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Review Open Access

Gasotransmitters in the tumor microenvironment: Impacts on cancer chemotherapy (Review)

  • Authors:
    • Abbas Salihi
    • Mohammed A. Al‑Naqshabandi
    • Zhikal Omar Khudhur
    • Zjwan Housein
    • Harmand A. Hama
    • Ramyar M. Abdullah
    • Bashdar Mahmud Hussen
    • Twana Alkasalias
  • View Affiliations / Copyright

    Affiliations: Department of Biology, College of Science, Salahaddin University‑Erbil, Erbil, Kurdistan Region 44001, Iraq, Department of Clinical Biochemistry, College of Health Sciences, Hawler Medical University, Erbil, Kurdistan Region 44001, Iraq, Department of Medical Analysis, Faculty of Applied Science, Tishk International University, Erbil, Kurdistan Region 44001, Iraq, Department of Medical Laboratory Technology, Technical Health and Medical College, Erbil Polytechnique University, Erbil, Kurdistan Region 44002, Iraq, Department of Biology, Faculty of Education, Tishk International University, Erbil, Kurdistan Region 44002, Iraq, College of Medicine, Hawler Medical University, Erbil, Kurdistan Region 44002, Iraq, Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region 44002, Iraq, General Directorate of Scientific Research Center, Salahaddin University‑Erbil, Erbil, Kurdistan Region 44002, Iraq
    Copyright: © Salihi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 233
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    Published online on: May 25, 2022
       https://doi.org/10.3892/mmr.2022.12749
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Abstract

Nitric oxide, carbon monoxide and hydrogen sulfide are three endogenous gasotransmitters that serve a role in regulating normal and pathological cellular activities. They can stimulate or inhibit cancer cell proliferation and invasion, as well as interfere with cancer cell responses to drug treatments. Understanding the molecular pathways governing the interactions between these gases and the tumor microenvironment can be utilized for the identification of a novel technique to disrupt cancer cell interactions and may contribute to the conception of effective and safe cancer therapy strategies. The present review discusses the effects of these gases in modulating the action of chemotherapies, as well as prospective pharmacological and therapeutic interfering approaches. A deeper knowledge of the mechanisms that underpin the cellular and pharmacological effects, as well as interactions, of each of the three gases could pave the way for therapeutic treatments and translational research.
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Copy and paste a formatted citation
Spandidos Publications style
Salihi A, Al‑Naqshabandi MA, Khudhur ZO, Housein Z, Hama HA, Abdullah RM, Hussen BM and Alkasalias T: Gasotransmitters in the tumor microenvironment: Impacts on cancer chemotherapy (Review). Mol Med Rep 26: 233, 2022.
APA
Salihi, A., Al‑Naqshabandi, M.A., Khudhur, Z.O., Housein, Z., Hama, H.A., Abdullah, R.M. ... Alkasalias, T. (2022). Gasotransmitters in the tumor microenvironment: Impacts on cancer chemotherapy (Review). Molecular Medicine Reports, 26, 233. https://doi.org/10.3892/mmr.2022.12749
MLA
Salihi, A., Al‑Naqshabandi, M. A., Khudhur, Z. O., Housein, Z., Hama, H. A., Abdullah, R. M., Hussen, B. M., Alkasalias, T."Gasotransmitters in the tumor microenvironment: Impacts on cancer chemotherapy (Review)". Molecular Medicine Reports 26.1 (2022): 233.
Chicago
Salihi, A., Al‑Naqshabandi, M. A., Khudhur, Z. O., Housein, Z., Hama, H. A., Abdullah, R. M., Hussen, B. M., Alkasalias, T."Gasotransmitters in the tumor microenvironment: Impacts on cancer chemotherapy (Review)". Molecular Medicine Reports 26, no. 1 (2022): 233. https://doi.org/10.3892/mmr.2022.12749
Copy and paste a formatted citation
x
Spandidos Publications style
Salihi A, Al‑Naqshabandi MA, Khudhur ZO, Housein Z, Hama HA, Abdullah RM, Hussen BM and Alkasalias T: Gasotransmitters in the tumor microenvironment: Impacts on cancer chemotherapy (Review). Mol Med Rep 26: 233, 2022.
APA
Salihi, A., Al‑Naqshabandi, M.A., Khudhur, Z.O., Housein, Z., Hama, H.A., Abdullah, R.M. ... Alkasalias, T. (2022). Gasotransmitters in the tumor microenvironment: Impacts on cancer chemotherapy (Review). Molecular Medicine Reports, 26, 233. https://doi.org/10.3892/mmr.2022.12749
MLA
Salihi, A., Al‑Naqshabandi, M. A., Khudhur, Z. O., Housein, Z., Hama, H. A., Abdullah, R. M., Hussen, B. M., Alkasalias, T."Gasotransmitters in the tumor microenvironment: Impacts on cancer chemotherapy (Review)". Molecular Medicine Reports 26.1 (2022): 233.
Chicago
Salihi, A., Al‑Naqshabandi, M. A., Khudhur, Z. O., Housein, Z., Hama, H. A., Abdullah, R. M., Hussen, B. M., Alkasalias, T."Gasotransmitters in the tumor microenvironment: Impacts on cancer chemotherapy (Review)". Molecular Medicine Reports 26, no. 1 (2022): 233. https://doi.org/10.3892/mmr.2022.12749
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