Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November-2021 Volume 24 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2021 Volume 24 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Intermittent hypoxia mimicking obstructive sleep apnea aggravates early brain injury following ICH via neuroinflammation and apoptosis

  • Authors:
    • Wenjing Fei
    • Wei Jiao
    • Xiaoyan Feng
    • Xufeng Chen
    • Yuhai Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, 904th Hospital of Joint Logistic Support Force of PLA, Wuxi Clinical College of Anhui Medical University, Wuxi, Jiangsu 214044, P.R. China, Department of Nursing, 904th Hospital of Joint Logistic Support Force of PLA, Wuxi Clinical College of Anhui Medical University, Wuxi, Jiangsu 214044, P.R. China, Department of Neurosurgery, 904th Hospital of Joint Logistic Support Force of PLA, Wuxi Clinical College of Anhui Medical University, Wuxi, Jiangsu 214044, P.R. China, Department of Gastroenterology, 904th Hospital of Joint Logistic Support Force of PLA, Wuxi Clinical College of Anhui Medical University, Wuxi, Jiangsu 214044, P.R. China
    Copyright: © Fei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 824
    |
    Published online on: September 24, 2021
       https://doi.org/10.3892/mmr.2021.12464
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Spontaneous intracerebral hemorrhage (ICH) is a subtype of stroke associated with high mortality and morbidity due to the lack of effective therapy. Obstructive sleep apnea (OSA) has been reported to aggravate early brain injury (EBI) and worsen the overall outcome of patients with ICH. However, the precise role of OSA‑mediated neuroinflammation and apoptosis following ICH has not been confirmed. The present study aimed to investigate the neuronal damage induced by OSA and the potential molecular mechanisms by which ICH‑induced EBI regulates neural apoptosis in a C57BL/6 mouse ICH model. Mortality, neurological score, brain water content and neuronal death were evaluated by Evans blue extravasation, TUNEL staining, ELISA, analysis of reactive oxygen species/lipid peroxidation and western blotting. The results showed that OSA induction decreased survival rate, neurological score and neuron survival and upregulated the protein expression levels of Caspase‑3, Bax, cytokines IL‑1β, IL‑6 and TNF‑α and NF‑κB, which indicated that OSA‑mediated induction of apoptosis and neuroinflammation aggravated neuronal death following ICH. The molecular mechanism was partly dependent on the activating transcription factor/CHOP pathway. Taken together, the results demonstrated that OSA worsens neurological outcomes in mice and increases neuronal death by enhancing neural apoptosis and neuroinflammation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

van Asch CJ, Luitse MJ, Rinkel GJ, van der Tweel I, Algra A and Klijn CJ: Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: A systematic review and meta-analysis. Lancet Neurol. 9:167–176. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Zhang Y, Zhang X, Wei Q, Leng S, Li C, Han B, Bai Y, Zhang H and Yao H: Activation of sigma-1 receptor enhanced pericyte survival via the interplay between apoptosis and autophagy: Implications for blood-brain barrier integrity in stroke. Transl Stroke Res. 11:267–287. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Zhang Z, Cho S, Rehni AK, Quero HN, Dave KR and Zhao W: Automated assessment of hematoma volume of rodents subjected to experimental intracerebral hemorrhagic stroke by bayes segmentation approach. Transl Stroke Res. 11:789–798. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Gross BA, Jankowitz BT and Friedlander RM: Cerebral intraparenchymal hemorrhage: A review. JAMA. 321:1295–1303. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Wu X, Luo J, Liu H, Cui W, Guo K, Zhao L, Bai H, Guo W, Guo H, Feng D and Qu Y: Recombinant adiponectin peptide ameliorates brain injury following intracerebral hemorrhage by suppressing astrocyte-derived inflammation via the inhibition of Drp1-mediated mitochondrial fission. Transl Stroke Res. 11:924–939. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Hanley DF, Thompson RE, Rosenblum M, Yenokyan G, Lane K, McBee N, Mayo SW, Bistran-Hall AJ, Gandhi D, Mould WA, et al: Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): A randomised, controlled, open-label, blinded endpoint phase 3 trial. Lancet. 393:1021–1032. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Chen J, Zhu J, He J, Wang Y, Chen L, Zhang C, Zhou J and Yang L: Ultra-early microsurgical treatment within 24 h of SAH improves prognosis of poor-grade aneurysm combined with intracerebral hematoma. Oncol Lett. 11:3173–3178. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Chen J, Wang Y, Wu J, Yang J, Li M and Chen Q: The potential value of targeting ferroptosis in early brain injury after acute CNS disease. Front Mol Neurosci. 13:1102020. View Article : Google Scholar : PubMed/NCBI

