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Serum‑derived exosomes from house dust mite‑sensitized guinea pigs contribute to inflammation in BEAS‑2B cells via the TLR4‑NF‑κB pathway

  • Authors:
    • Chao Liu
    • Xiao-Lin Huang
    • Jian-Ping Liang
    • Xu Zhong
    • Zi-Feng Wei
    • Li-Xue Dai
    • Jun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Disease, Zhongshan People's Hospital, Zhongshan, Guangdong 528403, P.R. China, Dental Implant and Restoration Centre, Zhongshan People's Hospital, Zhongshan, Guangdong 528403, P.R. China, The Second Department of Respiratory Disease, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 747
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    Published online on: August 27, 2021
       https://doi.org/10.3892/mmr.2021.12387
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Abstract

Airway epithelial cells, which are the first physical defense barrier against allergens, play a pivotal role in immunity, airway inflammation and airway remodeling. The damage and dysfunction of these cells trigger the development of airway inflammatory diseases. Exosomes, which exist in various bodily fluids, mediate cell‑cell communication and participate in the immune response process. The present study aimed to investigate whether serum exosomes play a pro‑inflammatory role in bronchial epithelial cells (BEAS‑2B cells) and, if so, explore the underlying molecular mechanisms. A guinea pig model of House dust mite (HDM)‑induced asthma was established by sensitizing the rodents with HDM and PBS, and serum‑derived exosomes were harvested. It was found that serum‑derived exosomes from HDM‑sensitized guinea pigs displayed higher levels of exosomal markers than those from controls. Additionally, western blot analysis and reverse transcription‑quantitative PCR indicated that serum‑derived exosomes from HDM‑sensitized guinea pigs carried heat shock protein 70 and triggered an inflammatory response in BEAS‑2B cells via the toll‑like receptor 4 (TLR4)‑NF‑κB pathway. However, TAK‑242, an inhibitor of the expression of TLR4, blocked the activation of the TLR4‑NF‑κB pathway. These findings provided a novel mechanism for exosome‑mediated inflammatory responses and a new perspective for the intervention of inflammatory airway disorders.
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1 

Zanini A, Cherubino F, Zampogna E, Croce S, Pignatti P and Spanevello A: Bronchial hyperresponsiveness, airway inflammation, and reversibility in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 10:1155–1161. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Alashkar AB, Miethe S, Pogge VSE, Potaczek DP and Garn H: Epigenetic regulation of airway epithelium immune functions in asthma. Front Immunol. 11:17472020. View Article : Google Scholar : PubMed/NCBI

3 

Fujita Y, Kosaka N, Araya J, Kuwano K and Ochiya T: Extracellular vesicles in lung microenvironment and pathogenesis. Trends Mol Med. 21:533–542. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Weitnauer M, Mijošek V and Dalpke AH: Control of local immunity by airway epithelial cells. Mucosal Immunol. 9:287–298. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Holgate ST: Epithelium dysfunction in asthma. J Allergy Clin Immunol. 120:1233–1246. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Gon Y and Hashimoto S: Role of airway epithelial barrier dysfunction in pathogenesis of asthma. Allergol Int. 67:12–17. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Mitchell PD and O'Byrne PM: Epithelial-derived cytokines in asthma. Chest. 151:1338–1344. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Mitchell PD and O'Byrne PM: Biologics and the lung: TSLP and other epithelial cell-derived cytokines in asthma. Pharmacol Ther. 169:104–112. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Sun Z, Ji N, Ma Q, Zhu R, Chen Z, Wang Z, Qian Y, Wu C, Hu F, Huang M and Zhang M: Epithelial-mesenchymal transition in asthma airway remodeling is regulated by the IL-33/CD146 axis. Front Immunol. 11:15982020. View Article : Google Scholar : PubMed/NCBI

10 

Kato A and Schleimer RP: Beyond inflammation: Airway epithelial cells are at the interface of innate and adaptive immunity. Curr Opin Immunol. 19:711–720. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Videira RF and da Costa Martins PA: Non-coding RNAs in cardiac intercellular communication. Front Physiol. 11:7382020. View Article : Google Scholar : PubMed/NCBI

12 

Barros FM, Carneiro F, Machado JC and Melo SA: Exosomes and immune response in cancer: Friends or foes? Front Immunol. 9:7302018. View Article : Google Scholar : PubMed/NCBI

13 

Smith VL, Cheng Y, Bryant BR and Schorey JS: Exosomes function in antigen presentation during an in vivo mycobacterium tuberculosis infection. Sci Rep. 7:435782017. View Article : Google Scholar : PubMed/NCBI

