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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December-2021 Volume 24 Issue 6

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Medial tunica degeneration of the ascending aortic wall is associated with specific microRNA changes in bicuspid aortic valve disease

Calogera Pisano, Antonella Marino Gammazza, Francesca Rappa, Rosario Barone, Rosalinda Allegro, Alessandro Pitruzzella, Alessia Tagliavia, Virginia Agostara, Giovanni Ruvolo, Francesco Cappello, Vincenzo Argano
Article Number: 876
Published online on: 29 October 2021

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Review

Cardioprotective effects of hydrogen sulfide in attenuating myocardial ischemia‑reperfusion injury (Review)

Dan Wu, Yijing Gu, Deqiu Zhu
Article Number: 875
Published online on: 29 October 2021

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Article Open Access

Biological evaluation of linalool on the function of blood vessels

Yunyu Liang, Yan Zhong, Xinmei Li, Yingying Xiao, Yu Wu, Pingchang  Xie
Article Number: 874
Published online on: 28 October 2021

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Article Open Access

Ginsenoside Rh2 stimulates the production of mitochondrial reactive oxygen species and induces apoptosis of cervical cancer cells by inhibiting mitochondrial electron transfer chain complex

Ying Liu, Shiting Yu, Xin Xing, Juhui Qiao, Yiqiu Yin, Jiawen Wang, Meichen Liu, Wei Zhang
Article Number: 873
Published online on: 28 October 2021

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Article Open Access

Knockdown of lncRNA MEG8 inhibits cell proliferation and invasion, but promotes cell apoptosis in hemangioma, via miR‑203‑induced mediation of the Notch signaling pathway

Zhenfeng Hu, Xiangmei Liu, Jing Guo, Lei Zhuo, Yongdong Chen, Haojun Yuan
Article Number: 872
Published online on: 27 October 2021

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Review Open Access

Research methods for animal models of atherosclerosis (Review)

Yali Zhang, Mahreen Fatima, Siyuan Hou, Liang Bai, Sihai Zhao, Enqi Liu
Article Number: 871
Published online on: 27 October 2021

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Article Open Access

lncRNA KCNQ1OT1 may function as a competitive endogenous RNA in atrial fibrillation by sponging miR‑223‑3p

Weiran Dai, Xiaoying Chao, Zhiyuan Jiang, Guoqiang Zhong
Article Number: 870
Published online on: 25 October 2021

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Article

Role of Thrombospondin‑1 in sepsis‑induced myocardial injury Corrigendum in /10.3892/mmr.2023.13000

Yun Xie, Jiaxiang Zhang, Wei Jin, Rui Tian, Ruilan Wang
Article Number: 869
Published online on: 25 October 2021

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Article Open Access

All‑trans retinoic acid promotes macrophage phagocytosis and decreases inflammation via inhibiting CD14/TLR4 in acute lung injury

Shuangxue Li, Yuansheng Lei, Jieyun Lei, Hui Li
Article Number: 868
Published online on: 21 October 2021

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Article Open Access

Knockdown of TRIM9 attenuates irinotecan‑induced intestinal mucositis in IEC‑6 cells by regulating DUSP6 expression via the P38 pathway Retraction in /10.3892/mmr.2025.13504

Wenjun Zhao, Qingming Wang
Article Number: 867
Published online on: 20 October 2021

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Review Open Access

Multi‑faceted role of cancer‑associated adipocytes in the tumor microenvironment (Review)

Huihui Yao, Songbing He
Article Number: 866
Published online on: 20 October 2021

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Article Open Access

MicroRNA‑200c‑3p suppresses intervertebral disc degeneration by targeting RAP2C/ERK signaling

Jianping Cao, Meng Jiang, Huafeng Ren, Kai Xu
Article Number: 865
Published online on: 20 October 2021

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Article

Exosomal microRNA‑302a promotes trophoblast migration and proliferation, and represses angiogenesis by regulating the expression levels of VEGFA in preeclampsia

Maoqin Wu, Yongqiang Zhao, Lun Li, Gang Wang, Lin Xing
Article Number: 864
Published online on: 19 October 2021

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Retraction Open Access

[Retracted] Knockdown of AQP1 inhibits growth and invasion of human ovarian cancer cells

Yanli Wang, Yanyan Fan, Chunhua Zheng, Xiaomeng Zhang
Article Number: 863
Published online on: 19 October 2021

