Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2022 Volume 25 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2022 Volume 25 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Whole body vibration remodels skeletal muscle via autophagy and energy metabolism in diabetic mice

  • Authors:
    • Shanshan An
    • Dahao Wang
    • Xue Ma
    • Chang Liu
  • View Affiliations / Copyright

    Affiliations: First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China
    Copyright: © An et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 182
    |
    Published online on: March 23, 2022
       https://doi.org/10.3892/mmr.2022.12698
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hyperglycemia occurs due to a defect in insulin secretion or impaired biological functions, or both. The long‑term hyperglycemia during diabetes causes chronic damage and dysfunction of various tissues. Whole body vibration (WBV) has significant effects on lipid and glucose metabolism and endocrine and motor systems. In order to explore the effects of WBV on skeletal muscle, mice trained for 12 weeks with WBV (15 Hz, 30 min) were used as experimental subjects and their skeletal muscle morphology under the pathological state of diabetes was observed. In addition, the blood lipids, blood glucose, gastrocnemius muscle glycogen and mRNA and protein levels of autophagy and glucose metabolism biomarkers were compared among the three groups of mice via western blot and RT‑qPCR. The results showed that WBV can significantly reshape skeletal muscle morphology and upregulate high density lipoprotein. The expression of glucose‑6‑phosphatase (G6P), Beclin1 and Atg7 in the gastrocnemius muscle of the WBV group was significantly increased. Therefore, it can be concluded that WBV promotes skeletal muscle remodeling in diabetic mice. The present study confirmed that WBV can attenuate the development of diabetes melitus (DM) and lead to lower level low density lipoprotein in the blood. In addition, G6P level plays an important role in WBV‑treated DM model and may be used to monitor the effect of WBV in patients. The findings of the present study may provide a new molecular basis for WBV to play a therapeutic role in the treatment of diabetes and may have potential clinical applications in the future.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Wei H, Hu Q, Wu J, Yao C, Xu L, Xing F, Zhao X, Yu S, Wang X and Chen G: Molecular mechanism of the increased tissue uptake of trivalent inorganic arsenic in mice with type 1 diabetes mellitus. Biochem Biophys Res Commun. 504:393–399. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Rampogu S and Lemuel M: Network based approach in the establishment of the relationship between type 2 diabetes mellitus and its complications at the molecular level coupled with molecular docking mechanism. Biomed Res Int. 2016:60684372016. View Article : Google Scholar : PubMed/NCBI

3 

Maegawa H and Kashiwagi A: Molecular mechanism and clinical impact of insulin resistance in type 2 diabetes mellitus. Nihon Rinsho. 57:539–544. 1999.PubMed/NCBI

4 

Lai CC, Tu YK, Wang TG, Huang YT and Chien KL: Effects of resistance training, endurance training and whole-body vibration on lean body mass, muscle strength and physical performance in older people: A systematic review and network meta-analysis. Age Ageing. 47:367–373. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Sierra-Guzmán R, Jiménez-Diaz F, Ramírez C, Esteban P and Abián-Vicén J: Whole-body-vibration training and balance in recreational athletes with chronic ankle instability. J Athl Train. 53:355–363. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Sierra-Guzmán R, Jiménez JF, Ramírez C, Esteban P and Abián-Vicén J: Effects of synchronous whole body vibration training on a soft, unstable surface in athletes with chronic ankle instability. Int J Sports Med. 38:447–455. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Liu Y, Liu C, Lu ML, Tang FT, Hou XW, Yang J and Liu T: Vibration exercise decreases insulin resistance and modulates the insulin signaling pathway in a type 2 diabetic rat model. Int J Clin Exp Med. 8:13136–13144. 2015.PubMed/NCBI

8 

Szostak J, Miguet-Alfonsi C, Berthelot A and Laurant P: Training-induced anti-atherosclerotic effects are associated with increased vascular PPARgamma expression in apolipoprotein E-deficient mice. Acta Physiol (Oxf). 216:221–230. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Shing CM, Fassett RG, Peake JM and Coombes JS: Voluntary exercise decreases atherosclerosis in nephrectomised ApoE knockout mice. PLoS One. 10:e01202872015. View Article : Google Scholar : PubMed/NCBI

10 

Zhao C, Yang C, Wai STC, Zhang Y, P Portillo M, Paoli P, Wu Y, San Cheang W, Liu B, Carpéné C, et al: Regulation of glucose metabolism by bioactive phytochemicals for the management of type 2 diabetes mellitus. Crit Rev Food Sci Nutr. 59:830–847. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Wu H, Deng X, Shi Y, Su Y, Wei J and Duan H: PGC-1α, glucose metabolism and type 2 diabetes mellitus. J Endocrinol. 229:R99–R115. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Yoo JS and Lee SJ: A meta-analysis of the effects of exercise programs on glucose and lipid metabolism and cardiac function in patients with type II diabetes mellitus. Taehan Kanho Hakhoe Chi. 35:546–554. 2005.(In Korean). PubMed/NCBI