14 

Chan BD, Wong WY, Lee MM, Cho WC, Yee BK, Kwan YW and Tai WC: Exosomes in inflammation and inflammatory disease. Proteomics. 19:e18001492019. View Article : Google Scholar : PubMed/NCBI

15 

Zhao B, Li X, Shi X, Shi X, Zhang W, Wu G, Wang X, Su L and Hu D: Exosomal microRNAs derived from human amniotic epithelial cells accelerate wound healing by promoting the proliferation and migration of fibroblasts. Stem Cells Int. 2018:54204632018. View Article : Google Scholar : PubMed/NCBI

16 

Mazzeo C, Cañas JA, Zafra MP, Rojas Marco A, Fernández-Nieto M, Sanz V, Mittelbrunn M, Izquierdo M, Baixaulli F, Sastre J and Del Pozo V: Exosome secretion by eosinophils: A possible role in asthma pathogenesis. J Allergy Clin Immun. 135:1603–1613. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Zhao L, Yu J, Wang J, Li H, Che J and Cao B: Isolation and identification of miRNAs in exosomes derived from serum of colon cancer patients. J Cancer. 8:1145–1152. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Alipoor SD, Mortaz E, Garssen J, Movassaghi M, Mirsaeidi M and Adcock IM: Exosomes and exosomal miRNA in respiratory diseases. Mediat Inflamm. 2016:1–11. 2016. View Article : Google Scholar

19 

Mathivanan S, Ji H and Simpson RJ: Exosomes: Extracellular organelles important in intercellular communication. J Proteomics. 73:1907–1920. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Turturici G, Tinnirello R, Sconzo G and Geraci F: Extracellular membrane vesicles as a mechanism of Cell-to-Cell communication: Advantages and disadvantages. Am J Physiol Cell Physiol. 306:C621–C633. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Hough KP and Deshane JS: Exosomes in allergic airway diseases. Curr Allergy Asthma Rep. 19:262019. View Article : Google Scholar : PubMed/NCBI

22 

Kadota T, Fujita Y, Yoshioka Y, Araya J, Kuwano K and Ochiya T: Extracellular vesicles in chronic obstructive pulmonary disease. Int J Mol Sci. 17:18012016. View Article : Google Scholar : PubMed/NCBI

23 

Mortaz E, Alipoor SD, Varahram M, Jamaati H, Garssen J, Mumby SE and Adcock IM: Exosomes in severe asthma: Update in their roles and potential in therapy. Biomed Res Int. 2018:28621872018. View Article : Google Scholar : PubMed/NCBI

24 

Cañas JA, Sastre B, Rodrigo-Muñoz JM and Del PV: Exosomes: A new approach to asthma pathology. Clin Chim Acta. 495:139–147. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Huang F, Jia H, Zou Y, Yao Y and Deng Z: Exosomes: An important messenger in the asthma inflammatory microenvironment. J Int Med Res. 48:12207027722020.

26 

Levanen B, Bhakta NR, Torregrosa PP, Barbeau R, Hiltbrunner S, Pollack JL, Skold CM, Svartengren M, Grunewald J, Gabrielsson S, et al: Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients. J Allergy Clin Immunol. 131:894–903. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Bartel S, La Grutta S, Cilluffo G, Perconti G, Bongiovanni A, Giallongo A, Behrends J, Kruppa J, Hermann S, Chiang D, et al: Human airway epithelial extracellular vesicle miRNA signature is altered upon asthma development. Allergy. 75:346–356. 2020. View Article : Google Scholar : PubMed/NCBI

28 

Kulshreshtha A, Ahmad T, Agrawal A and Ghosh B: Proinflammatory role of epithelial cell-derived exosomes in allergic airway inflammation. J Allergy Clin Immun. 131:1194–1203. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Paredes PT, Esser J, Admyre C, Nord M, Rahman QK, Lukic A, Radmark O, Gronneberg R, Grunewald J, Eklund A, et al: Bronchoalveolar lavage fluid exosomes contribute to cytokine and leukotriene production in allergic asthma. Allergy. 67:911–919. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Hough KP, Chanda D, Duncan SR, Thannickal VJ and Deshane JS: Exosomes in immunoregulation of chronic lung diseases. Allergy. 72:534–544. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Tan D, Armitage J, Teo TH, Ong NE, Shin H and Moodley YP: Elevated levels of circulating exosome in COPD patients are associated with systemic inflammation. Respir Med. 132:261–264. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Xu H, Ling M, Xue J, Dai X, Sun Q, Chen C, Liu Y, Zhou L, Liu J, Luo F, et al: Exosomal microRNA-21 derived from bronchial epithelial cells is involved in aberrant epithelium-fibroblast cross-talk in COPD induced by cigarette smoking. Theranostics. 8:5419–5433. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Care NRCU and Animals AUOL: Guide for the Care and Use of Laboratory Animals. National Academies Press US; Washington, DC: 2011

