Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November-2024 Volume 30 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2024 Volume 30 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

Extracellular vesicles derived from mesenchymal stem cells suppress breast cancer progression by inhibiting angiogenesis

  • Authors:
    • Manqian Zhou
    • Huifang Li
    • Jinglei Zhao
    • Qiaonan Zhang
    • Zhibo Han
    • Zhong-Chao Han
    • Lihong Zhu
    • Hui Wang
    • Zongjin Li
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Tianjin Union Medical Center, Nankai University, Tianjin 300121, P.R. China, School of Medicine, Nankai University, Tianjin 300071, P.R. China, Jiangxi Engineering Research Center for Stem Cell, Health & Biotech Co., Shangrao, Jiangxi 334001, P.R. China, Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 192
    |
    Published online on: August 27, 2024
       https://doi.org/10.3892/mmr.2024.13316
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Previous studies have highlighted the antitumor effects of mesenchymal stem cell‑derived extracellular vesicles (MSC‑EVs), positioning them as a promising therapeutic avenue for cancer treatment. However, some researchers have proposed a bidirectional influence of MSC‑EVs on tumors, determined by the specific tissue origin of the MSCs and the types of tumors involved. The present study aimed to elucidate the effects of human placenta MSC‑derived extracellular vesicles (hPMSC‑EVs) on the malignant behavior of a mouse breast cancer model of 4T1 cells in vitro and in vivo. The findings revealed that hPMSC‑EVs significantly inhibited the proliferation, migration and colony formation of cultured 4T1 mouse breast cancer cells without inducing apoptosis. Exposure to conditioned medium from 4T1 cells pretreated with hPMSC‑EVs resulted in decreased angiogenic activity, accompanied by the downregulation of angiogenesis‑promoting genes in human umbilical vein endothelial cells. In murine xenograft models derived from the 4T1 cell line, local administration of hPMSC‑EVs substantially hindered tumor growth. Further results revealed that hPMSC‑EVs inhibited angiogenesis in vivo, as reflected by the use of a vascular growth factor receptor 2‑Fluc transgenic mouse model. In summary, the results confirmed that hPMSC‑EVs negatively modulated breast cancer growth by suppressing tumor cell proliferation and migration via an indirect antiangiogenic mechanism. These results underscored the therapeutic potential of EVs, suggesting a promising avenue for alternative anticancer treatments in the future.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Al-Awsi GRL, Alsaikhan F, Margiana R, Ahmad I, Patra I, Najm MAA, Yasin G, Rasulova I, Hammid AT, Kzar HH, et al: Shining the light on mesenchymal stem cell-derived exosomes in breast cancer. Stem Cell Res Ther. 14:212023. View Article : Google Scholar : PubMed/NCBI

2 

Wan W, Miao Y, Niu Y, Zhu K, Ma Y, Pan M, Ma B and Wei Q: Human umbilical cord mesenchymal stem cells conditioned medium exerts anti-tumor effects on KGN cells in a cell density-dependent manner through activation of the Hippo pathway. Stem Cell Res Ther. 14:462023. View Article : Google Scholar : PubMed/NCBI

3 

Bae J, Liu L, Moore C, Hsu E, Zhang A, Ren Z, Sun Z, Wang X, Zhu J, Shen J, et al: IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer. Nat Cell Biol. 24:1754–1765. 2022. View Article : Google Scholar : PubMed/NCBI

4 

Chen F, Zhong X, Dai Q, Li K, Zhang W, Wang J, Zhao Y, Shen J, Xiao Z, Xing H and Li J: Human umbilical cord MSC delivered-soluble TRAIL inhibits the proliferation and promotes apoptosis of B-ALL cell in vitro and in vivo. Pharmaceuticals (Basel). 15:13912022. View Article : Google Scholar : PubMed/NCBI

5 

Zhou X, Zhang W, Liu Y, Zhang L and Li Z: Chapter 5-Mesenchymal stem cells: A promising weapon for cancer therapy. Zhang L, Han Z, Wang J, Li Z and Huang Q: Mesenchymal Stem Cells. Academic Press; pp. 119–141. 2023, View Article : Google Scholar

