[Corrigendum] Type II cGMP‑dependent protein kinase inhibits the migration, invasion and proliferation of several types of human cancer cells

Wu,Min; Wu,Yan; Qian,Hai; Tao,Yan; Pang,Ji; Wang,Ying; Chen,Yongchang

doi:10.3892/mmr.2022.12679

May-2022 Volume 25 Issue 5

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

May-2022 Volume 25 Issue 5

Full Size Image

Correction Open Access

[Corrigendum] Type II cGMP‑dependent protein kinase inhibits the migration, invasion and proliferation of several types of human cancer cells

Authors:
- Min Wu
- Yan Wu
- Hai Qian
- Yan Tao
- Ji Pang
- Ying Wang
- Yongchang Chen
View Affiliations / Copyright

Affiliations: Department of Physiology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China

Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 163
|
Published online on: March 14, 2022

https://doi.org/10.3892/mmr.2022.12679
Expand metrics +

Article

Mol Med Rep 16: [Related article:] 5729–5737, 2017; DOI: 10.3892/mmr.2017.7290

Subsequently to the publication of this paper, an interested reader drew to the authors’ attention that Figs. 3 (showing how PKG II overexpression inhibits the migration of various types of cancer cells) and 6 (showing representative photomicrographs of apoptotic cells under different experimental conditions at ×200 magnification) contained apparently duplicated data panels within the figures. After having examined their original data, the authors have realized that these figures were inadvertently assembled incorrectly; specifically, the data shown in the HepG2-Ad-LacZ+EGF and OS-RC-2-Ad-LacZ+EGF panels in Fig. 3A and the HepG2-Ad-LacZ+cGMP+EGF, OS-RC-2-Ad-PKGII+cGMP+EGF and U251-Ad-PKGII+cGMP+EGF panels in Fig. 6A were selected incorrectly.

Figure 3.

PKG II overexpression inhibits cancer cell migration. The migratory capabilities of human A549 lung, HepG2 hepatic, OS-RC-2 renal, SW480 colon cancer and U251 glioma cells were examined using a Transwell assay. Cells were infected with Ad-LacZ or Ad-PKG II for 36 h, serum-starved overnight, stimulated with 8-pCPT-cGMP (250 µΜ) and EGF (100 ng/ml), and cell migration was analyzed after 12 h. (A) Representative photomicrographs of migrated cells following Giemsa staining (magnification, 50×). (B) The number of migrated cells in the various treatment groups. Data are presented as the mean ± standard deviation of 3 independent experiments. *P<0.05, comparison between groups as indicated by lines. PKG II, cGMP-dependent protein kinase type II; Ad-LacZ, adenoviral vector containing the β-galactosidase gene; Ad-PKG II, adenoviral vector containing the PKG II gene; 8-pCPT-cGMP, 8-(4-chlorophenylthio)-cGMP; cGMP, cyclic guanosine monophosphate; EGF, epidermal growth factor.

Figure 6.

PKG II overexpression counteracts the anti-apoptotic effects of EGF. A terminal deoxynucleotidyl transferase 2’-deoxyuridine, 5’-triphosphate nick-end labeling assay was performed to detect apoptotic cells among human A549 lung, HepG2 hepatic, OS-RC-2 renal, SW480 colon cancer and U251 glioma cells. (A) Representative photomicrographs of apoptotic cells under ×200 magnification. (B) The percentage of apoptotic cells/field of view in the various treatment groups. Data are expressed as the mean ± standard deviation of 3 independent experiments. *P<0.05, comparison between groups as indicated by lines. PKG II, cGMP-dependent protein kinase type II; EGF, epidermal growth factor; Ad-LacZ, adenoviral vector containing the β-galactosidase gene; Ad-PKG II, adenoviral vector containing the PKG II gene; cGMP, cyclic guanosine monophosphate.

The corrected versions of Figs. 3 and 6 are shown on the next two pages. Note that these errors did not significantly affect the results or the conclusions reported in this paper, and all the authors agree to this Corrigendum. The authors are grateful to the Editor of Molecular Medicine Reports for allowing them the opportunity to publish this and apologize to the readership for any inconvenience caused.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

[Corrigendum] Type II cGMP‑dependent protein kinase inhibits the migration, invasion and proliferation of several types of human cancer cells

This article is mentioned in:

Article

Figure 3.

Figure 6.

Related Articles