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Sigma‑1 receptor overexpression promotes proliferation and ameliorates cell apoptosis in β‑cells

  • Authors:
    • Mengting Ke
    • Fengping Lin
    • Huawei Wang
    • Guangzhen He
    • Jieyuan Feng
    • Linyang Song
    • Yancheng Xu
    • Jie Liu
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Endocrinology, Xianning Central Hospital, Xianning, Hubei 437100, P.R. China, Department of Pediatrics, Affiliated Taihe Hospital of Hubei University of Medicine, Shiyan, Hubei 442002, P.R. China
    Copyright: © Ke et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 170
    |
    Published online on: March 17, 2022
       https://doi.org/10.3892/mmr.2022.12686
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Abstract

Sigma‑1 receptor (Sig‑1R) is a class of orphan receptors, the potential role of which in pancreatic islet cells remains poorly understood. The present study aimed to investigate the role of Sig‑1R in islet β‑cell proliferation and examine the effects of Sig‑1R on islet β‑cell injury under lipotoxic conditions. Sig‑1R‑overexpressing MIN6 cells were generated by lentiviral vector transfection. The effect of Sig‑1R overexpression on cell proliferation detected by EdU staining, cell cycle progression by propidium iodide (PI), apoptosis by Annexin V‑APC/PI, mitochondrial membrane potential by Mitolite Red and cytoplasmic Ca2+ levelsby Fura‑2/AM in islet β‑cells were measured by flow cytometry. Western blot analysis was used to measure protein expression levels of endoplasmic reticulum (ER) stress markers glucose‑regulated protein 78 and C/EBP homologous protein, mitochondrial apoptotic proteins Bcl‑2‑associated X and Bcl‑2 and cytochrome c. In addition, ATP levels and insulin secretion were separately measured using ATP Assay and mouse insulin ELISA. Mitochondria‑associated ER membrane (MAM) structures in MIN6 cells were then detected using transmission electron microscopy. Protein disulfide isomerase expression and possible colocalization between inositol 1,4,5‑trisphosphate receptor and voltage‑dependent anion channel 1 were examined using immunofluorescence. Sig‑1R overexpression was found to promote β‑cell proliferation by accelerating cell cycle progression. Furthermore, Sig‑1R overexpression ameliorated the apoptosis rate whilst impairing insulin secretion induced by palmitic acid by relieving ER stress and mitochondrial dysfunction in MIN6 cells. Sig‑1R overexpression also promoted Ca2+ transport between mitochondria and ER by increasing the quantity of ER adjacent to mitochondria in the 50‑nm range. It was concluded that Sig‑1R overexpression conferred protective effects on β‑cells against lipotoxicity as a result of the promotion of cell proliferation and inhibition of ER stress and oxidative stress, by regulating the structure of MAM.
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1 

Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L, Motala AA, Ogurtsova K, et al: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the international diabetes federation diabetes Atlas. (9th edition). Diabetes Res Clin Pract. 157:1078432019. View Article : Google Scholar : PubMed/NCBI

2 

International Diabetes Federation: IDF Diabetes Atlas (9th edition). 2019.

3 

Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA and Butler PC: Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes. 52:102–110. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Ramachandran S, Lu H, Prabhu U and Ruoho AE: Purification and characterization of the guinea pig sigma-1 receptor functionally expressed in Escherichia coli. Protein Expr Purif. 51:283–292. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Hanner M, Moebius FF, Flandorfer A, Knaus HG, Striessnig J, Kempner E and Glossmann H: Purification, molecular cloning, and expression of the mammalian sigma1-binding site. Proc Natl Acad Sci USA. 93:8072–8077. 1996. View Article : Google Scholar : PubMed/NCBI

6 

Penke B, Fulop L, Szucs M and Frecska E: The role of sigma-1 receptor, an intracellular chaperone in neurodegenerative diseases. Curr Neuropharmacol. 16:97–116. 2018.PubMed/NCBI

7 

Maurice T, Strehaiano M, Duhr F and Chevallier N: Amyloid toxicity is enhanced after pharmacological or genetic invalidation of the σ1 receptor. Behav Brain Res. 339:1–10. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Jia H, Zhang Y and Huang Y: Imaging sigma receptors in the brain: New opportunities for diagnosis of Alzheimer's disease and therapeutic development. Neurosci Lett. 691:3–10. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Wang L, Prescott AR, Spruce BA, Sanderson J and Duncan G: Sigma receptor antagonists inhibit human lens cell growth and induce pigmentation. Invest Ophthalmol Vis Sci. 46:1403–1408. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Bucolo C, Drago F, Lin LR and Reddy VN: Sigma receptor ligands protect human retinal cells against oxidative stress. Neuroreport. 17:287–291. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Morihara R, Yamashita T, Liu X, Nakano Y, Fukui Y, Sato K, Ohta Y, Hishikawa N, Shang J and Abe K: Protective effect of a novel sigma-1 receptor agonist is associated with reduced endoplasmic reticulum stress in stroke male mice. J Neurosci Res. 96:1707–1716. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Omi T, Tanimukai H, Kanayama D, Sakagami Y, Tagami S, Okochi M, Morihara T, Sato M, Yanagida K, Kitasyoji A, et al: Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor. Cell Death Dis. 5:e13322014. View Article : Google Scholar : PubMed/NCBI

