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HOXD9‑induced SCNN1A upregulation promotes pancreatic cancer cell proliferation, migration and predicts prognosis by regulating epithelial‑mesenchymal transformation

  • Authors:
    • Jinhai Chang
    • Xuguang Hu
    • Jinniang Nan
    • Xianghua Zhang
    • Xintian Jin
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Yanbian Hospital of Traditional Chinese Medicine, Yanbian, Jilin 133000, P.R. China, Department of Hepatobiliary Surgery, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, P.R. China, Department of Clinical Medicine, Jiangxi Health Vocational College of China, Nanchang, Jiangxi 330052, P.R. China, Department of Thoracic Oncology, Jilin Province Cancer Hospital, Changchun, Jilin 130000, P.R. China, Department of Thoracic Surgery, Jilin Province Cancer Hospital, Changchun, Jilin 130000, P.R. China
    Copyright: © Chang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 819
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    Published online on: September 22, 2021
       https://doi.org/10.3892/mmr.2021.12459
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Abstract

Pancreatic cancer (PC) is a malignant tumor disease, whose molecular mechanism is not fully understood. Sodium channel epithelial 1α subunit (SCNN1A) serves an important role in tumor progression. The current study explored the role of homeobox D9 (HOXD9) and SCNN1A in the progression of PC. The expression of SCNN1A and HOXD9 in PC samples was predicted on online databases and detected in PC cell lines. The association between SCNN1A expression and PC prognosis was examined by the Gene Expression Profiling Interactive Analysis, The Cancer Genome Atlas and Genotype‑Tissue Expression databases and by a Kaplan‑Meier plotter. Subsequently, the biological effects of SCNN1A on PC cell growth, colony formation, migration and invasion were investigated through RNA interference and cell transfection. Next, the expression of E‑cadherin, N‑cadherin, Vimentin and Snail was detected by western blotting to discover whether HOXD9 dysregulation mediated PC metastasis. Binding sites of HOXD9 and SCNN1A promoters were predicted on JASPAR. Reverse transcription‑quantitative PCR and western blotting were used to detect the expression level of SCNN1A following interference and overexpression of HOXD9. Luciferase assay detected luciferase activity following interference with HOXD9 and the transcriptional activity of SCNN1A following binding site deletion. High expression of SCNN1A and HOXD9 in PC was predicted by online databases, signifying poor prognosis. The present study confirmed the above predictions in PC cell lines. Knockdown of SCNN1A and HOXD9 could effectively inhibit the proliferation, migration, invasion and epithelial‑mesenchymal transition of PC cells. Furthermore, HOXD9 activated SCNN1A transcription, forming a feedback regulatory loop. HOXD9 was demonstrated to activate SCNN1A and promote the malignant biological process of PC.
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1 

Vincent A, Herman J, Schulick R, Hruban RH and Goggins M: Pancreatic cancer. Lancet. 378:607–620. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

3 

McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG and McCain RS: Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes. World J Gastroenterol. 24:4846–4861. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Neoptolemos JP, Kleeff J, Michl P, Costello E, Greenhalf W and Palmer DH: Therapeutic developments in pancreatic cancer: Current and future perspectives. Nat Rev Gastroenterol Hepatol. 15:333–348. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Zeng S, Pöttler M, Lan B, Grutzmann R, Pilarsky C and Yang H: Chemoresistance in pancreatic cancer. Int J Mol Sci. 20:45042019. View Article : Google Scholar : PubMed/NCBI

6 

Collisson EA, Bailey P, Chang DK and Biankin AV: Molecular subtypes of pancreatic cancer. Nat Rev Gastroenterol Hepatol. 16:207–220. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, McAllister F, Reichert M, Beatty GL, Rustgi AK, Vonderheide RH, et al: EMT and dissemination precede pancreatic tumor formation. Cell. 148:349–361. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Reichert M, Bakir B, Moreira L, Pitarresi JR, Feldmann K, Simon L, Suzuki K, Maddipati R, Rhim AD, Schlitter AM, et al: Regulation of epithelial plasticity determines metastatic organotropism in pancreatic cancer. Dev Cell. 45:696–711.e8. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Canessa CM, Schild L, Buell G, Thorens B, Gautschi I, Horisberger JD and Rossier BC: Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature. 367:463–467. 1994. View Article : Google Scholar : PubMed/NCBI

10 

Jasti J, Furukawa H, Gonzales EB and Gouaux E: Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH. Nature. 449:316–323. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Liu C, Zhu LL, Xu SG, Ji HL and Li XM: ENaC/DEG in tumor development and progression. J Cancer. 7:1888–1891. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Xu S, Liu C, Ma Y, Ji HL and Li X: Potential roles of amiloride-sensitive sodium channels in cancer development. Biomed Res Int. 2016:21902162016. View Article : Google Scholar : PubMed/NCBI

