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Inhibin βA is an independent prognostic factor that promotes invasion via Hippo signaling in non‑small cell lung cancer

  • Authors:
    • Yijun Zhang
    • Shumei Yan
    • Yan Li
    • Jiangbo Zhang
    • Yuan Luo
    • Pengcheng Li
    • Yuanzhong Yang
    • Yong Li
    • Yuhua Huang
    • Enhua Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110010, P.R. China, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China, Department of Radiotherapy, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 789
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    Published online on: September 9, 2021
       https://doi.org/10.3892/mmr.2021.12429
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Abstract

Inhibin βA (INHBA) serves a prognostic and tumor‑promoting role in numerous types of cancer. The present study aimed to determine the clinical significance of INHBA in non‑small cell lung cancer (NSCLC) and the mechanisms underlying its potential tumor‑promoting effect. INHBA expression was detected in clinical NSCLC samples using immunohistochemistry. In vivo loss‑ and gain‑of‑function studies were performed to determine the effects of INHBA on NSCLC invasion. In addition, protein and mRNA expression levels of INHBA, yes‑associated protein (YAP), large tumor suppressor 1/2 kinase (LATS1/2), connective tissue growth factor, cysteine rich angiogenic inducer 61 and Merlin were assessed using western blotting and reverse transcription‑quantitative PCR, respectively, to investigate the mechanism by which INHBA may affect the invasion of NSCLC. The present study revealed that INHBA was significantly upregulated in 238 clinical NSCLC samples compared with its expression levels in paired adjacent non‑cancerous tissues, and in metastatic nodules compared with in primary tumors. Notably, high INHBA expression was statistically associated with clinicopathological features, including poor differentiation and advanced tumor stage. INHBA positivity was statistically related to decreased 5‑year overall survival, for which INHBA was an independent prognostic factor. Furthermore, INHBA promoted NSCLC invasion in vitro. In NSCLC, INHBA expression was associated with the nuclear levels of YAP and INHBA overexpression enhanced the invasive abilities of NSCLC cells via inhibiting the Hippo pathway. Mechanistically, INHBA inhibited l LATS1/2 phosphorylation and induced YAP nuclear translocation by downregulating the protein expression levels of Merlin. In conclusion, INHBA may negatively regulate the Hippo pathway to act as a tumor promotor, and could represent a marker of prognosis in NSCLC.
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1 

Spira A and Ettinger DS: Multidisciplinary management of lung cancer. N Engl J Med. 350:379–392. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Govindan R, Page N, Morgensztern D, Read W, Tierney R, Vlahiotis A, Spitznagel EL and Piccirillo J: Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: Analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol. 24:4539–4544. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Sun S, Schiller JH, Spinola M and Minna JD: New molecularly targeted therapies for lung cancer. J Clin Invest. 117:2740–2750. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C and Thun MJ: Cancer statistics, 2006. CA Cancer J Clin. 56:106–130. 2006. View Article : Google Scholar : PubMed/NCBI

5 

de Mello RA, Madureira P, Carvalho LS, Araújo A, O'Brien M and Popat S: EGFR and KRAS mutations, and ALK fusions: Current developments and personalized therapies for patients with advanced non-small-cell lung cancer. Pharmacogenomics. 14:1765–1777. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Wagner G, Stollenwerk HK, Klerings I, Pecherstorfer M, Gartlehner G and Singer J: Efficacy and safety of immune checkpoint inhibitors in patients with advanced non-small cell lung cancer (NSCLC): A systematic literature review. Oncoimmunology. 9:17743142020. View Article : Google Scholar : PubMed/NCBI

7 

Gaddy-Kurten D, Tsuchida K and Vale W: Activins and the receptor serine kinase superfamily. Recent Prog Horm Res. 50:109–129. 1995.PubMed/NCBI

8 

Loomans HA and Andl CD: Intertwining of activin A and TGFβ signaling: Dual roles in cancer progression and cancer cell invasion. Cancers (Basel). 7:70–91. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Green JB, New HV and Smith JC: Responses of embryonic xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. Cell. 71:731–739. 1992. View Article : Google Scholar : PubMed/NCBI

10 

Vale W, Rivier C, Hsueh A, Campen C, Meunier H, Bicsak T, Vaughan J, Corrigan A, Bardin W, Sawchenko P, et al: Chemical and biological characterization of the inhibin family of protein hormones. Recent Prog Horm Res. 44:1–34. 1988.PubMed/NCBI

