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Article Open Access

Zoledronic acid inhibits osteoclastogenesis and bone resorptive function by suppressing RANKL‑mediated NF‑κB and JNK and their downstream signalling pathways

  • Authors:
    • Xiao-Lin Huang
    • Chao Liu
    • Xue-Mei Shi
    • Yu-Ting Cheng
    • Qian Zhou
    • Jian-Ping Li
    • Jian Liao
  • View Affiliations / Copyright

    Affiliations: Stomatology Medical Center of Zhongshan People's Hospital, Zhongshan, Guangdong 528403, P.R. China, Department of Respiratory Disease, Zhongshan People's Hospital, Zhongshan, Guangdong 528403, P.R. China, School/Hospital of Stomatology, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 59
    |
    Published online on: December 17, 2021
       https://doi.org/10.3892/mmr.2021.12575
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Abstract

Targeting excessive osteoclast differentiation and activity is considered a valid therapeutic approach for osteoporosis. Zoledronic acid (ZOL) plays a pivotal role in regulating bone mineral density. However, the exact molecular mechanisms responsible for the inhibitory effects of ZOL on receptor activator of nuclear factor (NF)‑κB ligand (RANKL)‑induced osteoclast formation are not entirely clear. The present study aimed to investigate the role of ZOL in osteoclast differentiation and function, and to determine whether NF‑κB and mitogen‑activated protein kinase, and their downstream signalling pathways, are involved in this process. RAW264.7 cells were cultured with RANKL for differentiation into osteoclasts, in either the presence or absence of ZOL. Osteoclast formation was observed by tartrate‑resistant acid phosphatase staining and bone resorption pit assays using dentine slices. The expression of osteoclast‑specific molecules was analysed using reverse transcription‑quantitative polymerase chain reaction and western blotting assays to deduce the molecular mechanisms underlying the role of ZOL in osteoclastogenesis. The results showed that ZOL significantly attenuated osteoclastogenesis and bone resorptive capacity in vitro. ZOL also suppressed the activation of NF‑κB and the phosphorylation of c‑Jun N‑terminal kinase. Furthermore, it inhibited the expression of the downstream factors c‑Jun, c‑Fos and nuclear factor of activated T cells c1, thereby decreasing the expression of dendritic cell‑specific transmembrane protein and other osteoclast‑specific markers. In conclusion, ZOL may have therapeutic potential for osteoporosis.
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1 

Li DZ, Zhang QX, Dong XX, Li HD and Ma X: Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells. J Bone Miner Metab. 32:494–504. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S and Lindsay R; National Osteoporosis Foundation, : Clinician's guide to prevention and treatment of osteoporosis. Osteoporos Int. 25:2359–2381. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Yang JH, Li B, Wu Q, Lv JG and Nie HY: Echinocystic acid inhibits RANKL-induced osteoclastogenesis by regulating NF-κB and ERK signaling pathways. Biochem Biophys Res Commun. 477:673–677. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Madel MB, Ibáñez L, Wakkach A, de Vries TJ, Teti A, Apparailly F and Blin-Wakkach C: Immune function and diversity of osteoclasts in normal and pathological conditions. Front Immunol. 10:14082019. View Article : Google Scholar : PubMed/NCBI

5 

Islam R, Bae HS, Yoon WJ, Woo KM, Baek JH, Kim HH, Uchida T and Ryoo HM: Pin1 regulates osteoclast fusion through suppression of the master regulator of cell fusion DC-STAMP. J Cell Physiol. 229:2166–2174. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Lee JW, Kobayashi Y, Nakamichi Y, Udagawa N, Takahashi N, Im NK, Seo HJ, Jeon WB, Yonezawa T, Cha BY and Woo JT: Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice. Biochem Pharmacol. 80:352–361. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Nakashima T and Takayanagi H: New regulation mechanisms of osteoclast differentiation. Ann NY Acad Sci. 1240:E13–E18. 2011. View Article : Google Scholar : PubMed/NCBI

