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Regulation of hematopoiesis by hedgehog signaling (Review)

  • Authors:
    • Jianying Chen
    • Yan Sun
    • Zuohua Chi
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The First Affiliated Hospital/School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, P.R. China, Department of Biological Sciences, Guangdong Province Key Laboratory for Biotechnology Drug Candidates, College of Life Science and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, P.R. China
  • Article Number: 100
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    Published online on: March 28, 2023
       https://doi.org/10.3892/mmr.2023.12987
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Abstract

Hedgehog (Hh) signaling has a fundamental role in embryonic organogenesis, tissue repair, and the proliferation and differentiation of various cells, such as the hierarchy of blood cells. At present, the role of Hh signaling in hematopoiesis remains unclear. The present review highlighted recent findings focused on Hh signaling in the regulation of hematopoietic development during the early embryonic stage, and the proliferation and differentiation of hematopoietic stem and progenitor cells in adults. A greater understanding of the role of Hh signaling in fetal and postnatal hematopoiesis would provide therapeutic strategies to maintain hematopoietic homeostasis and enhance hematopoietic reconstruction through targeting of the Hh cascade.
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Copy and paste a formatted citation
Spandidos Publications style
Chen J, Sun Y and Chi Z: Regulation of hematopoiesis by hedgehog signaling (Review). Mol Med Rep 27: 100, 2023.
APA
Chen, J., Sun, Y., & Chi, Z. (2023). Regulation of hematopoiesis by hedgehog signaling (Review). Molecular Medicine Reports, 27, 100. https://doi.org/10.3892/mmr.2023.12987
MLA
Chen, J., Sun, Y., Chi, Z."Regulation of hematopoiesis by hedgehog signaling (Review)". Molecular Medicine Reports 27.5 (2023): 100.
Chicago
Chen, J., Sun, Y., Chi, Z."Regulation of hematopoiesis by hedgehog signaling (Review)". Molecular Medicine Reports 27, no. 5 (2023): 100. https://doi.org/10.3892/mmr.2023.12987
Copy and paste a formatted citation
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Spandidos Publications style
Chen J, Sun Y and Chi Z: Regulation of hematopoiesis by hedgehog signaling (Review). Mol Med Rep 27: 100, 2023.
APA
Chen, J., Sun, Y., & Chi, Z. (2023). Regulation of hematopoiesis by hedgehog signaling (Review). Molecular Medicine Reports, 27, 100. https://doi.org/10.3892/mmr.2023.12987
MLA
Chen, J., Sun, Y., Chi, Z."Regulation of hematopoiesis by hedgehog signaling (Review)". Molecular Medicine Reports 27.5 (2023): 100.
Chicago
Chen, J., Sun, Y., Chi, Z."Regulation of hematopoiesis by hedgehog signaling (Review)". Molecular Medicine Reports 27, no. 5 (2023): 100. https://doi.org/10.3892/mmr.2023.12987
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