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Article Open Access

Pleckstrin 2 is a potential drug target for colorectal carcinoma with activation of APC/β‑catenin

Bao Chai, Yarong Guo, Na Zhu, Junmei Jia, Zhuowei Zhang, Mei Ping, Kai Jia, Xiaolong Cui, Yuhong Suo
Article Number: 862
Published online on: 19 October 2021

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Article Open Access

Circular RNA hsa_circ_105039 promotes cardiomyocyte differentiation by sponging miR‑17 to regulate cyclinD2 expression

Boshi Yu, Mengmeng Li, Shu Ping Han, Zhangbin Yu, Jingai Zhu
Article Number: 861
Published online on: 19 October 2021

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Article Open Access

Peroxisome proliferator‑activated receptor β/δ regulates cerebral vasospasm after subarachnoid hemorrhage via modulating vascular smooth muscle cells phenotypic conversion

Li Xu, Jiang Wu, Yuan Liu, Gang Chen, Chao Ma, Hongrong Zhang
Article Number: 860
Published online on: 19 October 2021

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Article Open Access

Gomisin M2 alleviates psoriasis‑like skin inflammation by inhibiting inflammatory signaling pathways

Namkyung Kim, Soyoung Lee, Jinjoo Kang, Taeg Kyu Kwon, Dongwoo Khang, Sang-Hyun Kim
Article Number: 859
Published online on: 19 October 2021

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Review Open Access

Current treatment strategies for COVID‑19 (Review)

Fabin Han, Yanming Liu, Mei Mo, Juanli Chen, Cheng Wang, Yong Yang, Jibiao Wu
Article Number: 858
Published online on: 15 October 2021

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Article Open Access

hsa‑miR‑429 targets CBX8 to promote cell apoptosis in diffuse large B‑cell lymphoma

Yan Liang, Zhuo-Jun Yu, Min Liu, Hui-Min Liu, Jiang-Zhao Zhang, Tao Xiong, Yuan-Yan Tang, Zhi-Ping Huang
Article Number: 857
Published online on: 14 October 2021

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Article Open Access

Upregulation of CCT3 promotes cervical cancer progression through FN1

Lei Dou, Xinxin Zhang
Article Number: 856
Published online on: 14 October 2021

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Article Open Access

FABP4 knockdown suppresses inflammation, apoptosis and extracellular matrix degradation in IL-1β-induced chondrocytes by activating PPARγ to regulate the NF-κB signaling pathway

Huajie Mao, Bin Han, Hao Li, Yiqing Tao, Weigang Wu
Article Number: 855
Published online on: 14 October 2021

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Review

Sarcopenia, frailty and type 2 diabetes mellitus (Review)

Hiroki Nishikawa, Shinya Fukunishi, Akira Asai, Keisuke Yokohama, Hideko Ohama, Shuhei Nishiguchi, Kazuhide Higuchi
Article Number: 854
Published online on: 14 October 2021

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Article Open Access

miR‑302d‑3p regulates the viability, migration and apoptosis of breast cancer cells through regulating the TMBIM6‑mediated ERK signaling pathway

Yanru Liao, Zhenxiong Qiu, Ling Bai
Article Number: 853
Published online on: 14 October 2021

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Article Open Access

Diallyl sulfide protects against dilated cardiomyopathy via inhibition of oxidative stress and apoptosis in mice

Shuo Pang, Wei Dong, Ning Liu, Shan Gao, Jing Li, Xu Zhang, Dan Lu, Lianfeng Zhang
Article Number: 852
Published online on: 13 October 2021

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Article Open Access

Puerarin alleviates the ototoxicity of gentamicin by inhibiting the mitochondria‑dependent apoptosis pathway

Ping Niu, Yuxuan Sun, Shiyi Wang, Guang Li, Xiaomin Tang, Jiaqiang Sun, Chunchen Pan, Jingwu Sun
Article Number: 851
Published online on: 13 October 2021

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Article Open Access

Protective multi‑target effects of DL‑3‑n‑butylphthalide combined with 3‑methyl‑1‑phenyl‑2‑pyrazolin‑5‑one in mice with ischemic stroke

Yali Guan, Pengfei Li, Yingshuo Liu, Lan Guo, Qingwen Wu, Yuefa Cheng
Article Number: 850
Published online on: 12 October 2021

