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Multi‑faceted roles of cathepsins in ischemia reperfusion injury (Review)

  • Authors:
    • Jaime Huertas
    • H. Thomas Lee
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032‑3784, USA
    Copyright: © Huertas et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 368
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    Published online on: October 26, 2022
       https://doi.org/10.3892/mmr.2022.12885
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Abstract

Cathepsins are one of the most abundant proteases within the lysosomes with diverse physiological effects ranging from immune responses, cell death and intracellular protein degradation. Cathepsins are involved in extracellular and systemic functions such as systemic inflammation and extracellular matrix degradation. Ischemia reperfusion (IR) injury is responsible for numerous diseases including myocardial infarction, acute kidney injury, stroke and acute graft failure after transplant surgery. Inflammation plays a major role in the reperfusion phase of IR injury and previous research has shown that cathepsins are key mediators of the inflammation cascade as well as apoptosis. Taken together, cathepsins modulation could provide potential therapeutic approaches to attenuate IR injury. The present review summarized the current understanding of various cathepsin subtypes, their major physiologic functions, their roles in multi‑organ IR injury and detailed selective cathepsin inhibitors with therapeutic potential.
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1 

Patel S, Homaei A, El-Seedi HR and Akhtar N: Cathepsins: Proteases that are vital for survival but can also be fatal. Biomed Pharmacother. 105:526–532. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Cocchiaro P, De Pasquale V, Della Morte R, Tafuri S, Avallone L, Pizard A, Moles A and Pavone LM: The multifaceted role of the lysosomal protease cathepsins in kidney disease. Front Cell Dev Biol. 5:1142017. View Article : Google Scholar : PubMed/NCBI

3 

Brix K, Dunkhorst A, Mayer K and Jordans S: Cysteine cathepsins: Cellular roadmap to different functions. Biochimie. 90:194–207. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Vidak E, Javoršek U, Vizovišek M and Turk B: Cysteine cathepsins and their extracellular roles: Shaping the microenvironment. Cells. 8:2642019. View Article : Google Scholar : PubMed/NCBI

5 

Xu Y, Wang J, Song X, Wei R, He F, Peng G and Luo B: Protective mechanisms of CA074-me (other than cathepsin-B inhibition) against programmed necrosis induced by global cerebral ischemia/reperfusion injury in rats. Brain Res Bull. 120:97–105. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Stoka V, Turk V and Turk B: Lysosomal cysteine cathepsins: Signaling pathways in apoptosis. Biol Chem. 388:555–560. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Tan GJ, Peng ZK, Lu JP and Tang FQ: Cathepsins mediate tumor metastasis. World J Biol Chem. 4:91–101. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Hook G, Jacobsen JS, Grabstein K, Kindy M and Hook V: Cathepsin B is a new drug target for traumatic brain injury therapeutics: Evidence for E64d as a promising lead drug candidate. Front Neurol. 6:1782015. View Article : Google Scholar : PubMed/NCBI

9 

Ben-Ari Z, Mor E, Azarov D, Sulkes J, Tor R, Cheporko Y, Hochhauser E and Pappo O: Cathepsin B inactivation attenuates the apoptotic injury induced by ischemia/reperfusion of mouse liver. Apoptosis. 10:1261–1269. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Yadati T, Houben T, Bitorina A and Shiri-Sverdlov R: The Ins and outs of cathepsins: Physiological function and role in disease management. Cells. 9:16792020. View Article : Google Scholar : PubMed/NCBI

11 

Chevriaux A, Pilot T, Derangère V, Simonin H, Martine P, Chalmin F, Ghiringhelli F and Rébé C: Cathepsin B is required for NLRP3 inflammasome activation in macrophages, through NLRP3 interaction. Front Cell Dev Biol. 8:1672020. View Article : Google Scholar : PubMed/NCBI