11 

Kelner N, Rodrigues PC, Bufalino A, Fonseca FP, Santos-Silva AR, Miguel MC, Pinto CA, Leme AF, Graner E, Salo T, et al: Activin A immunoexpression as predictor of occult lymph node metastasis and overall survival in oral tongue squamous cell carcinoma. Head Neck. 37:479–486. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Fu S, Zhang N, Yopp AC, Chen D, Mao M, Chen D, Zhang H, Ding Y and Bromberg JS: TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25-precursors. Am J Transplant. 4:1614–1627. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Ogawa K and Funaba M: Activin in humoral immune responses. Vitam Horm. 85:235–253. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Wang Q, Wen YG, Li DP, Xia J, Zhou CZ, Yan DW, Tang HM and Peng ZH: Upregulated INHBA expression is associated with poor survival in gastric cancer. Med Oncol. 29:77–83. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Lee HY, Li CC, Huang CN, Li WM, Yeh HC, Ke HL, Yang KF, Liang PI, Li CF and Wu WJ: INHBA overexpression indicates poor prognosis in urothelial carcinoma of urinary bladder and upper tract. J Surg Oncol. 111:414–422. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Peng S, Wang J, Hu P, Zhang W, Li H and Xu L: INHBA knockdown inhibits proliferation and invasion of nasopharyngeal carcinoma SUNE1 cells in vitro. Int J Clin Exp Pathol. 13:854–868. 2020.PubMed/NCBI

17 

Seder CW, Hartojo W, Lin L, Silvers AL, Wang Z, Thomas DG, Giordano TJ, Chen G, Chang AC, Orringer MB and Beer DG: Upregulated INHBA expression may promote cell proliferation and is associated with poor survival in lung adenocarcinoma. Neoplasia. 11:388–396. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Wamsley JJ, Kumar M, Allison DF, Clift SH, Holzknecht CM, Szymura SJ, Hoang SA, Xu X, Moskaluk CA, Jones DR, et al: Activin upregulation by NF-κB is required to maintain mesenchymal features of cancer stem-like cells in non-small cell lung cancer. Cancer Res. 75:426–435. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Varelas X, Samavarchi-Tehrani P, Narimatsu M, Weiss A, Cockburn K, Larsen BG, Rossant J and Wrana JL: The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell. 19:831–844. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Narimatsu M, Samavarchi-Tehrani P, Varelas X and Wrana JL: Distinct polarity cues direct Taz/Yap and TGFβ receptor localization to differentially control TGFβ-induced smad signaling. Dev Cell. 32:652–656. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Fujii M, Toyoda T, Nakanishi H, Yatabe Y, Sato A, Matsudaira Y, Ito H, Murakami H, Kondo Y, Kondo E, et al: TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth. J Exp Med. 209:479–494. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Huang J, Wu S, Barrera J, Matthews K and Pan D: The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating yorkie, the drosophila homolog of YAP. Cell. 122:421–434. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Edgar BA: From cell structure to transcription: Hippo forges a new path. Cell. 124:267–273. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Pan D: The Hippo signaling pathway in development and cancer. Dev Cell. 19:491–505. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Han Q, Lin X, Zhang X, Jiang G, Zhang Y, Miao Y, Rong X, Zheng X, Han Y, Han X, et al: WWC3 regulates the Wnt and Hippo pathways via dishevelled proteins and large tumour suppressor 1, to suppress lung cancer invasion and metastasis. J Pathol. 242:435–447. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Travis WD, Brambilla E, Burke AP, Marx A and Nicholson AG: Introduction to the 2015 World Health Organization classification of tumors of the lung, pleura, thymus, and heart. J Thorac Oncol. 10:1240–1242. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Sobin LH, Gospodarowicz MK and Christian Wittekind C: International Union Against Cancer (UICC): TNM classification of malignant tumours. 8th edition. Oxford: Wiley-Blackwell; 2017

28 

Zhang Y, Zhao Y, Jiang G, Zhang X, Zhao H, Wu J, Xu K and Wang E: Impact of p120-catenin isoforms 1A and 3A on epithelial mesenchymal transition of lung cancer cells expressing E-cadherin in different subcellular locations. PLoS One. 9:e880642014. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Zhang Y, Yan S, Chen J, Gan C, Chen D, Li Y, Wen J, Kremerskothen J, Chen S, Zhang J and Cao Y: WWC2 is an independent prognostic factor and prevents invasion via Hippo signalling in hepatocellular carcinoma. J Cell Mol Med. 21:3718–3729. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Wang Y, Dong Q, Zhang Q, Li Z, Wang E and Qiu X: Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer. Cancer Sci. 101:1279–1285. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Sun PL, Kim JE, Yoo SB, Kim H, Jin Y, Jheon S, Kim K, Lee CT and Chung JH: Cytoplasmic YAP expression is associated with prolonged survival in patients with lung adenocarcinomas and epidermal growth factor receptor tyrosine kinase inhibitor treatment. Ann Surg Oncol. 21 (Suppl 4):S610–S618. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Su T, Ludwig MZ, Xu J and Fehon RG: Kibra and Merlin activate the Hippo pathway spatially distinct from and independent of expanded. Dev Cell. 40:478–490.e3. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Alcantara KMM and Garcia RL: MicroRNA-92a promotes cell proliferation, migration and survival by directly targeting the tumor suppressor gene NF2 in colorectal and lung cancer cells. Oncol Rep. 41:2103–2116. 2019.PubMed/NCBI

