Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
October-2021 Volume 24 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2021 Volume 24 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Isoalantolactone alleviates ovalbumin‑induced asthmatic inflammation by reducing alternatively activated macrophage and STAT6/PPAR‑γ/KLF4 signals

  • Authors:
    • Yunduan Song
    • Xiaozong Li
    • Fangfang Liu
    • Hongbo Zhu
    • Yao Shen
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, P.R. China, Department of Operation Management Office, Shanghai Pudong New Area Center for Disease Control and Prevention, Fudan University Pudong Institute of Preventive Medicine, Shanghai 200136, P.R. China, Department of Pathology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, P.R. China, Department of Respiratory and Critical Care Medicine, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, P.R. China
  • Article Number: 701
    |
    Published online on: August 5, 2021
       https://doi.org/10.3892/mmr.2021.12340
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Isoalantolactone (IAL), a sesquiterpene lactone, has anti‑inflammatory activity in lipopolysaccharide (LPS)‑induced sepsis. However, it remains to be elucidated whether IAL influences asthmatic inflammation. The present study found that IAL inhibited ovalbumin (OVA)‑induced asthmatic inflammation and attenuated OVA‑induced eosinophil infiltration, immunoglobulin E generation and the production of interleukin (IL)‑4, IL‑5, C‑C motif chemokine ligand (CCL)17 and CCL22. In addition, IAL treatment with IL‑4 reduced the expression of arginase‑1, Ym‑1, CCL17 and CCL22 in bone marrow‑derived macrophages in vitro. Furthermore, IAL inhibited IL‑4‑induced STAT6 phosphorylation and the expression of peroxisome proliferator‑activated receptor γ and Krüppel‑like factor 4. Collectively, the results suggested that IAL attenuated asthmatic inflammation and is a potential therapeutic agent for the treatment of asthma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Mims JW: Asthma: Definitions and pathophysiology. Int Forum Allergy Rhinol. 5 (Suppl 1):S2–S6. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Nanda A and Wasan AN: Asthma in adults. Med Clin North Am. 104:95–108. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Ober C and Yao TC: The genetics of asthma and allergic disease: A 21st century perspective. Immunol Rev. 242:10–30. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Ma Y, Ge A, Zhu W, Liu YN, Ji NF, Zha WJ, Zhang JX, Zeng XN and Huang M: Morin attenuates ovalbumin-induced airway inflammation by modulating oxidative stress-responsive MAPK signaling. Oxid Med Cell Longev. 2016:58436722016. View Article : Google Scholar : PubMed/NCBI

5 

Lambrecht BN and Hammad H: The immunology of asthma. Nat Immunol. 16:45–56. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Holgate ST: Innate and adaptive immune responses in asthma. Nat Med. 18:673–683. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Yi S, Zhai J, Niu R, Zhu G, Wang M, Liu J, Huang H, Wang Y, Jing X, Kang L, et al: Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge. Nat Commun. 9:38792018. View Article : Google Scholar : PubMed/NCBI

8 

Draijer C and Peters-Golden M: Alveolar macrophages in allergic asthma: The forgotten cell awakes. Curr Allergy Asthma Rep. 17:122017. View Article : Google Scholar : PubMed/NCBI

9 

Song Y, Wu Y, Li X, Shen Y, Ding Y, Zhu H, Liu F, Yu K, Sun L and Qian F: Protostemonine attenuates alternatively activated macrophage and DRA-induced asthmatic inflammation. Biochem Pharmacol. 155:198–206. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Liu J, He C, Tang Y, Liu W, Xu Y, Li Z, Qin X and Jin S: Cremastra appendiculata (D.Don) Makino, a potential anti-tumor traditional Chinese medicine: Review. J Ethnopharmacol. 279:1143572021. View Article : Google Scholar : PubMed/NCBI

11 

Lajter I, Vasas A, Béni Z, Forgo P, Binder M, Bochkov V, Zupkó I, Krupitza G, Frisch R, Kopp B and Hohmann J: Sesquiterpenes from Neurolaena lobata and their antiproliferative and anti-inflammatory activities. J Nat Prod. 77:576–582. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Butturini E, Carcereri de Prati A, Boriero D and Mariotto S: Natural sesquiterpene lactones enhance chemosensitivity of tumor cells through redox regulation of STAT3 signaling. Oxid Med Cell Longev. 2019:45689642019. View Article : Google Scholar : PubMed/NCBI