12 

Tang TT, Lv LL, Pan MM, Wen Y, Wang B, Li ZL, Wu M, Wang FM, Crowley SD and Liu BC: Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation. Cell Death Dis. 9:3512018. View Article : Google Scholar : PubMed/NCBI

13 

Korkmaz B, Caughey GH, Chapple I, Gauthier F, Hirschfeld J, Jenne DE, Kettritz R, Lalmanach G, Lamort AS, Lauritzen C, et al: Therapeutic targeting of cathepsin C: From pathophysiology to treatment. Pharmacol Ther. 190:202–236. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Rehm SRT, Smirnova NF, Morrone C, Götzfried J, Feuchtinger A, Pedersen J, Korkmaz B, Yildirim AÖ and Jenne DE: Premedication with a cathepsin C inhibitor alleviates early primary graft dysfunction in mouse recipients after lung transplantation. Sci Rep. 9:99252019. View Article : Google Scholar : PubMed/NCBI

15 

Dennemärker J, Lohmüller T, Müller S, Aguilar SV, Tobin DJ, Peters C and Reinheckel T: Impaired turnover of autophagolysosomes in cathepsin L deficiency. Biol Chem. 391:913–922. 2010. View Article : Google Scholar : PubMed/NCBI

16 

McComb S, Shutinoski B, Thurston S, Cessford E, Kumar K and Sad S: Cathepsins limit macrophage necroptosis through cleavage of Rip1 kinase. J Immunol. 192:5671–5678. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Figueiredo JL, Aikawa M, Zheng C, Aaron J, Lax L, Libby P, de Lima Filho JL, Gruener S, Fingerle J, Haap W, et al: Selective cathepsin S inhibition attenuates atherosclerosis in apolipoprotein E-deficient mice with chronic renal disease. Am J Pathol. 185:1156–1166. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Nakanishi H: Neuronal and microglial cathepsins in aging and age-related diseases. Ageing Res Rev. 2:367–381. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Kos J, Sekirnik A, Premzl A, Zavasnik Bergant V, Langerholc T, Turk B, Werle B, Golouh R, Repnik U, Jeras M and Turk V: Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues. Exp Cell Res. 306:103–113. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Polcyn R, Capone M, Hossain A, Matzelle D, Banik NL and Haque A: Neuron specific enolase is a potential target for regulating neuronal cell survival and death: Implications in neurodegeneration and regeneration. Neuroimmunol Neuroinflamm. 4:254–257. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Obermajer N, Premzl A, Zavasnik Bergant T, Turk B and Kos J: Carboxypeptidase cathepsin X mediates beta2-integrin-dependent adhesion of differentiated U-937 cells. Exp Cell Res. 312:2515–2527. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Ondr JK and Pham CT: Characterization of murine cathepsin W and its role in cell-mediated cytotoxicity. J Biol Chem. 279:27525–27533. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Wex T, Wex H, Hartig R, Wilhelmsen S and Malfertheiner P: Functional involvement of cathepsin W in the cytotoxic activity of NK-92 cells. FEBS Lett. 552:115–119. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Stoeckle C, Gouttefangeas C, Hammer M, Weber E, Melms A and Tolosa E: Cathepsin W expressed exclusively in CD8+ T cells and NK cells, is secreted during target cell killing but is not essential for cytotoxicity in human CTLs. Exp Hematol. 37:266–275. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Kakehashi H, Nishioku T, Tsukuba T, Kadowaki T, Nakamura S and Yamamoto K: Differential regulation of the nature and functions of dendritic cells and macrophages by cathepsin E. J Immunol. 179:5728–5737. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Chain BM, Free P, Medd P, Swetman C, Tabor AB and Terrazzini N: The expression and function of cathepsin E in dendritic cells. J Immunol. 174:1791–1800. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Yamamoto K, Kawakubo T, Yasukochi A and Tsukuba T: Emerging roles of cathepsin E in host defense mechanisms. Biochim Biophys Acta. 1824:105–112. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Deussing J, Roth W, Saftig P, Peters C, Ploegh HL and Villadangos JA: Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation. Proc Natl Acad Sci USA. 95:4516–4521. 1998. View Article : Google Scholar : PubMed/NCBI

