Open Access

Roles of circular RNAs in osteogenic differentiation of bone marrow mesenchymal stem cells (Review)

  • Authors:
    • Jicheng Wang
    • Tengyun Wang
    • Fujie Zhang
    • Yangyang Zhang
    • Yongzhi Guo
    • Xin Jiang
    • Bo Yang
  • View Affiliations

  • Published online on: May 20, 2022     https://doi.org/10.3892/mmr.2022.12743
  • Article Number: 227
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bone marrow mesenchymal stem cells (BMSCs) can differentiate into osteoblasts, chondrocytes, adipocytes and even myoblasts, and are therefore defined as pluripotent cells. BMSCs have become extremely important seed cells in gene therapy, tissue engineering, cell replacement therapy and regenerative medicine due to their potential in multilineage differentiation, self‑renewal, immune regulation and other fields. Circular RNAs (circRNAs) are a class of non‑coding RNAs that are widely present in eukaryotic cells. Unlike standard linear RNAs, circRNAs form covalently closed continuous loops with no 5' or 3' polarity. circRNAs are abundantly expressed in cells and tissues, and are highly conserved and relatively stable during evolution. Numerous studies have shown that circRNAs play an important role in the osteogenic differentiation of BMSCs. Further studies on the role of circRNAs in the osteogenic differentiation of BMSCs can provide a new theoretical and experimental basis for bone tissue engineering and clinical treatment.
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July-2022
Volume 26 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Wang J, Wang T, Zhang F, Zhang Y, Guo Y, Jiang X and Yang B: Roles of circular RNAs in osteogenic differentiation of bone marrow mesenchymal stem cells (Review). Mol Med Rep 26: 227, 2022
APA
Wang, J., Wang, T., Zhang, F., Zhang, Y., Guo, Y., Jiang, X., & Yang, B. (2022). Roles of circular RNAs in osteogenic differentiation of bone marrow mesenchymal stem cells (Review). Molecular Medicine Reports, 26, 227. https://doi.org/10.3892/mmr.2022.12743
MLA
Wang, J., Wang, T., Zhang, F., Zhang, Y., Guo, Y., Jiang, X., Yang, B."Roles of circular RNAs in osteogenic differentiation of bone marrow mesenchymal stem cells (Review)". Molecular Medicine Reports 26.1 (2022): 227.
Chicago
Wang, J., Wang, T., Zhang, F., Zhang, Y., Guo, Y., Jiang, X., Yang, B."Roles of circular RNAs in osteogenic differentiation of bone marrow mesenchymal stem cells (Review)". Molecular Medicine Reports 26, no. 1 (2022): 227. https://doi.org/10.3892/mmr.2022.12743