13 

Quintana J and Estévez F: Recent advances on cytotoxic sesquiterpene lactones. Curr Pharm Des. 24:4355–4361. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Xu R, Peng Y, Wang M and Li X: Intestinal absorption of isoalantolactone and alantolactone, two sesquiterpene lactones from radix inulae, using caco-2 cells. Eur J Drug Metab Pharmacokinet. 44:295–303. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Lu N, Lv Q, Sun X, Zhou Y, Guo Y, Qiu J, Zhang P and Wang J: Isoalantolactone restores the sensitivity of gram-negative enterobacteriaceae carrying MCR-1 to carbapenems. J Cell Mol Med. 24:2475–2483. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Jung YS, Lee HS, Cho HR, Kim KJ, Kim JH, Safe S and Lee SO: Dual targeting of Nur77 and AMPKα by isoalantolactone inhibits adipogenesis in vitro and decreases body fat mass in vivo. Int J Obes (Lond). 43:952–962. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Li X, Lu C, Liu S, Liu S, Su C, Xiao T, Bi Z, Sheng P, Huang M, Liu X, et al: Synthesis and discovery of a drug candidate for treatment of idiopathic pulmonary fibrosis through inhibition of TGF-β1 pathway. Eur J Med Chem. 157:229–247. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Yuan CB, Tian L, Yang B and Zhou HY: Isoalantolactone protects LPS-induced acute lung injury through Nrf2 activation. Microb Pathog. 123:213–218. 2018. View Article : Google Scholar : PubMed/NCBI

19 

He G, Zhang X, Chen Y, Chen J, Li L and Xie Y: Isoalantolactone inhibits LPS-induced inflammation via NF-κB inactivation in peritoneal macrophages and improves survival in sepsis. Biomed Pharmacother. 90:598–607. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Ding YH, Song YD, Wu YX, He HQ, Yu TH, Hu YD, Zhang DP, Jiang HC, Yu KK, Li XZ, et al: Isoalantolactone suppresses LPS-induced inflammation by inhibiting TRAF6 ubiquitination and alleviates acute lung injury. Acta Pharmacol Sin. 40:64–74. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Duchene B, Caffry S, Kaminsky DA, Que LG, Poynter ME and Dixon AE: Functional significance of 8-isoprostanes in sinonasal disease and asthma. Respir Med. 185:1065062021. View Article : Google Scholar : PubMed/NCBI

23 

Noel JC and Berin MC: Role of innate immunity and myeloid cells in susceptibility to allergic disease. Ann NY Acad Sci. Jun 22–2021.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

24 

Lee HS, Park DE, Bae B, Oh K, Jung JW, Lee DS, Kim IG, Cho SH and Kang HR: Tranglutaminase 2 contributes to the asthmatic inflammation by modulating activation of alveolar macrophages. Immun Inflamm Dis. May 4–2021.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

25 

Watanabe S, Suzukawa M, Tashimo H, Ohshima N, Asari I, Imoto S, Kobayashi N, Tohma S, Nagase T and Ohta K: High serum cytokine levels may predict the responsiveness of patients with severe asthma to benralizumab. J Asthma. Jul 1–2021.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

26 

Binnemars-Postma K, Bansal R, Storm G and Prakash J: Targeting the Stat6 pathway in tumor-associated macrophages reduces tumor growth and metastatic niche formation in breast cancer. FASEB J. 32:969–978. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Papi A, Brightling C, Pedersen SE and Reddel HK: Asthma. Lancet. 391:783–800. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Luo H, Vong CT, Chen H, Gao Y, Lyu P, Qiu L, Zhao M, Liu Q, Cheng Z, Zou J, et al: Naturally occurring anti-cancer compounds: Shining from Chinese herbal medicine. Chin Med. 14:482019. View Article : Google Scholar : PubMed/NCBI

29 

Gao Z, Li Q, Wu X, Zhao X, Zhao L and Tong X: New insights into the mechanisms of Chinese herbal products on diabetes: A focus on the ‘bacteria-mucosal immunity-inflammation-diabetes’ axis. J Immunol Res. 2017:18130862017. View Article : Google Scholar : PubMed/NCBI

30 

Liu C, Liao JZ and Li PY: Traditional Chinese herbal extracts inducing autophagy as a novel approach in therapy of nonalcoholic fatty liver disease. World J Gastroenterol. 23:1964–1973. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Fricker M and Gibson PG: Macrophage dysfunction in the pathogenesis and treatment of asthma. Eur Respir J. 50:17001962017. View Article : Google Scholar : PubMed/NCBI

32 

Saradna A, Do DC, Kumar S, Fu QL and Gao P: Macrophage polarization and allergic asthma. Transl Res. 191:1–14. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Li R, Shang Y, Hu X, Yu Y, Zhou T, Xiong W and Zou X: ATP/P2X7r axis mediates the pathological process of allergic asthma by inducing M2 polarization of alveolar macrophages. Exp Cell Res. 386:1117082020. View Article : Google Scholar : PubMed/NCBI

