|
1
|
Malmstrom V, Catrina AI and Klareskog L:
The immunopathogenesis of seropositive rheumatoid arthritis: From
triggering to targeting. Nat Rev Immunol. 17:60–75. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Weyand CM and Goronzy JJ: The immunology
of rheumatoid arthritis. Nat Immunol. 22:10–18. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Scherer HU, Haupl T and Burmester GR: The
etiology of rheumatoid arthritis. J Autoimmun. 110:1024002020.
View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Wu F, Gao J, Kang J, Wang X, Niu Q, Liu J
and Zhang L: B Cells in Rheumatoid Arthritis: Pathogenic mechanisms
and treatment prospects. Front Immunol. 12:7507532021. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Safiri S, Kolahi AA, Hoy D, Smith E,
Bettampadi D, Mansournia MA, Almasi-Hashiani A, Ashrafi-Asgarabad
A, Moradi-Lakeh M, Qorbani M, et al: Global, regional and national
burden of rheumatoid arthritis 1990–2017: A systematic analysis of
the Global Burden of Disease study 2017. Ann Rheum Dis.
78:1463–1471. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Galarza-Delgado DA, Azpiri-Lopez JR,
Colunga-Pedraza IJ, Cárdenas-de la Garza JA, Vera-Pineda R,
Wah-Suárez M, Arvizu-Rivera RI, Martínez-Moreno A, Ramos-Cázares
RE, Torres-Quintanilla FJ, et al: Prevalence of comorbidities in
Mexican mestizo patients with rheumatoid arthritis. Rheumatol Int.
37:1507–1511. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Cardiel MH, Pons-Estel BA, Sacnun MP,
Wojdyla D, Saurit V, Marcos JC, Pinto MR, Cordeiro de Azevedo AB,
da Silveira IG, Radominski SC, et al: Treatment of early rheumatoid
arthritis in a multinational inception cohort of Latin American
patients: The GLADAR experience. J Clin Rheumatol. 18:327–335.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Castillo-Canon JC, Trujillo-Caceres SJ,
Bautista-Molano W, Valbuena-García AM, Fernández-Ávila DG and
Acuña-Merchán L: Rheumatoid arthritis in Colombia: A clinical
profile and prevalence from a national registry. Clin Rheumatol.
40:3565–3573. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
D'elia HF, Larsen A, Mattsson LA,
Waltbrand E, Kvist G, Mellström D, Saxne T, Ohlsson C, Nordborg E
and Carlsten H: Influence of hormone replacement therapy on disease
progression and bone mineral density in rheumatoid arthritis. J
Rheumatol. 30:1456–1463. 2003.PubMed/NCBI
|
|
10
|
Rossouw JE, Anderson GL, Prentice RL,
LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA,
Howard BV, Johnson KC, et al: Risks and benefits of estrogen plus
progestin in healthy postmenopausal women: Principal results From
the Women's Health Initiative randomized controlled trial. JAMA.
288:321–333. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Anderson GL, Limacher M, Assaf AR,
Bassford T, Beresford SA, Black H, Bonds D, Brunner R, Brzyski R,
Caan B, et al: Effects of conjugated equine estrogen in
postmenopausal women with hysterectomy: The Women's Health
Initiative randomized controlled trial. JAMA. 291:1701–1712. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Daraghmeh DN, Hopkins AM, King C, Abuhelwa
AY, Wechalekar MD, Proudman SM, Sorich MJ and Wiese MD: Female
reproductive status and exogenous sex hormone use in rheumatoid
arthritis patients treated with tocilizumab and csDMARDs.
Rheumatology (Oxford). 62:583–595. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Gomez-Puerta JA, Celis R, Hernandez MV,
Ruiz-Esquide V, Ramírez J, Haro I, Cañete JD and Sanmartí R:
Differences in synovial fluid cytokine levels but not in synovial
tissue cell infiltrate between anti-citrullinated peptide/protein
antibody-positive and -negative rheumatoid arthritis patients.
Arthritis Res Ther. 15:R1822013. View
Article : Google Scholar : PubMed/NCBI
|
|
14
|
Van Den Broek M, Dirven L, Klarenbeek NB,
Molenaar TH, Han KH, Kerstens PJ, Huizinga TW, Dijkmans BA and
Allaart CF: The association of treatment response and joint damage
with ACPA-status in recent-onset RA: A subanalysis of the 8-year
follow-up of the BeSt study. Ann Rheum Dis. 71:245–248. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Berglin E, Padyukov L, Sundin U, Hallmans
G, Stenlund H, Van Venrooij WJ, Klareskog L and Dahlqvist SR: A
combination of autoantibodies to cyclic citrullinated peptide (CCP)
and HLA-DRB1 locus antigens is strongly associated with future
onset of rheumatoid arthritis. Arthritis Res Ther. 6:R303–R308.
