Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2022 Volume 25 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2022 Volume 25 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Long non‑coding RNA MALAT1 is involved in retinal pigment epithelial cell damage caused by high glucose treatment

  • Authors:
    • Xinli Jiang
    • Yan Liu
    • Yuling Wang
    • Yaru Zhou
    • Huipeng Miao
    • Peng Zhang
    • Jingxue Ma
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China, Department of Endocrinology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China, Department of Neurology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China, Department of Ophthalmology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China
  • Article Number: 177
    |
    Published online on: March 21, 2022
       https://doi.org/10.3892/mmr.2022.12693
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to explore the role of long non‑coding RNA metastasis associated lung adenocarcinoma transcript 1 (lncRNA MALAT1) in high glucose (HG)‑induced ARPE‑19 cell damage. ARPE‑19 cells were cultured and treated with HG (25 mmol/l glucose). MALAT1 expression was silenced following transfection of small interfering RNA. Cell apoptosis was measured using flow cytometry. The cellular levels of reactive oxygen species (ROS), malondialdehyde and superoxide dismutase activity were all measured to examine oxidative stress. Gene expression levels of MALAT1 were determined by reverse transcription‑quantitative (RT‑q)PCR, while expression of tumor necrosis factor (TNF)‑α, monocyte chemotactic protein 1 (MCP‑1), intercellular cell adhesion molecule 1 (ICAM‑1) and vascular endothelial growth factor (VEGF) was detected using RT‑qPCR and western blotting. MALAT1 expression was markedly increased in ARPE‑19 cells treated with HG. HG treatment caused increased apoptosis and elevated ROS‑induced stress in ARPE‑19 cells and these effects could be partly attenuated by MALAT1 knockdown. Increased gene expression levels of TNF‑α, MCP‑1, ICAM‑1 and VEGF induced by HG were also alleviated by MALAT1 inhibition. Therefore, lncRNA MALAT1 is the key factor in ARPE‑19 cell damage caused by HG and may be a promising therapeutic target for clinical DR therapy. However, further studies are still required to reveal the detailed mechanisms underlying lncRNA MALAT1 function.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Wong TY, Cheung CM, Larsen M, Sharma S and Simó R: Diabetic retinopathy. Nat Rev Dis Primers. 2:160122016. View Article : Google Scholar : PubMed/NCBI

2 

Saaddine JB, Honeycutt AA, Narayan KM, Zhang X, Klein R and Boyle JP: Projection of diabetic retinopathy and other major eye diseases among people with diabetes mellitus: United States, 2005-2050. Arch Ophthalmol. 126:1740–1747. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Mazhar K, Varma R, Choudhury F, McKean-Cowdin R, Shtir CJ and Azen SP; Los Angeles Latino Eye Study Group, : Severity of diabetic retinopathy and health-related quality of life: The Los Angeles latino eye study. Ophthalmology. 118:649–655. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Amadio M, Pascale A, Cupri S, Pignatello R, Osera C, D'Agata V, D'Amico AG, Leggio GM, Ruozi B, Govoni S, et al: Nanosystems based on siRNA silencing HuR expression counteract diabetic retinopathy in rat. Pharmacol Res. 111:713–720. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Xu HZ and Le YZ: Significance of outer blood-retina barrier breakdown in diabetes and ischemia. Invest Ophthalmol Vis Sci. 52:2160–2164. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Tarchick MJ, Bassiri P, Rohwer RM and Samuels IS: Early functional and morphologic abnormalities in the diabetic nyxnob mouse retina. Invest Ophthalmol Vis Sci. 57:3496–3508. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Simó R, Villarroel M, Corraliza L, Hernández C and Garcia-Ramírez M: The retinal pigment epithelium: Something more than a constituent of the blood-retinal barrier-implications for the pathogenesis of diabetic retinopathy. J Biomed Biotechnol. 2010:1907242010. View Article : Google Scholar : PubMed/NCBI

8 

Li H, Li R, Wang L, Liao D, Zhang W and Wang J: Proanthocyanidins attenuate the high glucose-induced damage of retinal pigment epithelial cells by attenuating oxidative stress and inhibiting activation of the NLRP3 inflammasome. J Biochem Mol Toxicol. 35:e228452021. View Article : Google Scholar : PubMed/NCBI

9 

Li W and Xiao H: Dihydromyricetin alleviates high glucose-induced oxidative stress and apoptosis in human retinal pigment epithelial cells by downregulating miR-34a expression. Diabetes Metab Syndr Obes. 14:387–397. 2021. View Article : Google Scholar : PubMed/NCBI

10 

Xiao H and Liu Z: Effects of microRNA-217 on high glucose-induced inflammation and apoptosis of human retinal pigment epithelial cells (ARPE-19) and its underlying mechanism. Mol Med Rep. 20:5125–5133. 2019.PubMed/NCBI