29 

Droga-Mazovec G, Bojic L, Petelin A, Ivanova S, Romih R, Repnik U, Salvesen GS, Stoka V, Turk V and Turk B: Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues. J Biol Chem. 283:19140–19150. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Conus S, Perozzo R, Reinheckel T, Peters C, Scapozza L, Yousefi S and Simon HU: Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation. J Exp Med. 205:685–698. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Bidère N, Lorenzo HK, Carmona S, Laforge M, Harper F, Dumont C and Senik A: Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. J Biol Chem. 278:31401–31411. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Seyrantepe V, Hinek A, Peng J, Fedjaev M, Ernest S, Kadota Y, Canuel M, Itoh K, Morales CR, Lavoie J, et al: Enzymatic activity of lysosomal carboxypeptidase (cathepsin) A is required for proper elastic fiber formation and inactivation of endothelin-1. Circulation. 117:1973–1981. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Jackman HL, Massad MG, Sekosan M, Tan F, Brovkovych V, Marcic BM and Erdös EG: Angiotensin 1–9 and 1–7 release in human heart: Role of cathepsin A. Hypertension. 39:976–981. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Burster T, Macmillan H, Hou T, Boehm BO and Mellins ED: Cathepsin G: Roles in antigen presentation and beyond. Mol Immunol. 47:658–665. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Meyer-Hoffert U: Neutrophil-derived serine proteases modulate innate immune responses. Front Biosci (Landmark Ed). 14:3409–3418. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Pintucci G, Iacoviello L, Castelli MP, Amore C, Evangelista V, Cerletti C and Donati MB: Cathepsin G-induced release of PAI-1 in the culture medium of endothelial cells: A new thrombogenic role for polymorphonuclear leukocytes? J Lab Clin Med. 122:69–79. 1993.PubMed/NCBI

37 

Richter R, Bistrian R, Escher S, Forssmann WG, Vakili J, Henschler R, Spodsberg N, Frimpong-Boateng A and Forssmann U: Quantum proteolytic activation of chemokine CCL15 by neutrophil granulocytes modulates mononuclear cell adhesiveness. J Immunol. 175:1599–1608. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Miao Z, Premack BA, Wei Z, Wang Y, Gerard C, Showell H, Howard M, Schall TJ and Berahovich R: Proinflammatory proteases liberate a discrete high-affinity functional FPRL1 (CCR12) ligand from CCL23. J Immunol. 178:7395–7404. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Brignone C, Munoz O, Batoz M, Rouquette-Jazdanian A and Cousin JL: Proteases produced by activated neutrophils are able to release soluble CD23 fragments endowed with proinflammatory effects. FASEB J. 15:2027–2029. 2001. View Article : Google Scholar : PubMed/NCBI

40 

Yang Z, Weian C, Susu H and Hanmin W: Protective effects of mangiferin on cerebral ischemia-reperfusion injury and its mechanisms. Eur J Pharmacol. 771:145–151. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Seyfried DM, Veyna R, Han Y, Li K, Tang N, Betts RL, Weinsheimer S, Chopp M and Anagli J: A selective cysteine protease inhibitor is non-toxic and cerebroprotective in rats undergoing transient middle cerebral artery ischemia. Brain Res. 901:94–101. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Benchoua A, Braudeau J, Reis A, Couriaud C and Onténiente B: Activation of proinflammatory caspases by cathepsin B in focal cerebral ischemia. J Cereb Blood Flow Metab. 24:1272–1279. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Guicciardi ME, Deussing J, Miyoshi H, Bronk SF, Svingen PA, Peters C, Kaufmann SH and Gores GJ: Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J Clin Invest. 106:1127–1137. 2000. View Article : Google Scholar : PubMed/NCBI

