|
1
|
Yamanaka K, Yamamoto O and Honda T:
Pathophysiology of psoriasis: A review. J Dermatol. 48:722–731.
2021. View Article : Google Scholar
|
|
2
|
Furue K, Ito T, Tsuji G, Kadono T and
Furue M: Psoriasis and the TNF/IL23/IL17 axis. G Ital Dermatol
Venereol. 154:418–424. 2019. View Article : Google Scholar
|
|
3
|
Molinelli E, Campanati A, Brisigotti V and
Offidani A: Biologic therapy in psoriasis (part II): Efficacy and
safety of new treatment targeting IL23/IL-17 pathways. Curr Pharm
Biotechnol. 18:964–978. 2017. View Article : Google Scholar
|
|
4
|
Ly K, Smith MP, Thibodeaux Q, Reddy V,
Liao W and Bhutani T: Anti IL-17 in psoriasis. Expert Rev Clin
Immunol. 15:1185–1194. 2019. View Article : Google Scholar
|
|
5
|
van der Fits L, Mourits S, Voerman JS,
Kant M, Boon L, Laman JD, Cornelissen F, Mus AM, Florencia E, Prens
EP and Lubberts E: Imiquimod-induced psoriasis-like skin
inflammation in mice is mediated via the IL-23/IL-17 axis. J
Immunol. 182:5836–5845. 2009. View Article : Google Scholar
|
|
6
|
Gratton R, Tricarico PM, Moltrasio C, Lima
Estevão de Oliveira AS, Brandão L, Marzano AV, Zupin L and Crovella
S: Pleiotropic role of Notch signaling in human skin diseases. Int
J Mol Sci. 21:42142020. View Article : Google Scholar
|
|
7
|
Gratton R, Tricarico PM, d'Adamo AP,
Bianco AM, Moura R, Agrelli A, Brandão L, Zupin L and Crovella S:
Notch signaling regulation in autoinflammatory diseases. Int J Mol
Sci. 21:88472020. View Article : Google Scholar
|
|
8
|
Fiúza UM and Arias AM: Cell and molecular
biology of Notch. J Endocrinol. 194:459–474. 2007. View Article : Google Scholar
|
|
9
|
Auderset F, Coutaz M and Tacchini-Cottier
F: The role of Notch in the differentiation of CD4+ T helper cells.
Curr Top Microbiol Immunol. 360:115–134. 2012.
|
|
10
|
Eagar TN, Tang Q, Wolfe M, He Y, Pear WS
and Bluestone JA: Notch 1 signaling regulates peripheral T cell
activation. Immunity. 20:407–415. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Keerthivasan S, Suleiman R, Lawlor R,
Roderick J, Bates T, Minter L, Anguita J, Juncadella I, Nickoloff
BJ, Le Poole IC, et al: Notch signaling regulates mouse and human
Th17 differentiation. J Immunol. 187:692–701. 2011. View Article : Google Scholar
|
|
12
|
Radtke F, Fasnacht N and MacDonald HR:
Notch signaling in the immune system. Immunity. 32:14–27. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Ma L, Xue H, Qi R, Wang Y and Yuan L:
Effect of γ-secretase inhibitor on Th17 cell differentiation and
function of mouse psoriasis-like skin inflammation. J Transl Med.
16:592018. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Qian Y, Liu C, Hartupee J, Altuntas CZ,
Gulen MF, Jane-Wit D, Xiao J, Lu Y, Giltiay N, Liu J, et al: The
adaptor Act1 is required for interleukin 17-dependent signaling
associated with autoimmune and inflammatory disease. Nat Immunol.
8:247–256. 2007. View
Article : Google Scholar
|
|
15
|
Wang C, Zhang CJ, Martin BN, Bulek K, Kang
Z, Zhao J, Bian G, Carman JA, Gao J, Dongre A, et al: IL-17 induced
NOTCH1 activation in oligodendrocyte progenitor cells enhances
proliferation and inflammatory gene expression. Nat Commun.
8:155082017. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Weichhart T and Säemann MD: The
PI3K/Akt/mTOR pathway in innate immune cells: Emerging therapeutic
applications. Ann Rheum Dis. 67 (Suppl 3):iii70–iii74. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Mercurio L, Albanesi C and Madonna S:
Recent updates on the involvement of PI3K/AKT/mTOR molecular
cascade in the pathogenesis of hyperproliferative skin disorders.