13 

Iizuka Y, Murase T and Iizuka Y: Abnormalities in lipid metabolism associated with diabetes mellitus. Nihon Rinsho. 55 (Suppl):S603–S608. 1997.PubMed/NCBI

14 

Kundu BK, Zhong M, Sen S, Davogustto G, Keller SR and Taegtmeyer H: Remodeling of glucose metabolism precedes pressure overload-induced left ventricular hypertrophy: review of a hypothesis. Cardiology. 130:211–220. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Herrera E and Desoye G: Maternal and fetal lipid metabolism under normal and gestational diabetic conditions. Horm Mol Biol Clin Investig. 26:109–127. 2016.PubMed/NCBI

16 

Jiao J and Demontis F: Skeletal muscle autophagy and its role in sarcopenia and organismal aging. Curr Opin Pharmacol. 34:1–6. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Lee DE, Bareja A, Bartlett DB and White JP: Autophagy as a therapeutic target to enhance aged muscle regeneration. Cells. 8:1832019. View Article : Google Scholar : PubMed/NCBI

18 

Oguntibeju OO: Type 2 diabetes mellitus, oxidative stress and inflammation: Examining the links. Int J Physiol Pathophysiol Pharmacol. 11:45–63. 2019.PubMed/NCBI

19 

Annunziata G, Barrea L, Ciampaglia R, Cicala C, Arnone A, Savastano S, Nabavi SM, Tenore GC and Novellino E: Arctium lappa contributes to the management of type 2 diabetes mellitus by regulating glucose homeostasis and improving oxidative stress: A critical review of in vitro and in vivo animal-based studies. Phytother Res. 33:2213–2220. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Ighodaro OM: Molecular pathways associated with oxidative stress in diabetes mellitus. Biomed Pharmacother. 108:656–662. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Teng S and Huang P: The effect of type 2 diabetes mellitus and obesity on muscle progenitor cell function. Stem Cell Res Ther. 10:1032019. View Article : Google Scholar : PubMed/NCBI

22 

Sala D and Zorzano A: Differential control of muscle mass in type 1 and type 2 diabetes mellitus. Cell Mol Life Sci. 72:3803–3817. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Tam BT and Siu PM: Autophagic cellular responses to physical exercise in skeletal muscle. Sports Med. 44:625–640. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Chen HC, Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert M, Farese RV Jr and Farese RV: Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport. J Biol Chem. 277:23554–23562. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Wu YT, Tan HL, Huang Q, Ong CN and Shen HM: Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy. Autophagy. 5:824–834. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Furuya N, Yu J, Byfield M, Pattingre S and Levine B: The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy. 1:46–52. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
An S, Wang D, Ma X and Liu C: Whole body vibration remodels skeletal muscle via autophagy and energy metabolism in diabetic mice. Mol Med Rep 25: 182, 2022.
APA
An, S., Wang, D., Ma, X., & Liu, C. (2022). Whole body vibration remodels skeletal muscle via autophagy and energy metabolism in diabetic mice. Molecular Medicine Reports, 25, 182. https://doi.org/10.3892/mmr.2022.12698
MLA
An, S., Wang, D., Ma, X., Liu, C."Whole body vibration remodels skeletal muscle via autophagy and energy metabolism in diabetic mice". Molecular Medicine Reports 25.5 (2022): 182.
Chicago
An, S., Wang, D., Ma, X., Liu, C."Whole body vibration remodels skeletal muscle via autophagy and energy metabolism in diabetic mice". Molecular Medicine Reports 25, no. 5 (2022): 182. https://doi.org/10.3892/mmr.2022.12698
Copy and paste a formatted citation
x
Spandidos Publications style
An S, Wang D, Ma X and Liu C: Whole body vibration remodels skeletal muscle via autophagy and energy metabolism in diabetic mice. Mol Med Rep 25: 182, 2022.
APA
An, S., Wang, D., Ma, X., & Liu, C. (2022). Whole body vibration remodels skeletal muscle via autophagy and energy metabolism in diabetic mice. Molecular Medicine Reports, 25, 182. https://doi.org/10.3892/mmr.2022.12698
MLA
An, S., Wang, D., Ma, X., Liu, C."Whole body vibration remodels skeletal muscle via autophagy and energy metabolism in diabetic mice". Molecular Medicine Reports 25.5 (2022): 182.
Chicago
An, S., Wang, D., Ma, X., Liu, C."Whole body vibration remodels skeletal muscle via autophagy and energy metabolism in diabetic mice". Molecular Medicine Reports 25, no. 5 (2022): 182. https://doi.org/10.3892/mmr.2022.12698
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team