13 

Geng Y, Zhao S, Jia Y, Xia G, Li H, Fang Z, Zhang Q and Tian R: miR95 promotes osteosarcoma growth by targeting SCNN1A. Oncol Rep. 43:1429–1436. 2020.PubMed/NCBI

14 

Wu L, Ling ZH, Wang H, Wang XY and Gui J: Upregulation of SCNN1A promotes cell proliferation, migration, and predicts poor prognosis in ovarian cancer through regulating epithelial-mesenchymal transformation. Cancer Biother Radiopharm. 34:642–649. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Jerkovic I, Ibrahim DM, Andrey G, Haas S, Hansen P, Janetzki C, González Navarrete I, Robinson PN, Hecht J and Mundlos S: Genome-wide binding of posterior HOXA/D transcription factors reveals subgrouping and association with CTCF. PLoS Genet. 13:e10065672017. View Article : Google Scholar : PubMed/NCBI

16 

Pernía O, Sastre-Perona A, Rodriguez-Antolin C, García-Guede A, Palomares-Bralo M, Rosas R, Sanchez-Cabrero D, Cruz P, Rodriguez C, Diestro M, et al: A novel role for the tumor suppressor gene ITF2 in tumorigenesis and chemotherapy response. Cancers (Basel). 12:7862020. View Article : Google Scholar : PubMed/NCBI

17 

Li ZG, Xiang WC, Shui SF, Han XW, Guo D and Yan L: 11 Long noncoding RNA UCA1 functions as miR-135a sponge to promote the epithelial to mesenchymal transition in glioma. J Cell Biochem. 121:2447–2457. 2020. View Article : Google Scholar : PubMed/NCBI

18 

Hirao N, Iwata T, Tanaka K, Nishio H, Nakamura M, Morisada T, Morii K, Maruyama N, Katoh Y, Yaguchi T, et al: Transcription factor homeobox D9 is involved in the malignant phenotype of cervical cancer through direct binding to the human papillomavirus oncogene promoter. Gynecol Oncol. 155:340–348. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Zhu H, Dai W, Li J, Xiang L, Wu X, Tang W, Chen Y, Yang Q, Liu M, Xiao Y, et al: HOXD9 promotes the growth, invasion and metastasis of gastric cancer cells by transcriptional activation of RUFY3. J Exp Clin Cancer Res. 38:4122019. View Article : Google Scholar : PubMed/NCBI

20 

Wen D, Wang L, Tan S, Tang R, Xie W, Liu S, Tang C and He Y: HOXD9 aggravates the development of cervical cancer by transcriptionally activating HMCN1. Panminerva Med. May 14–2020.doi: 10.23736/S0031-0808.20.03911-7 (Epub ahead of print).

21 

Liu X, Bing Z, Wu J, Zhang J, Zhou W, Ni M, Meng Z, Liu S, Tian J, Zhang X, et al: Integrative gene expression profiling analysis to investigate potential prognostic biomarkers for colorectal cancer. Med Sci Monit. 26:e9189062020.PubMed/NCBI

22 

Tomczak K, Czerwińska P and Wiznerowicz M: The cancer genome atlas (TCGA): An immeasurable source of knowledge. Contemp Oncol (Pozn). 19:A68–A77. 2015.PubMed/NCBI

23 

GTEx Consortium: The genotype-tissue expression (GTEx) project. Nat Genet. 45:580–585. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Lacny S, Wilson T, Clement F, Roberts DJ, Faris P, Ghali WA and Marshall DA: Kaplan-Meier survival analysis overestimates cumulative incidence of health-related events in competing risk settings: A meta-analysis. J Clin Epidemiol. 93:25–35. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Xu L, Faruqu FN, Lim YM, Lim KY, Liam-Or R, Walters AA, Lavender P, Fear D, Wells CM, Tzu-Wen Wang J and Al-Jamal KT: Exosome-mediated RNAi of PAK4 prolongs survival of pancreatic cancer mouse model after loco-regional treatment. Biomaterials. 264:1203692021. View Article : Google Scholar : PubMed/NCBI

27 

Lin C, Sun L, Huang S, Weng X and Wu Z: STC2 Is a potential prognostic biomarker for pancreatic cancer and promotes migration and invasion by inducing epithelial-mesenchymal transition. Biomed Res Int. 2019:80424892019. View Article : Google Scholar : PubMed/NCBI