6 

Wang J, Ma Y, Long Y and Chen Y: Extracellular vesicle derived from mesenchymal stem cells have bidirectional effects on the development of lung cancer. Front Oncol. 12:9148322022. View Article : Google Scholar : PubMed/NCBI

7 

Eiro N, Fraile M, Fernández-Francos S, Sánchez R, Costa LA and Vizoso FJ: Importance of the origin of mesenchymal (stem) stromal cells in cancer biology: ‘Alliance’ or ‘war’ in intercellular signals. Cell Biosci. 11:1092021. View Article : Google Scholar : PubMed/NCBI

8 

Ma Z, Xie W, Luo T, Hu Z, Hua J, Zhou J, Yang T, Wang W, Song Z, Yu X, et al: Exosomes from TNF-α preconditioned human umbilical cord mesenchymal stromal cells inhibit the autophagy of acinar cells of severe acute pancreatitis via shuttling bioactive metabolites. Cell Mol Life Sci. 80:2572023. View Article : Google Scholar : PubMed/NCBI

9 

Lee MW, Ryu S, Kim DS, Lee JW, Sung KW, Koo HH and Yoo KH: Mesenchymal stem cells in suppression or progression of hematologic malignancy: Current status and challenges. Leukemia. 33:597–611. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Xia C, Wang T, Cheng H, Dong Y, Weng Q, Sun G, Zhou P, Wang K, Liu X, Geng Y, et al: Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment. Leukemia. 34:2375–2383. 2020. View Article : Google Scholar : PubMed/NCBI

11 

Li R, Wang C, Zhou M, Liu Y, Chen S, Chai Z, Huang H, Zhang K, Han Z, Hua G, et al: Heparan sulfate proteoglycan-mediated internalization of extracellular vesicles ameliorates liver fibrosis by targeting hepatic stellate cells. Extracellul Vesicle. 1:1000182022. View Article : Google Scholar

12 

Zhao J, Lin H and Huang K: Mesenchymal stem cell-derived extracellular vesicles transmitting MicroRNA-34a-5p suppress tumorigenesis of colorectal cancer through c-MYC/DNMT3a/PTEN axis. Mol Neurobiol. 59:47–60. 2022. View Article : Google Scholar : PubMed/NCBI

13 

You B, Jin C, Zhang J, Xu M, Xu W, Sun Z and Qian H: MSC-derived extracellular vesicle-delivered L-PGDS inhibit gastric cancer progression by suppressing cancer cell stemness and STAT3 phosphorylation. Stem Cells Int. 2022:96682392022. View Article : Google Scholar : PubMed/NCBI

14 

Yang S, Wang L, Gu L, Wang Z, Wang Y, Wang J and Zhang Y: Mesenchymal stem cell-derived extracellular vesicles alleviate cervical cancer by delivering microRNA-331-3p to reduce LIM zinc finger domain containing 2 methylation in tumor cells. Hum Mol Genet. 31:3829–3845. 2022. View Article : Google Scholar : PubMed/NCBI

15 

Su W, Wang L, Zhou M, Liu Z, Hu S, Tong L, Liu Y, Fan Y, Kong D, Zheng Y, et al: Human embryonic stem cell-derived endothelial cells as cellular delivery vehicles for treatment of metastatic breast cancer. Cell Transplant. 22:2079–2090. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Arnold M, Morgan E, Rumgay H, Mafra A, Singh D, Laversanne M, Vignat J, Gralow JR, Cardoso F, Siesling S and Soerjomataram I: Current and future burden of breast cancer: Global statistics for 2020 and 2040. Breast. 66:15–23. 2022. View Article : Google Scholar : PubMed/NCBI

17 

Li Z and Han ZC: Introduction of perinatal tissue-derived stem cells. Han ZC, Takahashi TA, Han Z and Li Z: Perinatal Stem Cells: Biology, Manufacturing and Translational Medicine. Singapore: Springer Singapore; pp. 1–7. 2019