2004. View
Article : Google Scholar : PubMed/NCBI
|
|
16
|
Johansson M, Arlestig L, Hallmans G and
Rantapää-Dahlqvist S: PTPN22 polymorphism and anti-cyclic
citrullinated peptide antibodies in combination strongly predicts
future onset of rheumatoid arthritis and has a specificity of 100%
for the disease. Arthritis Res Ther. 8:R192006. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Ge C and Holmdahl R: The structure,
specificity and function of anti-citrullinated protein antibodies.
Nat Rev Rheumatol. 15:503–508. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Kissel T, Reijm S, Slot LM, Cavallari M,
Wortel CM, Vergroesen RD, Stoeken-Rijsbergen G, Kwekkeboom JC,
Kampstra A, Levarht E, et al: Antibodies and B cells recognising
citrullinated proteins display a broad cross-reactivity towards
other post-translational modifications. Ann Rheum Dis. 79:472–480.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Shlomchik MJ, Craft JE and Mamula MJ: From
T to B and back again: Positive feedback in systemic autoimmune
disease. Nat Rev Immunol. 1:147–153. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Yan J, Harvey BP, Gee RJ, Shlomchik MJ and
Mamula MJ: B cells drive early T cell autoimmunity in vivo prior to
dendritic cell-mediated autoantigen presentation. J Immunol.
177:4481–4487. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Weyand CM and Goronzy JJ: Immunometabolism
in early and late stages of rheumatoid arthritis. Nat Rev
Rheumatol. 13:291–301. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Weyand CM, Shen Y and Goronzy JJ:
Redox-sensitive signaling in inflammatory T cells and in autoimmune
disease. Free Radic Biol Med. 125:36–43. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Wu B, Goronzy JJ and Weyand CM: Metabolic
fitness of t cells in autoimmune disease. Immunometabolism.
2:e2000172020. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Ponchel F, Burska AN, Hunt L, Gul H, Rabin
T, Parmar R, Buch MH, Conaghan PG and Emery P: T-cell subset
abnormalities predict progression along the Inflammatory Arthritis
disease continuum: Implications for management. Sci Rep.
10:36692020. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Paunovic V, Carroll HP, Vandenbroeck K and
Gadina M: Signalling, inflammation and arthritis: crossed signals:
The role of interleukin (IL)-12, −17, −23 and −27 in autoimmunity.
Rheumatology (Oxford). 47:771–776. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Kim W, Min S, Cho M, Youn J, Min J, Lee S,
Park S, Cho C and Kim H: The role of IL-12 in inflammatory activity
of patients with rheumatoid arthritis (RA). Clin Exp Immunol.
119:175–181. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Chu CQ, Swart D, Alcorn D, Tocker J and
Elkon KB: Interferon-gamma regulates susceptibility to
collagen-induced arthritis through suppression of interleukin-17.
Arthritis Rheum. 56:1145–1151. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Geboes L, De Klerck B, Van Balen M,
Kelchtermans H, Mitera T, Boon L, De Wolf-Peeters C and Matthys P:
Freund's complete adjuvant induces arthritis in mice lacking a
functional interferon-gamma receptor by triggering tumor necrosis
factor alpha-driven osteoclastogenesis. Arthritis Rheum.
56:2595–2607. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Sigidin YA, Loukina GV, Skurkovich B and
Skurkovich S: Randomized, double-blind trial of
anti-interferon-gamma antibodies in rheumatoid arthritis. Scand J
Rheumatol. 30:203–207. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Ortmann RA and Shevach EM: Susceptibility
to collagen-induced arthritis: Cytokine-mediated regulation. Clin
Immunol. 98:109–118. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Haikal SM, Abdeltawab NF, Rashed LA, Abd
El-Galil TI, Elmalt HA and Amin MA: Combination Therapy of
Mesenchymal Stromal Cells and Interleukin-4 Attenuates Rheumatoid
Arthritis in a Collagen-Induced Murine Model. Cells. 8:8232019.
