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Multi‑faceted role of cancer‑associated adipocytes in the tumor microenvironment (Review)

  • Authors:
    • Huihui Yao
    • Songbing He
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
    Copyright: © Yao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 866
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    Published online on: October 20, 2021
       https://doi.org/10.3892/mmr.2021.12506
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Abstract

Adipocytes are a type of stromal cell found in numerous different tissues that serve an active role in the tumor microenvironment. Cancer‑associated adipocytes (CAAs) display a malignant phenotype and are found at the invasive tumor front, which mediates the crosstalk network between adipocytes (the precursor cells that will become cancer‑associated adipocytes in the future) and cancer cells. The present review covers the mechanisms of adipocytes in the development of cancer, including metabolic reprogramming, chemotherapy resistance and adipokine regulation. Furthermore, the potential mechanisms involved in the adipocyte‑cancer cell cycle in various types of cancer, including breast, ovarian, colon and rectal cancer, are discussed. Deciphering the complex network of CAA‑cancer cell crosstalk will provide insights into tumor biology and optimize therapeutic strategies.
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Spandidos Publications style
Yao H and He S: Multi‑faceted role of cancer‑associated adipocytes in the tumor microenvironment (Review). Mol Med Rep 24: 866, 2021.
APA
Yao, H., & He, S. (2021). Multi‑faceted role of cancer‑associated adipocytes in the tumor microenvironment (Review). Molecular Medicine Reports, 24, 866. https://doi.org/10.3892/mmr.2021.12506
MLA
Yao, H., He, S."Multi‑faceted role of cancer‑associated adipocytes in the tumor microenvironment (Review)". Molecular Medicine Reports 24.6 (2021): 866.
Chicago
Yao, H., He, S."Multi‑faceted role of cancer‑associated adipocytes in the tumor microenvironment (Review)". Molecular Medicine Reports 24, no. 6 (2021): 866. https://doi.org/10.3892/mmr.2021.12506
Copy and paste a formatted citation
x
Spandidos Publications style
Yao H and He S: Multi‑faceted role of cancer‑associated adipocytes in the tumor microenvironment (Review). Mol Med Rep 24: 866, 2021.
APA
Yao, H., & He, S. (2021). Multi‑faceted role of cancer‑associated adipocytes in the tumor microenvironment (Review). Molecular Medicine Reports, 24, 866. https://doi.org/10.3892/mmr.2021.12506
MLA
Yao, H., He, S."Multi‑faceted role of cancer‑associated adipocytes in the tumor microenvironment (Review)". Molecular Medicine Reports 24.6 (2021): 866.
Chicago
Yao, H., He, S."Multi‑faceted role of cancer‑associated adipocytes in the tumor microenvironment (Review)". Molecular Medicine Reports 24, no. 6 (2021): 866. https://doi.org/10.3892/mmr.2021.12506
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