|
1
|
Norman RJ, Dewailly D, Legro RS and Hickey
TE: Polycystic ovary syndrome. Lancet. 370:685–697. 2007.
View Article : Google Scholar
|
|
2
|
Ehrmann DA: Polycystic ovary syndrome. N
Engl J Med. 352:1223–1236. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Homburg R: Management of infertility and
prevention of ovarian hyperstimulation in women with polycystic
ovary syndrome. Best Pract Res Clin Obstet Gynaecol. 18:773–788.
2004. View Article : Google Scholar
|
|
4
|
Shang K, Jia X, Qiao J, Kang J and Guan Y:
Endometrial abnormality in women with polycystic ovary syndrome.
Reprod Sci. 19:674–683. 2012. View Article : Google Scholar
|
|
5
|
Mioni R, Mozzanega B, Granzotto M,
Pierobon A, Zuliani L, Maffei P, Blandamura S, Grassi S, Sicolo N
and Vettor R: Insulin receptor and glucose transporters mRNA
expression throughout the menstrual cycle in human endometrium: A
physiological and cyclical condition of tissue insulin resistance.
Gynecol Endocrinol. 28:1014–1018. 2012. View Article : Google Scholar
|
|
6
|
Mozzanega B, Mioni R, Granzotto M,
Chiarelli S, Xamin N, Zuliani L, Sicolo N, Marchesoni D and Vettor
R: Obesity reduces the expression of GLUT4 in the endometrium of
normoinsulinemic women affected by the polycystic ovary syndrome.
Ann N Y Acad Sci. 1034:364–374. 2004. View Article : Google Scholar
|
|
7
|
Carvajal R, Rosas C, Kohan K, Gabler F,
Vantman D, Romero C and Vega M: Metformin augments the levels of
molecules that regulate the expression of the insulin-dependent
glucose transporter GLUT4 in the endometria of hyperinsulinemic
PCOS patients. Hum Reprod. 28:2235–2244. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Emons G, Beckmann MW, Schmidt D and
Mallmann P; Uterus commission of the Gynecological Oncology Working
G, : New WHO classification of endometrial hyperplasias.
Geburtshilfe Frauenheilkd. 75:135–136. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Antonsen SL, Ulrich L and Høgdall C:
Patients with atypical hyperplasia of the endometrium should be
treated in oncological centers. Gynecol Oncol. 125:124–128. 2012.
View Article : Google Scholar
|
|
10
|
Kurman RJ, Kaminski PF and Norris HJ: The
behavior of endometrial hyperplasia. A long-term study of
‘untreated’ hyperplasia in 170 patients. Cancer. 56:403–412. 1985.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Cheung AP: Ultrasound and menstrual
history in predicting endometrial hyperplasia in polycystic ovary
syndrome. Obstet Gynecol. 98:325–331. 2001. View Article : Google Scholar
|
|
12
|
Jung CH, Ro SH, Cao J, Otto NM and Kim DH:
mTOR regulation of autophagy. FEBS Lett. 584:1287–1295. 2010.
View Article : Google Scholar
|
|
13
|
Brosius J: Waste not, want not-transcript
excess in multicellular eukaryotes. Trends Genet. 21:287–288. 2005.
View Article : Google Scholar
|
|
14
|
Mercer TR, Dinger ME and Mattick JS: Long
non-coding RNAs: Insights into functions. Nat Rev Genet.
10:155–159. 2009. View
Article : Google Scholar
|
|
15
|
Rapicavoli NA, Qu K, Zhang J, Mikhail M,
Laberge RM and Chang HY: A mammalian pseudogene lncRNA at the
interface of inflammation and anti-inflammatory therapeutics.