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Review Open Access

DNA barcode to trace the development and differentiation of cord blood stem cells (Review)

Mo-Yu Wang, Yang Zhou, Guang-Shun Lai, Qi Huang, Wen-Qi Cai, Zi-Wen Han, Yingying Wang, Zhaowu Ma, Xian-Wang Wang, Ying Xiang, Shu-Xian Fang, Xiao-Chun Peng, Hong-Wu Xin
Article Number: 849
Published online on: 12 October 2021

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Article Open Access

Role of tumor necrosis factor receptor‑associated factor 6 in pyroptosis during acute pancreatitis

Biwei Wei, Yahui Gong, Huiying Yang, Jie Zhou, Zhou Su, Zhihai Liang
Article Number: 848
Published online on: 11 October 2021

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Review

Tumor necrosis factor inhibitors as therapeutic agents for recurrent spontaneous abortion (Review)

Hong Wu, Qingxia You, Yi Jiang, Fangxiang Mu
Article Number: 847
Published online on: 11 October 2021

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Article Open Access

Silencing long noncoding RNA LINC01138 inhibits aerobic glycolysis to reduce glioma cell proliferation by regulating the microRNA‑375/SP1 axis

Chengning Xu, Haoran Yin, Xi Jiang, Chunming Sun
Article Number: 846
Published online on: 11 October 2021

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Article Open Access

Long non‑coding RNA HHIP‑AS1 inhibits lung cancer epithelial‑mesenchymal transition and stemness by regulating PCDHGA9

Zhuanzhuan Zhou, Yanping Lai, Shan Cao, Qifang Zhuo, Huiqin Tang
Article Number: 845
Published online on: 11 October 2021

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Article Open Access

NEP1‑40 promotes myelin regeneration via upregulation of GAP‑43 and MAP‑2 expression after focal cerebral ischemia in rats Corrigendum in /10.3892/mmr.2023.12945

Hong Zhao, Zhen-Dong Liu, Yong-Bo Zhang, Xiao-Yu Gao, Cui Wang, Yi Liu, Xun-Fen Wang
Article Number: 844
Published online on: 11 October 2021

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Article

Long non­‑coding RNA SNHG16 functions as a tumor activator by sponging miR‑373‑3p to regulate the TGF‑β‑R2/SMAD pathway in prostate cancer

Wubin Weng, Changming Liu, Guomin Li, Qiongfang Ruan, Huizhang Li, Ningfeng Lin, Guangbing Chen
Article Number: 843
Published online on: 11 October 2021

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Article Open Access

Radiation‑induced dysfunction of energy metabolism in the heart results in the fibrosis of cardiac tissues

Peng Xu, Yali Yi, Yijing Luo, Zhicheng Liu, Yilin Xu, Jing Cai, Zhimin Zeng, Anwen Liu
Article Number: 842
Published online on: 11 October 2021

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Article

Endostatin inhibits the proliferation and migration of B16 cells by inducing macrophage polarity to M1‑type

Hua Guo, Longyuan Zhou, Jun Guo, Xueqin Huang, Junlian Gu
Article Number: 841
Published online on: 11 October 2021

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Article Open Access

Tong‑fu‑li‑fei decoction attenuates immunosuppression to protect the intestinal‑mucosal barrier in sepsis by inhibiting the PD‑1/PD‑L1 signaling pathway

Li Chen, Lan Li, Suzhao Zou, Qianhua Liao, Bo Lv
Article Number: 840
Published online on: 11 October 2021

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Review Open Access

Mental depression: Relation to different disease status, newer treatments and its association with COVID-19 pandemic (Review)

Mohamed S. Abdel-Bakky, Elham Amin, Tarek M. Faris, Ahmed A.H. Abdellatif
Article Number: 839
Published online on: 08 October 2021

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Article Open Access

FPR2 serves a role in recurrent spontaneous abortion by regulating trophoblast function via the PI3K/AKT signaling pathway Corrigendum in /10.3892/mmr.2023.12998

Anna Li, Shuxian Li, Chongyu Zhang, Zhenya Fang, Yaqiong Sun, Yanjie Peng, Xietong Wang, Meihua Zhang
Article Number: 838
Published online on: 04 October 2021

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Article Open Access

Astaxanthin induces NADPH oxidase activation and receptor‑interacting protein kinase 1‑mediated necroptosis in gastric cancer AGS cells