8 

He Y, Zhang Q, Shen Y, Chen X, Zhou F and Peng D: Schisantherin A suppresses osteoclast formation and wear particle-induced osteolysis via modulating RANKL signaling pathways. Biochem Biophys Res Commun. 449:344–350. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Yen ML, Hsu PN, Liao HJ, Lee BH and Tsai HF: TRAF-6 dependent signaling pathway is essential for TNF-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation. PLoS One. 7:e380482012. View Article : Google Scholar : PubMed/NCBI

10 

Léotoing L, Wauquier F, Guicheux J, Miot-Noirault E, Wittrant Y and Coxam V: The polyphenol fisetin protects bone by repressing NF-κB and MKP-1-dependent signaling pathways in osteoclasts. PLoS One. 8:e683882013. View Article : Google Scholar : PubMed/NCBI

11 

Cheng B, Li J, Du J, Lv X, Weng L and Ling C: Ginsenoside Rb1 inhibits osteoclastogenesis by modulating NF-κB and MAPKs pathways. Food Chem Toxicol. 50:1610–1615. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Soysa NS, Alles N, Aoki K and Ohya K: Osteoclast formation and differentiation: An overview. J Med Dent Sci. 59:65–74. 2012.PubMed/NCBI

13 

Lieben L: Bone: The concept of RANKL-independent osteoclastogenesis refuted. Nat Rev Rheumatol. 12:6232016. View Article : Google Scholar : PubMed/NCBI

14 

Cai XJ, Wang Z, Cao JW, Ni JJ, Xu YY, Yao J, Xu H, Liu F and Yang GY: Anti-angiogenic and anti-tumor effects of metronomic use of novel liposomal zoledronic acid depletes tumor-associated macrophages in triple negative breast cancer. Oncotarget. 8:84248–84257. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Endo Y, Kumamoto H, Nakamura M, Sugawara S, Takano-Yamamoto T, Sasaki K and Takahashi T: Underlying mechanisms and therapeutic strategies for bisphosphonate-related osteonecrosis of the jaw (BRONJ). Biol Pharm Bull. 40:739–750. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Elsayed R, Abraham P, Awad ME, Kurago Z, Baladhandayutham B, Whitford GM, Pashley DH, McKenna CE and Elsalanty ME: Removal of matrix-bound zoledronate prevents post-extraction osteonecrosis of the jaw by rescuing osteoclast function. Bone. 110:141–149. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Russell RG: Bisphosphonates: The first 40 years. Bone. 49:2–19. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Qiao H, Wang TY, Yu ZF, Han XG, Liu XQ, Wang YG, Fan QM, Qin A and Tang TT: Structural simulation of adenosine phosphate via plumbagin and zoledronic acid competitively targets JNK/Erk to synergistically attenuate osteoclastogenesis in a breast cancer model. Cell Death Dis. 7:e20942016. View Article : Google Scholar : PubMed/NCBI

19 

Li X, Sun W, Li J, Wang M, Zhang H, Pei L, Boyce BF, Wang Z and Xing L: Clomipramine causes osteoporosis by promoting osteoclastogenesis via E3 ligase Itch, which is prevented by zoledronic acid. Sci Rep. 7:413582017. View Article : Google Scholar : PubMed/NCBI

20 

Li P, Yang H, Jia N, Jin X, Xu D and Shen Y: Experimental study on inhibitory effect of zoledronic acid on the action style of the osteoclast. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 34:78–82. 2017.(In Chinese). PubMed/NCBI

21 

de Oliveira MA, Asahi DA, Silveira CAE, Lima LAPA, Glick M and Gallottini M: The effects of zoledronic acid and dexamethasone on osseointegration of endosseous implants: Histological and histomorphometrical evaluation in rats. Clin Oral Implants Res. 26:e17–e21. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Weber JBB, Camilotti RS, Jasper J, Casagrande LCO and Maito FLDM: Effect of low-level laser therapy on tissue repair after dental extraction in rats administered zoledronic acid and dexamethasone. J Biomed Opt. 22:580012017. View Article : Google Scholar : PubMed/NCBI