Front Med (Lausanne). 8:6656472021. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Chamcheu JC, Chaves-Rodriquez MI, Adhami
VM, Siddiqui IA, Wood GS, Longley BJ and Mukhtar H: Upregulation of
PI3K/AKT/mTOR, FABP5 and PPARβ/δ in human psoriasis and
imiquimod-induced murine psoriasiform dermatitis model. Acta Derm
Venereol. 96:854–856. 2016.
|
|
19
|
Kurebayashi Y, Nagai S, Ikejiri A, Ohtani
M, Ichiyama K, Baba Y, Yamada T, Egami S, Hoshii T, Hirao A, et al:
PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by
regulating Gfi1 expression and nuclear translocation of RORγ. Cell
Rep. 1:360–373. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Nagai S, Kurebayashi Y and Koyasu S: Role
of PI3K/Akt and mTOR complexes in Th17 cell differentiation. Ann N
Y Acad Sci. 1280:30–34. 2013. View Article : Google Scholar
|
|
21
|
Palomero T, Sulis ML, Cortina M, Real PJ,
Barnes K, Ciofani M, Caparros E, Buteau J, Brown K, Perkins SL, et
al: Mutational loss of PTEN induces resistance to NOTCH1 inhibition
in T-cell leukemia. Nat Med. 13:1203–1210. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Hales EC, Taub JW and Matherly LH: New
insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling
axis: Targeted therapy of γ-secretase inhibitor resistant T-cell
acute lymphoblastic leukemia. Cell Signal. 26:149–161. 2014.
View Article : Google Scholar
|
|
23
|
Li X, Zou F, Lu Y, Fan X, Wu Y, Feng X,
Sun X and Liu Y: Notch1 contributes to TNF-α-induced proliferation
and migration of airway smooth muscle cells through regulation of
the Hes1/PTEN axis. Int Immunopharmacol. 88:1069112020. View Article : Google Scholar
|
|
24
|
Liu X, Zhang Y, Shi M, Wang Y, Zhang F,
Yan R, Liu L, Xiao Y and Guo B: Notch1 regulates PTEN expression to
exacerbate renal tubulointerstitial fibrosis in diabetic
nephropathy by inhibiting autophagy via interactions with Hes1.
Biochem Biophys Res Commun. 497:1110–1116. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Tian T, Fu X, Lu J, Ruan Z, Nan K, Yao Y
and Yang Y: MicroRNA-760 inhibits doxorubicin resistance in
hepatocellular carcinoma through regulating Notch1/Hes1-PTEN/Akt
signaling pathway. J Biochem Mol Toxicol. 32:e221672018. View Article : Google Scholar
|
|
26
|
Zhang X, Hu Y, Gao H, Lan X and Xue Y:
Downregulation of Notch1 inhibits the invasion and metastasis of
human gastric cancer cells SGC7901 and MKN74 in vitro
through PTEN activation and dephosphorylation of AKT and FAK. Mol
Med Rep. 16:2318–2324. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Sokolowski KM, Balamurugan M,
Kunnimalaiyaan S, Wilson J, Gamblin TC and Kunnimalaiyaan M: Role
of Akt inhibition on Notch1 expression in hepatocellular carcinoma:
Potential role for dual targeted therapy. Am J Surg. 211:755–760.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Lan XO, Wang HX, Qi RQ, Xu YY, Yu YJ, Yang
Y, Guo H, Gao XH and Geng L: Shikonin inhibits CEBPD downregulation
in IL-17-treated HaCaT cells and in an imiquimod-induced psoriasis
model. Mol Med Rep. 22:2263–2272. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Greb JE, Goldminz AM, Elder JT, Lebwohl
MG, Gladman DD, Wu JJ, Mehta NN, Finlay AY and Gottlieb AB:
Psoriasis. Nat Rev Dis Primers. 2:160822016. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Di Cesare A, Di Meglio P and Nestle FO:
The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J
Invest Dermatol. 129:1339–1350. 2009. View Article : Google Scholar
|
|
32
|
Li B, Huang L, Lv P, Li X, Liu G, Chen Y,
Wang Z, Qian X, Shen Y, Li Y and Fang W: The role of Th17 cells in
psoriasis. Immunol Res. 68:296–309. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Hawkes JE, Chan TC and Krueger JG:
Psoriasis pathogenesis and the development of novel targeted immune
therapies. J Allergy Clin Immunol. 140:645–653. 2017. View Article : Google Scholar
|
|
34
|
Ma L, Xue HB, Guan XH, Shu CM, Wang F,
Zhang JH and An RZ: The imbalance of Th17 cells and CD4(+)
CD25(high) Foxp3(+) Treg cells in patients with atopic dermatitis.