34 

Tang YT, Huang YY, Zheng L, Qin SH, Xu XP, An TX, Xu Y, Wu YS, Hu XM, Ping BH and Wang Q: Comparison of isolation methods of exosomes and exosomal RNA from cell culture medium and serum. Int J Mol Med. 40:834–844. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Zhang L and Yu D: Exosomes in cancer development, metastasis, and immunity. Biochim Biophys Acta Rev Cancer. 1871:455–468. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Anand PK, Anand E, Bleck CK, Anes E and Griffiths G: Exosomal Hsp70 induces a pro-inflammatory response to foreign particles including mycobacteria. PLoS One. 5:e101362010. View Article : Google Scholar : PubMed/NCBI

38 

Dickson RP, Erb-Downward JR and Huffnagle GB: Homeostasis and its disruption in the lung microbiome. Am J Physiol Lung Cell Mol Physiol. 309:L1047–L1055. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Mendez R and Banerjee S, Bhattacharya SK and Banerjee S: Lung Inflammation and disease: A perspective on microbial homeostasis and metabolism. Iubmb Life. 71:152–165. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Paplinska-Goryca M, Misiukiewicz-Stepien P, Nejman-Gryz P, Proboszcz M, Mlacki M, Gorska K and Krenke R: Epithelial-macrophage-dendritic cell interactions impact alarmins expression in asthma and COPD. Clin Immunol. 215:1084212020. View Article : Google Scholar : PubMed/NCBI

41 

Cornwell WD, Kim V, Song C and Rogers TJ: Pathogenesis of inflammation and repair in advanced COPD. Semin Respir Crit Care Med. 31:257–266. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Admyre C, Bohle B, Johansson SM, Focke-Tejkl M, Valenta R, Scheynius A and Gabrielsson S: B cell-derived exosomes can present allergen peptides and activate allergen-specific T cells to proliferate and produce TH2-like cytokines. J Allergy Clin Immunol. 120:1418–1424. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ and Lötvall JO: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 9:654–659. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Vargas A, Roux-Dalvai F, Droit A and Lavoie JP: Neutrophil-derived exosomes: A new mechanism contributing to airway smooth muscle remodeling. Am J Respir Cell Mol Biol. 55:450–461. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Sahoo S and Losordo DW: Exosomes and cardiac repair after myocardial infarction. Circ Res. 114:333–344. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Bretz NP, Ridinger J, Rupp AK, Rimbach K, Keller S, Rupp C, Marmé F, Umansky L, Umansky V, Eigenbrod T, et al: Body fluid exosomes promote secretion of inflammatory cytokines in monocytic cells via Toll-like receptor signaling. J Biol Chem. 288:36691–36702. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Rincon M and Irvin CG: Role of IL-6 in asthma and other inflammatory pulmonary diseases. Int J Biol Sci. 8:1281–1290. 2012. View Article : Google Scholar : PubMed/NCBI

48 

Abram M, Wegmann M, Fokuhl V, Sonar S, Luger EO, Kerzel S, Radbruch A, Renz H and Zemlin M: Nerve growth factor and neurotrophin-3 mediate survival of pulmonary plasma cells during the allergic airway inflammation. J Immunol. 182:4705–4712. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Othman N, Jamal R and Abu N: Cancer-derived exosomes as effectors of key inflammation-related players. Front Immunol. 10:21032019. View Article : Google Scholar : PubMed/NCBI

50 

Cañas JA, Sastre B, Rodrigo-Muñoz JM, Fernández-Nieto M, Barranco P, Quirce S, Sastre J and Del PV: Eosinophil-derived exosomes contribute to asthma remodelling by activating structural lung cells. Clin Exp Allergy. 48:1173–1185. 2018. View Article : Google Scholar : PubMed/NCBI

51 

Gao W, Liu H, Yuan J, Wu C, Huang D, Ma Y, Zhu J, Ma L, Guo J, Shi H, et al: Exosomes derived from mature dendritic cells increase endothelial inflammation and atherosclerosis via membrane TNF-α mediated NF-κB pathway. J Cell Mol Med. 20:2318–2327. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Ye W, Tang X, Yang Z, Liu C, Zhang X, Jin J and Lyu J: Plasma-derived exosomes contribute to inflammation via the TLR9-NF-κB pathway in chronic heart failure patients. Mol Immunol. 87:114–121. 2017. View Article : Google Scholar : PubMed/NCBI