View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Steinman L: A brief history of T(H)17, the
first major revision in the T(H)1/T(H)2 hypothesis of T
cell-mediated tissue damage. Nat Med. 13:139–145. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Krebs CF and Steinmetz OM: CD4(+) T Cell
Fate in Glomerulonephritis: A Tale of Th1, Th17, and Novel Treg
Subtypes. Mediators Inflamm. 2016:53938942016. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Zielinski CE, Mele F, Aschenbrenner D,
Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A and
Sallusto F: Pathogen-induced human TH17 cells produce IFN-ү or
IL-10 and are regulated by IL-1β. Nature. 484:514–518. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Evans HG, Roostalu U, Walter GJ, Gullick
NJ, Frederiksen KS, Roberts CA, Sumner J, Baeten DL, Gerwien JG,
Cope AP, et al: TNF-α blockade induces IL-10 expression in human
CD4+ T cells. Nat Commun. 5:31992014. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Penatti A, Facciotti F, De Matteis R,
Larghi P, Paroni M, Murgo A, De Lucia O, Pagani M, Pierannunzii L,
Truzzi M, et al: Differences in serum and synovial CD4+ T cells and
cytokine profiles to stratify patients with inflammatory
osteoarthritis and rheumatoid arthritis. Arthritis Res Ther.
19:1032017. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Van Hamburg JP, Asmawidjaja PS, Davelaar
N, Mus AM, Colin EM, Hazes JM, Dolhain RJ and Lubberts E: Th17
cells, but not Th1 cells, from patients with early rheumatoid
arthritis are potent inducers of matrix metalloproteinases and
proinflammatory cytokines upon synovial fibroblast interaction,
including autocrine interleukin-17A production. Arthritis Rheum.
63:73–83. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Nakae S, Nambu A, Sudo K and Iwakura Y:
Suppression of immune induction of collagen-induced arthritis in
IL-17-deficient mice. J Immunol. 171:6173–6177. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Lubberts E, Koenders MI, Oppers-Walgreen
B, van den Bersselaar L, Coenen-de Roo CJ, Joosten LA and van den
Berg WB: Treatment with a neutralizing anti-murine interleukin-17
antibody after the onset of collagen-induced arthritis reduces
joint inflammation, cartilage destruction, and bone erosion.
Arthritis Rheum. 50:650–659. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Corneth OB, Reijmers RM, Mus AM,
Asmawidjaja PS, van Hamburg JP, Papazian N, Siegers JY, Mourcin F,
Amin R, Tarte K, et al: Loss of IL-22 inhibits autoantibody
formation in collagen-induced arthritis in mice. Eur J Immunol.
46:1404–1414. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Kikuta J, Wada Y, Kowada T, Wang Z,
Sun-Wada GH, Nishiyama I, Mizukami S, Maiya N, Yasuda H, Kumanogoh
A, et al: Dynamic visualization of RANKL and Th17-mediated
osteoclast function. J Clin Invest. 123:866–873. 2013.PubMed/NCBI
|
|
42
|
Tlustochowicz W, Rahman P, Seriolo B,
Krammer G, Porter B, Widmer A and Richards HB: Efficacy and safety
of subcutaneous and intravenous loading dose regimens of
secukinumab in patients with active rheumatoid arthritis: Results
from a randomized phase II study. J Rheumatol. 43:495–503. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Corthay A: How do regulatory T cells work?
Scand J Immunol. 70:326–36. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Rudensky AY: Regulatory T cells and Foxp3.
Immunol Rev. 241:260–268. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Zhang R, Miao J, Zhang K, Zhang B, Luo X,
Sun H, Zheng Z and Zhu P: Th1-like treg cells are increased but
deficient in function in rheumatoid arthritis. Front Immunol.
13:8637532022. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Nie H, Zheng Y, Li R, Guo TB, He D, Fang
L, Liu X, Xiao L, Chen X, Wan B, et al: Phosphorylation of FOXP3
controls regulatory T cell function and is inhibited by TNF-α in
rheumatoid arthritis. Nat Med. 19:322–328. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Walter GJ, Fleskens V, Frederiksen KS,
Rajasekhar M, Menon B, Gerwien JG, Evans HG and Taams LS:
Phenotypic, functional, and gene expression profiling of peripheral
CD45RA+ and CD45RO+ CD4+CD25+CD127(low) Treg cells in patients with
chronic rheumatoid arthritis. Arthritis Rheumatol. 68:103–116.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Kommoju V, Mariaselvam CM, Bulusu SN,
Ganapathy CK, Narasimhan PB, Thabah MM and Negi VS: Conventional
Tregs in treatment-naive rheumatoid arthritis are deficient in
suppressive function with an increase in percentage of CXCR3 and
CCR6 expressing Tregs. Immunol Res. 72:396–408. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Komatsu N, Okamoto K, Sawa S, Nakashima T,
Oh-hora M, Kodama T, Tanaka S, Bluestone JA and Takayanagi H:
Pathogenic conversion of Foxp3+ T cells into TH17 cells in
autoimmune arthritis. Nat Med. 20:62–68. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Gonzalez-Rey E, Gonzalez MA, Varela N,
O'Valle F, Hernandez-Cortes P, Rico L, Büscher D and Delgado M:
Human adipose-derived mesenchymal stem cells reduce inflammatory