23 

Allen MR, Chu TM and Ruggiero SL: Absence of exposed bone following dental extraction in beagle dogs treated with 9 months of high-dose zoledronic acid combined with dexamethasone. J Oral Maxillofac Surg. 71:1017–1026. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Subramanian G, Fritton JC, Iyer S and Quek SY: Atypical dental implant failure with long-term bisphosphonate treatment-akin to atypical fractures? Oral Surg Oral Med Oral Pathol Oral Radiol. 114:e30–e35. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Qi M, Hu J, Li J, Li J, Dong W, Feng X and Yu J: Effect of zoledronate acid treatment on osseointegration and fixation of implants in autologous iliac bone grafts in ovariectomized rabbits. Bone. 50:119–127. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Khosla S and Shane E: A crisis in the treatment of osteoporosis. J Bone Miner Res. 31:1485–1487. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Kim SC, Kim DH, Mogun H, Eddings W, Polinski JM, Franklin JM and Solomon DH: Impact of the U.S. food and drug administration's safety-related announcements on the use of bisphosphonates after hip fracture. J Bone Miner Res. 31:1536–1540. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Nakagawa T, Ohta K, Uetsuki R, Kato H, Naruse T, Murodumi H, Yokoyama S, Sakuma M, Ono S and Takechi M: Zoledronate inhibits osteoclast differentiation via suppressing vascular endothelial growth factor receptor 2 expression. Biochem Genet. 58:473–489. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Dundar S, Yaman F, Gecor O, Cakmak O, Kirtay M, Yildirim TT, Karaman T and Benlidayi ME: Effects of local and systemic zoledronic acid application on titanium implant osseointegration: An experimental study conducted on two surface types. J Craniofac Surg. 28:935–938. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Chadha GK, Ahmadieh A, Kumar S and Sedghizadeh PP: Osseointegration of dental implants and osteonecrosis of the jaw in patients treated with bisphosphonate therapy: A systematic review. J Oral Implantol. 39:510–520. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Kim HJ, Kim HJ, Choi Y, Bae MK, Hwang DS, Shin SH and Lee JY: Zoledronate enhances osteocyte-mediated osteoclast differentiation by IL-6/RANKL axis. Int J Mol Sci. 2:14672019. View Article : Google Scholar

32 

Huang XL, Huang LY, Cheng YT, Li F, Zhou Q, Wu C, Shi QH, Guan ZZ, Liao J and Hong W: Zoledronic acid inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways. Int J Mol Med. 44:582–592. 2019.PubMed/NCBI

33 

Chen G, Huang L, Wu X, Liu X, Xu Q, Li F, Dai M and Zhang B: Adiponectin inhibits osteoclastogenesis by suppressing NF-κB and p38 signaling pathways. Biochem Biophys Res Commun. 503:2075–2082. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Jiao Z, Xu W, Zheng J, Shen P, Qin A, Zhang S and Yang C: Kaempferide prevents titanium particle induced osteolysis by suppressing JNK activation during osteoclast formation. Sci Rep. 7:166652017. View Article : Google Scholar : PubMed/NCBI

35 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Shibata K, Yoshimura Y, Kikuiri T, Hasegawa T, Taniguchi Y, Deyama Y, Suzuki K and Iida J: Effect of the release from mechanical stress on osteoclastogenesis in RAW264.7 cells. Int J Mol Med. 28:73–79. 2011.PubMed/NCBI

37 

Tsubaki M, Komai M, Itoh T, Imano M, Sakamoto K, Shimaoka H, Takeda T, Ogawa N, Mashimo K, Fujiwara D, et al: Nitrogen-containing bisphosphonates inhibit RANKL- and M-CSF-induced osteoclast formation through the inhibition of ERK1/2 and Akt activation. J Biomed Sci. 21:102014. View Article : Google Scholar : PubMed/NCBI