Elife. 2:e007622013. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Hu G, Gong AY, Wang Y, Ma S, Chen X, Chen
J, Su CJ, Shibata A, Strauss-Soukup JK, Drescher KM and Chen XM:
LincRNA-Cox2 promotes late inflammatory gene transcription in
macrophages through modulating SWI/SNF-mediated chromatin
remodeling. J Immunol. 196:2799–2808. 2016. View Article : Google Scholar
|
|
17
|
Paladini L, Fabris L, Bottai G, Raschioni
C, Calin GA and Santarpia L: Targeting microRNAs as key modulators
of tumor immune response. J Exp Clin Cancer Res. 35:1032016.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Shao R, Li X, Feng Y, Lin JF and Billig H:
Direct effects of metformin in the endometrium: A hypothetical
mechanism for the treatment of women with PCOS and endometrial
carcinoma. J Exp Clin Cancer Res. 33:412014. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Shen ZQ, Zhu HT and Lin JF: Reverse of
progestin-resistant atypical endometrial hyperplasia by metformin
and oral contraceptives. Obstet Gynecol. 112:465–467. 2008.
View Article : Google Scholar
|
|
20
|
Pal N, Broaddus RR, Urbauer DL,
Balakrishnan N, Milbourne A, Schmeler KM, Meyer LA, Soliman PT, Lu
KH, Ramirez PT, et al: Treatment of low-risk endometrial cancer and
complex atypical hyperplasia with the levonorgestrel-releasing
intrauterine device. Obstet Gynecol. 131:109–116. View Article : Google Scholar
|
|
21
|
Li X, Guo YR, Lin JF, Feng Y, Billig H and
Shao R: Combination of Diane-35 and metformin to treat early
endometrial carcinoma in PCOS women with insulin resistance. J
Cancer. 5:173–181. 2014. View
Article : Google Scholar : PubMed/NCBI
|
|
22
|
Stanosz S: An attempt at conservative
treatment in selected cases of type I endometrial carcinoma (stage
I a/G1) in young women. Eur J Gynaecol Oncol. 30:365–369. 2009.
|
|
23
|
Li X, Feng Y, Lin JF, Billig H and Shao R:
Endometrial progesterone resistance and PCOS. J Biomed Sci.
21:22014. View Article : Google Scholar
|
|
24
|
Cui P, Li X, Wang X, Feng Y, Lin JF,
Billig H and Shao R: Lack of cyclical fluctuations of endometrial
GLUT4 expression in women with polycystic ovary syndrome: Evidence
for direct regulation of GLUT4 by steroid hormones. BBA Clin.
4:85–91. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Li X, Cui P, Jiang HY, Guo YR, Pishdari B,
Hu M, Feng Y, Billig H and Shao R: Reversing the reduced level of
endometrial GLUT4 expression in polycystic ovary syndrome: A
mechanistic study of metformin action. Am J Transl Res. 7:574–586.
2015.PubMed/NCBI
|
|
26
|
Zhang Y, Hu M, Meng F, Sun X, Xu H, Zhang
J, Cui P, Morina N, Li X, Li W, et al: Metformin ameliorates
uterine defects in a rat model of polycystic ovary syndrome.
EBioMedicine. 18:157–170. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Zhang Y, Liu X, Bai X, Lin Y, Li Z, Fu J,
Li M, Zhao T, Yang H, Xu R, et al: Melatonin prevents endothelial
cell pyroptosis via regulation of long noncoding RNA
MEG3/miR-223/NLRP3 axis. J Pineal Res. 64:2018. View Article : Google Scholar
|
|
28
|
Liu J, Cheng LG and Li HG: LncRNA SNHG20
promoted the proliferation of glioma cells via sponging miR-4486 to
regulate the MDM2-p53 pathway. Eur Rev Med Pharmacol Sci.