Sori Kim, Hanbit Lee, Joo Weon Lim, Hyeyoung Kim
Article Number: 837
Published online on: 04 October 2021

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Retraction Open Access

[Retracted] Oncolytic adenovirus‑mediated mda‑7/IL‑24 expression suppresses osteosarcoma growth and enhances sensitivity to doxorubicin

Zongming Liu, Libo Xu, Hongping Yuan, Yang Zhang, Xiaona Zhang, Dongxu Zhao
Article Number: 836
Published online on: 04 October 2021

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Article Open Access

Spinal cord stimulation reduces cardiac pain through microglial deactivation in rats with chronic myocardial ischemia

Jian Wang, Xiao-Chen Wu, Ming-Ming Zhang, Jia-Hao Ren, Yi Sun, Jing-Zhen Liu, Xi-Qiang Wu, Si-Yi He, Yun-Qing Li, Jin-Bao Zhang
Article Number: 835
Published online on: 01 October 2021

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Article Open Access

Proteomics changes after negative pressure wound therapy in diabetic foot ulcers

Zeguo Jia, Lei Liu, Shiqi Zhang, Xiaotong Zhao, Li Luo, Yizhong Tang, Bing Shen, Mingwei Chen
Article Number: 834
Published online on: 01 October 2021

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Article Open Access

AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway Retraction in /10.3892/mmr.2025.13449

Xianjun Wang, Baocheng Yang, Yuyu Li, Jiye Luo, Yanli Wang
Article Number: 833
Published online on: 30 September 2021

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Article Open Access

Formononetin ameliorates IL‑13‑induced inflammation and mucus formation in human nasal epithelial cells by activating the SIRT1/Nrf2 signaling pathway

Juanjuan Huang, Xianfeng Chen, Aihua Xie
Article Number: 832
Published online on: 30 September 2021

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Article Open Access

FOXP4 promotes laryngeal squamous cell carcinoma progression through directly targeting LEF‑1

Jian Shi, Jingtian Wang, Hongkun Cheng, Shenghui Liu, Xiaowei Hao, Lili Lan, Gancun Wu, Meng Liu, Yan Zhao
Article Number: 831
Published online on: 28 September 2021

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Article Open Access

CMBs carrying PTX and CRISPR/Cas9 targeting C‑erbB‑2 plasmids interfere with endometrial cancer cells

Siyuan Peng, Junhong Cai, Shan Bao
Article Number: 830
Published online on: 28 September 2021

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Article Open Access

MAPK inhibitors protect against early‑stage osteoarthritis by activating autophagy

Chun-Na Lan, Wei-Jun Cai, Jie Shi, Zhong-Jie Yi
Article Number: 829
Published online on: 28 September 2021

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Article Open Access

Cholesterol biosynthesis inhibitor RO 48‑8071 inhibits pancreatic ductal adenocarcinoma cell viability by deactivating the JNK and ERK/MAPK signaling pathway

Zhen Ding, Yanan Gu, Dake Huang, Hong Zhou, Tingting Zhu, Xin Luo, Sumei Zhang, Shengquan Zhang, Yeben Qian
Article Number: 828
Published online on: 28 September 2021

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Article Open Access

Lycopus lucidus Turcz ameliorates DNCB‑induced atopic dermatitis in BALB/c mice

Ga-Yul Min, Eun-Young Kim, Sooyeon Hong, Jae-Hyun Kim, Minsun Kim, Eom Ji Kim, Jae Ho Park, Youngjoo Sohn, Hyuk-Sang Jung
Article Number: 827
Published online on: 27 September 2021

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Article Open Access

RHBDD1 promotes proliferation, migration, invasion and EMT in renal cell carcinoma via the EGFR/AKT signaling pathway

Mingyang Li, Licheng Cai, Xingyuan Wang, Yipeng Yu, Wengang Jian, Guochang Bao, Zhiming Gao, Junsheng Guo, Jian Zhang, Chunsheng Li, Cheng Zhang
Article Number: 826
Published online on: 27 September 2021

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

ISX promotes tumor migration and invasion in lung cancer by upregulating COL1A1 in vitro

Yihe Ma, Ye Chen, Yuhui Liang, Yun Huang, Miao Gong, Lifeng Tian, Xiaojun Xiao, Jingyan Liu, Qinmiao Huang
Article Number: 77
Published online on: 31 December 2025