11 

Kim DI, Park MJ, Lim SK, Choi JH, Kim JC, Han HJ, Kundu TK, Park JI, Yoon KC, Park SW, et al: High-glucose-induced CARM1 expression regulates apoptosis of human retinal pigment epithelial cells via histone 3 arginine 17 dimethylation: Role in diabetic retinopathy. Arch Biochem Biophys. 560:36–43. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Yin L, Sun Z, Ren Q, Su X and Zhang D: Long non-coding RNA BANCR is overexpressed in patients with diabetic retinopathy and promotes apoptosis of retinal pigment epithelial cells. Med Sci Monit. 25:2845–2851. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Kutty RK, Samuel W, Duncan T, Postnikova O, Jaworski C, Nagineni CN and Redmond TM: Proinflammatory cytokine interferon-γ increases the expression of BANCR, a long non-coding RNA, in retinal pigment epithelial cells. Cytokine. 104:147–150. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Yang J, Yang K, Meng X, Liu P, Fu Y and Wang Y: Silenced SNHG1 inhibited epithelial-mesenchymal transition and inflammatory response of ARPE-19 cells induced by high glucose. J Inflamm Res. 14:1563–1573. 2021. View Article : Google Scholar : PubMed/NCBI

15 

Zhang X, Hamblin MH and Yin KJ: The long noncoding RNA Malat1: Its physiological and pathophysiological functions. RNA Biol. 14:1705–1714. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Biswas S, Thomas AA, Chen S, Aref-Eshghi E, Feng B, Gonder J, Sadikovic B and Chakrabarti S: MALAT1: An epigenetic regulator of inflammation in diabetic retinopathy. Sci Rep. 8:65262018. View Article : Google Scholar : PubMed/NCBI

17 

Radhakrishnan R and Kowluru RA: Long noncoding RNA MALAT1 and regulation of the antioxidant defense system in diabetic retinopathy. Diabetes. 70:227–239. 2021. View Article : Google Scholar : PubMed/NCBI

18 

Huang K, Yu X, Yu Y, Zhang L, Cen Y and Chu J: Long noncoding RNA MALAT1 promotes high glucose-induced inflammation and apoptosis of vascular endothelial cells by regulating miR-361-3p/SOCS3 axis. Int J Clin Exp Pathol. 13:1243–1252. 2020.PubMed/NCBI

19 

Gong W, Zhu G, Li J and Yang X: LncRNA MALAT1 promotes the apoptosis and oxidative stress of human lens epithelial cells via p38MAPK pathway in diabetic cataract. Diabetes Res Clin Pract. 144:314–321. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Jiang Z, Zeng Q, Li D, Ding L, Lu W, Bian M and Wu J: Long non-coding RNA MALAT1 promotes high glucose-induced rat cartilage endplate cell apoptosis via the p38/MAPK signalling pathway. Mol Med Rep. 21:2220–2226. 2020.PubMed/NCBI

21 

Zhao X, Wang J, Li P, Tang L and Bai Y: Casein kinase 2-interacting protein-1 alleviates high glucose-reduced autophagy, oxidative stress, and apoptosis in retinal pigment epithelial cells via activating the p62/KEAP1/NRF2 signaling pathway. J Ophthalmol. 2021:66940502021. View Article : Google Scholar : PubMed/NCBI

22 

Li T, Niu L, Li M, Liu Y, Xu Z, Gao X and Liu D: Effects of small interfering RNA-mediated downregulation of the Krüppel-like factor 4 gene on collagen metabolism in human hepatic stellate cells. Mol Med Rep. 12:3972–3978. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Ho E, Karimi Galougahi K, Liu CC, Bhindi R and Figtree GA: Biological markers of oxidative stress: Applications to cardiovascular research and practice. Redox Biol. 1:483–491. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Fu SH, Lai MC, Zheng YY, Sun YW, Qiu JJ, Gui F, Zhang Q and Liu F: MiR-195 inhibits the ubiquitination and degradation of YY1 by Smurf2, and induces EMT and cell permeability of retinal pigment epithelial cells. Cell Death Dis. 12:7082021. View Article : Google Scholar : PubMed/NCBI

26 

Tong P, Peng QH, Gu LM, Xie WW and Li WJ: LncRNA-MEG3 alleviates high glucose induced inflammation and apoptosis of retina epithelial cells via regulating miR-34a/SIRT1 axis. Exp Mol Pathol. 107:102–109. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Dong Y, Wan G, Peng G, Yan P, Qian C and Li F: Long non-coding RNA XIST regulates hyperglycemia-associated apoptosis and migration in human retinal pigment epithelial cells. Biomed Pharmacother. 125:1099592020. View Article : Google Scholar : PubMed/NCBI