and T cell responses and induce regulatory T cells in vitro in
rheumatoid arthritis. Ann Rheum Dis. 69:241–248. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Pedrosa M, Gomes J, Laranjeira P, Duarte
C, Pedreiro S, Antunes B, Ribeiro T, Santos F, Martinho A, Fardilha
M, et al: Immunomodulatory effect of human bone marrow-derived
mesenchymal stromal/stem cells on peripheral blood T cells from
rheumatoid arthritis patients. J Tissue Eng Regen Med. 14:16–28.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Ji LS, Sun XH, Zhang X, Zhou ZH, Yu Z, Zhu
XJ, Huang LY, Fang M, Gao YT, Li M and Gao YQ: Mechanism of
follicular helper T cell differentiation regulated by transcription
factors. J Immunol Res. 2020:18265872020. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Liu R, Li X, Zhang Z, Zhou M, Sun Y, Su D,
Feng X, Gao X, Shi S, Chen W and Sun L: Allogeneic mesenchymal stem
cells inhibited T follicular helper cell generation in rheumatoid
arthritis. Sci Rep. 5:127772015. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Ma J, Zhu C, Ma B, Tian J, Baidoo SE, Mao
C, Wu W, Chen J, Tong J, Yang M, et al: Increased frequency of
circulating follicular helper T cells in patients with rheumatoid
arthritis. Clin Dev Immunol. 2012:8274802012. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Wang J, Shan Y, Jiang Z, Feng J, Li C, Ma
L and Jiang Y: High frequencies of activated B cells and T
follicular helper cells are correlated with disease activity in
patients with new-onset rheumatoid arthritis. Clin Exp Immunol.
174:212–220. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Kwok SK, Cho ML, Park MK, Oh HJ, Park JS,
Her YM, Lee SY, Youn J, Ju JH, Park KS, et al: Interleukin-21
promotes osteoclastogenesis in humans with rheumatoid arthritis and
in mice with collagen-induced arthritis. Arthritis Rheum.
64:740–751. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Jang E, Cho SH, Park H, Paik DJ, Kim JM
and Youn J: A positive feedback loop of IL-21 signaling provoked by
homeostatic CD4+CD25-T cell expansion is essential for the
development of arthritis in autoimmune K/BxN mice. J Immunol.
182:4649–4656. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Olsen NJ, Watson MB, Henderson GS and
Kovacs WJ: Androgen deprivation induces phenotypic and functional
changes in the thymus of adult male mice. Endocrinology.
129:2471–2476. 1991. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Xu D, Wu Y, Gao C, Qin Y, Zhao X, Liang Z,
Wang Y, Feng M, Zhang C, Liu G and Luo J: Characteristics of and
reference ranges for peripheral blood lymphocytes and CD4+ T cell
subsets in healthy adults in Shanxi Province, North China. J Int
Med Res. 48:3000605209131492020. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Wilkinson NM, Chen HC, Lechner MG and Su
MA: Sex differences in immunity. Annu Rev Immunol. 40:75–94. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Cutolo M, Sulli A and Straub RH: Estrogen
metabolism and autoimmunity. Autoimmun Rev. 11:A460–A464. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Chakraborty B, Byemerwa J, Krebs T, Lim F,
Chang CY and McDonnell DP: Estrogen receptor signaling in the
immune system. Endocr Rev. 44:117–141. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Bynote KK, Hackenberg JM, Korach KS,
Lubahn DB, Lane PH and Gould KA: Estrogen receptor-alpha deficiency
attenuates autoimmune disease in (NZB × NZW)F1 mice. Genes Immun.
9:137–152. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Li J and Mcmurray RW: Effects of estrogen
receptor subtype-selective agonists on autoimmune disease in
lupus-prone NZB/NZW F1 mouse model. Clin Immunol. 123:219–226.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Svenson JL, Eudaly J, Ruiz P, Korach KS
and Gilkeson GS: Impact of estrogen receptor deficiency on disease
expression in the NZM2410 lupus prone mouse. Clin Immunol.
128:259–268. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Maselli A, Conti F, Alessandri C,
Colasanti T, Barbati C, Vomero M, Ciarlo L, Patrizio M, Spinelli
FR, Ortona E, et al: Low expression of estrogen receptor beta in T
lymphocytes and high serum levels of anti-estrogen receptor alpha
antibodies impact disease activity in female patients with systemic
lupus erythematosus. Biol Sex Differ. 7:32016. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Pierdominici M, Maselli A, Varano B,
Barbati C, Cesaro P, Spada C, Zullo A, Lorenzetti R, Rosati M,
Rainaldi G, et al: Linking estrogen receptor β expression with
inflammatory bowel disease activity. Oncotarget. 6:40443–40451.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Kim DH, Park HJ, Park HS, Lee JU, Ko C,
Gye MC and Choi JM: Estrogen receptor α in T cells suppresses
follicular helper T cell responses and prevents autoimmunity. Exp
Mol Med. 51:1–9. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Guo D, Liu X, Zeng C, Cheng L, Song G, Hou
X, Zhu L and Zou K: Estrogen receptor β activation ameliorates
DSS-induced chronic colitis by inhibiting inflammation and
promoting Treg differentiation. Int Immunopharmacol. 77:1059712019.
