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Lack of an association between SCFD1 rs10139154 polymorphism and amyotrophic lateral sclerosis

  • Authors:
    • Vasileios Siokas
    • Athina-Maria Aloizou
    • Ioannis Liampas
    • Christos Bakirtzis
    • Grigorios Nasios
    • Konstantinos Paterakis
    • Markos Sgantzos
    • Dimitrios P. Bogdanos
    • Demetrios A. Spandidos
    • Aristidis Tsatsakis
    • Panayiotis D. Mitsias
    • Efthimios Dardiotis
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Laboratory of Neurogenetics, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41100 Larissa, Greece, B' Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece, Department of Speech and Language Therapy, University of Ioannina, 45500 Ioannina, Greece, Department of Neurosurgery, University Hospital of Larissa, Medical School, University of Thessaly, 41100 Larissa, Greece, Department of Rheumatology and Clinical Immunology, University General Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41100 Larissa, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Laboratory of Toxicology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Department of Neurology, School of Medicine, University of Crete, 71003 Heraklion, Greece
    Copyright: © Siokas et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 146
    |
    Published online on: March 1, 2022
       https://doi.org/10.3892/mmr.2022.12662
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Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease. Through a genome‑wide association study (GWAS), the Sec1 family domain‑containing protein 1 (SCFD1) rs10139154 variant at 14q12 has emerged as a risk factor gene for ALS. Moreover, it has been reported to influence the age at onset (AAO) of patients with ALS. The aim of the present study was to assess the association of the SCFD1 rs10139154 polymorphism with the risk of developing ALS. For this purpose, 155 patients with sporadic ALS and 155 healthy controls were genotyped for the SCFD1 rs10139154. The effect of the SCFD1 rs10139154 polymorphism was then examined on the following parameters: i) The risk of developing ALS; ii) the AAO of ALS; iii) the site of ALS onset (patients with bulbar onset ALS vs. healthy controls; and patients with limb onset ALS vs. healthy controls); and iv) the AAO of ALS onset with subgroup analyses based on the site of onset (bulbar and limb, crude and adjusted for sex). The analysis of all the outcomes was performed assuming five genetic models. Crude and adjusted analyses were applied. The threshold for statistical significance was set at 0.05. The results revealed no association between SCFD1 rs10139154 and any of the examined phenotypes in any of the models examined. On the whole, based on the findings of the present study, SCFD1 rs10139154 does not appear to play a determining role in the risk of developing ALS.
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Copy and paste a formatted citation
Spandidos Publications style
Siokas V, Aloizou A, Liampas I, Bakirtzis C, Nasios G, Paterakis K, Sgantzos M, Bogdanos DP, Spandidos DA, Tsatsakis A, Tsatsakis A, et al: Lack of an association between SCFD1 rs10139154 polymorphism and amyotrophic lateral sclerosis. Mol Med Rep 25: 146, 2022.
APA
Siokas, V., Aloizou, A., Liampas, I., Bakirtzis, C., Nasios, G., Paterakis, K. ... Dardiotis, E. (2022). Lack of an association between SCFD1 rs10139154 polymorphism and amyotrophic lateral sclerosis. Molecular Medicine Reports, 25, 146. https://doi.org/10.3892/mmr.2022.12662
MLA
Siokas, V., Aloizou, A., Liampas, I., Bakirtzis, C., Nasios, G., Paterakis, K., Sgantzos, M., Bogdanos, D. P., Spandidos, D. A., Tsatsakis, A., Mitsias, P. D., Dardiotis, E."Lack of an association between SCFD1 rs10139154 polymorphism and amyotrophic lateral sclerosis". Molecular Medicine Reports 25.4 (2022): 146.
Chicago
Siokas, V., Aloizou, A., Liampas, I., Bakirtzis, C., Nasios, G., Paterakis, K., Sgantzos, M., Bogdanos, D. P., Spandidos, D. A., Tsatsakis, A., Mitsias, P. D., Dardiotis, E."Lack of an association between SCFD1 rs10139154 polymorphism and amyotrophic lateral sclerosis". Molecular Medicine Reports 25, no. 4 (2022): 146. https://doi.org/10.3892/mmr.2022.12662
Copy and paste a formatted citation
x
Spandidos Publications style
Siokas V, Aloizou A, Liampas I, Bakirtzis C, Nasios G, Paterakis K, Sgantzos M, Bogdanos DP, Spandidos DA, Tsatsakis A, Tsatsakis A, et al: Lack of an association between SCFD1 rs10139154 polymorphism and amyotrophic lateral sclerosis. Mol Med Rep 25: 146, 2022.
APA
Siokas, V., Aloizou, A., Liampas, I., Bakirtzis, C., Nasios, G., Paterakis, K. ... Dardiotis, E. (2022). Lack of an association between SCFD1 rs10139154 polymorphism and amyotrophic lateral sclerosis. Molecular Medicine Reports, 25, 146. https://doi.org/10.3892/mmr.2022.12662
MLA
Siokas, V., Aloizou, A., Liampas, I., Bakirtzis, C., Nasios, G., Paterakis, K., Sgantzos, M., Bogdanos, D. P., Spandidos, D. A., Tsatsakis, A., Mitsias, P. D., Dardiotis, E."Lack of an association between SCFD1 rs10139154 polymorphism and amyotrophic lateral sclerosis". Molecular Medicine Reports 25.4 (2022): 146.
Chicago
Siokas, V., Aloizou, A., Liampas, I., Bakirtzis, C., Nasios, G., Paterakis, K., Sgantzos, M., Bogdanos, D. P., Spandidos, D. A., Tsatsakis, A., Mitsias, P. D., Dardiotis, E."Lack of an association between SCFD1 rs10139154 polymorphism and amyotrophic lateral sclerosis". Molecular Medicine Reports 25, no. 4 (2022): 146. https://doi.org/10.3892/mmr.2022.12662
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