28 

Yu X, Luo Y, Chen G, Liu H, Tian N, Zen X and Liu Q: Long noncoding RNA IGF2AS regulates high-glucose induced apoptosis in human retinal pigment epithelial cells. IUBMB Life. 71:1611–1618. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Ji P, Diederichs S, Wang W, Böing S, Metzger R, Schneider PM, Tidow N, Brandt B, Buerger H, Bulk E, et al: MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene. 22:8031–8041. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Lei L, Chen J, Huang J, Lu J, Pei S, Ding S, Kang L, Xiao R and Zeng Q: Functions and regulatory mechanisms of metastasis-associated lung adenocarcinoma transcript 1. J Cell Physiol. 234:134–151. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Abdulle LE, Hao JL, Pant OP, Liu XF, Zhou DD, Gao Y, Suwal A and Lu CW: MALAT1 as a diagnostic and therapeutic target in diabetes-related complications: A promising long-noncoding RNA. Int J Med Sci. 16:548–555. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Yan B, Tao ZF, Li XM, Zhang H, Yao J and Jiang Q: Aberrant expression of long noncoding RNAs in early diabetic retinopathy. Invest Ophthalmol Vis Sci. 55:941–951. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Liu JY, Yao J, Li XM, Song YC, Wang XQ, Li YJ, Yan B and Jiang Q: Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus. Cell Death Dis. 5:e15062014. View Article : Google Scholar : PubMed/NCBI

34 

Puthanveetil P, Chen S, Feng B, Gautam A and Chakrabarti S: Long non-coding RNA MALAT1 regulates hyperglycaemia induced inflammatory process in the endothelial cells. J Cell Mol Med. 19:1418–1425. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Postnikova OA, Rogozin IB, Samuel W, Nudelman G, Babenko VN, Poliakov E and Redmond TM: Volatile evolution of long non-coding RNA repertoire in retinal pigment epithelium: Insights from comparison of bovine and human RNA expression profiles. Genes (Basel). 10:2052019. View Article : Google Scholar : PubMed/NCBI

36 

Zhou RM, Wang XQ, Yao J, Shen Y, Chen SN, Yang H, Jiang Q and Yan B: Identification and characterization of proliferative retinopathy-related long noncoding RNAs. Biochem Biophys Res Commun. 465:324–330. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Yang S, Yao H, Li M, Li H and Wang F: Long non-coding RNA MALAT1 mediates transforming growth factor beta1-induced epithelial-mesenchymal transition of retinal pigment epithelial cells. PLoS One. 11:e01526872016. View Article : Google Scholar : PubMed/NCBI

38 

Wu MY, Yiang GT, Lai TT and Li CJ: The oxidative stress and mitochondrial dysfunction during the pathogenesis of diabetic retinopathy. Oxid Med Cell Longev. 2018:34201872018. View Article : Google Scholar : PubMed/NCBI

39 

Yang Q, Li S, Zhou Z, Fu M, Yang X, Hao K and Liu Y: HDAC6 inhibitor Cay10603 inhibits high glucose-induced oxidative stress, inflammation and apoptosis in retinal pigment epithelial cells via regulating NF-κB and NLRP3 inflammasome pathway. Gen Physiol Biophys. 39:169–177. 2020. View Article : Google Scholar : PubMed/NCBI

40 

Li F, Li X, Qiao L, Liu W, Xu C and Wang X: MALAT1 regulates miR-34a expression in melanoma cells. Cell Death Dis. 10:3892019. View Article : Google Scholar : PubMed/NCBI

41 

Song Y, Yang L, Guo R, Lu N, Shi Y and Wang X: Long noncoding RNA MALAT1 promotes high glucose-induced human endothelial cells pyroptosis by affecting NLRP3 expression through competitively binding miR-22. Biochem Biophys Res Commun. 509:359–366. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Maugeri G, Bucolo C, Drago F, Rossi S, Di Rosa M, Imbesi R, D'Agata V and Giunta S: Attenuation of high glucose-induced damage in RPE cells through p38 MAPK signaling pathway inhibition. Front Pharmacol. 12:6846802021. View Article : Google Scholar : PubMed/NCBI

43 

Zhang Y, Xi X, Mei Y, Zhao X, Zhou L, Ma M, Liu S, Zha X and Yang Y: High-glucose induces retinal pigment epithelium mitochondrial pathways of apoptosis and inhibits mitophagy by regulating ROS/PINK1/Parkin signal pathway. Biomed Pharmacother. 111:1315–1325. 2019. View Article : Google Scholar : PubMed/NCBI

44 

Gordon AD, Biswas S, Feng B and Chakrabarti S: MALAT1: A regulator of inflammatory cytokines in diabetic complications. Endocrinol Diabetes Metab. 1:e000102018. View Article : Google Scholar : PubMed/NCBI

