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Co‑expressed microRNAs, target genes and pathways related to metabolism, inflammation and endocrine function in individuals at risk for type 2 diabetes

  • Authors:
    • Elena Flowers
    • Kesava Asam
    • Isabel Elaine Allen
    • Alka M. Kanaya
    • Bradley E. Aouizerat
  • View Affiliations / Copyright

    Affiliations: Department of Physiological Nursing, University of California San Francisco, San Francisco, CA 94143‑0610, USA, Bluestone Center for Clinical Research, New York University, New York, NY 10010, USA, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94143‑0610, USA
    Copyright: © Flowers et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 156
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    Published online on: March 3, 2022
       https://doi.org/10.3892/mmr.2022.12672
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Abstract

MicroRNAs (miRNAs) may be considered important regulators of risk for type 2 diabetes (T2D). The aim of the present study was to identify novel sets of miRNAs associated with T2D risk, as well as their gene and pathway targets. Circulating miRNAs (n=59) were measured in plasma from participants in a previously completed clinical trial (n=82). An agnostic statistical approach was applied to identify novel sets of miRNAs with optimal co‑expression patterns. In silico analyses were used to identify the messenger RNA and biological pathway targets of the miRNAs within each factor. A total of three factors of miRNAs were identified, containing 18, seven and two miRNAs each. Eight biological pathways were revealed to contain genes targeted by the miRNAs in all three factors, 38 pathways contained genes targeted by the miRNAs in two factors, and 55, 18 and two pathways were targeted by the miRNAs in a single factor, respectively (all q<0.05). The pathways containing genes targeted by miRNAs in the largest factor shared a common theme of biological processes related to metabolism and inflammation. By contrast, the pathways containing genes targeted by miRNAs in the second largest factor were related to endocrine function and hormone activity. The present study focused on the pathways uniquely targeted by each factor of miRNAs in order to identify unique mechanisms that may be associated with a subset of individuals. Further exploration of the genes and pathways related to these biological themes may provide insights about the subtypes of T2D and lead to the identification of novel therapeutic targets.
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View References

1 

National Diabetes Statistics Report, . Centers for Diseaes Control and Prevention, U.S. Department of Health and Human Services; Atlanta, GA: 2017

2 

Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, et al: Finding the missing heritability of complex diseases. Nature. 461:747–753. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Xue A, Wu Y, Zhu Z, Zhang F, Kemper KE, Zheng Z, Yengo L, Lloyd-Jones LR, Sidorenko J, Wu Y, et al: Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. Nat Commun. 9:29412018. View Article : Google Scholar : PubMed/NCBI

4 

Bagchi D: Nutritional and therapeutic interventions for diabetes and metabolic syndrome. Elsevier; Waltham, MA: 2018

5 

Ahlqvist E, Storm P, Käräjämäki A, Martinell M, Dorkhan M, Carlsson A, Vikman P, Prasad RB, Aly DM, Almgren P, et al: Novel subgroups of adult-onset diabetes and their association with outcomes: A data-driven cluster analysis of six variables. Lancet Diabetes Endocrinol. 6:361–369. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Zou X, Zhou X, Zhu Z and Ji L: Novel subgroups of patients with adult-onset diabetes in Chinese and US populations. Lancet Diabetes Endocrinol. 7:9–11. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Anjana RM, Baskar V, Nair ATN, Jebarani S, Siddiqui MK, Pradeepa R, Unnikrishnan R, Palmer C, Pearson E and Mohan V: Novel subgroups of type 2 diabetes and their association with microvascular outcomes in an Asian Indian population: A data-driven cluster analysis: The INSPIRED study. BMJ Open Diabetes Res Care. 8:e0015062020. View Article : Google Scholar : PubMed/NCBI

