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lncRNA LINC00284 promotes nucleus pulposus cell proliferation and ECM synthesis via regulation of the miR‑205‑3p/Wnt/β‑catenin axis

  • Authors:
    • Min Zhu
    • Xiaoling Yan
    • Yin Zhao
    • Huawei Xue
    • Zhen Wang
    • Bo Wu
    • Xiangyang Li
    • Yixin Shen
  • View Affiliations / Copyright

    Affiliations: Department of Spine Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China, Chemotherapy Department, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Spine Surgery, Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai 200003, P.R. China, Department of Spine Surgery, Nantong Third People's Hospital, Nantong, Jiangsu 226006, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 179
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    Published online on: March 22, 2022
       https://doi.org/10.3892/mmr.2022.12695
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Abstract

Intervertebral disc degeneration (IDD) is a leading cause of degenerative spinal disease. Long non‑coding RNA (lncRNA) LINC00284 is overexpressed in multiple types of cancer and promotes cancer cell proliferation and inhibits apoptosis; however, its role in human IDD and nucleus pulposus (NP) remain unclear. In the present study, intervertebral disc (IVD) tissues were collected from IDD patients for detection of LINC00284 expression using reverse transcription‑quantitative PCR, the binding effect between miR‑205‑3p and LINC00284 was validated by dual‑luciferase reporter assay. miR‑205‑3p and small interfering RNA (siRNA) was used for LINC00240 knockdown to investigate the proliferation, apoptosis of cells in the NP cells measured by Cell Counting Kit (CCK)‑8 assay and Annexin V‑FITC/Propidium Iodide (PI) staining with flow cytometry receptivity. IDD animal models were constructed for in vivo study of the role LINC00284 in IDD improvement. The results showed that LINC00284 expression was upregulated in IDD tissue and IL‑1β‑induced NP cells. LINC00284 knockdown resulted in an increase in IL‑1β‑induced NP cell proliferation, a decrease in apoptosis and matrix metalloproteinase‑3 expression and an increase in expression of extracellular matrix (ECM) markers aggrecan and collagen II. In vivo experiments and histomorphometric analysis confirmed the protective effect of LINC00284 knockdown in IDD. LINC00284 was also shown to be a target of microRNA (miR)‑205‑3p, and there was a negative correlation between LINC00284 and miR‑205‑3p levels in IDD tissue. Additionally, LINC00284 knockdown or miR‑205‑3p upregulation resulted in inhibition of Wnt/β‑catenin signaling and subsequent degradation of the ECM. The present study demonstrated that LINC00284 activated the Wnt/β‑catenin signaling via sponging miR‑205‑3p, resulting in inhibition of NP cell proliferation and ECM synthesis. These results suggested that targeting LINC00284 to rescue miR‑205‑3p expression may be a potential method for IDD management.
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1 

Liu C, Yang M, Liu L, Zhang Y, Zhu Q, Huang C, Wang H, Zhang Y, Li H, Li C, et al: Molecular basis of degenerative spinal disorders from a proteomic perspective (Review). Mol Med Rep. 21:9–19. 2020.PubMed/NCBI