34 

Zhou Y, Do DC, Ishmael FT, Squadrito ML, Tang HM, Tang HL, Hsu MH, Qiu L, Li C, Zhang Y, et al: Mannose receptor modulates macrophage polarization and allergic inflammation through miR-511-3p. J Allergy Clin Immunol. 141:350–364.e8. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Becerra-Díaz M, Strickland AB, Keselman A and Heller NM: Androgen and androgen receptor as enhancers of M2 macrophage polarization in allergic lung inflammation. J Immunol. 201:2923–2933. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Han X, Huang S, Xue P, Fu J, Liu L, Zhang C, Yang L, Xia L, Sun L, Huang SK and Zhou Y: LncRNA PTPRE-AS1 modulates M2 macrophage activation and inflammatory diseases by epigenetic promotion of PTPRE. Sci Adv. 5:eaax92302019. View Article : Google Scholar : PubMed/NCBI

37 

Wang Y, Xu Y, Zhang P, Ruan W, Zhang L, Yuan S, Pang T and Jia AQ: Smiglaside A ameliorates LPS-induced acute lung injury by modulating macrophage polarization via AMPK-PPARγ pathway. Biochem Pharmacol. 156:385–395. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Chun JM, Lee AR, Kim HS, Lee AY, Gu GJ, Moon BC and Kwon BI: Peucedanum japonicum extract attenuates allergic airway inflammation by inhibiting Th2 cell activation and production of pro-inflammatory mediators. J Ethnopharmacol. 211:78–88. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Zhang F, Sang Y, Chen D, Wu X, Wang X, Yang W and Chen Y: M2 macrophage-derived exosomal long non-coding RNA AGAP2-AS1 enhances radiotherapy immunity in lung cancer by reducing microRNA-296 and elevating NOTCH2. Cell Death Dis. 12:4672021. View Article : Google Scholar : PubMed/NCBI

40 

Ying W, Gao H, Dos Reis FCG, Bandyopadhyay G, Ofrecio JM, Luo Z, Ji Y, Jin Z, Ly C and Olefsky JM: MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice. Cell Metab. 33:781–790.e5. 2021. View Article : Google Scholar : PubMed/NCBI

41 

Chung S, Kim JY, Song MA, Park GY, Lee YG, Karpurapu M, Englert JA, Ballinger MN, Pabla N, Chung HY and Christman JW: FoxO1 is a critical regulator of M2-like macrophage activation in allergic asthma. Allergy. 74:535–548. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Cao J, Dong R, Jiang L, Gong Y, Yuan M, You J, Meng W, Chen Z, Zhang N, Weng Q, et al: LncRNA-MM2P identified as a modulator of macrophage M2 polarization. Cancer Immunol Res. 7:292–305. 2019. View Article : Google Scholar : PubMed/NCBI

43 

Wheeler KC, Jena MK, Pradhan BS, Nayak N, Das S, Hsu CD, Wheeler DS, Chen K and Nayak NR: VEGF may contribute to macrophage recruitment and M2 polarization in the decidua. PLoS One. 13:e01910402018. View Article : Google Scholar : PubMed/NCBI

44 

Cortes JR, Perez-G M, Rivas MD and Zamorano J: Kaempferol inhibits IL-4-induced STAT6 activation by specifically targeting JAK3. J Immunol. 179:3881–3887. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Zhu T, Zhang W, Feng SJ and Yu HP: Emodin suppresses LPS-induced inflammation in RAW264.7 cells through a PPARγ-dependent pathway. Int Immunopharmacol. 34:16–24. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Wen Q, Mei L, Ye S, Liu X, Xu Q, Miao J, Du S, Chen D, Li C and Li H: Chrysophanol demonstrates anti-inflammatory properties in LPS-primed RAW 264.7 macrophages through activating PPAR-γ. Int Immunopharmacol. 56:90–97. 2018. View Article : Google Scholar : PubMed/NCBI

47 

Nelson VL, Nguyen HCB, Garcìa-Cañaveras JC, Briggs ER, Ho WY, DiSpirito JR, Marinis JM, Hill DA and Lazar MA: PPARγ is a nexus controlling alternative activation of macrophages via glutamine metabolism. Genes Dev. 32:1035–1044. 2018. View Article : Google Scholar : PubMed/NCBI

48 

Zhao M, Bian YY, Yang LL, Chen YQ, Wang YJ, Ma YT, Pei YQ, Li WL and Zeng L: HuoXueTongFu formula alleviates intraperitoneal adhesion by regulating macrophage polarization and the SOCS/JAK2/STAT/PPAR-γ signalling pathway. Mediators Inflamm. 2019:17693742019. View Article : Google Scholar : PubMed/NCBI

