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Article

Cellular response of lung fibroblasts and epithelial cells to particulate matter10 treatment examined via comparative transcriptome analysis

  • Authors:
    • Kunhyang Park
    • Kwangho Kim
    • Tae Young Ryu
    • Jinkwon Lee
    • Moo-Seung Lee
    • Mi-Young Son
    • Seon-Jin Lee
    • Young-Jun Park
    • Hyun-Soo Cho
    • Dae-Soo Kim
  • View Affiliations / Copyright

    Affiliations: Environmental Diseases Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea
  • Article Number: 82
    |
    Published online on: January 13, 2022
       https://doi.org/10.3892/mmr.2022.12598
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Abstract

Particulate matter (PM) can be categorized by particle size (PM10, PM2.5 and PM1.0), which is an important factor affecting the biological response. Exposure to PM in the air (dust, smoke, dirt and biological contaminants) is clearly associated with lung disease (lung cancer, pneumonia and asthma). Although PM primarily affects lung epithelial cells, the specific response of related cell types to PM remains to be elucidated. The present study performed Gene Ontology (GO) analysis programs (Clustering GO and Database for Annotation, Visualization and Integrated Discovery) on differentially expressed genes in lung epithelial cells (WI‑38 VA‑13) and fibroblasts (WI‑38) following treatment with PM10 and evaluated the cell‑specific biological responses related to cell proliferation, apoptosis, adhesion and extracellular matrix production. The results suggested that short‑ or long‑term exposure to PM may affect cell condition and may consequently be related to several human diseases, including lung cancer and cardiopulmonary disease.
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1 

Kyung SY and Jeong SH: Particulate-matter related respiratory diseases. Tuberc Respir Dis (Seoul). 83:116–121. 2020. View Article : Google Scholar : PubMed/NCBI

2 

Li T, Hu R, Chen Z, Li Q, Huang S, Zhu Z and Zhou LF: Fine particulate matter (PM2.5): The culprit for chronic lung diseases in China. Chronic Dis Transl Med. 4:176–186. 2018.PubMed/NCBI

3 

Zou Y, Wu Y, Wang Y, Li Y and Jin C: Physicochemical properties, in vitro cytotoxic and genotoxic effects of PM1.0 and PM2.5 from Shanghai, China. Environ Sci Pollut Res Int. 24:19508–19516. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Huang SL, Hsu MK and Chan CC: Effects of submicrometer particle compositions on cytokine production and lipid peroxidation of human bronchial epithelial cells. Environ Health Perspect. 111:478–482. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Mu Q, Jiang G, Chen L, Zhou H, Fourches D, Tropsha A and Yan B: Chemical basis of interactions between engineered nanoparticles and biological systems. Chem Rev. 114:7740–7781. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Huang F, Wang P, Pan X, Wang Y and Ren S: Effects of short-term exposure to particulate matters on heart rate variability: A systematic review and meta-analysis based on controlled animal studies. Environ Pollut. 256:1133062020. View Article : Google Scholar : PubMed/NCBI

7 

Pfeffer PE, Lu H, Mann EH, Chen YH, Ho TR, Cousins DJ, Corrigan C, Kelly FJ, Mudway IS and Hawrylowicz CM: Effects of vitamin D on inflammatory and oxidative stress responses of human bronchial epithelial cells exposed to particulate matter. PLoS One. 13:e02000402018. View Article : Google Scholar : PubMed/NCBI

8 

Watterson TL, Hamilton B, Martin RS and Coulombe RA Jr: Urban particulate matter activates Akt in human lung cells. Arch Toxicol. 86:121–135. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Hesselbach K, Kim GJ, Flemming S, Häupl T, Bonin M, Dornhof R, Günther S, Merfort I and Humar M: Disease relevant modifications of the methylome and transcriptome by particulate matter (PM2.5) from biomass combustion. Epigenetics. 12:779–792. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Zhang N, Liu K, Wang K, Zhou C, Wang H, Che S, Liu Z and Yang H: Dust induces lung fibrosis through dysregulated DNA methylation. Environ Toxicol. 34:728–741. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Wei T and Tang M: Biological effects of airborne fine particulate matter (PM2.5) exposure on pulmonary immune system. Environ Toxicol Pharmacol. 60:195–201. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Travaglini KJ, Nabhan AN, Penland L, Sinha R, Gillich A, Sit RV, Chang S, Conley SD, Mori Y, Seita J, et al: A molecular cell atlas of the human lung from single-cell RNA sequencing. Nature. 587:619–625. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Ito Y, Correll K, Schiel JA, Finigan JH, Prekeris R and Mason RJ: Lung fibroblasts accelerate wound closure in human alveolar epithelial cells through hepatocyte growth factor/c-Met signaling. Am J Physiol Lung Cell Mol Physiol. 307:L94–L105. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Hsia CC, Hyde DM and Weibel ER: Lung structure and the intrinsic challenges of gas exchange. Compr Physiol. 6:827–895. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Lee J, Kim K, Ryu TY, Jung CR, Lee MS, Lim JH, Park K, Kim DS, Son MY, et al: EHMT1 knockdown induces apoptosis and cell cycle arrest in lung cancer cells by increasing CDKN1A expression. Mol Oncol. 15:2989–3002. 2021. View Article : Google Scholar : PubMed/NCBI

