, Yongwu Hu, Hongzhi Li
Article Number: 697
Published online on: 03 August 2021

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Review Open Access

Protective effect of hydrogen sulfide on the kidney (Review)

Hu Zhang, Haitian Zhao, Nannan Guo
Article Number: 696
Published online on: 03 August 2021

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Retraction Open Access

[Retracted] MicroRNA‑214 promotes proliferation and inhibits apoptosis via targeting Bax in nasopharyngeal carcinoma cells

Jian He, Yaoyun Tang, Yongquan Tian
Article Number: 695
Published online on: 02 August 2021

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Retraction Open Access

[Retracted] MicroRNA‑101 induces apoptosis in cisplatin‑resistant gastric cancer cells by targeting VEGF‑C

Guangyan Li, Fang Yang, Shiyu Gu, Zhenjuan Li, Minghui Xue
Article Number: 694
Published online on: 02 August 2021

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Correction Open Access

[Corrigendum] Synergic effect between 5‑fluorouracil and celecoxib on hypoxic gastric cancer cells

Xiao-Qian Zhang, Xiu-E Sun, Wen-Dong Liu, Yu-Guang Feng, Hong-Mei Zhang, Li-Hong Shi, Xiu-Ning Sun, Yan-Qing Li, Zhi-Xing Gao
Article Number: 693
Published online on: 02 August 2021

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Article Open Access

Salidroside inhibits endothelial‑mesenchymal transition via the KLF4/eNOS signaling pathway

Yongpan Huang, Xiaodong Han, Jiayu Tang, Xian Long, Xiaoye Wang
Article Number: 692
Published online on: 01 August 2021

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Article Open Access

Atractylenolide‑1 alleviates gastroparesis in diabetic rats by activating the stem cell factor/c‑kit signaling pathway

Hui Li, Wen Cao, Xun-Bin Zhang, Xi-Xia Zhang, Chao Gu, Li-Mei Gu, Cheng-Yu Pan, Yao-Zhou Tian, Min Lu
Article Number: 691
Published online on: 01 August 2021

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Article Open Access

Heat shock protein 70 attenuates hypoxia‑induced apoptosis of pulmonary microvascular endothelial cells isolated from neonatal rats

Jing Cao, Lingjie Yang, Le Wang, Qian Zhao, Dian Wu, Mingxia Li, Yuming Mu
Article Number: 690
Published online on: 30 July 2021

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Article Open Access

miR‑351‑5p aggravates lipopolysaccharide‑induced acute lung injury via inhibiting AMPK

Fen Hu, Xianfeng Dong, Weixin Li, Jianfa Lv, Feng Lin, Gan Song, Guoqiang Hou, Ruiyun Li
Article Number: 689
Published online on: 30 July 2021

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Article Open Access

Urantide prevents CCl4‑induced acute liver injury in rats by regulating the MAPK signalling pathway

Ying Li, Zheming Guo, Haipeng Cui, Tu Wang, Yuhang Xu, Juan Zhao
Article Number: 688
Published online on: 30 July 2021

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Article

Prevention of streptozotocin‑induced Neuro‑2a cell death by C8‑B4 microglia transformed with repetitive low‑dose lipopolysaccharide

Haruka Mizobuchi, Kazushi Yamamoto, Masashi Yamashita, Hiroyuki Inagawa, Chie Kohchi, Gen-Ichiro Soma
Article Number: 687
Published online on: 30 July 2021

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Article Open Access

Liquiritigenin attenuates isoprenaline‑induced myocardial fibrosis in mice through the TGF‑β1/Smad2 and AKT/ERK signaling pathways

Li Li, Hui Fang, Yong-Hong Yu, Shan-Xin Liu, Zhi-Qiang Yang
Article Number: 686
Published online on: 30 July 2021

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Article Open Access

Galectin‑3 blockade suppresses the growth of cetuximab‑resistant human oral squamous cell carcinoma Retraction in /10.3892/mmr.2024.13275

Peng Yin, Shuanlong Cui, Xiangling Liao, Xiaoguang Yao
Article Number: 685
Published online on: 29 July 2021

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Article Open Access

Knockdown of circ‑PVT1 inhibits the progression of lung adenocarcinoma and enhances the sensitivity to cisplatin via the miR‑429/FOXK1 signaling axis

Limin Cao, Xuefeng Zhou, Xi Ding, Dongyun Gao
Article Number: 684
Published online on: 29 July 2021

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Article Open Access

miR‑214 ameliorates sepsis‑induced acute kidney injury via PTEN/AKT/mTOR‑regulated autophagy