View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Maret A, Coudert JD, Garidou L, Foucras G,
Gourdy P, Krust A, Dupont S, Chambon P, Druet P, Bayard F and Guéry
JC: Estradiol enhances primary antigen-specific CD4 T cell
responses and Th1 development in vivo. Essential role of estrogen
receptor alpha expression in hematopoietic cells. Eur J Immunol.
33:512–521. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Lambert KC, Curran EM, Judy BM, Milligan
GN, Lubahn DB and Estes DM: Estrogen receptor alpha (ERalpha)
deficiency in macrophages results in increased stimulation of CD4+
T cells while 17beta-estradiol acts through ERalpha to increase
IL-4 and GATA-3 expression in CD4+ T cells independent of antigen
presentation. J Immunol. 175:5716–5723. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Polanczyk MJ, Hopke C, Huan J, Vandenbark
AA and Offner H: Enhanced FoxP3 expression and Treg cell function
in pregnant and estrogen-treated mice. J Neuroimmunol. 170:85–92.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Tai P, Wang J, Jin H, Song X, Yan J, Kang
Y, Zhao L, An X, Du X, Chen X, et al: Induction of regulatory T
cells by physiological level estrogen. J Cell Physiol. 214:456–464.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Haghmorad D, Amini AA, Mahmoudi MB, Rastin
M, Hosseini M and Mahmoudi M: Pregnancy level of estrogen
attenuates experimental autoimmune encephalomyelitis in both
ovariectomized and pregnant C57BL/6 mice through expansion of Treg
and Th2 cells. J Neuroimmunol. 277:85–95. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Pfeilschifter J, Koditz R, Pfohl M and
Schatz H: Changes in proinflammatory cytokine activity after
menopause. Endocr Rev. 23:90–119. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Sinatora RV, Chagas EFB, Mattera FOP,
Mellem LJ, Santos AROD, Pereira LP, Aranão ALC, Guiguer EL, Araújo
AC, Haber JFDS, et al: Relationship of inflammatory markers and
metabolic syndrome in postmenopausal women. Metabolites. 12:732022.
View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Ralston SH, Russell RG and Gowen M:
Estrogen inhibits release of tumor necrosis factor from peripheral
blood mononuclear cells in postmenopausal women. J Bone Miner Res.
5:983–988. 1990. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Lucas-Herald AK and Touyz RM: Androgens
and androgen receptors as determinants of vascular sex differences
across the lifespan. Can J Cardiol. 38:1854–1864. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Kwon H, Schafer JM, Song NJ, Kaneko S, Li
A, Xiao T, Ma A, Allen C, Das K, Zhou L, et al: Androgen conspires
with the CD8(+) T cell exhaustion program and contributes to sex
bias in cancer. Sci Immunol. 7:eabq26302022. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Yang C, Jin J, Yang Y, Sun H, Wu L, Shen
M, Hong X, Li W, Lu L, Cao D, et al: Androgen receptor-mediated
CD8(+) T cell stemness programs drive sex differences in antitumor
immunity. Immunity. 55:1268–1283. e92022. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Berrih-Aknin S, Panse RL and Dragin N:
AIRE: A missing link to explain female susceptibility to autoimmune
diseases. Ann N Y Acad Sci. 1412:21–32. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Zhu ML, Bakhru P, Conley B, Nelson JS,
Free M, Martin A, Starmer J, Wilson EM and Su MA: Sex bias in CNS
autoimmune disease mediated by androgen control of autoimmune
regulator. Nat Commun. 7:113502016. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Dragin N, Bismuth J, Cizeron-Clairac G,
Biferi MG, Berthault C, Serraf A, Nottin R, Klatzmann D, Cumano A,
Barkats M, et al: Estrogen-mediated downregulation of AIRE
influences sexual dimorphism in autoimmune diseases. J Clin Invest.
126:1525–1537. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Afshan G, Afzal N and Qureshi S:
CD4+CD25(hi) regulatory T cells in healthy males and females
mediate gender difference in the prevalence of autoimmune diseases.
