Open Access

HIF‑1α in cerebral ischemia (Review)

  • Authors:
    • Peiliang Dong
    • Qingna Li
    • Hua Han
  • View Affiliations

  • Published online on: December 7, 2021
  • Article Number: 41
  • Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Cerebral ischemic injury may lead to a series of serious brain diseases, death or different degrees of disability. Hypoxia‑inducible factor‑1α (HIF‑1α) is an oxygen‑sensitive transcription factor, which mediates the adaptive metabolic response to hypoxia and serves a key role in cerebral ischemia. HIF‑1α is the main molecule that responds to hypoxia. HIF‑1α serves an important role in the development of cerebral ischemia by participating in numerous processes, including metabolism, proliferation and angiogenesis. The present review focuses on the endogenous protective mechanism of cerebral ischemia and elaborates on the role of HIF‑1α in cerebral ischemia. In addition, it focuses on cerebral ischemia interventions that act on the HIF‑1α target, including biological factors, non‑coding RNA, hypoxic‑ischemic preconditioning and drugs, and expands upon the measures to strengthen the endogenous compensatory response to support HIF‑1α as a therapeutic target, thus providing novel suggestions for the treatment of cerebral ischemia.
View Figures
View References

Related Articles

Journal Cover

Volume 25 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
Spandidos Publications style
Dong P, Li Q and Han H: HIF‑1α in cerebral ischemia (Review). Mol Med Rep 25: 41, 2022
Dong, P., Li, Q., & Han, H. (2022). HIF‑1α in cerebral ischemia (Review). Molecular Medicine Reports, 25, 41.
Dong, P., Li, Q., Han, H."HIF‑1α in cerebral ischemia (Review)". Molecular Medicine Reports 25.2 (2022): 41.
Dong, P., Li, Q., Han, H."HIF‑1α in cerebral ischemia (Review)". Molecular Medicine Reports 25, no. 2 (2022): 41.