Open Access

Role of non‑coding RNA intertwined with the Wnt/β‑catenin signaling pathway in endometrial cancer (Review)

  • Authors:
    • Yanpeng Tian
    • Tianjiao Lai
    • Zhongkang Li
    • Meng Mao
    • Yuxi Jin
    • Yana Liu
    • Ruixia Guo
  • View Affiliations

  • Published online on: June 20, 2023     https://doi.org/10.3892/mmr.2023.13037
  • Article Number: 150
  • Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Endometrial cancer (EC) ranks as the sixth most common malignancy in women around the world. Although low‑grade and early‑stage EC commonly have an excellent prognosis, ~20% of EC patients experience an unfavorable prognosis. Identifying the pathogenesis and novel therapeutic targets may help address this group of patients. Non‑coding (nc)RNAs, such as long non‑coding RNAs (lncRNAs), microRNAs and circular RNAs (circRNAs), have been associated with EC occurrence and development. In addition, the aberrant activation of the Wnt/β‑catenin signaling pathway can promote the proliferation, invasion, migration and epithelial‑to‑mesenchymal transition (EMT) of EC cells. The network of ncRNAs has also been demonstrated to inhibit or activate the Wnt/β‑catenin signaling pathway. In the present review, ncRNAs, the Wnt/β‑catenin signaling pathway, and their crosstalk in EC were summarized and highlighted. This information is expected to provide novel insights into improving the management of EC using RNA as therapeutics.
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August-2023
Volume 28 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Tian Y, Lai T, Li Z, Mao M, Jin Y, Liu Y and Guo R: Role of non‑coding RNA intertwined with the Wnt/β‑catenin signaling pathway in endometrial cancer (Review). Mol Med Rep 28: 150, 2023
APA
Tian, Y., Lai, T., Li, Z., Mao, M., Jin, Y., Liu, Y., & Guo, R. (2023). Role of non‑coding RNA intertwined with the Wnt/β‑catenin signaling pathway in endometrial cancer (Review). Molecular Medicine Reports, 28, 150. https://doi.org/10.3892/mmr.2023.13037
MLA
Tian, Y., Lai, T., Li, Z., Mao, M., Jin, Y., Liu, Y., Guo, R."Role of non‑coding RNA intertwined with the Wnt/β‑catenin signaling pathway in endometrial cancer (Review)". Molecular Medicine Reports 28.2 (2023): 150.
Chicago
Tian, Y., Lai, T., Li, Z., Mao, M., Jin, Y., Liu, Y., Guo, R."Role of non‑coding RNA intertwined with the Wnt/β‑catenin signaling pathway in endometrial cancer (Review)". Molecular Medicine Reports 28, no. 2 (2023): 150. https://doi.org/10.3892/mmr.2023.13037