13 

Demirtas L, Guclu A, Erdur FM, Akbas EM, Ozcicek A, Onk D and Turkmen K: Apoptosis, autophagy & endoplasmic reticulum stress in diabetes mellitus. Indian J Med Res. 144:515–524. 2016.PubMed/NCBI

14 

Eizirik DL, Pasquali L and Cnop M: Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure. Nat Rev Endocrinol. 16:349–362. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Shi X, Deng H, Dai Z, Xu Y, Xiong X, Ma P and Cheng J: Nr2e1 deficiency augments palmitate-induced oxidative stress in beta cells. Oxid Med Cell Longev. 2016:96487692016. View Article : Google Scholar : PubMed/NCBI

17 

Dingreville F, Panthu B, Thivolet C, Ducreux S, Gouriou Y, Pesenti S, Chauvin MA, Chikh K, Errazuriz-Cerda E, Van Coppenolle F, et al: Differential effect of glucose on ER-Mitochondria Ca2+ exchange participates in insulin secretion and glucotoxicity-mediated dysfunction of β-cells. Diabetes. 68:1778–1794. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Hetz C and Papa FR: The unfolded protein response and cell fate control. Mol Cell. 69:169–181. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Baehr LM, West DW, Marcotte G, Marshall AG, De Sousa LG, Baar K and Bodine SC: Age-related deficits in skeletal muscle recovery following disuse are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis. Aging (Albany NY). 8:127–146. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Bâ A: Alcohol and thiamine deficiency trigger differential mitochondrial transition pore opening mediating cellular death. Apoptosis. 22:741–752. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Filadi R, Theurey P and Pizzo P: The endoplasmic reticulum-mitochondria coupling in health and disease: Molecules, functions and significance. Cell Calcium. 62:1–15. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Sasi USS, Ganapathy S, Palayyan SR and Gopal RK: Mitochondria associated membranes (MAMs): Emerging drug targets for diabetes. Curr Med Chem. 27:3362–3385. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Kim FJ: Introduction to Sigma proteins: Evolution of the concept of Sigma receptors. Handb Exp Pharmacol. 244:1–11. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Alenzi FQ: Links between apoptosis, proliferation and the cell cycle. Br J Biomed Sci. 61:99–102. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Ojo OO, Srinivasan DK, Owolabi BO, Conlon JM, Flatt PR and Abdel-Wahab YH: Magainin-AM2 improves glucose homeostasis and beta cell function in high-fat fed mice. Biochim Biophys Acta. 1850:80–87. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Cnop M, Abdulkarim B, Bottu G, Cunha DA, Igoillo-Esteve M, Masini M, Turatsinze JV, Griebel T, Villate O, Santin I, et al: RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate. Diabetes. 63:1978–1993. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Zhai M, Liu C, Li Y, Zhang P, Yu Z, Zhu H, Zhang L, Zhang Q and Wang J and Wang J: Dexmedetomidine inhibits neuronal apoptosis by inducing Sigma-1 receptor signaling in cerebral ischemia-reperfusion injury. Aging (Albany NY). 11:9556–9568. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Shinoda Y, Haga Y, Akagawa K and Fukunaga K: Wildtype σ1 receptor and the receptor agonist improve ALS-associated mutation-induced insolubility and toxicity. J Biol Chem. 295:17573–17587. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Rutter GA and Pinton P: Mitochondria-associated endoplasmic reticulum membranes in insulin signaling. Diabetes. 63:3163–3165. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Ono Y, Tanaka H, Tsuruma K, Shimazawa M and Hara H: A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells. Biochem Biophys Res Commun. 434:904–909. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Zhong S, Ye W, Lin SH, Liu JY, Leong J, Ma C and Lin YC: Zeranol induces cell proliferation and protein disulfide isomerase expression in mammary gland of ACI rat. Anticancer Res. 31:1659–1665. 2011.PubMed/NCBI

