Regulation of hematopoiesis by hedgehog signaling (Review)

  • Authors:
    • Jianying Chen
    • Yan Sun
    • Zuohua Chi
  • View Affiliations

  • Published online on: March 28, 2023     https://doi.org/10.3892/mmr.2023.12987
  • Article Number: 100
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Abstract

Hedgehog (Hh) signaling has a fundamental role in embryonic organogenesis, tissue repair, and the proliferation and differentiation of various cells, such as the hierarchy of blood cells. At present, the role of Hh signaling in hematopoiesis remains unclear. The present review highlighted recent findings focused on Hh signaling in the regulation of hematopoietic development during the early embryonic stage, and the proliferation and differentiation of hematopoietic stem and progenitor cells in adults. A greater understanding of the role of Hh signaling in fetal and postnatal hematopoiesis would provide therapeutic strategies to maintain hematopoietic homeostasis and enhance hematopoietic reconstruction through targeting of the Hh cascade.
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May-2023
Volume 27 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Chen J, Sun Y and Chi Z: Regulation of hematopoiesis by hedgehog signaling (Review). Mol Med Rep 27: 100, 2023
APA
Chen, J., Sun, Y., & Chi, Z. (2023). Regulation of hematopoiesis by hedgehog signaling (Review). Molecular Medicine Reports, 27, 100. https://doi.org/10.3892/mmr.2023.12987
MLA
Chen, J., Sun, Y., Chi, Z."Regulation of hematopoiesis by hedgehog signaling (Review)". Molecular Medicine Reports 27.5 (2023): 100.
Chicago
Chen, J., Sun, Y., Chi, Z."Regulation of hematopoiesis by hedgehog signaling (Review)". Molecular Medicine Reports 27, no. 5 (2023): 100. https://doi.org/10.3892/mmr.2023.12987