49 

Kapoor N, Niu J, Saad Y, Kumar S, Sirakova T, Becerra E, Li X and Kolattukudy PE: Transcription factors STAT6 and KLF4 implement macrophage polarization via the dual catalytic powers of MCPIP. J Immunol. 194:6011–6023. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Li S, Zhou Q, He H, Zhao Y and Liu Z: Peroxisome proliferator-activated receptor γ agonists induce cell cycle arrest through transcriptional regulation of Kruppel-like factor 4 (KLF4). J Biol Chem. 288:4076–4084. 2013. View Article : Google Scholar : PubMed/NCBI

51 

Chen W, Li X, Guo S, Song N, Wang J, Jia L and Zhu A: Tanshinone IIA harmonizes the crosstalk of autophagy and polarization in macrophages via miR-375/KLF4 pathway to attenuate atherosclerosis. Int Immunopharmacol. 70:486–497. 2019. View Article : Google Scholar : PubMed/NCBI

52 

Almatroodi SA, Almatroudi A, Alsahli MA, Aljasir MA, Syed MA and Rahmani AH: Epigallocatechin-3-Gallate (EGCG), an active compound of green tea attenuates acute lung injury regulating macrophage polarization and Krüpple-like-factor 4 (KLF4) expression. Molecules. 25:28532020. View Article : Google Scholar : PubMed/NCBI

53 

Handa P, Thomas S, Morgan-Stevenson V, Maliken BD, Gochanour E, Boukhar S, Yeh MM and Kowdley KV: Iron alters macrophage polarization status and leads to steatohepatitis and fibrogenesis. J Leukoc Biol. 105:1015–1026. 2019. View Article : Google Scholar : PubMed/NCBI

54 

Chen W, Li P, Liu Y, Yang Y, Ye X, Zhang F and Huang H: Isoalantolactone induces apoptosis through ROS-mediated ER stress and inhibition of STAT3 in prostate cancer cells. J Exp Clin Cancer Res. 37:3092018. View Article : Google Scholar : PubMed/NCBI

55 

Wang J, Cui L, Feng L, Zhang Z, Song J, Liu D and Jia X: Isoalantolactone inhibits the migration and invasion of human breast cancer MDA-MB-231 cells via suppression of the p38 MAPK/NF-κB signaling pathway. Oncol Rep. 36:1269–1276. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Song Y, Li X, Liu F, Zhu H and Shen Y: Isoalantolactone alleviates ovalbumin‑induced asthmatic inflammation by reducing alternatively activated macrophage and STAT6/PPAR‑γ/KLF4 signals. Mol Med Rep 24: 701, 2021.
APA
Song, Y., Li, X., Liu, F., Zhu, H., & Shen, Y. (2021). Isoalantolactone alleviates ovalbumin‑induced asthmatic inflammation by reducing alternatively activated macrophage and STAT6/PPAR‑γ/KLF4 signals. Molecular Medicine Reports, 24, 701. https://doi.org/10.3892/mmr.2021.12340
MLA
Song, Y., Li, X., Liu, F., Zhu, H., Shen, Y."Isoalantolactone alleviates ovalbumin‑induced asthmatic inflammation by reducing alternatively activated macrophage and STAT6/PPAR‑γ/KLF4 signals". Molecular Medicine Reports 24.4 (2021): 701.
Chicago
Song, Y., Li, X., Liu, F., Zhu, H., Shen, Y."Isoalantolactone alleviates ovalbumin‑induced asthmatic inflammation by reducing alternatively activated macrophage and STAT6/PPAR‑γ/KLF4 signals". Molecular Medicine Reports 24, no. 4 (2021): 701. https://doi.org/10.3892/mmr.2021.12340
Copy and paste a formatted citation
x
Spandidos Publications style
Song Y, Li X, Liu F, Zhu H and Shen Y: Isoalantolactone alleviates ovalbumin‑induced asthmatic inflammation by reducing alternatively activated macrophage and STAT6/PPAR‑γ/KLF4 signals. Mol Med Rep 24: 701, 2021.
APA
Song, Y., Li, X., Liu, F., Zhu, H., & Shen, Y. (2021). Isoalantolactone alleviates ovalbumin‑induced asthmatic inflammation by reducing alternatively activated macrophage and STAT6/PPAR‑γ/KLF4 signals. Molecular Medicine Reports, 24, 701. https://doi.org/10.3892/mmr.2021.12340
MLA
Song, Y., Li, X., Liu, F., Zhu, H., Shen, Y."Isoalantolactone alleviates ovalbumin‑induced asthmatic inflammation by reducing alternatively activated macrophage and STAT6/PPAR‑γ/KLF4 signals". Molecular Medicine Reports 24.4 (2021): 701.
Chicago
Song, Y., Li, X., Liu, F., Zhu, H., Shen, Y."Isoalantolactone alleviates ovalbumin‑induced asthmatic inflammation by reducing alternatively activated macrophage and STAT6/PPAR‑γ/KLF4 signals". Molecular Medicine Reports 24, no. 4 (2021): 701. https://doi.org/10.3892/mmr.2021.12340
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team