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Cycloastragenol alleviates airway inflammation in asthmatic mice by inhibiting autophagy

  • Authors:
    • Xueyi Zhu
    • Yuxue Cao
    • Mingyue Su
    • Mengmeng Chen
    • Congcong Li
    • La Yi
    • Jingjing Qin
    • Wuniqiemu Tulake
    • Fangzhou Teng
    • Yuanyuan Zhong
    • Weifeng Tang
    • Shiyuan Wang
    • Jingcheng Dong
  • View Affiliations / Copyright

    Affiliations: Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Pulmonary Diseases and Oncology, Pu'er Hospital of Traditional Chinese Medicine, Kunming, Yunnan 665000, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 805
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    Published online on: September 17, 2021
       https://doi.org/10.3892/mmr.2021.12445
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Abstract

Cycloastragenol (CAG), a secondary metabolite from the roots of Astragalus zahlbruckneri, has been reported to exert anti‑inflammatory effects in heart, skin and liver diseases. However, its role in asthma remains unclear. The present study aimed to investigate the effect of CAG on airway inflammation in an ovalbumin (OVA)‑induced mouse asthma model. The current study evaluated the lung function and levels of inflammation and autophagy via measurement of airway hyperresponsiveness (AHR), lung histology examination, inflammatory cytokine measurement and western blotting, amongst other techniques. The results demonstrated that CAG attenuated OVA‑induced AHR in vivo. In addition, the total number of leukocytes and eosinophils, as well as the secretion of inflammatory cytokines, including interleukin (IL)‑5, IL‑13 and immunoglobulin E were diminished in bronchoalveolar lavage fluid of the OVA‑induced murine asthma model. Histological analysis revealed that CAG suppressed inflammatory cell infiltration and goblet cell secretion. Notably, based on molecular docking simulation, CAG was demonstrated to bind to the active site of autophagy‑related gene 4‑microtubule‑associated proteins light chain 3 complex, which explains the reduced autophagic flux in asthma caused by CAG. The expression levels of proteins associated with autophagy pathways were inhibited following treatment with CAG. Taken together, the results of the present study suggest that CAG exerts an anti‑inflammatory effect in asthma, and its role may be associated with the inhibition of autophagy in lung cells.
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View References

1 

Cevhertas L, Ogulur I, Maurer DJ, Burla D, Ding M, Jansen K, Koch J, Liu C, Ma S, Mitamura Y, et al: Advances and recent developments in asthma in 2020. Allergy. 75:3124–3146. 2020. View Article : Google Scholar : PubMed/NCBI

2 

Papi A, Brightling C, Pedersen SE and Reddel HK: Asthma. Lancet. 391:783–800. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Bao W, Zhang Y, Zhang M, Bao A, Fei X, Zhang X and Zhou X: Effects of ozone repeated short exposures on the airway/lung inflammation, airway hyperresponsiveness and mucus production in a mouse model of ovalbumin-induced asthma. Biomed Pharmacother. 101:293–303. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Busse W, Kraft M, Rabe KF, Deniz Y, Rowe PJ, Ruddy M and Castro M: Understanding the key issues in the treatment of uncontrolled persistent asthma with type 2 inflammation. Eur Respir J. 58:20033932021. View Article : Google Scholar : PubMed/NCBI

5 

Piñeros YS, Bal SM, Dijkhuis A, Majoor CJ, Dierdorp BS, Dekker T, Hoefsmit EP, Bonta PI, Picavet D, van der Wel NN, et al: Eosinophils capture viruses, a capacity that is defective in asthma. Allergy. 74:1898–1909. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Reddel HK, Bateman ED, Becker A, Boulet LP, Cruz AA, Drazen JM, Haahtela T, Hurd SS, Inoue H, de Jongste JC, et al: A summary of the new GINA strategy: A roadmap to asthma control. Eur Respir J. 46:622–639. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Heffler E, Madeira LNG, Ferrando M, Puggioni F, Racca F, Malvezzi L, Passalacqua G and Canonica GW: Inhaled corticosteroids safety and adverse effects in patients with asthma. J Allergy Clin Immunol Pract. 6:776–781. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Xu Y and Eissa NT: Autophagy in innate and adaptive immunity. Proc Am Thorac Soc. 7:22–28. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Levine B, Mizushima N and Virgin HW: Autophagy in immunity and inflammation. Nature. 469:323–335. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Wang S, Wuniqiemu T, Tang W, Teng F, Bian Q, Yi L, Qin J, Zhu X, Wei Y and Dong J: Luteolin inhibits autophagy in allergic asthma by activating PI3K/Akt/mTOR signaling and inhibiting Beclin-1-PI3KC3 complex. Int Immunopharmacol. 94:1074602021. View Article : Google Scholar : PubMed/NCBI