35 

Sánchez NC, Medrano-Jiménez E, Aguilar-León D, Pérez-Martínez L and Pedraza-Alva G: Tumor necrosis factor-induced miR-146a upregulation promotes human lung adenocarcinoma metastasis by targeting Merlin. DNA Cell Biol. 39:484–497. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Wei Y, Yee PP, Liu Z, Zhang L, Guo H, Zheng H, Anderson B, Gulley M and Li W: NEDD4L-mediated Merlin ubiquitination facilitates Hippo pathway activation. EMBO Rep. 21:e506422020. View Article : Google Scholar : PubMed/NCBI

37 

Tang X, Jang SW, Wang X, Liu Z, Bahr SM, Sun SY, Brat D, Gutmann DH and Ye K: Akt phosphorylation regulates the tumour-suppressor Merlin through ubiquitination and degradation. Nat Cell Biol. 9:1199–1207. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Mota MSV, Jackson WP, Bailey SK, Vayalil P, Landar A, Rostas JW III, Mulekar MS, Samant RS and Shevde LA: Deficiency of tumor suppressor Merlin facilitates metabolic adaptation by co-operative engagement of SMAD-Hippo signaling in breast cancer. Carcinogenesis. 39:1165–1175. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH and Wrana JL: Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Mol Cell. 6:1365–1375. 2000. View Article : Google Scholar : PubMed/NCBI

40 

Zhang Z, Liu C, Chen B, Tang W, Liu Z, Cao W and Li X: Smad7 down-regulation via ubiquitin degradation mediated by Smurf2 in fibroblasts of hypertrophic scars in burned patients. Burns. 47:1333–1341. 2021. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Yan S, Li Y, Zhang J, Luo Y, Li P, Yang Y, Li Y, Huang Y, Wang E, Wang E, et al: Inhibin βA is an independent prognostic factor that promotes invasion via Hippo signaling in non‑small cell lung cancer. Mol Med Rep 24: 789, 2021.
APA
Zhang, Y., Yan, S., Li, Y., Zhang, J., Luo, Y., Li, P. ... Wang, E. (2021). Inhibin βA is an independent prognostic factor that promotes invasion via Hippo signaling in non‑small cell lung cancer. Molecular Medicine Reports, 24, 789. https://doi.org/10.3892/mmr.2021.12429
MLA
Zhang, Y., Yan, S., Li, Y., Zhang, J., Luo, Y., Li, P., Yang, Y., Li, Y., Huang, Y., Wang, E."Inhibin βA is an independent prognostic factor that promotes invasion via Hippo signaling in non‑small cell lung cancer". Molecular Medicine Reports 24.5 (2021): 789.
Chicago
Zhang, Y., Yan, S., Li, Y., Zhang, J., Luo, Y., Li, P., Yang, Y., Li, Y., Huang, Y., Wang, E."Inhibin βA is an independent prognostic factor that promotes invasion via Hippo signaling in non‑small cell lung cancer". Molecular Medicine Reports 24, no. 5 (2021): 789. https://doi.org/10.3892/mmr.2021.12429
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Yan S, Li Y, Zhang J, Luo Y, Li P, Yang Y, Li Y, Huang Y, Wang E, Wang E, et al: Inhibin βA is an independent prognostic factor that promotes invasion via Hippo signaling in non‑small cell lung cancer. Mol Med Rep 24: 789, 2021.
APA
Zhang, Y., Yan, S., Li, Y., Zhang, J., Luo, Y., Li, P. ... Wang, E. (2021). Inhibin βA is an independent prognostic factor that promotes invasion via Hippo signaling in non‑small cell lung cancer. Molecular Medicine Reports, 24, 789. https://doi.org/10.3892/mmr.2021.12429
MLA
Zhang, Y., Yan, S., Li, Y., Zhang, J., Luo, Y., Li, P., Yang, Y., Li, Y., Huang, Y., Wang, E."Inhibin βA is an independent prognostic factor that promotes invasion via Hippo signaling in non‑small cell lung cancer". Molecular Medicine Reports 24.5 (2021): 789.
Chicago
Zhang, Y., Yan, S., Li, Y., Zhang, J., Luo, Y., Li, P., Yang, Y., Li, Y., Huang, Y., Wang, E."Inhibin βA is an independent prognostic factor that promotes invasion via Hippo signaling in non‑small cell lung cancer". Molecular Medicine Reports 24, no. 5 (2021): 789. https://doi.org/10.3892/mmr.2021.12429
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