Open Access

Τelomerase inhibitors and activators in aging and cancer: A systematic review

  • Authors:
    • Persefoni Fragkiadaki
    • Elisavet Renieri
    • Katerina Kalliantasi
    • Elisavet Kouvidi
    • Evita Apalaki
    • Elena Vakonaki
    • Charalampos Mamoulakis
    • Demetrios A. Spandidos
    • Aristidis Tsatsakis
  • View Affiliations

  • Published online on: March 8, 2022     https://doi.org/10.3892/mmr.2022.12674
  • Article Number: 158
  • Copyright: © Fragkiadaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The main aim of the present systematic review was to summarize the most frequently used telomerase regulators with an impact on aging and cancer that are referred to in in vitro and in vivo studies. For this purpose, a systematic review of the available literature on telomerase regulators referred to in articles from PubMed and Scopus libraries published from 2002 to 2021 and in accordance with PRISMA 2020 criteria, was conducted. Articles were included if they met the following criteria: They referred to telomerase modulators in aging and in cancer and were in vitro and/or in vivo studies, while studies that did not provide sufficient data or studies not written in English were excluded. In the present systematic review, 54 publications were included, of which 29 were full‑text published studies, 11 were full‑text reviews, 10 structure‑based design studies and 4 abstracts are reported in this review. Telomerase regulators were then categorized as synthetic direct telomerase inhibitors, synthetic indirect telomerase inhibitors, synthetic telomerase activators, natural direct telomerase activators, natural telomerase inhibitors and natural indirect telomerase activators, according to their origin and their activity. On the whole, as demonstrated herein, telomerase regulators appear to be promising treatment agents in various age‑related diseases. However, further in vivo and in vitro studies need to be performed in order to clarify the potentiality of telomerase as a therapeutic target.
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May-2022
Volume 25 Issue 5

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Spandidos Publications style
Fragkiadaki P, Renieri E, Kalliantasi K, Kouvidi E, Apalaki E, Vakonaki E, Mamoulakis C, Spandidos DA and Tsatsakis A: Τelomerase inhibitors and activators in aging and cancer: A systematic review. Mol Med Rep 25: 158, 2022
APA
Fragkiadaki, P., Renieri, E., Kalliantasi, K., Kouvidi, E., Apalaki, E., Vakonaki, E. ... Tsatsakis, A. (2022). Τelomerase inhibitors and activators in aging and cancer: A systematic review. Molecular Medicine Reports, 25, 158. https://doi.org/10.3892/mmr.2022.12674
MLA
Fragkiadaki, P., Renieri, E., Kalliantasi, K., Kouvidi, E., Apalaki, E., Vakonaki, E., Mamoulakis, C., Spandidos, D. A., Tsatsakis, A."Τelomerase inhibitors and activators in aging and cancer: A systematic review". Molecular Medicine Reports 25.5 (2022): 158.
Chicago
Fragkiadaki, P., Renieri, E., Kalliantasi, K., Kouvidi, E., Apalaki, E., Vakonaki, E., Mamoulakis, C., Spandidos, D. A., Tsatsakis, A."Τelomerase inhibitors and activators in aging and cancer: A systematic review". Molecular Medicine Reports 25, no. 5 (2022): 158. https://doi.org/10.3892/mmr.2022.12674