11 

Hill S, Wrobel L and Rubinsztein D: Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation. Cell Death Differ. 26:617–629. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Matsuzawa-Ishimoto Y, Hwang S and Cadwell K: Autophagy and Inflammation. Ann Rev Immunol. 36:73–101. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Kirkin V, McEwan D, Novak I and Dikic I: A role for ubiquitin in selective autophagy. Mol Cell. 34:259–269. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Deretic V: Autophagy in inflammation, infection, and immunometabolism. Immunity. 54:437–453. 2021. View Article : Google Scholar : PubMed/NCBI

15 

Racanelli AC, Kikkers SA, Choi AMK and Cloonan SM: Autophagy and inflammation in chronic respiratory disease. Autophagy. 14:221–232. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Renz H: Autophagy: Nobel prize 2016 and allergy and asthma research. J Allergy Clin Immunol. 140:1548–1549. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Silveira JS, Antunes GL, Kaiber DB, da Costa MS, Ferreira FS, Marques EP, Schmitz F, Gassen RB, Breda RV, Wyse ATS, et al: Autophagy induces eosinophil extracellular traps formation and allergic airway inflammation in a murine asthma model. J Cell Physiol. 235:267–280. 2020. View Article : Google Scholar : PubMed/NCBI

18 

Liu JN, Suh DH, Trinh HK, Chwae YJ, Park HS and Shin YS: The role of autophagy in allergic inflammation: A new target for severe asthma. Exp Mol Med. 48:e2432016. View Article : Google Scholar : PubMed/NCBI

19 

McAlinden KD, Deshpande DA, Ghavami S, Xenaki D, Sohal SS, Oliver BG, Haghi M and Sharma P: Autophagy activation in asthma airways remodeling. Am J Respir Cell Mol Biol. 60:541–553. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Chan HHL and Ng T: Traditional Chinese medicine (TCM) and allergic diseases. Curr Allergy Asthma Rep. 20:672020. View Article : Google Scholar : PubMed/NCBI

21 

Wang W, Liu QB and Jing W: Astragalus membranaceus improves therapeutic efficacy of asthmatic children by regulating the balance of Treg/Th17 cells. Chin J Nat Med. 17:252–263. 2019.PubMed/NCBI

22 

Wang W, Jing W and Liu Q: Astragalus oral solution ameliorates allergic asthma in children by regulating relative contents of CD4+ CD25high CD127low treg cells. Front Pediatr. 6:2552018. View Article : Google Scholar : PubMed/NCBI

23 

Li L, Hou X, Xu R, Liu C and Tu M: Research review on the pharmacological effects of astragaloside IV. Fundam Clin Pharmacol. 31:17–36. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Li K, Chen Y, Jiang R, Chen D, Wang H, Xiong W, Li D, Liu Z, Li X, Li J and Yuan K: Protective effects of astragaloside IV against ovalbumin-induced allergic rhinitis are mediated by T-box protein expressed in T cells/GATA-3 and forkhead box protein 3/retinoic acid-related orphan nuclear receptor γt. Mol Med Rep. 16:1207–1215. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Huang X, Tang L, Wang F and Song G: Astragaloside IV attenuates allergic inflammation by regulation Th1/Th2 cytokine and enhancement CD4(+)CD25(+)Foxp3 T cells in ovalbumin-induced asthma. Immunobiology. 219:565–571. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Calis I, Gazar H, Piacente S and Pizza C: Secondary metabolites from the roots of Astragalus zahlbruckneri. J Nat Prod. 64:1179–1182. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Yu Y, Zhou L, Yang Y and Liu Y: Cycloastragenol: An exciting novel candidate for age-associated diseases. Exp Ther Med. 16:2175–2182. 2018.PubMed/NCBI