Zhenzhen Sang, Shimin Dong, Pu Zhang, Yunxia Wei
Article Number: 683
Published online on: 29 July 2021

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Journal Cover
August-2026 Volume 34 Issue 2

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Regulatory function of ten‑eleven translocation‑2 in transcriptional mechanisms of demethylated myeloma cells

Lenka Slavickova, Michaela Nemcova, Dominika Svehlova, Veronika Frybortova, Jirina Manakova, Eva Kriegova, Jiri Minarik, Katerina Smesny Trtkova
Article Number: 237
Published online on: 25 June 2026

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Article Open Access

Mulberroside A attenuates H2O2‑induced oxidative stress and barrier dysfunction in Caco‑2 cells through Nrf2/HO‑1‑associated antioxidant signaling

Jianxin Chen, Xiufeng Huang, Xi Chen, Wenhai Jin, Dawei Lin
Article Number: 236
Published online on: 25 June 2026

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Retraction Open Access

[Retracted] Puerarin promotes DUSP1 expression by regulating miR‑133a‑3p in breast cancer

Zhifeng Li, Weiwei Xu, Xiaoyan Ren, Jinhua Xu, Jianxin Chen
Article Number: 235
Published online on: 23 June 2026

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Article Open Access

Sulforaphane attenuates cisplatin‑induced acute kidney injury by inhibiting oxidative stress, inflammation and apoptosis via regulation of NRF2

Zeyu Wu, Mengting Lu, Lei Xu, Ming Luo, Limei Shan, Hongxia Xing, Wenwen Li, Junling Qian
Article Number: 234
Published online on: 19 June 2026

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Article Open Access

Effects of β‑hydroxybutyrate on restoring autophagic flux and mitochondrial function in macrophages exposed to oxidized low‑density lipoprotein

Weiguang Luo, Mei He, Huiling Wang
Article Number: 233
Published online on: 19 June 2026

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Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review)

Xiaokang Wang, Qiwen Tan, Jingcheng Xu, Yunlin Yang, Haoyue Huang, Xiaomei Teng, Weihua Wu
Article Number: 232
Published online on: 18 June 2026

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Degraded sulfated galactan derived from Gracilaria fisheri induces immunogenic cell death in MDA‑MB‑231 cells

Tawut Rudtanatip, Yada Polsan, Waraporn Sakaew, Somsuda Somintara, Jenjiralai Phanphak, Jamal El‑Abid, Kanokpan Wongprasert, Choowadee Pariwatthanakun
Article Number: 231
Published online on: 17 June 2026

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Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells

Qing Deng, Xiujuan Liu, Dan Wen, Yuhua Cheng, Qing Zhao, Yu Wang, Yu Xiang, Qinkai Chen, Jinlei Lv
Article Number: 230
Published online on: 17 June 2026

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A β‑1,3‑1,6‑glucan from Aureobasidium pullulans enhances apoptotic and autophagic pathways in colorectal cancer cells

Ji-Won Park, Gyeong Mim Mun, Tae Min Jo, Ji A Shin, Takao Kuge, Hisashi Kimoto, Jin-Kyung Kim
Article Number: 229
Published online on: 16 June 2026

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Growth pattern and molecular biological analysis of primary meningioma cell cultures under different conditions

Stefan Linsler, Anna-Lena Moroldo, Walter Schulz‑Schaeffer, Ralf Ketter, Joachim Oertel, Steffi Urbschat
Article Number: 228
Published online on: 12 June 2026

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Melatonin alleviates mitochondrial damage by regulating SIRT3‑mediated mitochondrial dynamics in granulosa cells under PCOS‑like conditions

Congcong Xie, Zehao Liu, Tong Chen, Hui Lu, Xiujia Zhang, Wenbo Yu, Jiaxin Zhang, Dandan Shang, Xueying Wang
Article Number: 227
Published online on: 11 June 2026

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Strontium‑based metal‑organic framework/alendronate‑silk fibroin hydrogels promote tendon‑bone interface healing

Tao Yang, Hanji Zhang, Mingjun Li, Yiming Ren, Yunbo Sun, Weiyu Hou, Mengqiang Tian
Article Number: 226
Published online on: 11 June 2026

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Retraction Open Access

[Retracted] Tripterygium glycoside suppresses epithelial‑to‑­­ mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He
Article Number: 225
Published online on: 08 June 2026

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Gut microbiota‑derived metabolites in cardiovascular disease: Focus on trimethylamine N‑oxide, short‑chain fatty acids and bile acids (Review)

Meizhu Gao, Zhenming Hao, Yiling Li, Weixue Liu, Fubao Zhang
Article Number: 224
Published online on: 08 June 2026