28 

Ge L, Wang H, Xu X, Zhou Z, He J, Peng W, Du F, Zhang Y, Gong A and Xu M: PRMT5 promotes epithelial-mesenchymal transition via EGFR-β-catenin axis in pancreatic cancer cells. J Cell Mol Med. 24:1969–1979. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Wang L, Wu H, Wang L, Zhang H, Lu J, Liang Z and Liu T: Asporin promotes pancreatic cancer cell invasion and migration by regulating the epithelial-to-mesenchymal transition (EMT) through both autocrine and paracrine mechanisms. Cancer Lett. 398:24–36. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Crosby JR, Zhao C, Jiang C, Bai D, Katz M, Greenlee S, Kawabe H, McCaleb M, Rotin D, Guo S and Monia BP: Inhaled ENaC antisense oligonucleotide ameliorates cystic fibrosis-like lung disease in mice. J Cyst Fibros. 16:671–680. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Dirlewanger M, Huser D, Zennaro MC, Girardin E, Schild L and Schwitzgebel VM: A homozygous missense mutation in SCNN1A is responsible for a transient neonatal form of pseudohypoaldosteronism type 1. Am J Physiol Endocrinol Metab. 301:E467–E473. 2011. View Article : Google Scholar : PubMed/NCBI

32 

D'Arcangelo D, Scatozza F, Giampietri C, Marchetti P, Facchiano F and Facchiano A: Ion channel expression in human melanoma samples: In silico identification and experimental validation of molecular targets. Cancers (Basel). 11:4462019. View Article : Google Scholar : PubMed/NCBI

33 

Pastushenko I and Blanpain C: EMT transition states during tumor progression and metastasis. Trends Cell Biol. 29:212–226. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Liu M, Xiao Y, Tang W, Li J, Hong L, Dai W, Zhang W, Peng Y, Wu X, Wang J, et al: HOXD9 promote epithelial-mesenchymal transition and metastasis in colorectal carcinoma. Cancer Med. 9:3932–3943. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Lv X, Li L, Lv L, Qu X, Jin S, Li K, Deng X, Cheng L, He H and Dong L: HOXD9 promotes epithelial-mesenchymal transition and cancer metastasis by ZEB1 regulation in hepatocellular carcinoma. J Exp Clin Cancer Res. 34:1332015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chang J, Hu X, Nan J, Zhang X and Jin X: HOXD9‑induced SCNN1A upregulation promotes pancreatic cancer cell proliferation, migration and predicts prognosis by regulating epithelial‑mesenchymal transformation. Mol Med Rep 24: 819, 2021.
APA
Chang, J., Hu, X., Nan, J., Zhang, X., & Jin, X. (2021). HOXD9‑induced SCNN1A upregulation promotes pancreatic cancer cell proliferation, migration and predicts prognosis by regulating epithelial‑mesenchymal transformation. Molecular Medicine Reports, 24, 819. https://doi.org/10.3892/mmr.2021.12459
MLA
Chang, J., Hu, X., Nan, J., Zhang, X., Jin, X."HOXD9‑induced SCNN1A upregulation promotes pancreatic cancer cell proliferation, migration and predicts prognosis by regulating epithelial‑mesenchymal transformation". Molecular Medicine Reports 24.5 (2021): 819.
Chicago
Chang, J., Hu, X., Nan, J., Zhang, X., Jin, X."HOXD9‑induced SCNN1A upregulation promotes pancreatic cancer cell proliferation, migration and predicts prognosis by regulating epithelial‑mesenchymal transformation". Molecular Medicine Reports 24, no. 5 (2021): 819. https://doi.org/10.3892/mmr.2021.12459
Copy and paste a formatted citation
x
Spandidos Publications style
Chang J, Hu X, Nan J, Zhang X and Jin X: HOXD9‑induced SCNN1A upregulation promotes pancreatic cancer cell proliferation, migration and predicts prognosis by regulating epithelial‑mesenchymal transformation. Mol Med Rep 24: 819, 2021.
APA
Chang, J., Hu, X., Nan, J., Zhang, X., & Jin, X. (2021). HOXD9‑induced SCNN1A upregulation promotes pancreatic cancer cell proliferation, migration and predicts prognosis by regulating epithelial‑mesenchymal transformation. Molecular Medicine Reports, 24, 819. https://doi.org/10.3892/mmr.2021.12459
MLA
Chang, J., Hu, X., Nan, J., Zhang, X., Jin, X."HOXD9‑induced SCNN1A upregulation promotes pancreatic cancer cell proliferation, migration and predicts prognosis by regulating epithelial‑mesenchymal transformation". Molecular Medicine Reports 24.5 (2021): 819.
Chicago
Chang, J., Hu, X., Nan, J., Zhang, X., Jin, X."HOXD9‑induced SCNN1A upregulation promotes pancreatic cancer cell proliferation, migration and predicts prognosis by regulating epithelial‑mesenchymal transformation". Molecular Medicine Reports 24, no. 5 (2021): 819. https://doi.org/10.3892/mmr.2021.12459
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