8 

Herder C, Maalmi H, Strassburger K, Zaharia OP, Ratter JM, Karusheva Y, Elhadad MA, Bódis K, Bongaerts BWC, Rathmann W, et al: Differences in biomarkers of inflammation between novel subgroups of recent-onset diabetes. Diabetes. 70:1198–1208. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Hill-Briggs F, Adler NE, Berkowitz SA, Chin MH, Gary-Webb TL, Navas-Acien A, Thornton PL and Haire-Joshu D: Social determinants of health and diabetes: A scientific review. Diabetes Care. 44:258–279. 2020. View Article : Google Scholar : PubMed/NCBI

10 

Flowers E, Won GY and Fukuoka Y: MicroRNAs associated with exercise and diet: A systematic review. Physiol Genomics. 47:1–11. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Parr EB, Camera DM, Burke LM, Phillips SM, Coffey VG and Hawley JA: Circulating microRNA responses between ‘high’ and ‘low’ responders to a 16-Wk diet and exercise weight loss intervention. PLoS One. 11:e01525452016. View Article : Google Scholar : PubMed/NCBI

12 

Vaishya S, Sarwade RD and Seshadri V: MicroRNA, proteins, and metabolites as novel biomarkers for prediabetes, diabetes, and related complications. Front Endocrinol (Lausanne). 9:1802018. View Article : Google Scholar : PubMed/NCBI

13 

Flowers E, Allen IE, Kanaya AM and Aouizerat BE: Circulating microRNAs predict glycemic improvement and response to a behavioral intervention. Biomark Res. 9:652021. View Article : Google Scholar : PubMed/NCBI

14 

Flowers E, Aouizerat BE, Abbasi F, Lamendola C, Grove KM, Fukuoka Y and Reaven GM: Circulating microRNA-320a and microRNA-486 predict thiazolidinedione response: Moving towards precision health for diabetes prevention. Metabolism. 64:1051–1059. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Flowers E, Gadgil M, Aouizerat BE and Kanaya AM: Circulating micrornas associated with glycemic impairment and progression in Asian Indians. Biomark Res. 3:1–8. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Wang Y, Luo J, Zhang H and Lu J: MicroRNAs in the same clusters evolve to coordinately regulate functionally related genes. Mol Biol Evol. 33:2232–2247. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Zhu H and Leung SW: Identification of microRNA biomarkers in type 2 diabetes: A meta-analysis of controlled profiling studies. Diabetologia. 58:900–911. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Mononen N, Lyytikäinen LP, Seppälä I, Mishra PP, Juonala M, Waldenberger M, Klopp N, Illig T, Leiviskä J, Loo BM, et al: Whole blood microRNA levels associate with glycemic status and correlate with target mRNAs in pathways important to type 2 diabetes. Sci Rep. 9:88872019. View Article : Google Scholar : PubMed/NCBI

19 

Kanaya AM, Araneta MR, Pawlowsky SB, Barrett-Connor E, Grady D, Vittinghoff E, Schembri M, Chang A, Carrion-Petersen ML, Coggins T, et al: Restorative yoga and metabolic risk factors: the practicing restorative yoga vs. stretching for the metabolic syndrome (PRYSMS) randomized trial. J Diabetes Complications. 28:406–412. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr, et al: Harmonizing the metabolic syndrome: A joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; American heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity. Circulation. 120:1640–1645. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Friedewald WT, Levy RI and Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 18:499–502. 1972. View Article : Google Scholar : PubMed/NCBI

22 

Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A and Speleman F: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3:RESEARCH00342002. View Article : Google Scholar : PubMed/NCBI

23 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Dweep H, Sticht C, Pandey P and Gretz N: MiRWalk-database: Prediction of possible miRNA binding sites by ‘walking’ the genes of three genomes. J Biomed Inform. 44:839–847. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Benjamini Y and Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. J Royal Statistical Society. Series B (Methodological). 57:289–300. 1995. View Article : Google Scholar : PubMed/NCBI

26 

Common Metabolic Diseases Knowledge Portal. https://hugeamp.org/phenotype.html?phenotype=T2DMay 26–2021