18 

Zhang K, Li R, Chen X, Yan H, Li H, Zhao X, Huang H, Chen S, Liu Y, Wang K, et al: Renal endothelial cell-targeted extracellular vesicles protect the kidney from ischemic injury. Adv Sci (Weinh). 10:e22046262023. View Article : Google Scholar : PubMed/NCBI

19 

Hezam K, Wang C, Fu E, Zhou M, Liu Y, Wang H, Zhu L, Han Z, Han ZC, Chang Y and Li Z: Superior protective effects of PGE2 priming mesenchymal stem cells against LPS-induced acute lung injury (ALI) through macrophage immunomodulation. Stem Cell Res Ther. 14:482023. View Article : Google Scholar : PubMed/NCBI

20 

Jia P, Zhao X, Liu Y, Liu M, Zhang Q, Chen S, Huang H, Jia Y, Chang Y, Chen S, et al: The RGD-modified self-assembling D-form peptide hydrogel enhances the therapeutic effects of mesenchymal stem cells (MSC) for hindlimb ischemia by promoting angiogenesis. Chem Eng J. 450:1380042022. View Article : Google Scholar

21 

Li H, Huang H, Chen X, Chen S, Yu L, Wang C, Liu Y, Zhang K, Wu L, Han ZC, et al: The delivery of hsa-miR-11401 by extracellular vesicles can relieve doxorubicin-induced mesenchymal stem cell apoptosis. Stem Cell Res Ther. 12:772021. View Article : Google Scholar : PubMed/NCBI

22 

Zhang K, Zhao X, Chen X, Wei Y, Du W, Wang Y, Liu L, Zhao W, Han Z, Kong D, et al: Enhanced therapeutic effects of mesenchymal stem cell-derived exosomes with an injectable hydrogel for hindlimb ischemia treatment. ACS Appl Mater Interfaces. 10:30081–30091. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Wang C, Hezam K, Fu E, Pan K, Liu Y and Li Z: In vivo tracking of mesenchymal stem cell dynamics and therapeutics in LPS-induced acute lung injury models. Exp Cell Res. 437:1140132024. View Article : Google Scholar : PubMed/NCBI

24 

National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals, . The National Academies Collection: Reports funded by National Institutes of Health. Guide for the Care and Use of Laboratory Animals. 8th edition. Washington (DC): National Academies Press (US). Copyright © 2011, National Academy of Sciences. 2011, PubMed/NCBI

25 

Zhou M, Wang L, Su W, Tong L, Liu Y, Fan Y, Luo N, Zheng Y, Zhao H, Xiang R and Li Z: Assessment of therapeutic efficacy of liposomal nanoparticles mediated gene delivery by molecular imaging for cancer therapy. J Biomed Nanotechnol. 8:742–750. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Moradi-Chaleshtori M, Bandehpour M, Heidari N, Mohammadi-Yeganeh S and Mahmoud Hashemi S: Exosome-mediated miR-33 transfer induces M1 polarization in mouse macrophages and exerts antitumor effect in 4T1 breast cancer cell line. Int Immunopharmacol. 90:1071982021. View Article : Google Scholar : PubMed/NCBI

28 

Wang M, Li J, Wang D, Xin Y and Liu Z: The effects of mesenchymal stem cells on the chemotherapy of colorectal cancer. Biomed Pharmacother. 160:1143732023. View Article : Google Scholar : PubMed/NCBI

29 

Hong IS, Lee HY and Kang KS: Mesenchymal stem cells and cancer: Friends or enemies? Mutat Res. 768:98–106. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Rahimi Tesiye M, Abrishami Kia Z and Rajabi-Maham H: Mesenchymal stem cells and prostate cancer: A concise review of therapeutic potentials and biological aspects. Stem Cell Res. 63:1028642022. View Article : Google Scholar : PubMed/NCBI

31 

Zhao Y, Shen M, Wu L, Yang H, Yao Y, Yang Q, Du J, Liu L, Li Y and Bai Y: Stromal cells in the tumor microenvironment: Accomplices of tumor progression? Cell Death Dis. 14:5872023. View Article : Google Scholar : PubMed/NCBI

