Open Access

Role of the AMPK/SIRT1 pathway in non‑alcoholic fatty liver disease (Review)

  • Authors:
    • Putri Anggreini
    • Hadi Kuncoro
    • Sri Adi Sumiwi
    • Jutti Levita
  • View Affiliations

  • Published online on: December 21, 2022     https://doi.org/10.3892/mmr.2022.12922
  • Article Number: 35
  • Copyright: © Anggreini et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Non‑alcoholic fatty liver disease (NAFLD) is an increasingly prevalent ailment worldwide. Moreover, de novo lipogenesis (DNL) is considered a critical factor in the development of NAFLD; hence, its inhibition is a promising target for the prevention of fatty liver disease. There is evidence to indicate that AMP‑activated protein kinase (AMPK) and sirtuin 1 (SIRT1) may play a crucial role in DNL and are the regulatory proteins in type 2 diabetes mellitus, obesity and cardiovascular disease. Therefore, AMPK and SIRT1 may be promising targets for the treatment of NAFLD. The present review article thus aimed to summarize the findings of clinical studies published during the past decade that suggested the beneficial effects of AMPK and SIRT1, using their specific activators and their combined effects on fatty liver disease.
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February-2023
Volume 27 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Anggreini P, Kuncoro H, Sumiwi SA and Levita J: Role of the AMPK/SIRT1 pathway in non‑alcoholic fatty liver disease (Review). Mol Med Rep 27: 35, 2023
APA
Anggreini, P., Kuncoro, H., Sumiwi, S.A., & Levita, J. (2023). Role of the AMPK/SIRT1 pathway in non‑alcoholic fatty liver disease (Review). Molecular Medicine Reports, 27, 35. https://doi.org/10.3892/mmr.2022.12922
MLA
Anggreini, P., Kuncoro, H., Sumiwi, S. A., Levita, J."Role of the AMPK/SIRT1 pathway in non‑alcoholic fatty liver disease (Review)". Molecular Medicine Reports 27.2 (2023): 35.
Chicago
Anggreini, P., Kuncoro, H., Sumiwi, S. A., Levita, J."Role of the AMPK/SIRT1 pathway in non‑alcoholic fatty liver disease (Review)". Molecular Medicine Reports 27, no. 2 (2023): 35. https://doi.org/10.3892/mmr.2022.12922