45 

Gong YP, Zhang YW, Su XQ and Gao HB: Inhibition of long noncoding RNA MALAT1 suppresses high glucose-induced apoptosis and inflammation in human umbilical vein endothelial cells by suppressing the NF-κB signaling pathway. Biochem Cell Biol. 98:669–675. 2020. View Article : Google Scholar : PubMed/NCBI

46 

Chen X, Han R, Hao P, Wang L, Liu M, Jin M, Kong D and Li X: Nepetin inhibits IL-1β induced inflammation via NF-κB and MAPKs signaling pathways in ARPE-19 cells. Biomed Pharmacother. 101:87–93. 2018. View Article : Google Scholar : PubMed/NCBI

47 

Zhang J, Zhou K, Zhang X, Zhou Y, Li Z and Shang F: Celastrol ameliorates inflammation in human retinal pigment epithelial cells by suppressing NF-κB signaling. J Ocul Pharmacol Ther. 35:116–123. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Sant DW, Camarena V, Mustafi S, Li Y, Wilkes Z, Van Booven D, Wen R and Wang G: Ascorbate suppresses VEGF expression in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 59:3608–3618. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Qin D and Jiang YR: Tangeretin inhibition of high-glucose-induced IL-1β, IL-6, TGF-β1, and VEGF expression in human RPE cells. J Diabetes Res. 2020:94906422020. View Article : Google Scholar : PubMed/NCBI

50 

Hwang S, Seong H, Ryu J, Jeong JY, Kang TS, Nam KY, Seo SW, Kim SJ, Kang SS and Han YS: Phosphorylation of STAT3 and ERBB2 mediates hypoxia-induced VEGF release in ARPE-19 cells. Mol Med Rep. 22:2733–2740. 2020.PubMed/NCBI

51 

Du W, An Y, He X, Zhang D and He W: Protection of kaempferol on oxidative stress-induced retinal pigment epithelial cell damage. Oxid Med Cell Longev. 2018:16107512018. View Article : Google Scholar : PubMed/NCBI

52 

Yu L, Fu J, Yu N, Wu Y and Han N: Long noncoding RNA MALAT1 participates in the pathological angiogenesis of diabetic retinopathy in an oxygen-induced retinopathy mouse model by sponging miR-203a-3p. Can J Physiol Pharmacol. 98:219–227. 2020. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jiang X, Liu Y, Wang Y, Zhou Y, Miao H, Zhang P and Ma J: Long non‑coding RNA MALAT1 is involved in retinal pigment epithelial cell damage caused by high glucose treatment. Mol Med Rep 25: 177, 2022.
APA
Jiang, X., Liu, Y., Wang, Y., Zhou, Y., Miao, H., Zhang, P., & Ma, J. (2022). Long non‑coding RNA MALAT1 is involved in retinal pigment epithelial cell damage caused by high glucose treatment. Molecular Medicine Reports, 25, 177. https://doi.org/10.3892/mmr.2022.12693
MLA
Jiang, X., Liu, Y., Wang, Y., Zhou, Y., Miao, H., Zhang, P., Ma, J."Long non‑coding RNA MALAT1 is involved in retinal pigment epithelial cell damage caused by high glucose treatment". Molecular Medicine Reports 25.5 (2022): 177.
Chicago
Jiang, X., Liu, Y., Wang, Y., Zhou, Y., Miao, H., Zhang, P., Ma, J."Long non‑coding RNA MALAT1 is involved in retinal pigment epithelial cell damage caused by high glucose treatment". Molecular Medicine Reports 25, no. 5 (2022): 177. https://doi.org/10.3892/mmr.2022.12693
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang X, Liu Y, Wang Y, Zhou Y, Miao H, Zhang P and Ma J: Long non‑coding RNA MALAT1 is involved in retinal pigment epithelial cell damage caused by high glucose treatment. Mol Med Rep 25: 177, 2022.
APA
Jiang, X., Liu, Y., Wang, Y., Zhou, Y., Miao, H., Zhang, P., & Ma, J. (2022). Long non‑coding RNA MALAT1 is involved in retinal pigment epithelial cell damage caused by high glucose treatment. Molecular Medicine Reports, 25, 177. https://doi.org/10.3892/mmr.2022.12693
MLA
Jiang, X., Liu, Y., Wang, Y., Zhou, Y., Miao, H., Zhang, P., Ma, J."Long non‑coding RNA MALAT1 is involved in retinal pigment epithelial cell damage caused by high glucose treatment". Molecular Medicine Reports 25.5 (2022): 177.
Chicago
Jiang, X., Liu, Y., Wang, Y., Zhou, Y., Miao, H., Zhang, P., Ma, J."Long non‑coding RNA MALAT1 is involved in retinal pigment epithelial cell damage caused by high glucose treatment". Molecular Medicine Reports 25, no. 5 (2022): 177. https://doi.org/10.3892/mmr.2022.12693
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team