38 

Kang MR, Jo SA, Yoon YD, Park KH, Oh SJ, Yun J, Lee CW, Nam KH, Kim Y, Han SB, et al: Agelasine D suppresses RANKL-induced osteoclastogenesis via down-regulation of c-Fos, NFATc1 and NF-κB. Mar Drugs. 12:5643–5656. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Kong X, Wu W, Yang Y, Wan H, Li X, Zhong M, Zhao H, Su X, Jia S, Ju D and Lin N: Total saponin from anemone flaccida Fr. Schmidt abrogates osteoclast differentiation and bone resorption via the inhibition of RANKL-induced NF-κB, JNK and p38 MAPKs activation. J Transl Med. 13:912015. View Article : Google Scholar : PubMed/NCBI

40 

Prideaux M, Findlay DM and Atkins GJ: Osteocytes: The master cells in bone remodelling. Curr Opin Pharmacol. 28:24–30. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Tseng HC, Kanayama K, Kaur K, Park SH, Park S, Kozlowska A, Sun S, McKenna CE, Nishimura I and Jewett A: Bisphosphonate-induced differential modulation of immune cell function in gingiva and bone marrow in vivo: Role in osteoclast-mediated NK cell activation. Oncotarget. 6:20002–20025. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Otero JE, Chen T, Zhang K and Abu-Amer Y: Constitutively active canonical NF-κB pathway induces severe bone loss in mice. PLoS One. 7:e386942012. View Article : Google Scholar : PubMed/NCBI

43 

Kim HK, Kim MG and Leem KH: Osteogenic activity of collagen peptide via ERK/MAPK pathway mediated boosting of collagen synthesis and its therapeutic efficacy in osteoporotic bone by back-scattered electron imaging and microarchitecture analysis. Molecules. 18:15474–15489. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Sui X, Kong N, Ye L, Han W, Zhou J, Zhang Q, He C and Pan H: p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents. Cancer Lett. 344:174–179. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Zhai ZJ, Li HW, Liu GW, Qu XH, Tian B, Yan W, Lin Z, Tang TT, Qin A and Dai KR: Andrographolide suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo. Br J Pharmacol. 171:663–675. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Huh JE, Jung IT, Choi J, Baek YH, Lee JD, Park DS and Choi DY: The natural flavonoid galangin inhibits osteoclastic bone destruction and osteoclastogenesis by suppressing NF-κB in collagen-induced arthritis and bone marrow-derived macrophages. Eur J Pharmacol. 698:57–66. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Yamanaka Y, Clohisy JC, Ito H, Matsuno T and Abu-Amer Y: Blockade of JNK and NFAT pathways attenuates orthopedic particle-stimulated osteoclastogenesis of human osteoclast precursors and murine calvarial osteolysis. J Orthop Res. 31:67–72. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Park JH, Lee NK and Lee SY: Current understanding of RANK signaling in osteoclast differentiation and maturation. Mol Cells. 40:706–713. 2017.PubMed/NCBI

49 

Liu X, Qu X, Wu C, Zhai Z, Tian B, Li H, Ouyang Z, Xu X, Wang W, Fan Q, et al: The effect of enoxacin on osteoclastogenesis and reduction of titanium particle-induced osteolysis via suppression of JNK signaling pathway. Biomaterials. 35:5721–5730. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Zhao Q, Wang X, Liu Y, He A and Jia R: NFATc1: Functions in osteoclasts. Int J Biochem Cell Biol. 42:576–579. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Lee JH, Jin H, Shim HE, Kim HN, Ha H and Lee ZH: Epigallocatechin-3-gallate inhibits osteoclastogenesis by down-regulating c-Fos expression and suppressing the nuclear factor-kappaB signal. Mol Pharmacol. 77:17–25. 2010. View Article : Google Scholar : PubMed/NCBI

52 

Zhang C, Dou CE, Xu J and Dong S: DC-STAMP, the key fusion-mediating molecule in osteoclastogenesis. J Cell Physiol. 229:1330–1335. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Chiu YH, Mensah KA, Schwarz EM, Ju Y, Takahata M, Feng C, McMahon LA, Hicks DG, Panepento B, Keng PC and Ritchlin CT: Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP). J Bone Miner Res. 27:79–92. 2012. View Article : Google Scholar : PubMed/NCBI