Clin Lab. 58:567–571. 2012.PubMed/NCBI
|
|
85
|
Gandhi VD, Cephus JY, Norlander AE,
Chowdhury NU, Zhang J, Ceneviva ZJ, Tannous E, Polosukhin VV, Putz
ND, Wickersham N, et al: Androgen receptor signaling promotes Treg
suppressive function during allergic airway inflammation. J Clin
Invest. 132:e1533972022. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Vargas-Villavicencio JA, Larralde C and
Morales-Montor J: Gonadectomy and progesterone treatment induce
protection in murine cysticercosis. Parasite Immunol. 28:667–674.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Xia T, Ma J and Sun Y and Sun Y: Androgen
receptor suppresses inflammatory response of airway epithelial
cells in allergic asthma through MAPK1 and MAPK14. Hum Exp Toxicol.
41:96032712211213202022. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Kalidhindi RSR, Ambhore NS, Balraj P,
Schmidt T, Khan MN and Sathish V: Androgen receptor activation
alleviates airway hyperresponsiveness, inflammation, and remodeling
in a murine model of asthma. Am J Physiol Lung Cell Mol Physiol.
320:L803–L818. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Kissick HT, Sanda MG, Dunn LK, Pellegrini
KL, On ST, Noel JK and Arredouani MS: Androgens alter T-cell
immunity by inhibiting T-helper 1 differentiation. Proc Natl Acad
Sci USA. 111:9887–9892. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Klein SL, Jedlicka A and Pekosz A: The Xs
and Y of immune responses to viral vaccines. Lancet Infect Dis.
10:338–349. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Hong CY, Park JH, Ahn RS, Im SY, Choi HS,
Soh J, Mellon SH and Lee K: Molecular mechanism of suppression of
testicular steroidogenesis by proinflammatory cytokine tumor
necrosis factor alpha. Mol Cell Biol. 24:2593–2604. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Druckmann R and Druckmann MA: Progesterone
and the immunology of pregnancy. J Steroid Biochem Mol Biol.
97:389–396. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Scarpin KM, Graham JD, Mote PA and Clarke
CL: Progesterone action in human tissues: Regulation by
progesterone receptor (PR) isoform expression, nuclear positioning
and coregulator expression. Nucl Recept Signal. 7:e0092009.
View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Quispe Calla NE, Ghonime MG, Cherpes TL
and Vicetti Miguel RD: Medroxyprogesterone acetate impairs human
dendritic cell activation and function. Hum Reprod. 30:1169–1177.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Mao G, Wang J, Kang Y, Tai P, Wen J, Zou
Q, Li G, Ouyang H, Xia G and Wang B: Progesterone increases
systemic and local uterine proportions of CD4+CD25+ Treg cells
during midterm pregnancy in mice. Endocrinology. 151:5477–5488.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Hierweger AM, Engler JB, Friese MA,
Reichardt HM, Lydon J, DeMayo F, Mittrücker HW and Arck PC:
Progesterone modulates the T-cell response via glucocorticoid
receptor-dependent pathways. Am J Reprod Immunol. 81:e130842019.
View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Robinson DP and Klein SL: Pregnancy and
pregnancy-associated hormones alter immune responses and disease
pathogenesis. Horm Behav. 62:263–271. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Hughes GC, Martin D, Zhang K, Hudkins KL,
Alpers CE, Clark EA and Elkon KB: Decrease in glomerulonephritis
and Th1-associated autoantibody production after progesterone
treatment in NZB/NZW mice. Arthritis Rheum. 60:1775–1784. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Hughes GC and Choubey D: Modulation of
autoimmune rheumatic diseases by oestrogen and progesterone. Nat
Rev Rheumatol. 10:740–751. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Carreno PC, Sacedon R, Jimenez E, Vicente
A and Zapata AG: Prolactin affects both survival and
differentiation of T-cell progenitors. J Neuroimmunol. 160:135–145.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Legorreta-Haquet MV, Chavez-Rueda K,
Chavez-Sanchez L, Cervera-Castillo H, Zenteno-Galindo E,
Barile-Fabris L, Burgos-Vargas R, Álvarez-Hernández E and
Blanco-Favela F: Function of treg cells decreased in patients with
systemic lupus erythematosus due to the effect of prolactin.
Medicine (Baltimore). 95:e23842016. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Dimitrov S, Lange T, Fehm HL and Born J: A
regulatory role of prolactin, growth hormone, and corticosteroids
for human T-cell production of cytokines. Brain Behav Immun.