2 

Setton LA and Chen J: Mechanobiology of the intervertebral disc and relevance to disc degeneration. J Bone Joint Surg Am. 88 (Suppl 2):S52–S57. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Balagué F, Mannion AF, Pellisé F and Cedraschi C: Non-specific low back pain. Lancet. 379:482–891. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Battié MC, Videman T and Parent E: Lumbar disc degeneration: Epidemiology and genetic influences. Spine (Phila Pa 1976). 29:2679–2690. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Battié MC and Videman T: Lumbar disc degeneration: Epidemiology and genetics. J Bone Joint Surg Am. 88 (Suppl 2):S3–S9. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Feng H, Danfelter M, Strömqvist B and Heinegård D: Extracellular matrix in disc degeneration. J Bone Joint Surg Am. 88 (Suppl 2):S25–S29. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Roberts S, Caterson B, Menage J, Evans EH, Jaffray DC and Eisenstein SM: Matrix metalloproteinases and aggrecanase: Their role in disorders of the human intervertebral disc. Spine (Phila Pa 1976). 25:3005–3013. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Wang SZ, Chang Q, Lu J and Wang C: Growth factors and platelet-rich plasma: Promising biological strategies for early intervertebral disc degeneration. Int Orthop. 39:927–934. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Richardson SM, Kalamegam G, Pushparaj PN, Matta C, Memic A, Khademhosseini A, Mobasheri R, Poletti FL, Hoyland JA and Mobasheri A: Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration. Methods. 99:69–80. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Liu H, Pan H, Yang H, Wang J, Zhang K, Li X, Wang H, Ding W, Li B and Zheng Z: LIM mineralization protein-1 suppresses TNF-α induced intervertebral disc degeneration by maintaining nucleus pulposus extracellular matrix production and inhibiting matrix metalloproteinases expression. J Orthop Res. 33:294–303. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Bach FC, Zhang Y, Miranda-Bedate A, Verdonschot LC, Bergknut N, Creemers LB, Ito K, Sakai D, Chan D, Meij BP and Tryfonidou MA: Increased caveolin-1 in intervertebral disc degeneration facilitates repair. Arthritis Res Ther. 18:592016. View Article : Google Scholar : PubMed/NCBI

12 

Fujita K, Ando T, Ohba T, Wako M, Sato N, Nakamura Y, Ohnuma Y, Hara Y, Kato R, Nakao A, et al: Age-related expression of MCP-1 and MMP-3 in mouse intervertebral disc in relation to TWEAK and TNF-α stimulation. J Orthop Res. 30:599–605. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Chen WK, Yu XH, Yang W, Wang C, He WS, Yan YG, Zhang J and Wang WJ: lncRNAs: Novel players in intervertebral disc degeneration and osteoarthritis. Cell Prolif. 50:e123132017. View Article : Google Scholar : PubMed/NCBI

14 

Chen Y, Ni H, Zhao Y, Chen K, Li M, Li C, Zhu X and Fu Q: Potential role of lncRNAs in contributing to pathogenesis of intervertebral disc degeneration based on microarray data. Med Sci Monit. 21:3449–3458. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Wan ZY, Song F, Sun Z, Chen YF, Zhang WL, Samartzis D, Ma CJ, Che L, Liu X, Ali MA, et al: Aberrantly expressed long noncoding RNAs in human intervertebral disc degeneration: A microarray related study. Arthritis Res Ther. 16:4652014. View Article : Google Scholar : PubMed/NCBI

16 

Cui S, Liu Z, Tang B, Wang Z and Li B: LncRNA MAGI2-AS3 is down-regulated in intervertebral disc degeneration and participates in the regulation of FasL expression in nucleus pulposus cells. BMC Musculoskelet Disord. 21:1492020. View Article : Google Scholar : PubMed/NCBI

17 

Zhang Z, Huo Y, Zhou Z, Zhang P and Hu J: Role of lncRNA PART1 in intervertebral disc degeneration and associated underlying mechanism. Exp Ther Med. 21:1312021. View Article : Google Scholar : PubMed/NCBI

18 

Yildiz-Arslan S, Coon JS, Hope TJ and Kim JJ: Transcriptional profiling of human endocervical tissues reveals distinct gene expression in the follicular and luteal phases of the menstrual cycle. Biol Reprod. 94:1382016. View Article : Google Scholar : PubMed/NCBI