32 

Smith SB, Wang J, Cui X, Mysona BA, Zhao J and Bollinger KE: Sigma 1 receptor: A novel therapeutic target in retinal disease. Prog Retin Eye Res. 67:130–149. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Shioda N, Ishikawa K, Tagashira H, Ishizuka T, Yawo H and Fukunaga K: Expression of a truncated form of the endoplasmic reticulum chaperone protein, σ1 receptor, promotes mitochondrial energy depletion and apoptosis. J Biol Chem. 287:23318–23331. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Tagashira H, Bhuiyan MS and Fukunaga K: Diverse regulation of IP3 and ryanodine receptors by pentazocine through σ1-receptor in cardiomyocytes. Am J Physiol Heart Circ Physiol. 305:H1201–H1212. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Marchi S, Patergnani S and Pinton P: The endoplasmic reticulum-mitochondria connection: one touch, multiple functions. Biochim Biophys Acta. 1837:461–469. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Hedskog L, Pinho CM, Filadi R, Rönnbäck A, Hertwig L, Wiehager B, Larssen P, Gellhaar S, Sandebring A, Westerlund M, et al: Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models. Proc Natl Acad Sci USA. 110:7916–7921. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Rückl M, Parker I, Marchant JS, Nagaiah C, Johenning FW and Rüdiger S: Modulation of elementary calcium release mediates a transition from puffs to waves in an IP3R cluster model. PLoS Comput Biol. 11:e10039652015. View Article : Google Scholar : PubMed/NCBI

38 

Janikiewicz J, Szymański J, Malinska D, Patalas-Krawczyk P, Michalska B, Duszyński J, Giorgi C, Bonora M, Dobrzyn A and Wieckowski MR: Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics. Cell Death Dis. 9:3322018. View Article : Google Scholar : PubMed/NCBI

39 

Kerkhofs M, Bultynck G, Vervliet T and Monaco G: Therapeutic implications of novel peptides targeting ER-mitochondria Ca2+-flux systems. Drug Discov Today. 24:1092–1103. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Bravo R, Vicencio JM, Parra V, Troncoso R, Munoz JP, Bui M, Quiroga C, Rodriguez AE, Verdejo HE, Ferreira J, et al: Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. J Cell Sci. 124:2143–2152. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Hayashi T: The Sigma-1 receptor in cellular stress signaling. Front Neurosci. 13:7332019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ke M, Lin F, Wang H, He G, Feng J, Song L, Xu Y and Liu J: Sigma‑1 receptor overexpression promotes proliferation and ameliorates cell apoptosis in β‑cells. Mol Med Rep 25: 170, 2022.
APA
Ke, M., Lin, F., Wang, H., He, G., Feng, J., Song, L. ... Liu, J. (2022). Sigma‑1 receptor overexpression promotes proliferation and ameliorates cell apoptosis in β‑cells. Molecular Medicine Reports, 25, 170. https://doi.org/10.3892/mmr.2022.12686
MLA
Ke, M., Lin, F., Wang, H., He, G., Feng, J., Song, L., Xu, Y., Liu, J."Sigma‑1 receptor overexpression promotes proliferation and ameliorates cell apoptosis in β‑cells". Molecular Medicine Reports 25.5 (2022): 170.
Chicago
Ke, M., Lin, F., Wang, H., He, G., Feng, J., Song, L., Xu, Y., Liu, J."Sigma‑1 receptor overexpression promotes proliferation and ameliorates cell apoptosis in β‑cells". Molecular Medicine Reports 25, no. 5 (2022): 170. https://doi.org/10.3892/mmr.2022.12686
Copy and paste a formatted citation
x
Spandidos Publications style
Ke M, Lin F, Wang H, He G, Feng J, Song L, Xu Y and Liu J: Sigma‑1 receptor overexpression promotes proliferation and ameliorates cell apoptosis in β‑cells. Mol Med Rep 25: 170, 2022.
APA
Ke, M., Lin, F., Wang, H., He, G., Feng, J., Song, L. ... Liu, J. (2022). Sigma‑1 receptor overexpression promotes proliferation and ameliorates cell apoptosis in β‑cells. Molecular Medicine Reports, 25, 170. https://doi.org/10.3892/mmr.2022.12686
MLA
Ke, M., Lin, F., Wang, H., He, G., Feng, J., Song, L., Xu, Y., Liu, J."Sigma‑1 receptor overexpression promotes proliferation and ameliorates cell apoptosis in β‑cells". Molecular Medicine Reports 25.5 (2022): 170.
Chicago
Ke, M., Lin, F., Wang, H., He, G., Feng, J., Song, L., Xu, Y., Liu, J."Sigma‑1 receptor overexpression promotes proliferation and ameliorates cell apoptosis in β‑cells". Molecular Medicine Reports 25, no. 5 (2022): 170. https://doi.org/10.3892/mmr.2022.12686
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