27 

Sell H, Habich C and Eckel J: Adaptive immunity in obesity and insulin resistance. Nat Rev Endocrinol. 8:709–716. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Xiang W, Zhang B, Lv F, Feng G, Chen L, Yang F, Zhang K, Cao C, Wang P and Chu M: The potential regulatory mechanisms of the gonadotropin-releasing hormone in gonadotropin transcriptions identified with bioinformatics analyses. Reprod Biol Endocrinol. 15:462017. View Article : Google Scholar : PubMed/NCBI

29 

Johnson JL: Diabetes control in thyroid disease. Diabetes Spectrum. 19:148–153. 2006. View Article : Google Scholar

30 

Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, et al: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 42:105–116. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Esteghamati A, Alamdari A, Zandieh A, Elahi S, Khalilzadeh O, Nakhjavani M and Meysamie A: Serum visfatin is associated with type 2 diabetes mellitus independent of insulin resistance and obesity. Diabetes Res Clin Pract. 91:154–158. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Yu Y, Wang J, Kang R, Dong J, Zhang Y, Liu F, Yan Y, Zhu R, Xia L, Peng X, et al: Association of KCNB1 polymorphisms with lipid metabolisms and insulin resistance: A case-control design of population-based cross-sectional study in Chinese Han population. Lipids Health Dis. 14:1122015. View Article : Google Scholar : PubMed/NCBI

33 

Raum JC, Soleimanpour SA, Groff DN, Coré N, Fasano L, Garratt AN, Dai C, Powers AC and Stoffers DA: Tshz1 regulates pancreatic β-cell maturation. Diabetes. 64:2905–2914. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Fogarty MP, Panhuis TM, Vadlamudi S, Buchkovich ML and Mohlke KL: Allele-specific transcriptional activity at type 2 diabetes-associated single nucleotide polymorphisms in regions of pancreatic islet open chromatin at the JAZF1 locus. Diabetes. 62:1756–1762. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Adabi E, Omidfar A, Farahani NA, Faghihi F, Asghar Malek Hosseini SA, Maghbooli Z and Shirvani A: The association of LRP5 (rs556442) polymorphism with body composition and obesity in postmenopausal women. Diabetes Metab Syndr. 13:2381–2385. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Zhang L, Wang J, Zhang M, Wang G, Shen Y, Wu D, Wang C, Li L, Ren Y, Wang B, et al: Association of type 2 diabetes mellitus with the interaction between low-density lipoprotein receptor-related protein 5 (LRP5) polymorphisms and overweight and obesity in rural Chinese adults. J Diabetes. 9:994–1002. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Perry JR, Voight BF, Yengo L, Amin N, Dupuis J, Ganser M, Grallert H, Navarro P, Li M, Qi L, et al: Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet. 8:e10027412012. View Article : Google Scholar : PubMed/NCBI

38 

Manning AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, Rybin D, Liu CT, Bielak LF, Prokopenko I, et al: A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet. 44:659–669. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Gene (Internet), . National Library of Medicine (US). National Center for Biotechnology Information; Bethesda, MD: 1988

40 

Chang AM and Halter JB: Aging and insulin secretion. Am J Physiol Endocrinol Metab. 284:E7–E12. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Newgard CB and Pessin JE: Recent progress in metabolic signaling pathways regulating aging and life span. J Gerontol A Biol Sci Med Sci. 69 (Suppl 1):S21–S27. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Corezola do Amaral ME, Kravets V, Dwulet JM, Farnsworth NL, Piscopio R, Schleicher WE, Miranda JG and Benninger RK: Caloric restriction recovers impaired β-cell-β-cell gap junction coupling, calcium oscillation coordination, and insulin secretion in prediabetic mice. Am J Physiol Endocrinol Metab. 319:E709–E720. 2020. View Article : Google Scholar : PubMed/NCBI