19 

Xing C, Cai Z, Gong J, Zhou J, Xu J and Guo F: Identification of potential biomarkers involved in gastric cancer through integrated analysis of non-coding RNA associated competing endogenous RNAs network. Clin Lab. 64:1661–1669. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Zhang L and Guo Y: Silencing circular RNA-ZNF652 represses proliferation and EMT process of renal carcinoma cells via raising miR-205. Artif Cells Nanomed Biotechnol. 48:648–655. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Song Y, Guo NH and Zheng JF: LncRNA-MALAT1 regulates proliferation and apoptosis of acute lymphoblastic leukemia cells via miR-205-PTK7 pathway. Pathol Int. 70:724–732. 2020. View Article : Google Scholar : PubMed/NCBI

22 

Chen B, Li Y, Liu Y and Xu Z: circLRP6 regulates high glucose-induced proliferation, oxidative stress, ECM accumulation, and inflammation in mesangial cells. J Cell Physiol. 234:21249–21259. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Frank S, Peters MA, Wehmeyer C, Strietholt S, Koers-Wunrau C, Bertrand J, Heitzmann M, Hillmann A, Sherwood J, Seyfert C, et al: Regulation of matrixmetalloproteinase-3 and matrixmetalloproteinase-13 by SUMO-2/3 through the transcription factor NF-κB. Ann Rheum Dis. 72:1874–1881. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Hiyama A, Gogate SS, Gajghate S, Mochida J, Shapiro IM and Risbud MV: BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: Role of MAPKs. J Bone Miner Res. 25:1179–1190. 2010.PubMed/NCBI

25 

Mäkitie RE, Niinimäki T, Nieminen MT, Schalin-Jäntti C, Niinimäki J and Mäkitie O: Impaired WNT signaling and the spine-Heterozygous WNT1 mutation causes severe age-related spinal pathology. Bone. 101:3–9. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Ge XP, Gan YH, Zhang CG, Zhou CY, Ma KT, Meng JH and Ma XC: Requirement of the NF-κB pathway for induction of Wnt-5A by interleukin-1β in condylar chondrocytes of the temporomandibular joint: Functional crosstalk between the Wnt-5A and NF-κB signaling pathways. Osteoarthritis Cartilage. 19:111–117. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Reya T and Clevers H: Wnt signalling in stem cells and cancer. Nature. 434:843–850. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Söderholm S and Cantù C: The WNT/β-catenin dependent transcription: A tissue-specific business. WIREs Mech Dis. 13:e15112021.PubMed/NCBI

29 

Rauner M, Stein N, Winzer M, Goettsch C, Zwerina J, Schett G, Distler JH, Albers J, Schulze J, Schinke T, et al: WNT5A is induced by inflammatory mediators in bone marrow stromal cells and regulates cytokine and chemokine production. J Bone Miner Res. 27:575–585. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Nakamura Y, Nawata M and Wakitani S: Expression profiles and functional analyses of Wnt-related genes in human joint disorders. Am J Pathol. 167:97–105. 2005. View Article : Google Scholar : PubMed/NCBI

31 

World Medical Association, . World medical association declaration of Helsinki: Ethical principles for medical research involving human subjects. JAMA. 310:2191–2194. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Paraskevopoulou MD, Vlachos IS, Karagkouni D, Georgakilas G, Kanellos I, Vergoulis T, Zagganas K, Tsanakas P, Floros E, Dalamagas T and Hatzigeorgiou AG: DIANA-LncBase v2: Indexing microRNA targets on non-coding transcripts. Nucleic Acids Res. 44:D231–D238. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Li Z, Liu H, Yang H, Wang J, Wang H, Zhang K, Ding W and Zheng Z: Both expression of cytokines and posterior annulus fibrosus rupture are essential for pain behavior changes induced by degenerative intervertebral disc: An experimental study in rats. J Orthop Res. 32:262–272. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Council N: Guide for the care and use of laboratory animals: Eighth edition. Publication. 327:pp963–965. 2010.

