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Article

lncRNA TUG1 protects intestinal epithelial cells from damage induced by high glucose and high fat via AMPK/SIRT1

  • Authors:
    • Weiwei Wei
    • Xingquan Wang
    • Yaqing Wei
    • Shilin Liu
    • Shengyu Gao
    • Hao Tian
    • Dewang Su
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China, Department of Infectious Diseases, The Central Hospital of Jiamusi City, Jiamusi, Heilongjiang 154002, P.R. China, Department of General Surgery, Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China
  • Article Number: 139
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    Published online on: February 24, 2022
       https://doi.org/10.3892/mmr.2022.12655
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Abstract

he incidence of obesity and type 2 diabetes mellitus (T2DM) is increasing year by year and shows a trend towards younger age groups worldwide. It has become a disease that endangers the health of individuals all over the world. Among numerous weight loss surgeries, sleeve gastrectomy (SG) has become one of the most common surgical strategies for the treatment of T2DM. However, SG‑mediated alterations to the molecular mechanism of metabolism require further investigation. Thus, reverse transcription‑quantitative PCR was used to detect the expression levels of long non‑coding (lnc)RNA taurine‑upregulated gene 1 (TUG1), Sirtuin 1 (SIRT1), AMP‑activated protein kinase (AMPK) and uncoupling protein 2 (UCP2) in the serum of T2DM patients, as well as in HIEC‑6 and SW480 cells following treatment with high glucose and high fat (HGHF). Protein expression was detected by western blotting. Cell Counting Kit‑8 assays were performed to analyze cell viability, and flow cytometry and a TUNEL assay was performed to evaluate cell apoptosis. The secretion of ILs in the culture medium was detected by conducting ELISAs. The results showed that lncRNA TUG1 and UCP2 expression was upregulated, SIRT1 and AMPK expression levels were decreased by SG. Under HGHF conditions, HIEC‑6 and SW480 cell viability was inhibited, apoptosis was promoted, TUG1 expression was downregulated, and SIRT1 and AMPK expression levels were upregulated. The secretory levels of IL‑1β, IL‑6 and IL‑8 were increased, whereas the secretion of IL‑10 was decreased under HGHF conditions. lncRNA TUG1 overexpression significantly reversed the effects of HGHF on cell viability, apoptosis and SIRT1, AMPK, UCP2 and Bcl‑2 expression levels. Together, the findings of the present study demonstrated that lncRNA TUG1 alleviated the damage induced by HGHF in intestinal epithelial cells by downregulating SIRT1 and AMPK expression, and upregulating UCP2 expression. Thus, the lncRNA TUG1/AMPK/SIRT1/UCP2 axis may serve an important role in the treatment of T2DM.
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View References

1 

Wang Y, Xue H, Sun M, Zhu X, Zhao L and Yang Y: Prevention and control of obesity in China. Lancet Glob Health. 9:e1166–e1167. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Jia W, Weng J, Zhu D, Ji L, Lu J, Zhou Z, Zou D, Guo L, Ji Q, Chen L, et al: Standards of medical care for type 2 diabetes in China 2019. Diabetes Metab Res Rev. 35:e31582019. View Article : Google Scholar : PubMed/NCBI

3 

Ortega MA, Fraile-Martínez O, Naya I, García-Honduvilla N, Álvarez-Mon M, Buján J, Asúnsolo Á and de la Torre B: Type 2 diabetes mellitus associated with obesity (diabesity). The central role of gut microbiota and its translational applications. Nutrients. 12:27492020. View Article : Google Scholar : PubMed/NCBI

4 

Tsilingiris D, Koliaki C and Kokkinos A: Remission of type 2 diabetes mellitus after bariatric surgery: Fact or fiction? Int J Environ Res Public Health. 16:31712019. View Article : Google Scholar : PubMed/NCBI

5 

Zeng ZY, Sun J and Kang WM: History, recent advancements, and prospects in bariatric/metabolic surgery. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 40:581–590. 2018.(In Chinese). PubMed/NCBI