9 

Adeoye O and Broderick JP: Advances in the management of intracerebral hemorrhage. Nat Rev Neurol. 6:593–601. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Mendelow AD, Gregson BA, Rowan EN, Murray GD, Gholkar A and Mitchell PM; STICH II Investigators, : Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): A randomised trial. Lancet. 382:397–408. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Zhou Y, Wang Y, Wang J, Anne Stetler R and Yang QW: Inflammation in intracerebral hemorrhage: From mechanisms to clinical translation. Prog Neurobiol. 115:25–44. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Xue M and Yong VW: Neuroinflammation in intracerebral haemorrhage: Immunotherapies with potential for translation. Lancet Neurol. 19:1023–1032. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Chen JH, Yang LK, Chen L, Wang YH, Wu Y, Jiang BJ, Zhu J and Li PP: Atorvastatin ameliorates early brain injury after subarachnoid hemorrhage via inhibition of AQP4 expression in rabbits. Int J Mol Med. 37:1059–1066. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Bao WD, Zhou XT, Zhou LT, Wang F, Yin X, Lu Y, Zhu LQ and Liu D: Targeting miR-124/Ferroportin signaling ameliorated neuronal cell death through inhibiting apoptosis and ferroptosis in aged intracerebral hemorrhage murine model. Aging Cell. 19:e132352020. View Article : Google Scholar : PubMed/NCBI

15 

Gautam J, Xu L, Nirwane A, Nguyen B and Yao Y: Loss of mural cell-derived laminin aggravates hemorrhagic brain injury. J Neuroinflammation. 17:1032020. View Article : Google Scholar : PubMed/NCBI

16 

Karuppagounder SS, Alim I, Khim SJ, Bourassa MW, Sleiman SF, John R, Thinnes CC, Yeh TL, Demetriades M, Neitemeier S, et al: Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Sci Transl Med. 8:328ra3292016. View Article : Google Scholar : PubMed/NCBI

17 

Chen J, Xuan Y, Chen Y, Wu T, Chen L, Guan H, Yang S, He J, Shi D and Wang Y: Netrin-1 alleviates subarachnoid haemorrhage-induced brain injury via the PPARγ/NF-KB signalling pathway. J Cell Mol Med. 23:2256–2262. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Zhou Y, Tao T, Liu G, Gao X, Gao Y, Zhuang Z, Lu Y, Wang H, Li W, Wu L, et al: TRAF3 mediates neuronal apoptosis in early brain injury following subarachnoid hemorrhage via targeting TAK1-dependent MAPKs and NF-κB pathways. Cell Death Dis. 12:102021. View Article : Google Scholar : PubMed/NCBI

19 

Chernyshev OY, Bir SC, Maiti TK, Patra DP, Sun H, Guthikonda B, Kelley RE, Cuellar H, Minagar A and Nanda A: The relationship between obstructive sleep apnea and ruptured intracranial aneurysms. J Clin Sleep Med. 15:1839–1848. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Mason RH, Ruegg G, Perkins J, Hardinge M, Amann-Vesti B, Senn O, Stradling JR and Kohler M: Obstructive sleep apnea in patients with abdominal aortic aneurysms: Highly prevalent and associated with aneurysm expansion. Am J Respir Crit Care Med. 183:668–674. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Zaremba S, Albus L, Schuss P, Vatter H, Klockgether T and Güresir E: Increased risk for subarachnoid hemorrhage in patients with sleep apnea. J Neurol. 266:1351–1357. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Geer JH, Falcone GJ, Vanent KN, Leasure AC, Woo D, Molano JR, Sansing LH, Langefeld CD, Pisani MA, Yaggi HK and Sheth KN: Obstructive sleep apnea as a risk factor for intracerebral hemorrhage. Stroke. 52:1835–1838. 2021. View Article : Google Scholar : PubMed/NCBI