54 

Zeng XZ, He LG, Wang S, Wang K, Zhang YY, Tao L, Li XJ and Liu SW: Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-κB and NFATc1 activation and DC-STAMP expression. Acta Pharmacol Sin. 37:255–263. 2016. View Article : Google Scholar : PubMed/NCBI

55 

Kimachi K, Kajiya H, Nakayama S, Ikebe T and Okabe K: Zoledronic acid inhibits RANK expression and migration of osteoclast precursors during osteoclastogenesis. Naunyn Schmiedebergs Arch Pharmacol. 383:297–308. 2011. View Article : Google Scholar : PubMed/NCBI

56 

Lee H, Jin Y, Roh M, Tsacogianis TN, Park S, Choi NK and Kim SC: Risk of cataract surgery and age-related macular degeneration after initiation of denosumab vs zoledronic acid for osteoporosis: A multi-database cohort study. Drugs Aging. 37:311–320. 2020. View Article : Google Scholar : PubMed/NCBI

57 

Kondo H, Okimoto N, Yoshioka T, Akahoshi S, Fuse Y, Ogawa T, Okazaki Y, Katae Y, Tsukamoto M, Yamanaka Y, et al: Zoledronic acid sequential therapy could avoid disadvantages due to the discontinuation of less than 3-year denosumab treatment. J Bone Miner Metab. 38:894–902. 2020. View Article : Google Scholar : PubMed/NCBI

58 

Mori T, Crandall CJ, Fujii T and Ganz DA: Cost-effectiveness of zoledronic acid compared with sequential denosumab/alendronate for older osteoporotic women in Japan. Arch Osteoporos. 16:1132021. View Article : Google Scholar : PubMed/NCBI

59 

Ikesue H, Mouri M, Tomita H, Hirabatake M, Ikemura M, Muroi N, Yamamoto S, Takenobu T, Tomii K, Kawakita M, et al: Associated characteristics and treatment outcomes of medication-related osteonecrosis of the jaw in patients receiving denosumab or zoledronic acid for bone metastases. Support Care Cancer. 29:4763–4772. 2021. View Article : Google Scholar : PubMed/NCBI

60 

Ikesue H, Doi K, Morimoto M, Hirabatake M, Muroi N, Yamamoto S, Takenobu T and Hashida T: Switching from zoledronic acid to denosumab increases the risk for developing medication-related osteonecrosis of the jaw in patients with bone metastases. Cancer Chemother Pharmacol. 87:871–877. 2021. View Article : Google Scholar : PubMed/NCBI

61 

Chen C, Li R, Yang T, Ma L, Zhou S, Li M, Zhou Y and Cui Y: Denosumab versus zoledronic acid in the prevention of skeletal-related events in vulnerable cancer patients: A meta-analysis of randomized, controlled trials. Clin Ther. 42:1494–1507.e1. 2020. View Article : Google Scholar : PubMed/NCBI

62 

Yang G, Singh S, Chen Y, Hamadeh IS, Langaee T, McDonough CW, Holliday LS, Lamba JK, Moreb JS, Katz J and Gong Y: Pharmacogenomics of osteonecrosis of the jaw. Bone. 124:75–82. 2019. View Article : Google Scholar : PubMed/NCBI

63 

Fliefel RM, Entekhabi SA, Ehrenfeld M and Otto S: Geranylgeraniol (GGOH) as a mevalonate pathway activator in the rescue of bone cells treated with zoledronic acid: An in vitro study. Stem Cells Int. 2019:43513272019. View Article : Google Scholar : PubMed/NCBI

64 

Nakagawa T, Ohta K, Kubozono K, Ishida Y, Naruse T, Takechi M and Kamata N: Zoledronate inhibits receptor activator of nuclear factor kappa-B ligand-induced osteoclast differentiation via suppression of expression of nuclear factor of activated T-cell c1 and carbonic anhydrase 2. Arch Oral Biol. 60:557–565. 2015. View Article : Google Scholar : PubMed/NCBI

