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Article Open Access

Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522

Corrigendum in: /10.3892/mmr.2024.13189
  • Authors:
    • Hong-Gang Qian
    • Qiong Wu
    • Jian-Hui Wu
    • Xiu-Yun Tian
    • Wei Xu
    • Chun-Yi Hao
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Hepato‑Pancreato‑Biliary Surgery, Peking University Cancer Hospital and Institute, Beijing 100142, P.R. China, MOE Key Lab, Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China
    Copyright: © Qian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 71
    |
    Published online on: January 5, 2022
       https://doi.org/10.3892/mmr.2022.12587
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Abstract

Long non‑coding RNAs can regulate the malignant tumor phenotype either as tumor suppressors or oncogenes. The present study investigated the underlying mechanism of LINC00238 in liver cancer. LINC00238 was identified as a downregulated molecule in The Cancer Genome Atlas liver hepatocellular carcinoma dataset through Gene Expression Profiling Interactive Analysis software. Through gain‑ and loss‑of‑function experiments, LINC00238 was confirmed as a tumor suppressor that could not only decrease cell viability, migration and invasion in vitro, but also tumorigenesis and tumor metastasis in vivo. By cytoplasmic and nuclear RNA isolation, LINC00238 was confirmed to be predominantly cytoplasmic. Mechanistically, RNA pull‑down assays showed that LINC00238 sponged microRNA (miR)‑522 and then reversed the inhibitory effects on two downstream targets, secreted frizzled related protein 2 and dickkopf1. Collectively, LINC00238 was identified as a tumor suppressor that acts via sponging miR‑522 followed by silencing of downstream targets, suggesting that LINC00238 may have a key role in suppressing the malignant phenotype of liver cancer cells.
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Copy and paste a formatted citation
Spandidos Publications style
Qian H, Wu Q, Wu J, Tian X, Xu W and Hao C: Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522 Corrigendum in /10.3892/mmr.2024.13189. Mol Med Rep 25: 71, 2022.
APA
Qian, H., Wu, Q., Wu, J., Tian, X., Xu, W., & Hao, C. (2022). Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522 Corrigendum in /10.3892/mmr.2024.13189. Molecular Medicine Reports, 25, 71. https://doi.org/10.3892/mmr.2022.12587
MLA
Qian, H., Wu, Q., Wu, J., Tian, X., Xu, W., Hao, C."Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522 Corrigendum in /10.3892/mmr.2024.13189". Molecular Medicine Reports 25.2 (2022): 71.
Chicago
Qian, H., Wu, Q., Wu, J., Tian, X., Xu, W., Hao, C."Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522 Corrigendum in /10.3892/mmr.2024.13189". Molecular Medicine Reports 25, no. 2 (2022): 71. https://doi.org/10.3892/mmr.2022.12587
Copy and paste a formatted citation
x
Spandidos Publications style
Qian H, Wu Q, Wu J, Tian X, Xu W and Hao C: Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522 Corrigendum in /10.3892/mmr.2024.13189. Mol Med Rep 25: 71, 2022.
APA
Qian, H., Wu, Q., Wu, J., Tian, X., Xu, W., & Hao, C. (2022). Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522 Corrigendum in /10.3892/mmr.2024.13189. Molecular Medicine Reports, 25, 71. https://doi.org/10.3892/mmr.2022.12587
MLA
Qian, H., Wu, Q., Wu, J., Tian, X., Xu, W., Hao, C."Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522 Corrigendum in /10.3892/mmr.2024.13189". Molecular Medicine Reports 25.2 (2022): 71.
Chicago
Qian, H., Wu, Q., Wu, J., Tian, X., Xu, W., Hao, C."Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522 Corrigendum in /10.3892/mmr.2024.13189". Molecular Medicine Reports 25, no. 2 (2022): 71. https://doi.org/10.3892/mmr.2022.12587
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