36 

Zhang J, Li Z, Chen F, Liu H, Wang H, Li X, Liu X, Wang J and Zheng Z: TGF-β1 suppresses CCL3/4 expression through the ERK signaling pathway and inhibits intervertebral disc degeneration and inflammation-related pain in a rat model. Exp Mol Med. 49:e3792017. View Article : Google Scholar : PubMed/NCBI

37 

Miyagi M, Ishikawa T, Kamoda H, Suzuki M, Sakuma Y, Orita S, Oikawa Y, Aoki Y, Toyone T, Takahashi K, et al: Assessment of pain behavior in a rat model of intervertebral disc injury using the CatWalk gait analysis system. Spine (Phila Pa 1976). 38:1459–1465. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Han B, Zhu K, Li FC, Xiao YX, Feng J, Shi ZL, Lin M, Wang J and Chen QX: A simple disc degeneration model induced by percutaneous needle puncture in the rat tail. Spine (Phila Pa 1976). 33:1925–1934. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J and Boos N: Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine (Phila Pa 1976). 26:1873–1878. 2001. View Article : Google Scholar : PubMed/NCBI

40 

Masuda K, Aota Y, Muehleman C, Imai Y, Okuma M, Thonar EJ, Andersson GB and An HS: A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: Correlation between the degree of disc injury and radiologi and histological appearances of disc degeneration. Spine (Phila Pa 1976). 30:5–14. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Liu ZM, Lu CC, Shen PC, Chou SH, Shih CL, Chen JC and Tien YC: Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway. Bone Joint Res. 10:498–513. 2021. View Article : Google Scholar : PubMed/NCBI

42 

Li H, Li W, Zhang L, He J, Tang L, Li Z, Chen F, Fan Q and Wei J: Comprehensive network analysis identified SIRT7, NTRK2, and CHI3L1 as new potential markers for intervertebral disc degeneration. J Oncol. 2022:44075412022. View Article : Google Scholar : PubMed/NCBI

43 

Wang XB, Wang H, Long HQ, Li DY and Zheng X: LINC00641 regulates autophagy and intervertebral disc degeneration by acting as a competitive endogenous RNA of miR-153-3p under nutrition deprivation stress. J Cell Physiol. 234:7115–7127. 2019. View Article : Google Scholar : PubMed/NCBI

44 

Tang N, Dong Y, Xiao T and Zhao H: LncRNA TUG1 promotes the intervertebral disc degeneration and nucleus pulposus cell apoptosis though modulating miR-26a/HMGB1 axis and regulating NF-κB activation. Am J Transl Res. 12:5449–5464. 2020.PubMed/NCBI

45 

Kirnaz S, Singh S, Capadona C, Lintz M, Goldberg JL, McGrath LB Jr, Medary B, Sommer F, Bonassar LJ and Härtl R: Innovative biological treatment methods for degenerative disc disease. World Neurosurg. 157:282–299. 2022. View Article : Google Scholar : PubMed/NCBI

46 

Johnson WE, Eisenstein SM and Roberts S: Cell cluster formation in degenerate lumbar intervertebral discs is associated with increased disc cell proliferation. Connect Tissue Res. 42:197–207. 2001. View Article : Google Scholar : PubMed/NCBI

47 

Daisuke T and Horton P: Inference of scale-free networks from gene expression time series. J Bioinform Comput Biol. 4:503–514. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Ruan Z and Zhao D: Long intergenic noncoding RNA LINC00284 knockdown reduces angiogenesis in ovarian cancer cells via up-regulation of MEST through NF-κB1. FASEB J. 33:12047–12059. 2019. View Article : Google Scholar : PubMed/NCBI

49 

Xi Y, Jiang T, Wang W, Yu J, Wang Y, Wu X and He Y: Long non-coding HCG18 promotes intervertebral disc degeneration by sponging miR-146a-5p and regulating TRAF6 expression. Sci Rep. 7:132342017. View Article : Google Scholar : PubMed/NCBI

50 

Wang X, Peng L, Gong X, Zhang X, Sun R and Du J: LncRNA-RMRP promotes nucleus pulposus cell proliferation through regulating miR-206 expression. J Cell Mol Med. 22:5468–5476. 2018. View Article : Google Scholar : PubMed/NCBI