J Eur Acad Dermatol Venereol. 28:1079–1086. 2014. View Article : Google Scholar
|
|
35
|
Ma L, Xue H, Gao T, Gao M and Zhang Y:
Notch1 signaling regulates the Th17/Treg immune imbalance in
patients with psoriasis vulgaris. Mediators Inflamm.
2018:30695212018. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Wang Y, Li X, Xing X, Xue H, Qi R, Ji H
and Ma L: Notch-Hes1 signaling regulates IL-17A+ γδ
+T cell expression and IL-17A secretion of mouse
psoriasis-like skin inflammation. Mediators Inflamm.
2020:82971342020. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Korman NJ: Management of psoriasis as a
systemic disease: What is the evidence? Br J Dermatol. 182:840–848.
2020. View Article : Google Scholar
|
|
38
|
Kim CH, Yoo JK, Jeon SH, Lim CY, Lee JH,
Koo DB and Park MY: Anti-psoriatic effect of myeloid-derived
suppressor cells on imiquimod-induced skin inflammation in mice.
Scand J Immunol. 89:e127422019.
|
|
39
|
Frenzel DF, Borkner L, Scheurmann J, Singh
K, Scharffetter-Kochanek K and Weiss JM: Osteopontin deficiency
affects imiquimod-induced psoriasis-like murine skin inflammation
and lymphocyte distribution in skin, draining lymph nodes and
spleen. Exp Dermatol. 24:305–307. 2015. View Article : Google Scholar
|
|
40
|
Chamcheu JC, Adhami VM, Esnault S, Sechi
M, Siddiqui IA, Satyshur KA, Syed DN, Dodwad SJ, Chaves-Rodriquez
MI, Longley BJ, et al: Dual inhibition of PI3K/Akt and mTOR by the
dietary antioxidant, delphinidin, ameliorates psoriatic features in
vitro and in an imiquimod-induced psoriasis-like disease in mice.
Antioxid Redox Signal. 26:49–69. 2017. View Article : Google Scholar
|
|
41
|
Coutaz M, Hurrell BP, Auderset F, Wang H,
Siegert S, Eberl G, Ho PC, Radtke F and Tacchini-Cottier F: Notch
regulates Th17 differentiation and controls trafficking of IL-17
and metabolic regulators within Th17 cells in a context-dependent
manner. Sci Rep. 6:391172016. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Nagase H and Nakayama K:
γ-Secretase-regulated signaling typified by Notch signaling in the
immune system. Curr Stem Cell Res Ther. 8:341–356. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Palomero T, Dominguez M and Ferrando AA:
The role of the PTEN/AKT pathway in NOTCH1-induced leukemia. Cell
Cycle. 7:965–970. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Liu S, Ma X, Ai Q, Huang Q, Shi T, Zhu M,
Wang B and Zhang X: NOTCH1 functions as an oncogene by regulating
the PTEN/PI3K/AKT pathway in clear cell renal cell carcinoma. Urol
Oncol. 31:938–948. 2013. View Article : Google Scholar
|
|
45
|
Ma L, Xue HB, Guan XH, Qi RQ, An RZ, Shu
CM, Zhang YJ, Wei YH and Zhang JH: Possible role of Th17 cells and
IL-17 in the pathogenesis of atopic dermatitis in northern China. J
Dermatol Sci. 68:66–68. 2012. View Article : Google Scholar
|
|
46
|
Ma L, Xue HB, Wang F, Shu CM and Zhang JH:
MicroRNA-155 may be involved in the pathogenesis of atopic
dermatitis by modulating the differentiation and function of T
helper type 17 (Th17) cells. Clin Exp Immunol. 181:142–149. 2015.
View Article : Google Scholar
|
|
47
|
Peng X, Zhou J, Li B, Zhang T, Zuo Y and
Gu X: Notch1 and PI3K/Akt signaling blockers DAPT and LY294002
coordinately inhibit metastasis of gastric cancer through mutual
enhancement. Cancer Chemother Pharmacol. 85:309–320. 2020.
View Article : Google Scholar
|
|
48
|
Zhao J, Di T, Wang Y, Liu X, Liang D,
Zhang G and Li P: Multi-glycoside of tripterygium wilfordii Hook.
f. ameliorates imiquimod-induced skin lesions through a
STAT3-dependent mechanism involving the inhibition of Th17-mediated
inflammatory responses. Int J Mol Med. 38:747–757. 2016. View Article : Google Scholar : PubMed/NCBI
|