44 

Tsubokawa T, Solaroglu I, Yatsushige H, Cahill J, Yata K and Zhang JH: Cathepsin and calpain inhibitor E64d attenuates matrix metalloproteinase-9 activity after focal cerebral ischemia in rats. Stroke. 37:1888–1894. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Qin XF, Lu XJ, Ge JB, Xu HZ, Qin HD and Xu F: Ginkgolide B prevents cathepsin-mediated cell death following cerebral ischemia/reperfusion injury. Neuroreport. 25:267–273. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Wei R, Wang J, Xu Y, Yin B, He F, Du Y, Peng G and Luo B: Probenecid protects against cerebral ischemia/reperfusion injury by inhibiting lysosomal and inflammatory damage in rats. Neuroscience. 301:168–177. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Zhu YM, Gao X, Ni Y, Li W, Kent TA, Qiao SG, Wang C, Xu XX and Zhang HL: Sevoflurane postconditioning attenuates reactive astrogliosis and glial scar formation after ischemia-reperfusion brain injury. Neuroscience. 356:125–141. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Cui DR, Wang L, Jiang W, Qi AH, Zhou QH and Zhang XL: Propofol prevents cerebral ischemia-triggered autophagy activation and cell death in the rat hippocampus through the NF-κB/p53 signaling pathway. Neuroscience. 246:117–132. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Ahsan A, Zheng Y, Ma S, Liu M, Cao M, Li Y, Zheng W, Zhou X, Xin M, Hu WW, et al: Tomatidine protects against ischemic neuronal injury by improving lysosomal function. Eur J Pharmacol. 882:1732802020. View Article : Google Scholar : PubMed/NCBI

50 

Kilinc M, Gürsoy-Ozdemir Y, Gürer G, Erdener SE, Erdemli E, Can A and Dalkara T: Lysosomal rupture, necroapoptotic interactions and potential crosstalk between cysteine proteases in neurons shortly after focal ischemia. Neurobiol Dis. 40:293–302. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Wang F, Gómez-Sintes R and Boya P: Lysosomal membrane permeabilization and cell death. Traffic. 19:918–931. 2018. View Article : Google Scholar : PubMed/NCBI

52 

Kirkegaard T, Roth AG, Petersen NH, Mahalka AK, Olsen OD, Moilanen I, Zylicz A, Knudsen J, Sandhoff K, Arenz C, et al: Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology. Nature. 463:549–553. 2010. View Article : Google Scholar : PubMed/NCBI

53 

Yamashima T: Hsp70.1 and related lysosomal factors for necrotic neuronal death. J Neurochem. 120:477–494. 2012. View Article : Google Scholar : PubMed/NCBI

54 

Heusch G and Gersh BJ: The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: A continual challenge. Eur Heart J. 38:774–784. 2017.PubMed/NCBI

55 

Vander Heide RS and Steenbergen C: Cardioprotection and myocardial reperfusion: Pitfalls to clinical application. Circ Res. 113:464–477. 2013. View Article : Google Scholar : PubMed/NCBI

56 

Frangogiannis NG: Regulation of the inflammatory response in cardiac repair. Circ Res. 110:159–173. 2012. View Article : Google Scholar : PubMed/NCBI

57 

Kain V, Prabhu SD and Halade GV: Inflammation revisited: Inflammation versus resolution of inflammation following myocardial infarction. Basic Res Cardiol. 109:4442014. View Article : Google Scholar : PubMed/NCBI

58 

Meyer-Hoffert U and Wiedow O: Neutrophil serine proteases: Mediators of innate immune responses. Curr Opin Hematol. 18:19–24. 2011. View Article : Google Scholar : PubMed/NCBI

59 

Sabri A, Alcott SG, Elouardighi H, Pak E, Derian C, Andrade-Gordon P, Kinnally K and Steinberg SF: Neutrophil cathepsin G promotes detachment-induced cardiomyocyte apoptosis via a protease-activated receptor-independent mechanism. J Biol Chem. 278:23944–23954. 2003. View Article : Google Scholar : PubMed/NCBI