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Article Open Access

Role and mechanism of miR‑222‑5p in endothelial cell apoptosis

Shimeng Wang, Boxin Zhao, Ying Cui, Lin Gui, Jingyao Fan, Lijuan Huang
Article Number: 76
Published online on: 31 December 2025

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Expression of Concern Open Access

[Expression of Concern] MicroRNA-29c inhibits proliferation and promotes apoptosis in non-small cell lung cancer cells by targeting VEGFA

Shijuan Zhan, Chunfeng Wang, Fangqing Yin
Article Number: 75
Published online on: 22 December 2025

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Article Open Access

Melatonin induces autophagy in neuroblastoma by alleviating Pak2‑mediated endoplasmic reticulum stress

Qian-Qi Qiu, Na Zhang, Ying-Yi Xu, Jing-Wen Qin, Gao-Feng Yu, Xing-Rong Song
Article Number: 74
Published online on: 22 December 2025

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Article Open Access

ST3Gal1 modulates intestinal barrier function and impacts human ulcerative colitis

Yin Tian, Yun Liu, Yangyang Shang, Lijian Ran, Li Liu, Rongquan Wang, Jun Ye
Article Number: 73
Published online on: 18 December 2025

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Article Open Access

Mechanistic study of miR‑369‑3p in regulating the Wnt/β‑catenin signaling pathway via targeting SPTBN1 in inflammatory response and bone destruction of rheumatoid arthritis

Aihong Wu, Yuan Wang, Feifei Liu, Zhoufang Cao, Shuhui Du, Mengyu Sun
Article Number: 72
Published online on: 18 December 2025

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Article Open Access

CACNB1 alleviates mepivacaine‑induced myocardial ischemia/reperfusion injury by promoting Nrf2 nuclear translocation

Qingbo Shao, Ji Zhang, Huaying Wang
Article Number: 71
Published online on: 17 December 2025

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Expression of Concern Open Access

[Expression of Concern] Effects of cullin 4B on the proliferation and invasion of human gastric cancer cells

Feng He, Xiu-Mei Cheng, Wen-Long Gu
Article Number: 70
Published online on: 17 December 2025

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Article Open Access

Aggravated effects of human parvovirus B19 NS1 protein on bleomycin‑induced pulmonary fibrosis

Tsai-Ching Hsu, Chih-Chen Tzang, Chia-Wei Kuo, Zhi-Han Wen, Der-Yuan Chen, Bor-Show Tzang
Article Number: 69
Published online on: 16 December 2025

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Review Open Access

Advances regarding the mechanism of endoplasmic reticulum stress in diabetic kidney disease and pharmacological interventions (Review)

Pai Zhang, Yabin Cui, Chunyan Liu, Chengji Cui, Shoulin Zhang, Yue Zhang, Fan Li
Article Number: 68
Published online on: 16 December 2025

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Retraction Open Access

[Retracted] N‑Myc downstream‑regulated gene 2 suppresses the proliferation of T24 human bladder cancer cells via induction of oncosis

Jie Huang, Zhou Wu, Guangxiu Wang, Yingxian Cai, Minshan Cai, Yaozhang Li
Article Number: 67
Published online on: 15 December 2025

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Deciphering epigenetic regulation in cardiac developmental toxicity: Mechanisms and implications (Review)

Ziling Qin, Ranran Chen, Dianrong Song
Article Number: 66
Published online on: 11 December 2025

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Gut microbiota as a multifaceted modulator of prostate cancer: Mechanistic insights, therapeutic opportunities and clinical challenges (Review)

Zhenming Hao, Yongqiang Xie, Ru Zhang, Hui Sang, Luxi Li, Yulin Liu, Jinbo Hu, Jijun Wang, Keqiang Chai, Qiang Zhao
Article Number: 65
Published online on: 11 December 2025

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Expression of Concern Open Access

[Expression of Concern] lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis

Yi Han, Xiaoyan Wang, Enqiang Mao, Boyong Shen, Liang Huang
Article Number: 64
Published online on: 10 December 2025

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Influence and treatment of insulin receptor substrate/PI3K/Akt‑mediated insulin resistance in diabetes mellitus (Review)

Weikang Tang, Huixia Liu, Xuan Li, Siyao Deng, Changyu Gao
Article Number: 63
Published online on: 09 December 2025

