Potential clinical applications of alpha‑ketoglutaric acid in diseases (Review)

  • Authors:
    • Xingqi Meng
    • Huiqing Liu
    • Lixuan Peng
    • Weiguo He
    • Suyun Li
  • View Affiliations

  • Published online on: March 2, 2022     https://doi.org/10.3892/mmr.2022.12667
  • Article Number: 151
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Abstract

As an intermediate of the tricarboxylic acid cycle, also known as 2‑oxoglutarate, α‑ketoglutaric acid (AKG) plays an important role in maintaining physiological functions and cell metabolism. AKG is involved in both energy metabolism, and carbon and nitrogen metabolism; thus, exhibiting a variety of functions. Moreover, AKG plays an important role in various systems of the body. Results of previous research indicated that AKG may act as a regulator in the progression of a variety of diseases; thus, it exhibits potential as a novel drug for the clinical treatment of age‑related diseases. The present review aimed to summarize the latest research progress and potential clinical applications of AKG and provided novel directions and scope for future research.
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May-2022
Volume 25 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Meng X, Liu H, Peng L, He W and Li S: Potential clinical applications of alpha‑ketoglutaric acid in diseases (Review). Mol Med Rep 25: 151, 2022
APA
Meng, X., Liu, H., Peng, L., He, W., & Li, S. (2022). Potential clinical applications of alpha‑ketoglutaric acid in diseases (Review). Molecular Medicine Reports, 25, 151. https://doi.org/10.3892/mmr.2022.12667
MLA
Meng, X., Liu, H., Peng, L., He, W., Li, S."Potential clinical applications of alpha‑ketoglutaric acid in diseases (Review)". Molecular Medicine Reports 25.5 (2022): 151.
Chicago
Meng, X., Liu, H., Peng, L., He, W., Li, S."Potential clinical applications of alpha‑ketoglutaric acid in diseases (Review)". Molecular Medicine Reports 25, no. 5 (2022): 151. https://doi.org/10.3892/mmr.2022.12667