23 

Bir SC, Nanda A, Cuellar H, Sun H, Guthikonda B, Liendo C, Minagar A and Chernyshev OY: Coexistence of obstructive sleep apnea worsens the overall outcome of intracranial aneurysm: A pioneer study. J Neurosurg. 128:735–746. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Pontes-Neto OM, Fernandes RM, Sander HH, da Silva LA, Mariano DC, Nobre F, Simão G, de Araujo DB, dos Santos AC and Leite JP: Obstructive sleep apnea is frequent in patients with hypertensive intracerebral hemorrhage and is related to perihematoma edema. Cerebrovasc Dis. 29:36–42. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Orrù G, Storari M, Scano A, Piras V, Taibi R and Viscuso D: Obstructive sleep apnea, oxidative stress, inflammation and endothelial dysfunction-an overview of predictive laboratory biomarkers. Eur Rev Med Pharmacol Sci. 24:6939–6948. 2020.PubMed/NCBI

26 

Hung MW, Tipoe GL, Poon AM, Reiter RJ and Fung ML: Protective effect of melatonin against hippocampal injury of rats with intermittent hypoxia. J Pineal Res. 44:214–221. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Chen J, Zhang C, Yan T, Yang L, Wang Y, Shi Z, Li M and Chen Q: Atorvastatin ameliorates early brain injury after subarachnoid hemorrhage via inhibition of pyroptosis and neuroinflammation. J Cell Physiol. Mar 31–2021.(Epub ahead of print). View Article : Google Scholar

28 

Wu X, Luo J, Liu H, Cui W, Guo W, Zhao L, Guo H, Bai H, Guo K, Feng D and Qu Y: Recombinant adiponectin peptide promotes neuronal survival after intracerebral haemorrhage by suppressing mitochondrial and ATF4-CHOP apoptosis pathways in diabetic mice via Smad3 signalling inhibition. Cell Prolif. 53:e127592020. View Article : Google Scholar : PubMed/NCBI

29 

Lu Z, Wang Z, Yu L, Ding Y, Xu Y, Xu N, Li R, Tang J, Chen G and Zhang JH: GCN2 reduces inflammation by p-eIF2α/ATF4 pathway after intracerebral hemorrhage in mice. Exp Neurol. 313:16–25. 2019. View Article : Google Scholar : PubMed/NCBI

30 

National Research Council Institute for Laboratory Animal Research, . Guide for the Care and Use of Laboratory Animals National Academies Press. National Academy of Sciences; Washington, DC: 1996

31 

Deng S, Sherchan P, Jin P, Huang L, Travis Z, Zhang JH, Gong Y and Tang J: Recombinant CCL17 enhances hematoma resolution and activation of CCR4/ERK/Nrf2/CD163 signaling pathway after intracerebral hemorrhage in mice. Neurotherapeutics. 17:1940–1953. 2020. View Article : Google Scholar : PubMed/NCBI

32 

Li L, Ren F, Qi C, Xu L, Fang Y, Liang M, Feng J, Chen B, Ning W and Cao J: Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea. Respir Res. 19:282018. View Article : Google Scholar : PubMed/NCBI

33 

Chen JH, Wu T, Xia WY, Shi ZH, Zhang CL, Chen L, Chen QX and Wang YH: An early neuroprotective effect of atorvastatin against subarachnoid hemorrhage. Neural Regen Res. 15:1947–1954. 2020. View Article : Google Scholar : PubMed/NCBI

34 

Li G, Dong Y, Liu D, Zou Z, Hao G, Gao X, Pan P and Liang G: NEK7 coordinates rapid neuroinflammation after subarachnoid hemorrhage in mice. Front Neurol. 11:5512020. View Article : Google Scholar : PubMed/NCBI

35 

Chen JH, Wu T, Yang LK, Chen L, Zhu J, Li PP, Hu X and Wang YH: Protective effects of atorvastatin on cerebral vessel autoregulation in an experimental rabbit model of subarachnoid hemorrhage. Mol Med Rep. 17:1651–1659. 2018.PubMed/NCBI

36 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Nguyen JQN, Resnick CM, Chang YH, Hansen RM, Fulton AB, Moskowitz A, Calabrese CE and Dagi LR: Impact of obstructive sleep apnea on optic nerve function in patients with craniosynostosis and recurrent intracranial hypertension. Am J Ophthalmol. 207:356–362. 2019. View Article : Google Scholar : PubMed/NCBI

