Open Access

Essential role of bromodomain proteins in renal cell carcinoma (Review)

  • Authors:
    • Qianghai Wen
    • Haicheng Liu
    • Kecheng Lou
    • Xing Zhang
    • Wei Chao
    • Jianhui Xin
    • Jiaxiang Gong
    • Junrong Zou
    • Xiaofeng Zou
  • View Affiliations

  • Published online on: June 8, 2023     https://doi.org/10.3892/mmr.2023.13026
  • Article Number: 139
  • Copyright: © Wen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Histone alterations are a hallmark of kidney cancer. Histone acetylation modification mediated by bromodomain proteins (BRD) has been indicated to be related to a variety of cancer types and several targeted inhibitors have been proven to be promising modalities for cancer adjuvant therapy. As renal cell carcinoma (RCC) is not sensitive to radiotherapy or chemotherapy, the exploration of effective adjuvant therapies remains an important research direction for advanced RCC. At present, studies on bromodomain family proteins in RCC are limited and the roles of bromodomain family proteins in RCC have remained to be fully elucidated. The present review discussed the role of bromodomain family proteins in RCC, aiming to explore possible potential therapeutic targets of BRD‑related drugs in this type of cancer.
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July-2023
Volume 28 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Wen Q, Liu H, Lou K, Zhang X, Chao W, Xin J, Gong J, Zou J and Zou X: Essential role of bromodomain proteins in renal cell carcinoma (Review). Mol Med Rep 28: 139, 2023
APA
Wen, Q., Liu, H., Lou, K., Zhang, X., Chao, W., Xin, J. ... Zou, X. (2023). Essential role of bromodomain proteins in renal cell carcinoma (Review). Molecular Medicine Reports, 28, 139. https://doi.org/10.3892/mmr.2023.13026
MLA
Wen, Q., Liu, H., Lou, K., Zhang, X., Chao, W., Xin, J., Gong, J., Zou, J., Zou, X."Essential role of bromodomain proteins in renal cell carcinoma (Review)". Molecular Medicine Reports 28.1 (2023): 139.
Chicago
Wen, Q., Liu, H., Lou, K., Zhang, X., Chao, W., Xin, J., Gong, J., Zou, J., Zou, X."Essential role of bromodomain proteins in renal cell carcinoma (Review)". Molecular Medicine Reports 28, no. 1 (2023): 139. https://doi.org/10.3892/mmr.2023.13026