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Retraction Open Access

[Retracted] Long non‑coding RNA ANRIL knockdown suppresses apoptosis and pro‑inflammatory cytokines while enhancing neurite outgrowth via binding microRNA‑125a in a cellular model of Alzheimer’s disease

Bingling Zhou, Lijuan Li, Xin Qiu, Jiashun Wu, Lei Xu, Wei Shao
Article Number: 62
Published online on: 08 December 2025

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Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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Article Open Access

ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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Article

MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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Correction Open Access

[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Article Open Access

Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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Article Open Access

lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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March-2026 Volume 33 Issue 3

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article

CTRP4 ameliorates dexamethasone‑induced insulin resistance through the IRS‑1/PI3K/AKT pathway in 3T3‑L1 adipocytes

Maireyanmu Rouzi, Xi Sun, Luguang Sheng, Bilin Xu, Tao Lei, Jun Lu, Jie Gao
Article Number: 101
Published online on: 27 January 2026

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PTUPB, a soluble epoxide hydrolase/cyclooxygenase‑2 dual inhibitor, reduces endothelial‑to‑mesenchymal transition and improves doxorubicin‑induced vascular and cardiac toxicity

Hevna Dhulkifle, Lubna Therachiyil, Maram H. Hasan, Shahd M. Younis, Nizar A. Al‑Shar'i, Huseyin C. Yalcin, Zaid H. Maayah
Article Number: 100
Published online on: 27 January 2026

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Retraction Open Access

[Retracted] miR‑367 enhances the proliferation and invasion of cutaneous malignant melanoma by regulating phosphatase and tensin homolog expression

Jianwen Long, Jing Luo, Xuwen Yin
Article Number: 99
Published online on: 26 January 2026

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Advances in the mechanisms of the NLRP3 inflammasome in sepsis‑induced cardiomyopathy and targeted therapeutic studies 
(Review)

Yifei Chen, Zhaohui Zhang, Gaosheng Zhou
Article Number: 98
Published online on: 22 January 2026

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HMGN2 induces pyroptosis in tumour cells by modulating the STT3B/PD‑L1/caspase‑1/GSDMD axis

Wenwen Han, Hongli Chen, Bomiao Cui, Jiao Chen, Ping Zhang, Yun Feng
Article Number: 97
Published online on: 22 January 2026

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Naringin ameliorates intestinal injury in ulcerative colitis model mice by modulating the JAK2/STAT3 signaling pathway

Miaomiao Wu, Yating An, Yongmin Li, Wei He, Ying Wang, Yaqi Wang, Caixia Wu
Article Number: 96
Published online on: 22 January 2026

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PDX1 in human cancers: Molecular mechanisms, dual roles and clinical implications (Review)

Chen Zhou, Yifei Wang, Jie Zhao, Yantao Yang, Yuhang Yuan, Xiaochen Hou, Yu Tang, Lianhua Ye
Article Number: 95
Published online on: 22 January 2026

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Retraction Open Access

[Retracted] Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species

Uddin Md Nazim, Honghua Yin, Sang-Youel Park
Article Number: 94
Published online on: 19 January 2026

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Converting ‘cold’ to ‘hot’ hepatocellular carcinoma for improved immunotherapy (Review)

Ching-Hua Hsieh, Pei-Chin Chuang
Article Number: 93
Published online on: 15 January 2026

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Article Open Access

Pathological mechanism of ferroptosis in a rat model of α‑naphthyl isothiocyanate‑induced chronic cholestasis

Zhen Guo, Jiaxuan Wang, Yiwen Wang, Xinzhu Liu, Yubing Xia, Ping Liu, Li Qi, Jia Liu, Xiaoning Wang
Article Number: 92
Published online on: 14 January 2026

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Correction Open Access

[Corrigendum] Role of hypoxia‑inducible factor‑1α and CD146 in epidermal growth factor receptor‑mediated angiogenesis in salivary gland adenoid cystic carcinom

Wei-Ming Wang, Zhi-Li Zhao, Wen-Feng Zhang, Yi-Fang Zhao, Lu Zhang, Zhi-Jun Sun
Article Number: 91
Published online on: 13 January 2026

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Klebsiella pneumoniae and pyogenic liver abscess: Emerging clinical threats, virulence mechanisms and therapeutic strategies (Review)