6 

Macauley M, Percival K, Thelwall PE, Hollingsworth KG and Taylor R: Altered volume, morphology and composition of the pancreas in type 2 diabetes. PLoS One. 10:e01268252015. View Article : Google Scholar : PubMed/NCBI

7 

Fan M, Jiang H, Zhang Y, Ma Y, Li L and Wu J: Liraglutide enhances autophagy and promotes pancreatic β cell proliferation to ameliorate type 2 diabetes in high-fat-fed and streptozotocin-treated mice. Med Sci Monit. 24:2310–2316. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Xu H, Wang Q, Sun Q, Qin Y, Han A, Cao Y, Yang Q, Yang P, Lu J, Liu Q and Xiang Q: In type 2 diabetes induced by cigarette smoking, activation of p38 MAPK is involved in pancreatic β-cell apoptosis. Environ Sci Pollut Res Int. 25:9817–9827. 2018. View Article : Google Scholar : PubMed/NCBI

9 

St Laurent G, Wahlestedt C and Kapranov P: The landscape of long noncoding RNA classification. Trends Genet. 31:239–251. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Peng WX, Koirala P and Mo YY: lncRNA-mediated regulation of cell signaling in cancer. Oncogene. 36:5661–5667. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Zhang YX, Yuan J, Gao ZM and Zhang ZG: lncRNA TUC338 promotes invasion of lung cancer by activating MAPK pathway. Eur Rev Med Pharmacol Sci. 22:443–449. 2018.PubMed/NCBI

12 

Zhang M, Weng W, Zhang Q, Wu Y, Ni S, Tan C, Xu M, Sun H, Liu C, Wei P and Du X: The lncRNA NEAT1 activates Wnt/β-catenin signaling and promotes colorectal cancer progression via interacting with DDX5. J Hematol Oncol. 11:1132018. View Article : Google Scholar : PubMed/NCBI

13 

Tang J, Yan T, Bao Y, Shen C, Yu C, Zhu X, Tian X, Guo F, Liang Q, Liu Q, et al: lncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc. Nat Commun. 10:34992019. View Article : Google Scholar : PubMed/NCBI

14 

Zheng X, Han H, Liu GP, Ma YX, Pan RL, Sang LJ, Li RH, Yang LJ, Marks JR, Wang W and Lin A: lncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism. EMBO J. 36:3325–3335. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Young TL, Matsuda T and Cepko CL: The noncoding RNA taurine upregulated gene 1 is required for differentiation of the murine retina. Curr Biol. 15:501–512. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Yu G, Zhou H, Yao W, Meng L and Lang B: lncRNA TUG1 promotes cisplatin resistance by regulating CCND2 via epigenetically silencing miR-194-5p in bladder cancer. Mol Ther Nucleic Acids. 16:257–271. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Li J, An G, Zhang M and Ma Q: Long non-coding RNA TUG1 acts as a miR-26a sponge in human glioma cells. Biochem Biophys Res Commun. 477:743–748. 2016. View Article : Google Scholar : PubMed/NCBI

18 

You G, Long X, Song F, Huang J, Tian M, Xiao Y, Deng S and Wu Q: Metformin activates the AMPK-mTOR pathway by modulating lncRNA TUG1 to induce autophagy and inhibit atherosclerosis. Drug Des Devel Ther. 14:457–468. 2020. View Article : Google Scholar : PubMed/NCBI

19 

Arocho A, Chen B, Ladanyi M and Pan Q: Validation of the 2-DeltaDeltaCt calculation as an alternate method of data analysis for quantitative PCR of BCR-ABL P210 transcripts. Diagn Mol Pathol. 15:56–61. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Umemura A, Sasaki A, Nitta H, Baba S, Ando T, Kajiwara T and Ishigaki Y: Pancreas volume reduction and metabolic effects in Japanese patients with severe obesity following laparoscopic sleeve gastrectomy. Endocr J. 64:487–498. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Li YX, Fang DH and Liu TX: Laparoscopic sleeve gastrectomy combined with single-anastomosis duodenal-jejunal bypass in the treatment of type 2 diabetes mellitus of patients with body mass index higher than 27.5 kg/m2 but lower than 32.5 kg/m2. Medicine (Baltimore). 97:e115372018. View Article : Google Scholar : PubMed/NCBI