18:368–374. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Tsampalas M, Gridelet V, Berndt S, Foidart
JM, Geenen V and Perrier d'Hauterive S: Human chorionic
gonadotropin: A hormone with immunological and angiogenic
properties. J Reprod Immunol. 85:93–98. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Lentz LS, Stutz AJ, Meyer N, Schubert K,
Karkossa I, von Bergen M, Zenclussen AC and Schumacher A: Human
chorionic gonadotropin promotes murine Treg cells and restricts
pregnancy-harmful proinflammatory Th17 responses. Front Immunol.
13:9892472022. View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Sha J, Liu F, Zhai J, Liu X, Zhang Q and
Zhang B: Alteration of Th17 and Foxp3(+) regulatory T cells in
patients with unexplained recurrent spontaneous abortion before and
after the therapy of hCG combined with immunoglobulin. Exp Ther
Med. 14:1114–1118. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Diao LH, Li GG, Zhu YC, Tu WW, Huang CY,
Lian RC, Chen X, Li YY, Zhang T, Huang Y and Zeng Y: Human
chorionic gonadotropin potentially affects pregnancy outcome in
women with recurrent implantation failure by regulating the homing
preference of regulatory T cells. Am J Reprod Immunol. 77:2017.
View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Schumacher A, Heinze K, Witte J, Poloski
E, Linzke N, Woidacki K and Zenclussen AC: Human chorionic
gonadotropin as a central regulator of pregnancy immune tolerance.
J Immunol. 190:2650–2658. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Iqbal J, Sun L, Kumar TR, Blair HC and
Zaidi M: Follicle-stimulating hormone stimulates TNF production
from immune cells to enhance osteoblast and osteoclast formation.
Proc Natl Acad Sci USA. 103:14925–14930. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Qian H, Jia J, Yang Y, Bian Z and Ji Y: A
follicle-stimulating hormone exacerbates the progression of
periapical inflammation through modulating the cytokine release in
periodontal tissue. Inflammation. 43:1572–1585. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Kvien TK, Uhlig T, Odegard S and Heiberg
MS: Epidemiological aspects of rheumatoid arthritis: The sex ratio.
Ann N Y Acad Sci. 1069:212–222. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Sokka T, Toloza S, Cutolo M, Kautiainen H,
Makinen H, Gogus F, Skakic V, Badsha H, Peets T, Baranauskaite A,
et al: Women, men, and rheumatoid arthritis: Analyses of disease
activity, disease characteristics, and treatments in the QUEST-RA
study. Arthritis Res Ther. 11:R72009.PubMed/NCBI
|
|
112
|
Castagnetta LA, Carruba G, Granata OM,
Stefano R, Miele M, Schmidt M, Cutolo M and Straub RH: Increased
estrogen formation and estrogen to androgen ratio in the synovial
fluid of patients with rheumatoid arthritis. J Rheumatol.
30:2597–2605. 2003.PubMed/NCBI
|
|
113
|
Nieminen P, Hamalainen W, Savinainen J,
Lehtonen M, Lehtiniemi S, Rinta-Paavola J, Lehenkari P, Kääriäinen
T, Joukainen A, Kröger H, et al: Metabolomics of synovial fluid and
infrapatellar fat pad in patients with osteoarthritis or rheumatoid
arthritis. Inflammation. 45:1101–1117. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Schmidt M, Weidler C, Naumann H, Anders S,
Schölmerich J and Straub RH: Androgen conversion in osteoarthritis
and rheumatoid arthritis synoviocytes-androstenedione and
testosterone inhibit estrogen formation and favor production of
more potent 5alpha-reduced androgens. Arthritis Res Ther.
