Open Access

Insights into the relationship between serum uric acid and pulmonary hypertension (Review)

  • Authors:
    • Yu Zhou
    • Meihong Chen
    • Jing Zheng
    • Xiaorong Shui
    • Yuan He
    • Hui Luo
    • Wei Lei
  • View Affiliations

  • Published online on: November 21, 2023     https://doi.org/10.3892/mmr.2023.13133
  • Article Number: 10
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pulmonary hypertension (PH) is a progressive lethal disease, which is characterized by abnormal vascular remodeling and persistently elevated pulmonary artery pressure, eventually leading to right heart failure and even death. Although great progress has been made in treating PH, the mortality rate remains high. Metabolic disorders are one of the important hallmarks of PH. Obesity, lipids, glucose tolerance and insulin resistance are risk factors for numerous cardiovascular diseases and are often accompanied by a considerable increase in serum uric acid (SUA) concentrations. Uric acid (UA) is the end product of purine nucleotide metabolism and is closely related to cardiovascular diseases including PH. Hyperuricemia promotes the development and progression of PH through endothelial dysfunction, oxidative stress, inflammatory responses and activation of the renin‑angiotensin system. In the present review, the advancements in knowledge about UA metabolism and PH, and the current understanding of the potential interactions and mechanisms of SUA in PH were systematically summarized, which may provide new insights into the pathogenesis of PH.
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January-2024
Volume 29 Issue 1

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Copy and paste a formatted citation
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Spandidos Publications style
Zhou Y, Chen M, Zheng J, Shui X, He Y, Luo H and Lei W: Insights into the relationship between serum uric acid and pulmonary hypertension (Review). Mol Med Rep 29: 10, 2024
APA
Zhou, Y., Chen, M., Zheng, J., Shui, X., He, Y., Luo, H., & Lei, W. (2024). Insights into the relationship between serum uric acid and pulmonary hypertension (Review). Molecular Medicine Reports, 29, 10. https://doi.org/10.3892/mmr.2023.13133
MLA
Zhou, Y., Chen, M., Zheng, J., Shui, X., He, Y., Luo, H., Lei, W."Insights into the relationship between serum uric acid and pulmonary hypertension (Review)". Molecular Medicine Reports 29.1 (2024): 10.
Chicago
Zhou, Y., Chen, M., Zheng, J., Shui, X., He, Y., Luo, H., Lei, W."Insights into the relationship between serum uric acid and pulmonary hypertension (Review)". Molecular Medicine Reports 29, no. 1 (2024): 10. https://doi.org/10.3892/mmr.2023.13133