Open Access

Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522

  • Authors:
    • Hong-Gang Qian
    • Qiong Wu
    • Jian-Hui Wu
    • Xiu-Yun Tian
    • Wei Xu
    • Chun-Yi Hao
  • View Affiliations

  • Published online on: January 5, 2022     https://doi.org/10.3892/mmr.2022.12587
  • Article Number: 71
  • Copyright: © Qian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long non‑coding RNAs can regulate the malignant tumor phenotype either as tumor suppressors or oncogenes. The present study investigated the underlying mechanism of LINC00238 in liver cancer. LINC00238 was identified as a downregulated molecule in The Cancer Genome Atlas liver hepatocellular carcinoma dataset through Gene Expression Profiling Interactive Analysis software. Through gain‑ and loss‑of‑function experiments, LINC00238 was confirmed as a tumor suppressor that could not only decrease cell viability, migration and invasion in vitro, but also tumorigenesis and tumor metastasis in vivo. By cytoplasmic and nuclear RNA isolation, LINC00238 was confirmed to be predominantly cytoplasmic. Mechanistically, RNA pull‑down assays showed that LINC00238 sponged microRNA (miR)‑522 and then reversed the inhibitory effects on two downstream targets, secreted frizzled related protein 2 and dickkopf1. Collectively, LINC00238 was identified as a tumor suppressor that acts via sponging miR‑522 followed by silencing of downstream targets, suggesting that LINC00238 may have a key role in suppressing the malignant phenotype of liver cancer cells.
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February-2022
Volume 25 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Qian H, Wu Q, Wu J, Tian X, Xu W and Hao C: Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522. Mol Med Rep 25: 71, 2022
APA
Qian, H., Wu, Q., Wu, J., Tian, X., Xu, W., & Hao, C. (2022). Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522. Molecular Medicine Reports, 25, 71. https://doi.org/10.3892/mmr.2022.12587
MLA
Qian, H., Wu, Q., Wu, J., Tian, X., Xu, W., Hao, C."Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522". Molecular Medicine Reports 25.2 (2022): 71.
Chicago
Qian, H., Wu, Q., Wu, J., Tian, X., Xu, W., Hao, C."Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522". Molecular Medicine Reports 25, no. 2 (2022): 71. https://doi.org/10.3892/mmr.2022.12587