65 

Cui P, Liu H, Sun J, Amizuka N, Sun Q and Li M: Zoledronate promotes bone formation by blocking osteocyte-osteoblast communication during bone defect healing. Histol Histopathol. 33:89–99. 2018.PubMed/NCBI

66 

Zhang J, Park J, Lee JW, Kwon YD and Kim EC: Bisphosphonates hinder osteoblastic/osteoclastic differentiation in the maxillary sinus mucosa-derived stem cells. Clin Oral Investig. 22:1933–1943. 2018. View Article : Google Scholar : PubMed/NCBI

67 

Pan B, Farrugia AN, To LB, Findlay DM, Green J, Lynch K and Zannettino AC: The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE). J Bone Miner Res. 19:147–154. 2004. View Article : Google Scholar : PubMed/NCBI

68 

Cheng YT, Liao J, Zhou Q, Huo H, Zellmer L, Tang ZL, Ma H, Hong W and Liao DJ: Zoledronic acid modulates osteoclast apoptosis through activation of the NF-κB signaling pathway in ovariectomized rats. Exp Biol Med (Maywood). 246:1727–1739. 2021. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang X, Liu C, Shi X, Cheng Y, Zhou Q, Li J and Liao J: Zoledronic acid inhibits osteoclastogenesis and bone resorptive function by suppressing RANKL‑mediated NF‑κB and JNK and their downstream signalling pathways. Mol Med Rep 25: 59, 2022.
APA
Huang, X., Liu, C., Shi, X., Cheng, Y., Zhou, Q., Li, J., & Liao, J. (2022). Zoledronic acid inhibits osteoclastogenesis and bone resorptive function by suppressing RANKL‑mediated NF‑κB and JNK and their downstream signalling pathways. Molecular Medicine Reports, 25, 59. https://doi.org/10.3892/mmr.2021.12575
MLA
Huang, X., Liu, C., Shi, X., Cheng, Y., Zhou, Q., Li, J., Liao, J."Zoledronic acid inhibits osteoclastogenesis and bone resorptive function by suppressing RANKL‑mediated NF‑κB and JNK and their downstream signalling pathways". Molecular Medicine Reports 25.2 (2022): 59.
Chicago
Huang, X., Liu, C., Shi, X., Cheng, Y., Zhou, Q., Li, J., Liao, J."Zoledronic acid inhibits osteoclastogenesis and bone resorptive function by suppressing RANKL‑mediated NF‑κB and JNK and their downstream signalling pathways". Molecular Medicine Reports 25, no. 2 (2022): 59. https://doi.org/10.3892/mmr.2021.12575
Copy and paste a formatted citation
x
Spandidos Publications style
Huang X, Liu C, Shi X, Cheng Y, Zhou Q, Li J and Liao J: Zoledronic acid inhibits osteoclastogenesis and bone resorptive function by suppressing RANKL‑mediated NF‑κB and JNK and their downstream signalling pathways. Mol Med Rep 25: 59, 2022.
APA
Huang, X., Liu, C., Shi, X., Cheng, Y., Zhou, Q., Li, J., & Liao, J. (2022). Zoledronic acid inhibits osteoclastogenesis and bone resorptive function by suppressing RANKL‑mediated NF‑κB and JNK and their downstream signalling pathways. Molecular Medicine Reports, 25, 59. https://doi.org/10.3892/mmr.2021.12575
MLA
Huang, X., Liu, C., Shi, X., Cheng, Y., Zhou, Q., Li, J., Liao, J."Zoledronic acid inhibits osteoclastogenesis and bone resorptive function by suppressing RANKL‑mediated NF‑κB and JNK and their downstream signalling pathways". Molecular Medicine Reports 25.2 (2022): 59.
Chicago
Huang, X., Liu, C., Shi, X., Cheng, Y., Zhou, Q., Li, J., Liao, J."Zoledronic acid inhibits osteoclastogenesis and bone resorptive function by suppressing RANKL‑mediated NF‑κB and JNK and their downstream signalling pathways". Molecular Medicine Reports 25, no. 2 (2022): 59. https://doi.org/10.3892/mmr.2021.12575
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