53 

Zandi E, Rothwarf DM, Delhase M, Hayakawa M and Karin M: The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell. 91:243–252. 1997. View Article : Google Scholar : PubMed/NCBI

54 

Schuliga M: NF-kappaB signaling in chronic inflammatory airway disease. Biomolecules. 5:1266–1283. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Zhao M, Juanjuan L, Weijia F, Jing X, Qiuhua H, Hua Z, Fuhe L and Hao P: Expression levels of microRNA-125b in serum exosomes of patients with asthma of different severity and its diagnostic significance. Curr Drug Metab. 20:781–784. 2019. View Article : Google Scholar : PubMed/NCBI

56 

Hou C, Zhao H, Li W, Liang Z, Zhang D, Liu L, Tong W, Cai SX and Zou F: Increased heat shock protein 70 levels in induced sputum and plasma correlate with severity of asthma patients. Cell Stress Chaperones. 16:663–671. 2011. View Article : Google Scholar : PubMed/NCBI

57 

Spiering R, van der Zee R, Wagenaar J, van Eden W and Broere F: Mycobacterial and mouse HSP70 have immuno-modulatory effects on dendritic cells. Cell Stress Chaperones. 18:439–446. 2013. View Article : Google Scholar : PubMed/NCBI

58 

Li X, Wang S, Zhu R, Li H, Han Q and Zhao RC: Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway. J Hematol Oncol. 9:422016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu C, Huang X, Liang J, Zhong X, Wei Z, Dai L and Wang J: Serum‑derived exosomes from house dust mite‑sensitized guinea pigs contribute to inflammation in BEAS‑2B cells via the TLR4‑NF‑κB pathway. Mol Med Rep 24: 747, 2021.
APA
Liu, C., Huang, X., Liang, J., Zhong, X., Wei, Z., Dai, L., & Wang, J. (2021). Serum‑derived exosomes from house dust mite‑sensitized guinea pigs contribute to inflammation in BEAS‑2B cells via the TLR4‑NF‑κB pathway. Molecular Medicine Reports, 24, 747. https://doi.org/10.3892/mmr.2021.12387
MLA
Liu, C., Huang, X., Liang, J., Zhong, X., Wei, Z., Dai, L., Wang, J."Serum‑derived exosomes from house dust mite‑sensitized guinea pigs contribute to inflammation in BEAS‑2B cells via the TLR4‑NF‑κB pathway". Molecular Medicine Reports 24.5 (2021): 747.
Chicago
Liu, C., Huang, X., Liang, J., Zhong, X., Wei, Z., Dai, L., Wang, J."Serum‑derived exosomes from house dust mite‑sensitized guinea pigs contribute to inflammation in BEAS‑2B cells via the TLR4‑NF‑κB pathway". Molecular Medicine Reports 24, no. 5 (2021): 747. https://doi.org/10.3892/mmr.2021.12387
Copy and paste a formatted citation
x
Spandidos Publications style
Liu C, Huang X, Liang J, Zhong X, Wei Z, Dai L and Wang J: Serum‑derived exosomes from house dust mite‑sensitized guinea pigs contribute to inflammation in BEAS‑2B cells via the TLR4‑NF‑κB pathway. Mol Med Rep 24: 747, 2021.
APA
Liu, C., Huang, X., Liang, J., Zhong, X., Wei, Z., Dai, L., & Wang, J. (2021). Serum‑derived exosomes from house dust mite‑sensitized guinea pigs contribute to inflammation in BEAS‑2B cells via the TLR4‑NF‑κB pathway. Molecular Medicine Reports, 24, 747. https://doi.org/10.3892/mmr.2021.12387
MLA
Liu, C., Huang, X., Liang, J., Zhong, X., Wei, Z., Dai, L., Wang, J."Serum‑derived exosomes from house dust mite‑sensitized guinea pigs contribute to inflammation in BEAS‑2B cells via the TLR4‑NF‑κB pathway". Molecular Medicine Reports 24.5 (2021): 747.
Chicago
Liu, C., Huang, X., Liang, J., Zhong, X., Wei, Z., Dai, L., Wang, J."Serum‑derived exosomes from house dust mite‑sensitized guinea pigs contribute to inflammation in BEAS‑2B cells via the TLR4‑NF‑κB pathway". Molecular Medicine Reports 24, no. 5 (2021): 747. https://doi.org/10.3892/mmr.2021.12387
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