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Inhibitory effects and underlying mechanisms of Artemisia capillaris essential oil on melanogenesis in the B16F10 cell line

  • Authors:
    • Min Jae Kim
    • Elsayed A. Mohamed
    • Da Som Kim
    • Mi-Jin Park
    • Byoung-Jun Ahn
    • Eui-Bae Jeung
    • Beum-Soo An
  • View Affiliations / Copyright

    Affiliations: Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Miryang, Gyeongsangnam‑do 50463, Republic of Korea, Division of Forest Industrial Materials, Department of Forest Products and Industry, National Institute of Forest Science, Seoul 02455, Republic of Korea, Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 113
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    Published online on: February 4, 2022
       https://doi.org/10.3892/mmr.2022.12629
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Abstract

The present study investigated the anti‑melanogenic activity of 10 essential oils using the B16F10 cell model. Initially, a wide range of concentrations of these essential oils were screened in order to determine their toxicity levels. The assigned non‑toxic concentrations of the tested essential oils were then used to evaluate their effects on melanogenesis. The effects of the essential oils with potent anti‑melanogenic activity on cell proliferation, protection against H2O2‑induced cell death and the expression of certain melanogenesis‑related genes, including MITF, tyrosinase, tyrosinase related protein (TRP)‑1 and TRP‑2 were also evaluated. The results revealed that the essential oils extracted from Citrus unshiu, Juniperus chinensis L., Zanthoxylum piperitum and Artemisia capillaris (A. capillaris) inhibited melanogenesis. However, among these four extracts, only A. capillaris extract enhanced cell proliferation, exhibited anti‑H2O2 activities and decreased the expression level of TRP‑1. It was demonstrated that A. capillaris extract inhibited melanin synthesis via the downregulation of the TRP‑1 translational level. These essential oil extracts, particularly that of A. capillaris, may thus be used as natural anti‑melanogenic agents for therapeutic purposes and in the cosmetic industry for skin whitening effects with beneficial proliferative properties. However, further studies using in vivo models are required to validate these findings and to examine the effects of these extracts on various molecular pathways.
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Copy and paste a formatted citation
Spandidos Publications style
Kim MJ, Mohamed EA, Kim DS, Park M, Ahn B, Jeung E and An B: Inhibitory effects and underlying mechanisms of <em>Artemisia capillaris</em> essential oil on melanogenesis in the B16F10 cell line. Mol Med Rep 25: 113, 2022.
APA
Kim, M.J., Mohamed, E.A., Kim, D.S., Park, M., Ahn, B., Jeung, E., & An, B. (2022). Inhibitory effects and underlying mechanisms of <em>Artemisia capillaris</em> essential oil on melanogenesis in the B16F10 cell line. Molecular Medicine Reports, 25, 113. https://doi.org/10.3892/mmr.2022.12629
MLA
Kim, M. J., Mohamed, E. A., Kim, D. S., Park, M., Ahn, B., Jeung, E., An, B."Inhibitory effects and underlying mechanisms of <em>Artemisia capillaris</em> essential oil on melanogenesis in the B16F10 cell line". Molecular Medicine Reports 25.4 (2022): 113.
Chicago
Kim, M. J., Mohamed, E. A., Kim, D. S., Park, M., Ahn, B., Jeung, E., An, B."Inhibitory effects and underlying mechanisms of <em>Artemisia capillaris</em> essential oil on melanogenesis in the B16F10 cell line". Molecular Medicine Reports 25, no. 4 (2022): 113. https://doi.org/10.3892/mmr.2022.12629
Copy and paste a formatted citation
x
Spandidos Publications style
Kim MJ, Mohamed EA, Kim DS, Park M, Ahn B, Jeung E and An B: Inhibitory effects and underlying mechanisms of <em>Artemisia capillaris</em> essential oil on melanogenesis in the B16F10 cell line. Mol Med Rep 25: 113, 2022.
APA
Kim, M.J., Mohamed, E.A., Kim, D.S., Park, M., Ahn, B., Jeung, E., & An, B. (2022). Inhibitory effects and underlying mechanisms of <em>Artemisia capillaris</em> essential oil on melanogenesis in the B16F10 cell line. Molecular Medicine Reports, 25, 113. https://doi.org/10.3892/mmr.2022.12629
MLA
Kim, M. J., Mohamed, E. A., Kim, D. S., Park, M., Ahn, B., Jeung, E., An, B."Inhibitory effects and underlying mechanisms of <em>Artemisia capillaris</em> essential oil on melanogenesis in the B16F10 cell line". Molecular Medicine Reports 25.4 (2022): 113.
Chicago
Kim, M. J., Mohamed, E. A., Kim, D. S., Park, M., Ahn, B., Jeung, E., An, B."Inhibitory effects and underlying mechanisms of <em>Artemisia capillaris</em> essential oil on melanogenesis in the B16F10 cell line". Molecular Medicine Reports 25, no. 4 (2022): 113. https://doi.org/10.3892/mmr.2022.12629
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