Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
October-2022 Volume 26 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2022 Volume 26 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Lutein inhibits IL‑6 expression by inducing PPAR‑γ activation and SOCS3 expression in cerulein‑stimulated pancreatic acinar cells

  • Authors:
    • Yu Jin Ahn
    • Joo Weon Lim
    • Hyeyong Kim
  • View Affiliations / Copyright

    Affiliations: Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul 03722, Republic of Korea
    Copyright: © Ahn et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 302
    |
    Published online on: August 9, 2022
       https://doi.org/10.3892/mmr.2022.12818
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Acute pancreatitis is a severe inflammatory disease of the pancreas. In experimental acute pancreatitis, cerulein induces the expression of interleukin‑6 (IL‑6) by activating Janus kinase (JAK) 2/signal transducer and activator of transcription (STAT) 3 in pancreatic acinar cells. Ligands of peroxisome proliferator activated receptor‑γ (PPAR‑γ) and suppressor of cytokine signaling (SOCS) 3 inhibit IL‑6 expression by suppressing JAK2/STAT3 in cerulein‑stimulated pancreatic acinar AR42J cells. Lutein, an oxygenated carotenoid, upregulates and activates PPAR‑γ to regulate inflammation in a renal injury model. The present study aimed to determine whether lutein activated PPAR‑γ and induced SOCS3 expression in unstimulated AR42J cells, and whether lutein inhibited activation of JAK2/STAT3 and IL‑6 expression via activation of PPAR‑γ and SOCS3 expression in cerulein‑stimulated AR42J cells. The anti‑inflammatory mechanism of lutein was determined using reverse transcription‑quantitative PCR, western blot analysis and enzyme‑linked immunosorbent assay in AR42J cells stimulated with or without cerulein. In another experiment, cells were treated with lutein and the PPAR‑γ antagonist GW9662 or the PPAR‑γ agonist troglitazone prior to cerulein stimulation to determine the involvement of PPAR‑γ activation. The results indicated that lutein increased PPAR‑γ and SOCS3 levels in unstimulated cells. Cerulein increased phospho‑specific forms of JAK2 and STAT3, and mRNA and protein expression of IL‑6, but decreased SOCS3 levels in AR42J cells. Cerulein‑induced alterations were suppressed by lutein or troglitazone. GW9662 alleviated the inhibitory effect of lutein on JAK2/STAT3 activation and IL‑6 expression in cerulein‑stimulated cells. In conclusion, lutein inhibited the activation of JAK2/STAT3 and reduced IL‑6 levels via PPAR‑γ‑mediated SOCS3 expression in pancreatic acinar cells stimulated with cerulein.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Leach SD, Gorelick FS and Modlin IM: New perspectives on acute pancreatitis. Scand J Gastroenterol. 27 (Suppl 192):S29–S38. 1992. View Article : Google Scholar

2 

Banks P: Predictors of severity in acute pancreatitis. Pancreas. 6 (Suppl 1):S7–S12. 1991. View Article : Google Scholar : PubMed/NCBI

3 

Gu H, Werner J, Bergmann F, Whitcomb DC, Büchler MW and Fortunato F: Necro-inflammatory response of pancreatic acinar cells in the pathogenesis of acute alcoholic pancreatitis. Cell Death Dis. 4:e8162013. View Article : Google Scholar : PubMed/NCBI

4 

Biffl WL, Moore EE, Moore FA and Peterson VM: Interleukin-6 in the injured patients: Marker of injury or mediator of inflammation. Ann Surg. 224:647–664. 1996. View Article : Google Scholar : PubMed/NCBI

5 

Kishimoto T, Akira S, Narazaki M and Taga T: Interleukin-6 family of cytokines and gp130. Blood. 86:1243–1254. 1995. View Article : Google Scholar : PubMed/NCBI

6 

Hyun JJ and Lee HS: Experimental models of pancreatitis. Clin Endosc. 47:212–216. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Kim H: Cerulein pancreatitis: Oxidative stress inflammation and apoptosis. Gut Liver. 2:74–80. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Yu JH, Kim KH and Kim H: Suppression of IL-1beta expression by the Jak 2 inhibitor AG490 in cerulein-stimulated pancreatic acinar cells. Biochem Pharmacol. 72:1555–1562. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Yu JH, Kim KH and Kim H: SOCS 3 and PPAR-gamma ligands inhibit the expression of IL-6 and TGF-beta1 by regulating JAK2/STAT3 signaling in pancreas. Int J Biochem Cell Biol. 40:677–688. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Watowich SS, Wu H, Socolovsky M, Klingmuller U, Constantinescu SN and Lodish HF: Cytokine receptor signal transduction and the control of hematopoietic cell development. Annu Rev Cell Dev Biol. 12:91–128. 1996. View Article : Google Scholar : PubMed/NCBI