28 

Wan Y, Xu L, Wang Y, Tuerdi N, Ye M and Qi R: Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosis of mice by inhibiting the NLRP3 inflammasome. Eur J Pharmacol. 833:545–554. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Melgert BN, Postma DS, Kuipers I, Geerlings M, Luinge MA, van der Strate BW, Kerstjens HAM, Timens W and Hylkema MN: Female mice are more susceptible to the development of allergic airway inflammation than male mice. Clin Exp Allergy. 35:1496–1503. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Li Y, Chen S, Chi Y, Yang Y, Chen X, Wang H, Lv Z, Wang J, Yuan L, Huang P, et al: Kinetics of the accumulation of group 2 innate lymphoid cells in IL-33-induced and IL-25-induced murine models of asthma: A potential role for the chemokine CXCL16. Cell Mol Immunol. 16:75–86. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Peng H, Ning H, Wang Q, Lu W, Chang Y, Wang TT, Lai J, Kolattukudy PE, Hou R, Hoft DF, et al: Monocyte chemotactic protein-induced protein 1 controls allergic airway inflammation by suppressing IL-5-producing TH 2 cells through the Notch/Gata3 pathway. J Allergy Clin Immunol. 142:582–594. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Chen S, Yun F, Yao Y, Cao M, Zhang Y, Wang J, Song X and Qian Y: USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein. J Exp Med. 215:2850–2867. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Tel BC, Telli G, Onder S, Nemutlu E and Bozkurt TE: Investigation of the relationship between chronic montelukast treatment, asthma and depression-like behavior in mice. Exp Ther Med. 21:272021.PubMed/NCBI

34 

Tamaru S, Mishina H, Watanabe Y, Watanabe K, Fujioka D, Takahashi S, Suzuki K, Nakamura T, Obata JE, Kawabata K, et al: Deficiency of phospholipase A2 receptor exacerbates ovalbumin-induced lung inflammation. J Immunol. 191:1021–1028. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Kim S, Thiessen PA, Bolton EE, Chen J, Fu G, Gindulyte A, Han L, He J, He S, Shoemaker BA, et al: PubChem substance and compound databases. Nucleic Acids Res. 44:D1202–D1213. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Berman H, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN and Bourne PE: The protein data bank. Nucleic Acids Res. 28:235–242. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Morris G, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS and Olson AJ: AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. J Comput Chem. 30:2785–2791. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Trott O and Olson A: AutoDock vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem. 31:455–461. 2010.PubMed/NCBI

39 

Seeliger D and de Groot B: Ligand docking and binding site analysis with PyMOL and autodock/vina. J Comput Aided Mol Des. 24:417–422. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Wang C, Tu M, Wu D, Chen H, Chen C, Wang Z and Jiang L: Identification of an ACE-inhibitory peptide from walnut protein and its evaluation of the inhibitory mechanism. Int J Mol Sci. 19:11562018. View Article : Google Scholar : PubMed/NCBI

41 

Feng FB and Qiu HY: Effects of Artesunate on chondrocyte proliferation, apoptosis and autophagy through the PI3K/AKT/mTOR signaling pathway in rat models with rheumatoid arthritis. Biomed Pharmacother. 102:1209–1220. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Wei Y, Liu B, Sun J, Lv Y, Luo Q, Liu F and Dong J: Regulation of Th17/Treg function contributes to the attenuation of chronic airway inflammation by icariin in ovalbumin-induced murine asthma model. Immunobiology. 220:789–797. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Tang W, Dong M, Teng F, Cui J, Zhu X, Wang W, Wuniqiemu T, Qin J, Yi L, Wang S, et al: TMT-based quantitative proteomics reveals suppression of SLC3A2 and ATP1A3 expression contributes to the inhibitory role of acupuncture on airway inflammation in an OVA-induced mouse asthma model. Biomed Pharmacother. 134:1110012021. View Article : Google Scholar : PubMed/NCBI