23:5323–5331. 2019.
|
|
29
|
Zhang Y, Sun X, Sun X, Meng F, Hu M, Li X,
Li W, Wu XK, Brännström M, Shao R and Billig H: Molecular
characterization of insulin resistance and glycolytic metabolism in
the rat uterus. Sci Rep. 6:306792016. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
National Research Council (US) Committee
for the Update of the Guide for the Care and Use of Laboratory
Animals, . Guide for the Care and Use of Laboratory Animals. 8th
edition. National Academies Press (US); Washington, DC: 2011
|
|
31
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2 (−Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Markowicz-Piasecka M, Sikora J, Szydlowska
A, Skupien A, Mikiciuk-Olasik E and Huttunen KM: Metformin-a future
therapy for neurodegenerative diseases: Theme: Drug discovery,
development and delivery in Alzheimer's disease guest editor:
Davide Brambilla. Pharm Res. 34:2614–2627. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Pernicova I and Korbonits M:
Metformin-mode of action and clinical implications for diabetes and
cancer. Nat Rev Endocrinol. 10:143–156. 2014. View Article : Google Scholar
|
|
34
|
Miyoshi N, Wagatsuma H, Wakana S,
Shiroishi T, Nomura M, Aisaka K, Kohda T, Surani MA, Kaneko-Ishino
T and Ishino F: Identification of an imprinted gene, Meg3/Gtl2 and
its human homologue MEG3, first mapped on mouse distal chromosome
12 and human chromosome 14q. Genes Cells. 5:211–220. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Zhang X, Zhou Y, Mehta KR, Danila DC,
Scolavino S, Johnson SR and Klibanski A: A pituitary-derived MEG3
isoform functions as a growth suppressor in tumor cells. J Clin
Endocrinol Metab. 88:5119–5126. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Menon AG, Rutter JL, von Sattel JP, Synder
H, Murdoch C, Blumenfeld A, Martuza RL, von Deimling A, Gusella JF
and Houseal TW: Frequent loss of chromosome 14 in atypical and
malignant meningioma: Identification of a putative ‘tumor
progression’ locus. Oncogene. 14:611–616. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Itoyama T, Chaganti RS, Yamada Y,
Tsukasaki K, Atogami S, Nakamura H, Tomonaga M, Ohshima K, Kikuchi
M and Sadamori N: Cytogenetic analysis and clinical significance in
adult T-cell leukemia/lymphoma: A study of 50 cases from the human
T-cell leukemia virus type-1 endemic area, Nagasaki. Blood.
97:3612–3620. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Zhang D, Cao C, Liu L and Wu D:
Up-regulation of LncRNA SNHG20 predicts poor prognosis in
hepatocellular carcinoma. J Cancer. 7:608–617. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Li C, Zhou L, He J, Fang XQ, Zhu SW and
Xiong MM: Increased long noncoding RNA SNHG20 predicts poor
prognosis in colorectal cancer. BMC Cancer. 16:6552016. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Aravinthan A, Challis B, Shannon N, Hoare
M, Heaney J and Alexander GJM: Selective insulin resistance in
hepatocyte senescence. Exp Cell Res. 331:38–45. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Li Y, Li C, Yang M, Shi L, Tao W, Shen K,
Li X, Wang X, Yang Y and Yao Y: Association of single nucleotide
polymorphisms of miRNAs involved in the GLUT4 pathway in T2DM in a
Chinese population. Mol Genet Genomic Med. 7:e9072019. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Li H, Li Y, Liu D, Sun H and Liu J:
miR-224 is critical for celastrol-induced inhibition of migration
and invasion of hepatocellular carcinoma cells. Cell Physiol
Biochem. 32:448–458. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Sha M, Ye J, Zhang LX, Luan ZY, Chen YB
and Huang JX: Celastrol induces apoptosis of gastric cancer cells
by miR-21 inhibiting PI3K/Akt-NF-κB signaling pathway.
Pharmacology. 93:39–46. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Zhang X, Xue XC, Wang Y, Cao FF, You J,
Uzan G, Peng B and Zhang DH: Celastrol reverses palmitic
acid-induced insulin resistance in HepG2 cells via restoring the
miR-223 and GLUT4 pathway. Can J Diabetes. 43:165–172. 2019.
View Article : Google Scholar : PubMed/NCBI
|