22 

Ramos AC, Bastos EL, Ramos MG, Bertin NT, Galvão TD, de Lucena RT and Campos JM: Medium-term follow-up results with laparoscopic sleeve gastrectomy. Arq Bras Cir Dig. 28 Suppl 1:S61–S64. 2015.(In English, Portuguese).s. View Article : Google Scholar : PubMed/NCBI

23 

Murillo-Maldonado JM and Riesgo-Escovar JR: The various and shared roles of lncRNAs during development. Dev Dyn. 248:1059–1069. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Wei GH and Wang X: lncRNA MEG3 inhibit proliferation and metastasis of gastric cancer via p53 signaling pathway. Eur Rev Med Pharmacol Sci. 21:3850–3856. 2017.PubMed/NCBI

25 

Xiong H, Ni Z, He J, Jiang S, Li X, He J, Gong W, Zheng L, Chen S, Li B, et al: lncRNA HULC triggers autophagy via stabilizing Sirt1 and attenuates the chemosensitivity of HCC cells. Oncogene. 36:3528–3540. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Sun Y, Zhong L, He X, Wang S, Lai Y, Wu W, Song H, Chen Y, Yang Y, Liao W, et al: lncRNA H19 promotes vascular inflammation and abdominal aortic aneurysm formation by functioning as a competing endogenous RNA. J Mol Cell Cardiol. 131:66–81. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Wang X, Chang X, Zhang P, Fan L, Zhou T and Sun K: Aberrant expression of long non-coding RNAs in newly diagnosed type 2 diabetes indicates potential roles in chronic inflammation and insulin resistance. Cell Physiol Biochem. 43:2367–2378. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Sathishkumar C, Prabu P, Mohan V and Balasubramanyam M: Linking a role of lncRNAs (long non-coding RNAs) with insulin resistance, accelerated senescence, and inflammation in patients with type 2 diabetes. Hum Genomics. 12:412018. View Article : Google Scholar : PubMed/NCBI

29 

Chen J, Ke S, Zhong L, Wu J, Tseng A, Morpurgo B, Golovko A, Wang G, Cai JJ, Ma X, et al: Long noncoding RNA MALAT1 regulates generation of reactive oxygen species and the insulin responses in male mice. Biochem Pharmacol. 152:94–103. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Zhu X, Li H, Wu Y, Zhou J, Yang G, Wang W, Kang D and Ye S: CREB-upregulated lncRNA MEG3 promotes hepatic gluconeogenesis by regulating miR-302a-3p-CRTC2 axis. J Cell Biochem. 120:4192–4202. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Liu S, Sheng L, Miao H, Saunders TL, MacDougald OA, Koenig RJ and Xu B: SRA gene knockout protects against diet-induced obesity and improves glucose tolerance. J Biol Chem. 289:13000–13009. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Long J, Galvan DL, Mise K, Kanwar YS, Li L, Poungavrin N, Overbeek PA, Chang BH and Danesh FR: Role for carbohydrate response element-binding protein (ChREBP) in high glucose-mediated repression of long noncoding RNA Tug1. J Biol Chem. 295:15840–15852. 2020. View Article : Google Scholar : PubMed/NCBI

33 

Li Y, Zhi K, Han S, Li X, Li M, Lian W, Zhang H and Zhang X: TUG1 enhances high glucose-impaired endothelial progenitor cell function via miR-29c-3p/PDGF-BB/Wnt signaling. Stem Cell Res Ther. 11:4412020. View Article : Google Scholar : PubMed/NCBI

34 

Zhao L, Li W and Zhao H: Inhibition of long non-coding RNA TUG1 protects against diabetic cardiomyopathy induced diastolic dysfunction by regulating miR-499-5p. Am J Transl Res. 12:718–730. 2020.PubMed/NCBI