60 

Iacoviello L, Kolpakov V, Salvatore L, Amore C, Pintucci G, de Gaetano G and Donati MB: Human endothelial cell damage by neutrophil-derived cathepsin G. Role of cytoskeleton rearrangement and matrix-bound plasminogen activator inhibitor-1. Arterioscler Thromb Vasc Biol. 15:2037–2046. 1995. View Article : Google Scholar : PubMed/NCBI

61 

Hooshdaran B, Kolpakov MA, Guo X, Miller SA, Wang T, Tilley DG, Rafiq K and Sabri A: Dual inhibition of cathepsin G and chymase reduces myocyte death and improves cardiac remodeling after myocardial ischemia reperfusion injury. Basic Res Cardiol. 112:622017. View Article : Google Scholar : PubMed/NCBI

62 

Taleb S, Cancello R, Clément K and Lacasa D: Cathepsin S promotes human preadipocyte differentiation: Possible involvement of fibronectin degradation. Endocrinology. 147:4950–4959. 2006. View Article : Google Scholar : PubMed/NCBI

63 

Chen H, Wang J, Xiang MX, Lin Y, He A, Jin CN, Guan J, Sukhova GK, Libby P, Wang JA and Shi GP: Cathepsin S-mediated fibroblast trans-differentiation contributes to left ventricular remodelling after myocardial infarction. Cardiovasc Res. 100:84–94. 2013. View Article : Google Scholar : PubMed/NCBI

64 

Peng K, Liu H, Yan B, Meng XW, Song SY, Ji FH and Xia Z: Inhibition of cathepsin S attenuates myocardial ischemia/reperfusion injury by suppressing inflammation and apoptosis. J Cell Physiol. 236:1309–1320. 2021. View Article : Google Scholar : PubMed/NCBI

65 

Linz D, Hohl M, Dhein S, Ruf S, Reil JC, Kabiri M, Wohlfart P, Verheule S, Böhm M, Sadowski T and Schotten U: Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats. Cardiovasc Res. 110:371–380. 2016. View Article : Google Scholar : PubMed/NCBI

66 

Hohl M, Erb K, Lang L, Ruf S, Hübschle T, Dhein S, Linz W, Elliott AD, Sanders P, Zamyatkin O, et al: Cathepsin A mediates ventricular remote remodeling and atrial cardiomyopathy in rats with ventricular ischemia/reperfusion. JACC Basic Transl Sci. 4:332–344. 2019. View Article : Google Scholar : PubMed/NCBI

67 

Turski WA and Zasłonka J: Activity of cathepsin D and L in the heart muscle of coronary patients during coronary-aortal bypass graft operation. Med Sci Monit. 6:853–860. 2000.PubMed/NCBI

68 

Turski WA and Zasłonka J: Effects of Bretschneider cardioplegic fluid on the lysosomal cathepsins D and L of myocardium of coronary patients during coronary-aortal bypass graft operation. Med Sci Monit. 6:861–866. 2000.PubMed/NCBI

69 

Zhai Y, Petrowsky H, Hong JC, Busuttil RW and Kupiec-Weglinski JW: Ischaemia-reperfusion injury in liver transplantation-from bench to bedside. Nat Rev Gastroenterol Hepatol. 10:79–89. 2013. View Article : Google Scholar : PubMed/NCBI

70 

Baskin-Bey ES, Canbay A, Bronk SF, Werneburg N, Guicciardi ME, Nyberg SL and Gores GJ: Cathepsin B inactivation attenuates hepatocyte apoptosis and liver damage in steatotic livers after cold ischemia-warm reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 288:G396–G402. 2005. View Article : Google Scholar : PubMed/NCBI

71 

Guicciardi ME, Miyoshi H, Bronk SF and Gores GJ: Cathepsin B knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: Implications for therapeutic applications. Am J Pathol. 159:2045–2054. 2001. View Article : Google Scholar : PubMed/NCBI