11 

Ferrand A, Kowalski-Chauvel A, Bertrand C, Escrieut C, Mathieu A, Portolan G, Pradayrol L, Fourmy D, Dufresne M and Seva C: A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: Implication of this signaling pathway in pancreatic tumor models. J Biol Chem. 280:10710–10715. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Fenner JE, Starr R, Cornish AL, Zhang JG, Metcalf D, Schreiber RD, Sheehan K, Hilton DJ, Alexander WS and Hertzog PJ: Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity. Nature Immunol. 7:33–39. 2005. View Article : Google Scholar

13 

Hilton DJ, Richardson RT, Alexander WS, Viney EM, Willson TA, Sprigg NS, Starr R, Nicholson SE, Metcalf D and Nicola NA: Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc Nat Acad Sci USA. 95:114–119. 1998. View Article : Google Scholar : PubMed/NCBI

14 

Berlato C, Cassatella MA, Kinjyo I, Gatto L, Yoshimura A and Bazzoni F: Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation. J Immunol. 168:6404–6411. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Lazar MA: PPAR gamma, 10 years later. Biochimie. 87:9–13. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Barish GD, Downes M, Alaynick WA, Yu RT, Ocampo CB, Bookout AL, Mangelsdorf DJ and Evans RM: Nuclear receptor atlas: Macrophage activation. Mol Endocrinol. 19:2466–2477. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Zhao W, Shi G, Gu H and Nguyen BN: Role of PPARγ in the nutritional and pharmacological actions of carotenoids. Res Report Biochem. 6:13–24. 2016. View Article : Google Scholar

18 

Rollins MD, Sudarshan S, Firpo MA, Etherington BH, Hart BJ, Jackson HH, Jackson JD, Emerson LL, Yang DT, Mulvihill SJ and Glasgow RE: Anti-inflammatory effects of PPAR-gamma agonists directly correlate with PPAR-gamma expression during acute pancreatitis. J Gastrointest Surg. 10:1120–1130. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Berger H, Végran F, Chikh M, Gilardi F, Ladoire S, Bugaut H, Mignot G, Chalmin F, Bruchard M, Derangère V, et al: SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth. Cancer Res. 73:3578–3590. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Végran F, Berger H, Ghiringhelli F and Apetoh L: Socs3 induction by PPARγ restrains cancer-promoting inflammation. Cell Cycle. 12:2157–2158. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Ahn YJ and Kim H: Lutein as a modulator of oxidative stress-mediated inflammatory diseases. Antioxidants (Basel). 10:14482021. View Article : Google Scholar : PubMed/NCBI

22 

Selvaraj RK, Shanmugasundaram R and Klasing KC: Effects of dietary lutein and PUFA on PPAR and RXR isomer expression in chickens during an inflammatory response. Comp Biochem Physiol A Mol Integr Physiol. 157:198–203. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Emeka PM, Rasool ST, Morsy MA, Islam MIH and Chohan MS: Protective effects of lutein against vancomycin-induced acute renal injury in mice via upregulation of peroxisome proliferator-activated receptor gamma/nuclear factor erythroid 2-related factor 2 and inhibition nuclear factor-kappaB/caspase 3. Kor J Physiol Pharmacol. 25:321–331. 2021. View Article : Google Scholar : PubMed/NCBI

24 

Yu JH, Kim KH and Kim H: Role of NADPH oxidase and calcium in cerulein-induced apoptosis: Involvement of apoptosis-inducing factor. Ann NY Acad Sci. 1090:292–297. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Kwak MS, Lim JW and Kim H: Astaxanthin inhibits interleukin-6 expression in cerulein/resistin-stimulated pancreatic acinar cells. Med Inflamm. 2021:55872972021. View Article : Google Scholar : PubMed/NCBI

26 

Lim JW, Kim KH and Kim H: NF-kappaB p65 regulates nuclear translocation of Ku70 via degradation of heat shock cognate protein 70 in pancreatic acinar AR42J cells. Int J Biochem Cell Biol. 40:2065–2077. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Song EA, Lim JW and Kim H: Docosahexaenoic acid inhibits IL-6 expression via PPARγ-mediated expression of catalase in cerulein-stimulated pancreatic acinar cells. Int J Biochem Cell Biol. 88:60–68. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Kapadia R, Yi JH and Vemuganti R: Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists. Front Biosci. 13:1813–1826. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Carow B and Rottenberg ME: SOCS3, a major regulator of infection and inflammation. Front Immunol. 5:582014. View Article : Google Scholar : PubMed/NCBI