38 

Wei C, Guo S, Liu W, Jin F, Wei B, Fan H, Su H, Liu J, Zhang N, Fang D, et al: Resolvin D1 ameliorates inflammation-mediated blood-brain barrier disruption after subarachnoid hemorrhage in rats by modulating A20 and NLRP3 inflammasome. Front Pharmacol. 11:6107342020. View Article : Google Scholar : PubMed/NCBI

39 

Deng S, Liu S, Jin P, Feng S, Tian M, Wei P, Zhu H, Tan J, Zhao F and Gong Y: Albumin reduces oxidative stress and neuronal apoptosis via the ERK/Nrf2/HO-1 pathway after intracerebral hemorrhage in rats. Oxid Med Cell Longev. 2021:88913732021. View Article : Google Scholar : PubMed/NCBI

40 

Prabhakar NR, Peng YJ and Nanduri J: Hypoxia-inducible factors and obstructive sleep apnea. J Clin Invest. 130:5042–5051. 2020. View Article : Google Scholar : PubMed/NCBI

41 

Tan J, Xing H, Sha S, Li J, Miao Y and Zhang Q: Analysis of circulating microvesicles levels and effects of associated factors in elderly patients with obstructive sleep apnea. Front Aging Neurosci. 13:6092822021. View Article : Google Scholar : PubMed/NCBI

42 

Strausz S, Ruotsalainen S, Ollila HM, Karjalainen J, Kiiskinen T, Reeve M, Kurki M, Mars N, Havulinna AS, Luonsi E, et al: Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health. Eur Respir J. 57:20030912021. View Article : Google Scholar : PubMed/NCBI

43 

Li J, McEvoy RD, Zheng D, Loffler KA, Wang X, Redline S, Woodman RJ and Anderson CS: Self-reported snoring patterns predict stroke events in high-risk patients with osa: Post hoc analyses of the save study. Chest. 158:2146–2154. 2020. View Article : Google Scholar : PubMed/NCBI

44 

Yu LM, Zhang WH, Han XX, Li YY, Lu Y, Pan J, Mao JQ, Zhu LY, Deng JJ, Huang W and Liu YH: Hypoxia-induced ROS contribute to myoblast pyroptosis during obstructive sleep apnea via the NF-κB/HIF-1α signaling pathway. Oxid Med Cell Longev. 2019:45963682019. View Article : Google Scholar : PubMed/NCBI

45 

Zhu Y, Fenik P, Zhan G, Mazza E, Kelz M, Aston-Jones G and Veasey SC: Selective loss of catecholaminergic wake active neurons in a murine sleep apnea model. J Neurosci. 27:10060–10071. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Lim DC and Pack AI: Obstructive sleep apnea and cognitive impairment: Addressing the blood-brain barrier. Sleep Med Rev. 18:35–48. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Halder SK and Milner R: Mild hypoxia triggers transient blood-brain barrier disruption: A fundamental protective role for microglia. Acta Neuropathol Commun. 8:1752020. View Article : Google Scholar : PubMed/NCBI

48 

Zolotoff C, Voirin AC, Puech C, Roche F and Perek N: Intermittent hypoxia and its impact on Nrf2/HIF-1α expression and ABC transporters: An in vitro human blood-brain barrier model study. Cell Physiol Biochem. 54:1231–1248. 2020. View Article : Google Scholar : PubMed/NCBI

49 

Gong LJ, Wang XY, Gu WY and Wu X: Pinocembrin ameliorates intermittent hypoxia-induced neuroinflammation through BNIP3-dependent mitophagy in a murine model of sleep apnea. J Neuroinflammation. 17:3372020. View Article : Google Scholar : PubMed/NCBI

50 

Deng Y, Liu K, Pan Y, Ren J, Shang J, Chen L and Liu H: TLR2 antagonism attenuates the hippocampal neuronal damage in a murine model of sleep apnea via inhibiting neuroinflammation and oxidative stress. Sleep Breath. 24:1613–1621. 2020. View Article : Google Scholar : PubMed/NCBI

51 

Johnson SM, Randhawa KS, Epstein JJ, Gustafson E, Hocker AD, Huxtable AG, Baker TL and Watters JJ: Gestational intermittent hypoxia increases susceptibility to neuroinflammation and alters respiratory motor control in neonatal rats. Respir Physiol Neurobiol. 256:128–142. 2018. View Article : Google Scholar : PubMed/NCBI