72 

Zhou H, Zhou S, Shi Y, Wang Q, Wei S, Wang P, Cheng F, Auwerx J, Schoonjans K and Lu L: TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury. Am J Transplant. 21:1453–1464. 2021. View Article : Google Scholar : PubMed/NCBI

73 

Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG and Levin A; Acute Kidney Injury Network, : Acute Kidney Injury Network: Report of an initiative to improve outcomes in acute kidney injury. Crit Care. 11:R312007. View Article : Google Scholar : PubMed/NCBI

74 

Eltzschig HK, Bonney SK and Eckle T: Attenuating myocardial ischemia by targeting A2B adenosine receptors. Trends Mol Med. 19:345–354. 2013. View Article : Google Scholar : PubMed/NCBI

75 

Yap SC and Lee HT: Adenosine and protection from acute kidney injury. Curr Opin Nephrol Hypertens. 21:24–32. 2012. View Article : Google Scholar : PubMed/NCBI

76 

Suzuki C, Tanida I, Ohmuraya M, Oliva Trejo JA, Kakuta S, Sunabori T and Uchiyama Y: Lack of Cathepsin D in the renal proximal tubular cells resulted in increased sensitivity against renal ischemia/reperfusion injury. Int J Mol Sci. 20:17112019. View Article : Google Scholar : PubMed/NCBI

77 

Cocchiaro P, Fox C, Tregidgo NW, Howarth R, Wood KM, Situmorang GR, Pavone LM, Sheerin NS and Moles A: Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury. Sci Rep. 6:271122016. View Article : Google Scholar : PubMed/NCBI

78 

Fox C, Cocchiaro P, Oakley F, Howarth R, Callaghan K, Leslie J, Luli S, Wood KM, Genovese F, Sheerin NS and Moles A: Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease. Sci Rep. 6:201012016. View Article : Google Scholar : PubMed/NCBI

79 

Shimoda N, Fukazawa N, Nonomura K and Fairchild RL: Cathepsin G is required for sustained inflammation and tissue injury after reperfusion of ischemic kidneys. Am J Pathol. 170:930–940. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huertas J and Lee H: Multi‑faceted roles of cathepsins in ischemia reperfusion injury (Review). Mol Med Rep 26: 368, 2022.
APA
Huertas, J., & Lee, H. (2022). Multi‑faceted roles of cathepsins in ischemia reperfusion injury (Review). Molecular Medicine Reports, 26, 368. https://doi.org/10.3892/mmr.2022.12885
MLA
Huertas, J., Lee, H."Multi‑faceted roles of cathepsins in ischemia reperfusion injury (Review)". Molecular Medicine Reports 26.6 (2022): 368.
Chicago
Huertas, J., Lee, H."Multi‑faceted roles of cathepsins in ischemia reperfusion injury (Review)". Molecular Medicine Reports 26, no. 6 (2022): 368. https://doi.org/10.3892/mmr.2022.12885
Copy and paste a formatted citation
x
Spandidos Publications style
Huertas J and Lee H: Multi‑faceted roles of cathepsins in ischemia reperfusion injury (Review). Mol Med Rep 26: 368, 2022.
APA
Huertas, J., & Lee, H. (2022). Multi‑faceted roles of cathepsins in ischemia reperfusion injury (Review). Molecular Medicine Reports, 26, 368. https://doi.org/10.3892/mmr.2022.12885
MLA
Huertas, J., Lee, H."Multi‑faceted roles of cathepsins in ischemia reperfusion injury (Review)". Molecular Medicine Reports 26.6 (2022): 368.
Chicago
Huertas, J., Lee, H."Multi‑faceted roles of cathepsins in ischemia reperfusion injury (Review)". Molecular Medicine Reports 26, no. 6 (2022): 368. https://doi.org/10.3892/mmr.2022.12885
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