51 

Zhao Y, Wang H, Wu C, Yan M, Wu H, Wang J, Yang X and Shao Q: Construction and investigation of lncRNA-associated ceRNA regulatory network in papillary thyroid cancer. Oncol Rep. 39:1197–1206. 2018.PubMed/NCBI

52 

Xie H, Jing Y, Xia J, Wang X, You C and Yan J: Aquaporin 3 protects against lumbar intervertebral disc degeneration via the Wnt/β-catenin pathway. Int J Mol Med. 37:859–864. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Hiyama A, Sakai D, Risbud MV, Tanaka M, Arai F, Abe K and Mochida J: Enhancement of intervertebral disc cell senescence by WNT/β-catenin signaling-induced matrix metalloproteinase expression. Arthritis Rheum. 62:3036–3047. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhu M, Yan X, Zhao Y, Xue H, Wang Z, Wu B, Li X and Shen Y: lncRNA LINC00284 promotes nucleus pulposus cell proliferation and ECM synthesis via regulation of the miR‑205‑3p/Wnt/β‑catenin axis. Mol Med Rep 25: 179, 2022.
APA
Zhu, M., Yan, X., Zhao, Y., Xue, H., Wang, Z., Wu, B. ... Shen, Y. (2022). lncRNA LINC00284 promotes nucleus pulposus cell proliferation and ECM synthesis via regulation of the miR‑205‑3p/Wnt/β‑catenin axis. Molecular Medicine Reports, 25, 179. https://doi.org/10.3892/mmr.2022.12695
MLA
Zhu, M., Yan, X., Zhao, Y., Xue, H., Wang, Z., Wu, B., Li, X., Shen, Y."lncRNA LINC00284 promotes nucleus pulposus cell proliferation and ECM synthesis via regulation of the miR‑205‑3p/Wnt/β‑catenin axis". Molecular Medicine Reports 25.5 (2022): 179.
Chicago
Zhu, M., Yan, X., Zhao, Y., Xue, H., Wang, Z., Wu, B., Li, X., Shen, Y."lncRNA LINC00284 promotes nucleus pulposus cell proliferation and ECM synthesis via regulation of the miR‑205‑3p/Wnt/β‑catenin axis". Molecular Medicine Reports 25, no. 5 (2022): 179. https://doi.org/10.3892/mmr.2022.12695
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu M, Yan X, Zhao Y, Xue H, Wang Z, Wu B, Li X and Shen Y: lncRNA LINC00284 promotes nucleus pulposus cell proliferation and ECM synthesis via regulation of the miR‑205‑3p/Wnt/β‑catenin axis. Mol Med Rep 25: 179, 2022.
APA
Zhu, M., Yan, X., Zhao, Y., Xue, H., Wang, Z., Wu, B. ... Shen, Y. (2022). lncRNA LINC00284 promotes nucleus pulposus cell proliferation and ECM synthesis via regulation of the miR‑205‑3p/Wnt/β‑catenin axis. Molecular Medicine Reports, 25, 179. https://doi.org/10.3892/mmr.2022.12695
MLA
Zhu, M., Yan, X., Zhao, Y., Xue, H., Wang, Z., Wu, B., Li, X., Shen, Y."lncRNA LINC00284 promotes nucleus pulposus cell proliferation and ECM synthesis via regulation of the miR‑205‑3p/Wnt/β‑catenin axis". Molecular Medicine Reports 25.5 (2022): 179.
Chicago
Zhu, M., Yan, X., Zhao, Y., Xue, H., Wang, Z., Wu, B., Li, X., Shen, Y."lncRNA LINC00284 promotes nucleus pulposus cell proliferation and ECM synthesis via regulation of the miR‑205‑3p/Wnt/β‑catenin axis". Molecular Medicine Reports 25, no. 5 (2022): 179. https://doi.org/10.3892/mmr.2022.12695
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