35 

Rajendran R, Garva R, Krstic-Demonacos M and Demonacos C: Sirtuins: Molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. J Biomed Biotechnol. 2011:3682762011. View Article : Google Scholar : PubMed/NCBI

36 

D'Onofrio N, Servillo L and Balestrieri ML: SIRT1 and SIRT6 signaling pathways in cardiovascular disease protection. Antioxid Redox Signal. 28:711–732. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Kitada M, Ogura Y, Monno I and Koya D: Sirtuins and type 2 diabetes: Role in inflammation, oxidative stress, and mitochondrial function. Front Endocrinol (Lausanne). 10:1872019. View Article : Google Scholar : PubMed/NCBI

38 

Herzig S and Shaw RJ: AMPK: Guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol. 19:121–135. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Bai B, Man AW, Yang K, Guo Y, Xu C, Tse HF, Han W, Bloksgaard M, De Mey JG, Vanhoutte PM, et al: Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1. Oncotarget. 7:39065–39081. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Sun LY, Li XJ, Sun YM, Huang W, Fang K, Han C, Chen ZH, Luo XQ, Chen YQ and Wang WT: lncRNA ANRIL regulates AML development through modulating the glucose metabolism pathway of AdipoR1/AMPK/SIRT1. Mol Cancer. 17:1272018. View Article : Google Scholar : PubMed/NCBI

41 

Bordone L, Motta MC, Picard F, Robinson A, Jhala US, Apfeld J, McDonagh T, Lemieux M, McBurney M, Szilvasi A, et al: Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol. 4:e312006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wei W, Wang X, Wei Y, Liu S, Gao S, Tian H and Su D: lncRNA TUG1 protects intestinal epithelial cells from damage induced by high glucose and high fat via AMPK/SIRT1. Mol Med Rep 25: 139, 2022.
APA
Wei, W., Wang, X., Wei, Y., Liu, S., Gao, S., Tian, H., & Su, D. (2022). lncRNA TUG1 protects intestinal epithelial cells from damage induced by high glucose and high fat via AMPK/SIRT1. Molecular Medicine Reports, 25, 139. https://doi.org/10.3892/mmr.2022.12655
MLA
Wei, W., Wang, X., Wei, Y., Liu, S., Gao, S., Tian, H., Su, D."lncRNA TUG1 protects intestinal epithelial cells from damage induced by high glucose and high fat via AMPK/SIRT1". Molecular Medicine Reports 25.4 (2022): 139.
Chicago
Wei, W., Wang, X., Wei, Y., Liu, S., Gao, S., Tian, H., Su, D."lncRNA TUG1 protects intestinal epithelial cells from damage induced by high glucose and high fat via AMPK/SIRT1". Molecular Medicine Reports 25, no. 4 (2022): 139. https://doi.org/10.3892/mmr.2022.12655
Copy and paste a formatted citation
x
Spandidos Publications style
Wei W, Wang X, Wei Y, Liu S, Gao S, Tian H and Su D: lncRNA TUG1 protects intestinal epithelial cells from damage induced by high glucose and high fat via AMPK/SIRT1. Mol Med Rep 25: 139, 2022.
APA
Wei, W., Wang, X., Wei, Y., Liu, S., Gao, S., Tian, H., & Su, D. (2022). lncRNA TUG1 protects intestinal epithelial cells from damage induced by high glucose and high fat via AMPK/SIRT1. Molecular Medicine Reports, 25, 139. https://doi.org/10.3892/mmr.2022.12655
MLA
Wei, W., Wang, X., Wei, Y., Liu, S., Gao, S., Tian, H., Su, D."lncRNA TUG1 protects intestinal epithelial cells from damage induced by high glucose and high fat via AMPK/SIRT1". Molecular Medicine Reports 25.4 (2022): 139.
Chicago
Wei, W., Wang, X., Wei, Y., Liu, S., Gao, S., Tian, H., Su, D."lncRNA TUG1 protects intestinal epithelial cells from damage induced by high glucose and high fat via AMPK/SIRT1". Molecular Medicine Reports 25, no. 4 (2022): 139. https://doi.org/10.3892/mmr.2022.12655
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