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Fucoxanthin alleviates chondrocyte inflammation and osteoarthritis by modulating the JAK2/STAT3 signaling pathway

Miradj Siddick Adam, Huangming Zhuang, Xunshan Ren, Yuelong Zhang, Panghu Zhou
Article Number: 223
Published online on: 08 June 2026

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Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer

Huaiyong Li, Lili Liu, Qingzhu Yang, Yao Li, Yongli Song, Jing Jiang, Zhenzhong Wu, Weiwei Zhang, Baisong Lou
Article Number: 222
Published online on: 08 June 2026

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Molecular mechanisms of iron metabolism and ferroptosis in cardiovascular diseases and intervention strategies targeting natural products (Review)

Liangqing Ge, Tianqing Zhang, Jiangbiao Yu, Sijie Xiao, Yu Zhou, Li Luo
Article Number: 221
Published online on: 05 June 2026

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Correction Open Access

[Corrigendum] Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 220
Published online on: 03 June 2026

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LINC01117 promotes the malignant proliferation of lung adenocarcinoma by increasing HOXD8 mRNA stability

Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang
Article Number: 219
Published online on: 03 June 2026

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Targeting regulatory T cells in the prostate cancer microenvironment: From mechanisms to therapeutics (Review)

Hua Luo
Article Number: 218
Published online on: 03 June 2026

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Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis

Sailiang Ding, Hao Yang, Ting Lu, Yibin Luo, Liang Xu, Xianghui Zeng
Article Number: 217
Published online on: 03 June 2026

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Retraction Open Access

[Retracted] Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models

Yong Liu, Yan Zhang, Ming Hu, Yu-Hu Li, Xing-Hua Cao
Article Number: 216
Published online on: 02 June 2026

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SIRT1/AMPK/PGC1α pathway in ischemic stroke: Elucidating neuroprotective strategies (Review)

Irum Naz Abbasi, Nashwa Amin, Qiaolu Xu, Azhar Badry Hussain, Fei Wu, Xia Yuan, Yang Yang, Suhong Ye, Marong Fang, Yihua Jiang
Article Number: 215
Published online on: 02 June 2026

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Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)

Yinhuan Wang, Jiefang Guan
Article Number: 214
Published online on: 29 May 2026

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September-2026 Volume 34 Issue 3

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Sedanolide alleviates LPS‑induced depressive‑like behaviors by modulating the C3a/C3aR signaling axis and microglial glycolysis

Shaocong Lu, Fangla Luo, Niqi Chen, Gongde Shi, Yeru Chen
Article Number: 257
Published online on: 16 July 2026

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Expression of Concern Open Access

[Expression of Concern] Chrysophanol inhibits proliferation and induces apoptosis through NF‑κB/cyclin D1 and NF‑κB/Bcl‑2 signaling cascade in breast cancer cell lines

Li Ren, Zhouping Li, Chunmei Dai, Danyu Zhao, Yanjie Wang, Chunyu Ma, Chun Liu
Article Number: 256
Published online on: 15 July 2026

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Article Open Access

PCSK9 alleviates doxorubicin‑induced pyroptosis of cardiomyocytes

Chaochu Cui, Jinyu Zhao, Xiaoqian Li, Shengming Huang, Gang Liu, Xinhui Xu, Can Guo, Tiesuo Zhao, Jiang Du, Shipeng Li, Xianwei Wang, Jianbo Yang
Article Number: 255
Published online on: 14 July 2026

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From cell to disease: Regulatory networks and mechanisms of super‑enhancers in aging (Review)

Xiaodan Wang, Weiqian Deng, Shuangxi Tu, Haojun Tang, Kai Yin, Xiao Zhu
Article Number: 254
Published online on: 14 July 2026

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Retraction Open Access

[Retracted] Matrine‑induced apoptosis in Hep3B cells via the inhibition of MDM2

Ning Zhou, Jiequn Li, Ting Li, Guangshun Chen, Zhongqiang Zhang, Zhongzhou Si
Article Number: 253
Published online on: 13 July 2026

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Role of PANoptosis in the development of gastric immunity and related gastric mucosal disease (Review)

Lan Wang, Zhiyuan Ma, Bei Ji, Shuhui Liu, Shuji Terai, Biguang Tuo, Taolang Li, Xuemei Liu
Article Number: 252
Published online on: 09 July 2026

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Leonurine inhibits the proliferation and metastasis of liver cancer cells by regulating the PI3K/AKT signaling pathway via epithelial‑mesenchymal transition