Gulam Mustafa Hasan, Taj Mohammad, Sobia Zaidi, Anas Shamsi, Sukhwinder Singh Sohal, Md. Imtaiyaz Hassan
Article Number: 90
Published online on: 13 January 2026

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Collagen III regulates the termination of liver regeneration by suppressing hepatocyte proliferation and promoting functional recovery

Haiyang Peng, Zhiyong Chen, Qiwei Zhang, Yuezhou Zhang, Peng Yang, Jianping Gong, Andong Zhao
Article Number: 89
Published online on: 13 January 2026

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Application of extracellular vesicles in the diagnosis and treatment of chronic obstructive pulmonary disease (Review)

Yixin Zhang, Tong Ren, Jianbo Xue, Yan Yu, Xianqiang Zhou, Xiaoyi Hu, Wenyi Yu, Zhancheng Gao, Cuiling Feng
Article Number: 88
Published online on: 13 January 2026

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Article Open Access

Cigarette smoke combined with Klebsiella pneumoniae induce damage to the air‑blood barrier in chronic obstructive pulmonary disease rats via the MAPK/NF‑κB/IκBα pathway

Yange Tian, Kexin Xu, Ruilong Lu, Kangchen Li, Xuejie Shao, Yixi Liao, Yakun Zhao, Zhiguang Qiu, Haoran Dong, Xuefang Liu
Article Number: 87
Published online on: 12 January 2026

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Retraction Open Access

[Retracted] 8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells

Qing Ding, Yi Chen, Qing Zhang, Yanling Guo, Zhi Huang, Liqing Dai, Sudan Cao
Article Number: 86
Published online on: 12 January 2026

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Article Open Access

Anxiety‑induced overactive bladder: The role of oxidative stress and NF‑κB signaling pathway with Hsp90 as a potential biomarker

Zhipeng Zhou, Lina Xu, Han Wu, Huaishan Hong
Article Number: 85
Published online on: 12 January 2026

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Article Open Access

Echinacoside alleviates asthenozoospermia by upregulating Sox5‑mediated transcriptional activation of the CatSper gene

Zi-Run Jin, Yong-Wei Huo, Bo-Heng Liu, Hong Tian, Shuo Yuan, Yue Tian, Ke Xi, Jie Cai, Hui Jiang, Yong Jiang, Guo-Gang Xing
Article Number: 84
Published online on: 12 January 2026

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Article Open Access

Artemisiae Scopariae Herba (Yinchen) suppresses ferroptosis in mice with osteoporosis via the Nrf2/Slc7a11/Gpx4 pathway

Pei Li, Xinyu Wan, Wenjie Li, Ding Cheng, Ying Yang, Yuhan Wang, Ruyuan Zhu, Yanjing Chen, Haixia Liu, Zhiguo Zhang
Article Number: 83
Published online on: 12 January 2026

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Review Open Access

Prolyl hydroxylase domain proteins: Localization, regulation, function and their role in erythropoiesis (Review)

Yan Hou, Zhao-Hua Zhang, Wen-Qian Li, Guo-Xiong Han, Kuo Shen, You-Bang Xie
Article Number: 82
Published online on: 12 January 2026

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Review Open Access

Therapeutic potential of saponins for allergic rhinitis: Molecular mechanisms and clinical perspectives (Review)

Bing-Yu Liang, Zi-Yue Fu, Fen-Fen Li, Ping-Ting Zhou, Zi-Hui Xie, Ke Han, Yan-Xun Han, Shan-Wen Chen, Yi Zhao, Hai-Feng Pan, Ye-Hai Liu, Yu-Chen Liu
Article Number: 81
Published online on: 07 January 2026

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Review Open Access

Interleukin‑6 and ischemic stroke: From mechanisms to clinical prospects (Review)

Xinyue Wang, Xiaohang Zhang, Jianing Lin, Ping Lin
Article Number: 80
Published online on: 05 January 2026

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Article Open Access

Preliminary exploration of the putative function of SF3A2 in clear cell renal cell carcinoma

Ru Chen, Jie Xu
Article Number: 79
Published online on: 05 January 2026

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Retraction Open Access

[Retracted] TIPE‑2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3‑kinase/AKT signaling pathway

Lin Wang, Chen Chen, Shuzhi Feng, Jianli Tian
Article Number: 78
Published online on: 05 January 2026

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