32 

Li T, Zhang C, Ding Y, Zhai W, Liu K, Bu F, Tu T, Sun L, Zhu W, Zhou F, et al: Umbilical cord-derived mesenchymal stem cells promote proliferation and migration in MCF-7 and MDA-MB-231 breast cancer cells through activation of the ERK pathway. Oncol Rep. 34:1469–1477. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Du L, Tao X and Shen X: Human umbilical cord mesenchymal stem cell-derived exosomes inhibit migration and invasion of breast cancer cells via miR-21-5p/ZNF367 pathway. Breast Cancer. 28:829–837. 2021. View Article : Google Scholar : PubMed/NCBI

34 

Bailey AJM, Tieu A, Gupta M, Slobodian M, Shorr R, Ramsay T, Rodriguez RA, Fergusson DA, Lalu MM and Allan DS: Mesenchymal stromal cell-derived extracellular vesicles in preclinical animal models of tumor growth: Systematic review and meta-analysis. Stem Cell Rev Rep. 18:993–1006. 2022. View Article : Google Scholar : PubMed/NCBI

35 

Aravindhan S, Ejam SS, Lafta MH, Markov A, Yumashev AV and Ahmadi M: Mesenchymal stem cells and cancer therapy: Insights into targeting the tumour vasculature. Cancer Cell Int. 21:1582021. View Article : Google Scholar : PubMed/NCBI

36 

Luo T, von der Ohe J and Hass R: MSC-Derived extracellular vesicles in tumors and therapy. Cancers (Basel). 13:52122021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhou M, Li H, Zhao J, Zhang Q, Han Z, Han Z, Zhu L, Wang H and Li Z: Extracellular vesicles derived from mesenchymal stem cells suppress breast cancer progression by inhibiting angiogenesis. Mol Med Rep 30: 192, 2024.
APA
Zhou, M., Li, H., Zhao, J., Zhang, Q., Han, Z., Han, Z. ... Li, Z. (2024). Extracellular vesicles derived from mesenchymal stem cells suppress breast cancer progression by inhibiting angiogenesis. Molecular Medicine Reports, 30, 192. https://doi.org/10.3892/mmr.2024.13316
MLA
Zhou, M., Li, H., Zhao, J., Zhang, Q., Han, Z., Han, Z., Zhu, L., Wang, H., Li, Z."Extracellular vesicles derived from mesenchymal stem cells suppress breast cancer progression by inhibiting angiogenesis". Molecular Medicine Reports 30.5 (2024): 192.
Chicago
Zhou, M., Li, H., Zhao, J., Zhang, Q., Han, Z., Han, Z., Zhu, L., Wang, H., Li, Z."Extracellular vesicles derived from mesenchymal stem cells suppress breast cancer progression by inhibiting angiogenesis". Molecular Medicine Reports 30, no. 5 (2024): 192. https://doi.org/10.3892/mmr.2024.13316
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou M, Li H, Zhao J, Zhang Q, Han Z, Han Z, Zhu L, Wang H and Li Z: Extracellular vesicles derived from mesenchymal stem cells suppress breast cancer progression by inhibiting angiogenesis. Mol Med Rep 30: 192, 2024.
APA
Zhou, M., Li, H., Zhao, J., Zhang, Q., Han, Z., Han, Z. ... Li, Z. (2024). Extracellular vesicles derived from mesenchymal stem cells suppress breast cancer progression by inhibiting angiogenesis. Molecular Medicine Reports, 30, 192. https://doi.org/10.3892/mmr.2024.13316
MLA
Zhou, M., Li, H., Zhao, J., Zhang, Q., Han, Z., Han, Z., Zhu, L., Wang, H., Li, Z."Extracellular vesicles derived from mesenchymal stem cells suppress breast cancer progression by inhibiting angiogenesis". Molecular Medicine Reports 30.5 (2024): 192.
Chicago
Zhou, M., Li, H., Zhao, J., Zhang, Q., Han, Z., Han, Z., Zhu, L., Wang, H., Li, Z."Extracellular vesicles derived from mesenchymal stem cells suppress breast cancer progression by inhibiting angiogenesis". Molecular Medicine Reports 30, no. 5 (2024): 192. https://doi.org/10.3892/mmr.2024.13316
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team