Open Access

Let‑7b‑5p promotes cell apoptosis in Parkinson's disease by targeting HMGA2

  • Authors:
    • Yujing Huang
    • Ying Liu
    • Jing Huang
    • Lu Gao
    • Zhenggang Wu
    • Lu Wang
    • Lin Fan
  • View Affiliations

  • Published online on: September 24, 2021     https://doi.org/10.3892/mmr.2021.12461
  • Article Number: 820
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Parkinson's disease (PD), a common multifactorial neurodegenerative disease, is characterized by irreversible loss of dopaminergic neurons in the substantia nigra. In‑depth study of the pathogenesis of PD is of great importance. High‑mobility group AT‑hook 2 (HMGA2) has been proposed to be implicated with neuronal differentiation and impairment of cognitive function. However, whether HMGA2 plays a role in PD is rarely explored. In the present study, N‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine (MPTP)‑treated PD mice models and N‑methyl‑4‑ phenylpyridinium (MPP+)‑treated SH‑SY5Y cell models were established. Reverse transcription‑quantitative PCR showed that HMGA2 displayed low levels in brain tissues of MPTP‑treated mice and MPP+‑treated SH‑SY5Y cells. Moreover, HMGA2 overexpression suppressed SH‑SY5Y cell apoptosis. Additionally, let‑7b‑5p bound with HMGA2 3' untranslated region (UTR), and its expression was negatively correlated with HMGA2 level. Moreover, let‑7b‑5p presented high levels in brain tissues of PD mice and MPP+‑treated SH‑SY5Y cells, and knockdown of let‑7b‑5p inhibited SH‑SY5Y cell apoptosis. Rescue assays illustrated that HMGA2 neutralized the promotive effects of let‑7b‑5p mimics on SH‑SY5Y cell apoptosis. In conclusion, the present study demonstrated that let‑7b‑5p contributes to cell apoptosis in PD by targeting HMGA2, which offers a potential theoretical basis for the study of effective therapy in PD.
View Figures
View References

Related Articles

Journal Cover

November-2021
Volume 24 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Huang Y, Liu Y, Huang J, Gao L, Wu Z, Wang L and Fan L: Let‑7b‑5p promotes cell apoptosis in Parkinson's disease by targeting HMGA2. Mol Med Rep 24: 820, 2021
APA
Huang, Y., Liu, Y., Huang, J., Gao, L., Wu, Z., Wang, L., & Fan, L. (2021). Let‑7b‑5p promotes cell apoptosis in Parkinson's disease by targeting HMGA2. Molecular Medicine Reports, 24, 820. https://doi.org/10.3892/mmr.2021.12461
MLA
Huang, Y., Liu, Y., Huang, J., Gao, L., Wu, Z., Wang, L., Fan, L."Let‑7b‑5p promotes cell apoptosis in Parkinson's disease by targeting HMGA2". Molecular Medicine Reports 24.5 (2021): 820.
Chicago
Huang, Y., Liu, Y., Huang, J., Gao, L., Wu, Z., Wang, L., Fan, L."Let‑7b‑5p promotes cell apoptosis in Parkinson's disease by targeting HMGA2". Molecular Medicine Reports 24, no. 5 (2021): 820. https://doi.org/10.3892/mmr.2021.12461