44 

Kubo M: Innate and adaptive type 2 immunity in lung allergic inflammation. Immunol Rev. 278:162–172. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Zhu X, Cui J, Yi L, Qin J, Tulake W, Teng F, Tang W, Wei Y and Dong J: The role of T cells and macrophages in asthma pathogenesis: A new perspective on mutual crosstalk. Mediators Inflamm. 2020:78352842020. View Article : Google Scholar : PubMed/NCBI

46 

Bleecker ER, Menzies-Gow AN, Price DB, Bourdin A, Sweet S, Martin AL, Alacqua M and Tran TN: Systematic literature review of systemic corticosteroid use for asthma management. Am J Respir Crit Care Med. 201:276–293. 2020. View Article : Google Scholar : PubMed/NCBI

47 

Zhu J, Lee S, Ho MK, Hu Y, Pang H, Ip FC, Chin AC, Harley CB, Ip NY and Wong YH: In vitro intestinal absorption and first-pass intestinal and hepatic metabolism of cycloastragenol, a potent small molecule telomerase activator. Drug Metab Pharmacokinet. 25:477–486. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Li M, Li SC, Dou BK, Zou YX, Han HZ, Liu DX, Ke ZJ and Wang ZF: Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia. Acta Pharmacol Sin. 41:1025–1032. 2020. View Article : Google Scholar : PubMed/NCBI

49 

Gu M, Zhang S, Zhao Y, Huang J, Wang Y, Li Y, Fan S, Yang L, Ji G, Tong Q and Huang C: Cycloastragenol improves hepatic steatosis by activating farnesoid X receptor signalling. Pharmacol Res. 121:22–32. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Wang Y, Chen C, Wang Q, Cao Y, Xu L and Qi R: Inhibitory effects of cycloastragenol on abdominal aortic aneurysm and its related mechanisms. Br J Pharmacol. 176:282–296. 2019. View Article : Google Scholar : PubMed/NCBI

51 

Liu J, Gao D, Dan J, Liu D, Peng L, Zhou R and Luo Y: The protective effect of cycloastragenol on aging mouse circadian rhythmic disorder induced by d-galactose. J Cell Biochem. 120:16408–16415. 2019. View Article : Google Scholar : PubMed/NCBI

52 

Deng G, Chen W, Wang P, Zhan T, Zheng W, Gu Z, Wang X, Ji X and Sun Y: Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice. Int Immunopharmacol. 74:1056822019. View Article : Google Scholar : PubMed/NCBI

53 

Kanehiro A, Takeda K, Joetham A, Tomkinson A, Ikemura T, Irvin CG and Gelfand EW: Timing of administration of anti-VLA-4 differentiates airway hyperresponsiveness in the central and peripheral airways in mice. Am J Respir Crit Care Med. 162:1132–1139. 2000. View Article : Google Scholar : PubMed/NCBI

54 

Dong L, Wang Y, Zheng T, Pu Y, Ma Y, Qi X, Zhang W, Xue F, Shan Z, Liu J, et al: Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice. Stem Cell Res Ther. 12:42021. View Article : Google Scholar : PubMed/NCBI

55 

Hammad H and Lambrecht BN: The basic immunology of asthma. Cell. 184:1469–1485. 2021. View Article : Google Scholar : PubMed/NCBI

56 

Chen W, Sivaprasad U, Gibson AM, Ericksen MB, Cunningham CM, Bass SA, Kinker KG, Finkelman FD, Wills-Karp M and Hershey GK: IL-13 receptor α2 contributes to development of experimental allergic asthma. J Allergy Clin Immunol. 132:951–958. 2013. View Article : Google Scholar : PubMed/NCBI

57 

Lambrecht BN, Hammad H and Fahy JV: The cytokines of asthma. Immunity. 50:975–991. 2019. View Article : Google Scholar : PubMed/NCBI

58 

Gould HJ and Sutton BJ: IgE in allergy and asthma today. Nat Rev Immunol. 8:205–217. 2008. View Article : Google Scholar : PubMed/NCBI

59 

Wang J, Wu ML, Cao SP, Cai H, Zhao ZM and Song YH: Cycloastragenol ameliorates experimental heart damage in rats by promoting myocardial autophagy via inhibition of AKT1-RPS6KB1 signaling. Biomed Pharmacother. 107:1074–1081. 2018. View Article : Google Scholar : PubMed/NCBI