52 

Wang C and Guo F: Effects of activating transcription factor 4 deficiency on carbohydrate and lipid metabolism in mammals. IUBMB Life. 64:226–230. 2012. View Article : Google Scholar : PubMed/NCBI

53 

Aimé P, Karuppagounder SS, Rao A, Chen Y, Burke RE, Ratan RR and Greene LA: The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease. Neurobiol Dis. 136:1047252020. View Article : Google Scholar : PubMed/NCBI

54 

Galehdar Z, Swan P, Fuerth B, Callaghan SM, Park DS and Cregan SP: Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. J Neurosci. 30:16938–16948. 2010. View Article : Google Scholar : PubMed/NCBI

55 

Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, Sadri N, Yun C, Popko B, Paules R, et al: An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell. 11:619–633. 2003. View Article : Google Scholar : PubMed/NCBI

56 

Baleriola J, Walker CA, Jean YY, Crary JF, Troy CM, Nagy PL and Hengst U: Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions. Cell. 158:1159–1172. 2014. View Article : Google Scholar : PubMed/NCBI

57 

Liu Y: Hydrogen peroxide induces nucleus pulposus cell apoptosis by ATF4/CHOP signaling pathway. Exp Ther Med. 20:3244–3252. 2020.PubMed/NCBI

58 

Zhao YS, An JR, Yang S, Guan P, Yu FY, Li W, Li JR, Guo Y, Sun ZM and Ji ES: Hydrogen and oxygen mixture to improve cardiac dysfunction and myocardial pathological changes induced by intermittent hypoxia in rats. Oxid Med Cell Longev. 2019:74152122019. View Article : Google Scholar : PubMed/NCBI

59 

Lange PS, Chavez JC, Pinto JT, Coppola G, Sun CW, Townes TM, Geschwind DH and Ratan RR: ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo. J Exp Med. 205:1227–1242. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fei W, Jiao W, Feng X, Chen X and Wang Y: Intermittent hypoxia mimicking obstructive sleep apnea aggravates early brain injury following ICH via neuroinflammation and apoptosis. Mol Med Rep 24: 824, 2021.
APA
Fei, W., Jiao, W., Feng, X., Chen, X., & Wang, Y. (2021). Intermittent hypoxia mimicking obstructive sleep apnea aggravates early brain injury following ICH via neuroinflammation and apoptosis. Molecular Medicine Reports, 24, 824. https://doi.org/10.3892/mmr.2021.12464
MLA
Fei, W., Jiao, W., Feng, X., Chen, X., Wang, Y."Intermittent hypoxia mimicking obstructive sleep apnea aggravates early brain injury following ICH via neuroinflammation and apoptosis". Molecular Medicine Reports 24.5 (2021): 824.
Chicago
Fei, W., Jiao, W., Feng, X., Chen, X., Wang, Y."Intermittent hypoxia mimicking obstructive sleep apnea aggravates early brain injury following ICH via neuroinflammation and apoptosis". Molecular Medicine Reports 24, no. 5 (2021): 824. https://doi.org/10.3892/mmr.2021.12464
Copy and paste a formatted citation
x
Spandidos Publications style
Fei W, Jiao W, Feng X, Chen X and Wang Y: Intermittent hypoxia mimicking obstructive sleep apnea aggravates early brain injury following ICH via neuroinflammation and apoptosis. Mol Med Rep 24: 824, 2021.
APA
Fei, W., Jiao, W., Feng, X., Chen, X., & Wang, Y. (2021). Intermittent hypoxia mimicking obstructive sleep apnea aggravates early brain injury following ICH via neuroinflammation and apoptosis. Molecular Medicine Reports, 24, 824. https://doi.org/10.3892/mmr.2021.12464
MLA
Fei, W., Jiao, W., Feng, X., Chen, X., Wang, Y."Intermittent hypoxia mimicking obstructive sleep apnea aggravates early brain injury following ICH via neuroinflammation and apoptosis". Molecular Medicine Reports 24.5 (2021): 824.
Chicago
Fei, W., Jiao, W., Feng, X., Chen, X., Wang, Y."Intermittent hypoxia mimicking obstructive sleep apnea aggravates early brain injury following ICH via neuroinflammation and apoptosis". Molecular Medicine Reports 24, no. 5 (2021): 824. https://doi.org/10.3892/mmr.2021.12464
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team