30 

Roberts AW, Robb L, Rakar S, Hartley L, Cluse L, Nicola NA, Metcalf D, Hilton DJ and Alexander WS: Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc Nat Acad Sci USA. 98:9324–9329. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Carballo M, Conde M, El Bekay R, Martín-Nieto J, Camacho MJ, Monteseirín J, Conde J, Bedoya FJ and Sobrino F: Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes. J Biol Chem. 274:17580–17586. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Gallmeier E, Schäfer C, Moubarak P, Tietz A, Plössl I, Huss R, Göke B and Wagner ACC: JAK and STAT proteins are expressed and activated by IFN-gamma in rat pancreatic acinar cells. J Cell Physiol. 203:209–216. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Vona-Davis LC, Frankenberry KA, Waheed U, Peterson E and McFadden DW: Expression of STAT3 and SOCS3 in pancreatic acinar cells. J Surg Res. 127:14–20. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Yoon S, Woo SU, Kang JH, Kim K, Kwon MH, Park S, Shin HJ, Gwak HS and Chwae YJ: STAT3 transcriptional factor activated by reactive oxygen species induces IL6 in starvation-induced autophagy of cancer cells. Autophagy. 6:1125–1138. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Ortiz-Muñoz G, Martin-Ventura JL, Hernandez-Vargas P, Mallavia B, Lopez-Parra V, Lopez-Franco O, Muñoz-Garcia B, Fernandez-Vizarra P, Ortega L, Egido J and Gomez-Guerrero C: Suppressors of cytokine signaling modulate JAK/STAT-mediated cell responses during atherosclerosis. Arterioscler Thromb Vasc Biol. 29:525–531. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Kim JE, Clark RM, Park Y, Lee J and Fernandez ML: Lutein decreases oxidative stress and inflammation in liver and eyes of guinea pigs fed a hypercholesterolemic diet. Nutr Res Pract. 6:113–119. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Ma Y, Shi M, Wang Y and Liu J: PPARγ and its agonists in chronic kidney disease. Int J Nephrol. 2020:29174742020. View Article : Google Scholar : PubMed/NCBI

38 

Desvergne B and Wahli W: Peroxisome proliferator-activated receptors: Nuclear control of metabolism. Endocr Rev. 20:649–688. 1999. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ahn YJ, Lim JW and Kim H: Lutein inhibits IL‑6 expression by inducing PPAR‑γ activation and SOCS3 expression in cerulein‑stimulated pancreatic acinar cells. Mol Med Rep 26: 302, 2022.
APA
Ahn, Y.J., Lim, J.W., & Kim, H. (2022). Lutein inhibits IL‑6 expression by inducing PPAR‑γ activation and SOCS3 expression in cerulein‑stimulated pancreatic acinar cells. Molecular Medicine Reports, 26, 302. https://doi.org/10.3892/mmr.2022.12818
MLA
Ahn, Y. J., Lim, J. W., Kim, H."Lutein inhibits IL‑6 expression by inducing PPAR‑γ activation and SOCS3 expression in cerulein‑stimulated pancreatic acinar cells". Molecular Medicine Reports 26.4 (2022): 302.
Chicago
Ahn, Y. J., Lim, J. W., Kim, H."Lutein inhibits IL‑6 expression by inducing PPAR‑γ activation and SOCS3 expression in cerulein‑stimulated pancreatic acinar cells". Molecular Medicine Reports 26, no. 4 (2022): 302. https://doi.org/10.3892/mmr.2022.12818
Copy and paste a formatted citation
x
Spandidos Publications style
Ahn YJ, Lim JW and Kim H: Lutein inhibits IL‑6 expression by inducing PPAR‑γ activation and SOCS3 expression in cerulein‑stimulated pancreatic acinar cells. Mol Med Rep 26: 302, 2022.
APA
Ahn, Y.J., Lim, J.W., & Kim, H. (2022). Lutein inhibits IL‑6 expression by inducing PPAR‑γ activation and SOCS3 expression in cerulein‑stimulated pancreatic acinar cells. Molecular Medicine Reports, 26, 302. https://doi.org/10.3892/mmr.2022.12818
MLA
Ahn, Y. J., Lim, J. W., Kim, H."Lutein inhibits IL‑6 expression by inducing PPAR‑γ activation and SOCS3 expression in cerulein‑stimulated pancreatic acinar cells". Molecular Medicine Reports 26.4 (2022): 302.
Chicago
Ahn, Y. J., Lim, J. W., Kim, H."Lutein inhibits IL‑6 expression by inducing PPAR‑γ activation and SOCS3 expression in cerulein‑stimulated pancreatic acinar cells". Molecular Medicine Reports 26, no. 4 (2022): 302. https://doi.org/10.3892/mmr.2022.12818
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team