60 

Cadwell K: Crosstalk between autophagy and inflammatory signalling pathways: Balancing defence and homeostasis. Nat Rev Immunol. 16:661–675. 2016. View Article : Google Scholar : PubMed/NCBI

61 

Mizushima N and Levine B: Autophagy in human diseases. N Engl J Med. 383:1564–1576. 2020. View Article : Google Scholar : PubMed/NCBI

62 

Maneechotesuwan K, Kasetsinsombat K, Wongkajornsilp A and Barnes PJ: Role of autophagy in regulating interleukin-10 and the responses to corticosteroids and statins in asthma. Clin Exp Allergy. 19:138252021. View Article : Google Scholar

63 

Xia F, Deng C, Jiang Y, Qu Y, Deng J, Cai Z, Ding Y, Guo Z and Wang J: IL4 (interleukin 4) induces autophagy in B cells leading to exacerbated asthma. Autophagy. 14:450–464. 2018. View Article : Google Scholar : PubMed/NCBI

64 

Zhang Y, Do DC, Hu X, Wang J, Zhao Y, Mishra S, Zhang X, Wan M and Gao P: CaMKII oxidation regulates cockroach allergen-induced mitophagy in asthma. J Allergy Clin Immunol. 147:1464–1477. 2021. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Zhu X, Cao Y, Su M, Chen M, Li C, Yi L, Qin J, Tulake W, Teng F, Zhong Y, Zhong Y, et al: Cycloastragenol alleviates airway inflammation in asthmatic mice by inhibiting autophagy. Mol Med Rep 24: 805, 2021.
APA
Zhu, X., Cao, Y., Su, M., Chen, M., Li, C., Yi, L. ... Dong, J. (2021). Cycloastragenol alleviates airway inflammation in asthmatic mice by inhibiting autophagy. Molecular Medicine Reports, 24, 805. https://doi.org/10.3892/mmr.2021.12445
MLA
Zhu, X., Cao, Y., Su, M., Chen, M., Li, C., Yi, L., Qin, J., Tulake, W., Teng, F., Zhong, Y., Tang, W., Wang, S., Dong, J."Cycloastragenol alleviates airway inflammation in asthmatic mice by inhibiting autophagy". Molecular Medicine Reports 24.5 (2021): 805.
Chicago
Zhu, X., Cao, Y., Su, M., Chen, M., Li, C., Yi, L., Qin, J., Tulake, W., Teng, F., Zhong, Y., Tang, W., Wang, S., Dong, J."Cycloastragenol alleviates airway inflammation in asthmatic mice by inhibiting autophagy". Molecular Medicine Reports 24, no. 5 (2021): 805. https://doi.org/10.3892/mmr.2021.12445
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Spandidos Publications style
Zhu X, Cao Y, Su M, Chen M, Li C, Yi L, Qin J, Tulake W, Teng F, Zhong Y, Zhong Y, et al: Cycloastragenol alleviates airway inflammation in asthmatic mice by inhibiting autophagy. Mol Med Rep 24: 805, 2021.
APA
Zhu, X., Cao, Y., Su, M., Chen, M., Li, C., Yi, L. ... Dong, J. (2021). Cycloastragenol alleviates airway inflammation in asthmatic mice by inhibiting autophagy. Molecular Medicine Reports, 24, 805. https://doi.org/10.3892/mmr.2021.12445
MLA
Zhu, X., Cao, Y., Su, M., Chen, M., Li, C., Yi, L., Qin, J., Tulake, W., Teng, F., Zhong, Y., Tang, W., Wang, S., Dong, J."Cycloastragenol alleviates airway inflammation in asthmatic mice by inhibiting autophagy". Molecular Medicine Reports 24.5 (2021): 805.
Chicago
Zhu, X., Cao, Y., Su, M., Chen, M., Li, C., Yi, L., Qin, J., Tulake, W., Teng, F., Zhong, Y., Tang, W., Wang, S., Dong, J."Cycloastragenol alleviates airway inflammation in asthmatic mice by inhibiting autophagy". Molecular Medicine Reports 24, no. 5 (2021): 805. https://doi.org/10.3892/mmr.2021.12445
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