16 

Lee H, Son YS, Lee MO, Ryu JW, Park K, Kwon O, Jung KB, Kim K, Ryu TY, Baek A, et al: Low-dose interleukin-2 alleviates dextran sodium sulfate-induced colitis in mice by recovering intestinal integrity and inhibiting AKT-dependent pathways. Theranostics. 10:5048–5063. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Cappiello F, Casciaro B and Mangoni ML: A novel in vitro wound healing assay to evaluate cell migration. J Vis Exp. 568252018.PubMed/NCBI

18 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The gene ontology consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Chen X, Zhang LW, Huang JJ, Song FJ, Zhang LP, Qian ZM, Trevathan E, Mao HJ, Han B, Vaughn M, et al: Long-term exposure to urban air pollution and lung cancer mortality: A 12-year cohort study in Northern China. Sci Total Environ. 571:855–861. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Quezada-Maldonado EM, Sanchez-Perez Y, Chirino YI, Vaca-Paniagua F and Garcia-Cuellar CM: miRNAs deregulation in lung cells exposed to airborne particulate matter (PM10) is associated with pathways deregulated in lung tumors. Environ Pollut. 241:351–358. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Croasdell Lucchini A, Gachanja NN, Rossi AG, Dorward DA and Lucas CD: Epithelial cells and inflammation in pulmonary wound repair. Cells. 10:3392021. View Article : Google Scholar : PubMed/NCBI

22 

Farooqui R and Fenteany G: Multiple rows of cells behind an epithelial wound edge extend cryptic lamellipodia to collectively drive cell-sheet movement. J Cell Sci. 118:51–63. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Pardo A and Selman M: Lung fibroblasts, aging, and idiopathic pulmonary fibrosis. Ann Am Thorac Soc. 13 (Suppl 5):S417–S421. 2016. View Article : Google Scholar : PubMed/NCBI

24 

White ES: Lung extracellular matrix and fibroblast function. Ann Am Thorac Soc. 12 (Suppl 1):S30–S33. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Park K, Kim K, Ryu TY, Lee J, Lee M, Son M, Lee S, Park Y, Cho H, Kim D, Kim D, et al: Cellular response of lung fibroblasts and epithelial cells to particulate matter<sub>10</sub> treatment examined via comparative transcriptome analysis. Mol Med Rep 25: 82, 2022.
APA
Park, K., Kim, K., Ryu, T.Y., Lee, J., Lee, M., Son, M. ... Kim, D. (2022). Cellular response of lung fibroblasts and epithelial cells to particulate matter<sub>10</sub> treatment examined via comparative transcriptome analysis. Molecular Medicine Reports, 25, 82. https://doi.org/10.3892/mmr.2022.12598
MLA
Park, K., Kim, K., Ryu, T. Y., Lee, J., Lee, M., Son, M., Lee, S., Park, Y., Cho, H., Kim, D."Cellular response of lung fibroblasts and epithelial cells to particulate matter<sub>10</sub> treatment examined via comparative transcriptome analysis". Molecular Medicine Reports 25.3 (2022): 82.
Chicago
Park, K., Kim, K., Ryu, T. Y., Lee, J., Lee, M., Son, M., Lee, S., Park, Y., Cho, H., Kim, D."Cellular response of lung fibroblasts and epithelial cells to particulate matter<sub>10</sub> treatment examined via comparative transcriptome analysis". Molecular Medicine Reports 25, no. 3 (2022): 82. https://doi.org/10.3892/mmr.2022.12598
Copy and paste a formatted citation
x
Spandidos Publications style
Park K, Kim K, Ryu TY, Lee J, Lee M, Son M, Lee S, Park Y, Cho H, Kim D, Kim D, et al: Cellular response of lung fibroblasts and epithelial cells to particulate matter<sub>10</sub> treatment examined via comparative transcriptome analysis. Mol Med Rep 25: 82, 2022.
APA
Park, K., Kim, K., Ryu, T.Y., Lee, J., Lee, M., Son, M. ... Kim, D. (2022). Cellular response of lung fibroblasts and epithelial cells to particulate matter<sub>10</sub> treatment examined via comparative transcriptome analysis. Molecular Medicine Reports, 25, 82. https://doi.org/10.3892/mmr.2022.12598
MLA
Park, K., Kim, K., Ryu, T. Y., Lee, J., Lee, M., Son, M., Lee, S., Park, Y., Cho, H., Kim, D."Cellular response of lung fibroblasts and epithelial cells to particulate matter<sub>10</sub> treatment examined via comparative transcriptome analysis". Molecular Medicine Reports 25.3 (2022): 82.
Chicago
Park, K., Kim, K., Ryu, T. Y., Lee, J., Lee, M., Son, M., Lee, S., Park, Y., Cho, H., Kim, D."Cellular response of lung fibroblasts and epithelial cells to particulate matter<sub>10</sub> treatment examined via comparative transcriptome analysis". Molecular Medicine Reports 25, no. 3 (2022): 82. https://doi.org/10.3892/mmr.2022.12598
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