Bowen Hu, Maher Al Hussan, Jiakai Zhang, Peihao Wen, Changjun Huang, Yang Chen, Huanfei Ding
Article Number: 251
Published online on: 08 July 2026

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Correction Open Access

[Corrigendum] Resistin aggravates the expression of proinflammatory cytokines in cerulein‑stimulated AR42J pancreatic acinar cells

Chong-Yi Jiang, Wei Wang
Article Number: 250
Published online on: 08 July 2026

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A‑Raf: A serine/threonine protein kinase with important biological functions (Review)

Muhan Yang, Mengying Chen, Jinmei Wei, Yanling Li, Chen Long, Yan Lei, Yanhong Zhou
Article Number: 249
Published online on: 07 July 2026

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Gut dysbiosis‑derived butyrate loss predicts feeding intolerance: Multiomics evidence guiding nurse‑driven microbiota‑supportive interventions (Review)

Ling Wei, Xiaohua Kong, Yuying Li, Huixia Wu, Yirong Gan, Fang Sun
Article Number: 248
Published online on: 07 July 2026

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Retraction Open Access

[Retracted] Network pharmacology combined with experimental validation to investigate the effect of Rongjin Niantong Fang on chondrocyte apoptosis in knee osteoarthritis

Jun Chen, Ting Zhang, Qingqing Luo, Ruyi Wang, Yuting Dai, Zhenyuan Chen, Chutian Zhang, Xuzheng Chen, Guangwen Wu
Article Number: 247
Published online on: 06 July 2026

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Laggera alata attenuates LPS‑induced systemic inflammation and hepatic‑pulmonary injury by regulating PINK1/Parkin-associated mitophagy and macrophage polarization

Jiangcun Wei, Wen Zhong, Guangyun Zhou, Mingtao Huang, Xiaodong Huang, Jing Liang
Article Number: 246
Published online on: 02 July 2026

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Proteolysis‑targeting chimeras in oral squamous cell carcinoma: Current evidence, translational challenges and future directions (Review)

Yun Bai, Danhua Ma, Xi Yang, Min Wang
Article Number: 245
Published online on: 02 July 2026

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Evolving role of biomarkers beyond prostate‑specific antigen in refining prostate cancer screening: From blood‑based tests to urinary and genetic markers (Review)

Luxi Li, Linyue Zhang, Zehong Li, Keqiang Chai, Weidong Ren
Article Number: 244
Published online on: 02 July 2026

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Nanocurcumin attenuates brain injury in rats with desert dry‑heat‑induced exertional heat stroke by suppressing TLR4/MyD88/NF‑κB signaling

Lisong Su, Jinquan Qu, Jiajia Li, Wenhui Shi, Laiyang Song, Feixing Liang, Jiangwei Liu
Article Number: 243
Published online on: 02 July 2026

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TREM2 in glioma: Reprogramming the immune microenvironment from mechanistic understanding to clinical translation (Review)

Junqi Fan, Hongyan Shen, Dan Liu, Songbai Luo, Qingqing Huang, Yi Wen, Libang Yuan
Article Number: 242
Published online on: 02 July 2026

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Human parvovirus B19 VP1u‑induced osteoclastogenesis is enhanced by RANKL in RAW264.7 macrophage cells

Chun-Yu Lin, Bor-Show Tzang, Yi-Hsuan Lin, Chih-Chen Tzang, Tsai-Ching Hsu
Article Number: 241
Published online on: 30 June 2026

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Retraction Open Access

[Retracted] Anti‑tumor peptide AP25 decreases cyclin D1 expression and inhibits MGC‑803 proliferation via phospho­extracellular signal‑regulated kinase‑, Src‑, c‑Jun N‑terminal kinase‑ and phosphoinositide 3­-kinase‑associated pathways  

Jialiang Hu, Tao Cheng, Lijun Zhang, Beicheng Sun, Lei Deng, Hanmei Xu
Article Number: 240
Published online on: 29 June 2026

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Aspirin prevents postoperative peritoneal adhesions by inhibiting the TGF‑β1/Smad signaling pathway in rats

Siqi Yan, Yuan Ren, Bingyan Liu, Pai Xiong, Yimin Sun
Article Number: 239
Published online on: 29 June 2026

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Morinda officinalis oligosaccharides ameliorate corticosterone‑induced depression‑like behaviour in mice by modulating the BDNF signalling pathway and gut microbiota

Mengjie He, Zixuan Liu, Yuxin Chen, Xiaoru Wu, Xueling Dai, Qian Liu, Shuo Wang, Zeping Zuo, Yaxuan Sun
Article Number: 238
Published online on: 29 June 2026

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