43 

He XY, Zhao XL, Gu Q, Shen JP, Hu Y and Hu RM: Calorie restriction from a young age preserves the functions of pancreatic β cells in aging rats. Tohoku J Exp Med. 227:245–252. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Stienstra R, Haim Y, Riahi Y, Netea M, Rudich A and Leibowitz G: Autophagy in adipose tissue and the beta cell: Implications for obesity and diabetes. Diabetologia. 57:1505–1516. 2014. View Article : Google Scholar : PubMed/NCBI

45 

American Diabetes Association. 10. Cardiovascular disease, risk management, . Standards of medical care in diabetes-2021. Diabetes Care. 44 (Suppl 1):S125–S150. 2021. View Article : Google Scholar : PubMed/NCBI

46 

Condrat CE, Thompson DC, Barbu MG, Bugnar OL, Boboc A, Cretoiu D, Suciu N, Cretoiu SM and Voinea SC: miRNAs as biomarkers in disease: Latest findings regarding their role in diagnosis and prognosis. Cells. 9:2762020. View Article : Google Scholar : PubMed/NCBI

47 

Rupaimoole R and Slack FJ: MicroRNA therapeutics: Towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 16:203–222. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Flowers E, Asam K, Allen IE, Kanaya AM and Aouizerat BE: Co‑expressed microRNAs, target genes and pathways related to metabolism, inflammation and endocrine function in individuals at risk for type 2 diabetes. Mol Med Rep 25: 156, 2022.
APA
Flowers, E., Asam, K., Allen, I.E., Kanaya, A.M., & Aouizerat, B.E. (2022). Co‑expressed microRNAs, target genes and pathways related to metabolism, inflammation and endocrine function in individuals at risk for type 2 diabetes. Molecular Medicine Reports, 25, 156. https://doi.org/10.3892/mmr.2022.12672
MLA
Flowers, E., Asam, K., Allen, I. E., Kanaya, A. M., Aouizerat, B. E."Co‑expressed microRNAs, target genes and pathways related to metabolism, inflammation and endocrine function in individuals at risk for type 2 diabetes". Molecular Medicine Reports 25.5 (2022): 156.
Chicago
Flowers, E., Asam, K., Allen, I. E., Kanaya, A. M., Aouizerat, B. E."Co‑expressed microRNAs, target genes and pathways related to metabolism, inflammation and endocrine function in individuals at risk for type 2 diabetes". Molecular Medicine Reports 25, no. 5 (2022): 156. https://doi.org/10.3892/mmr.2022.12672
Copy and paste a formatted citation
x
Spandidos Publications style
Flowers E, Asam K, Allen IE, Kanaya AM and Aouizerat BE: Co‑expressed microRNAs, target genes and pathways related to metabolism, inflammation and endocrine function in individuals at risk for type 2 diabetes. Mol Med Rep 25: 156, 2022.
APA
Flowers, E., Asam, K., Allen, I.E., Kanaya, A.M., & Aouizerat, B.E. (2022). Co‑expressed microRNAs, target genes and pathways related to metabolism, inflammation and endocrine function in individuals at risk for type 2 diabetes. Molecular Medicine Reports, 25, 156. https://doi.org/10.3892/mmr.2022.12672
MLA
Flowers, E., Asam, K., Allen, I. E., Kanaya, A. M., Aouizerat, B. E."Co‑expressed microRNAs, target genes and pathways related to metabolism, inflammation and endocrine function in individuals at risk for type 2 diabetes". Molecular Medicine Reports 25.5 (2022): 156.
Chicago
Flowers, E., Asam, K., Allen, I. E., Kanaya, A. M., Aouizerat, B. E."Co‑expressed microRNAs, target genes and pathways related to metabolism, inflammation and endocrine function in individuals at risk for type 2 diabetes". Molecular Medicine Reports 25, no. 5 (2022): 156. https://doi.org/10.3892/mmr.2022.12672
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