7:R938–R948. 2005. View
Article : Google Scholar : PubMed/NCBI
|
|
115
|
Capellino S, Straub RH and Cutolo M:
Aromatase and regulation of the estrogen-to-androgen ratio in
synovial tissue inflammation: Common pathway in both sexes. Ann N Y
Acad Sci. 1317:24–31. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Weitoft T, Larsson A and Ronnblom L: Serum
levels of sex steroid hormones and matrix metalloproteinases after
intra-articular glucocorticoid treatment in female patients with
rheumatoid arthritis. Ann Rheum Dis. 67:422–424. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Capellino S, Montagna P, Villaggio B,
Soldano S, Straub RH and Cutolo M: Hydroxylated estrogen
metabolites influence the proliferation of cultured human
monocytes: possible role in synovial tissue hyperplasia. Clin Exp
Rheumatol. 26:903–909. 2008.PubMed/NCBI
|
|
118
|
Schmidt M, Hartung R, Capellino S, Cutolo
M, Pfeifer-Leeg A and Straub RH: Estrone/17beta-estradiol
conversion to, and tumor necrosis factor inhibition by, estrogen
metabolites in synovial cells of patients with rheumatoid arthritis
and patients with osteoarthritis. Arthritis Rheum. 60:2913–2922.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Cenci S, Toraldo G, Weitzmann MN, Roggia
C, Gao Y, Qian WP, Sierra O and Pacifici R: Estrogen deficiency
induces bone loss by increasing T cell proliferation and lifespan
through IFN-gamma-induced class II transactivator. Proc Natl Acad
Sci USA. 100:10405–10410. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Garcia-Perez MA, Noguera I, Hermenegildo
C, Martínez-Romero A, Tarín JJ and Cano A: Alterations in the
phenotype and function of immune cells in ovariectomy-induced
osteopenic mice. Hum Reprod. 21:880–887. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Yoneda T, Ishimaru N, Arakaki R, Kobayashi
M, Izawa T, Moriyama K and Hayashi Y: Estrogen deficiency
accelerates murine autoimmune arthritis associated with receptor
activator of nuclear factor-kappa B ligand-mediated
osteoclastogenesis. Endocrinology. 145:2384–2391. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
122
|
Andersson A, Grahnemo L, Engdahl C,
Stubelius A, Lagerquist MK, Carlsten H and Islander U:
IL-17-producing үδT cells are regulated by estrogen during
development of experimental arthritis. Clin Immunol. 161:324–332.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
123
|
Zai Z, Xu Y, Qian X, Li Z, Ou Z, Zhang T,
Wang L, Ling Y, Peng X, Zhang Y and Chen F: Estrogen antagonizes
ASIC1a-induced chondrocyte mitochondrial stress in rheumatoid
arthritis. J Transl Med. 20:5612022. View Article : Google Scholar : PubMed/NCBI
|
|
124
|
Ishizuka M, Hatori M, Suzuki T, Miki Y,
Darnel AD, Tazawa C, Sawai T, Uzuki M, Tanaka Y, Kokubun S and
Sasano H: Sex steroid receptors in rheumatoid arthritis. Clin Sci
(Lond). 106:293–300. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
125
|
Engdahl C, Borjesson AE, Forsman HF,
Andersson A, Stubelius A, Krust A, Chambon P, Islander U, Ohlsson
C, Carlsten H and Lagerquist MK: The role of total and
cartilage-specific estrogen receptor alpha expression for the
ameliorating effect of estrogen treatment on arthritis. Arthritis
Res Ther. 16:R1502014. View
Article : Google Scholar : PubMed/NCBI
|
|
126
|
Andersson A, Stubelius A, Karlsson MN,
Engdahl C, Erlandsson M, Grahnemo L, Lagerquist MK and Islander U:
Estrogen regulates T helper 17 phenotype and localization in
experimental autoimmune arthritis. Arthritis Res Ther. 17:322015.
View Article : Google Scholar : PubMed/NCBI
|
|
127
|
Xu X, Yang H, Bullock WA, Gallant MA,
Ohlsson C, Bellido TM and Main RP: Osteocyte estrogen receptor β
(Ot-ERβ) regulates bone turnover and skeletal adaptive response to
mechanical loading differently in male and female growing and adult
mice. J Bone Miner Res. 38:186–197. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
128
|
Sims NA, Dupont S, Krust A,
Clement-Lacroix P, Minet D, Resche-Rigon M, Gaillard-Kelly M and
Baron R: Deletion of estrogen receptors reveals a regulatory role
for estrogen receptors-beta in bone remodeling in females but not
in males. Bone. 30:18–25. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
129
|
Bove R: Autoimmune diseases and
reproductive aging. Clin Immunol. 149:251–264. 2015. View Article : Google Scholar
|
|
130
|
Cutolo M, Sulli A, Pizzorni C, Craviotto C
and Straub RH: Hypothalamic-pituitary-adrenocortical and gonadal
functions in rheumatoid arthritis. Ann N Y Acad Sci. 992:107–117.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
131
|
Yang DD, Krasnova A, Nead KT, Choueiri TK,
Hu JC, Hoffman KE, Yu JB, Spratt DE, Feng FY, Trinh QD and Nguyen
PL: Androgen deprivation therapy and risk of rheumatoid arthritis
in patients with localized prostate cancer. Ann Oncol. 29:386–391.
2018. View Article : Google Scholar : PubMed/NCBI
|
|
132
|
Drevinskaite M, Dadoniene J, Miltiniene D,
Patasius A and Smailyte G: Association between androgen deprivation
therapy and the risk of inflammatory rheumatic diseases in men with
prostate cancer: Nationwide Cohort Study in Lithuania. J Clin Med.
11:20392007. View Article : Google Scholar
|
|
133
|
Cutolo M, Seriolo B, Villaggio B, Pizzorni
C, Craviotto C and Sulli A: Androgens and estrogens modulate the
immune and inflammatory responses in rheumatoid arthritis. Ann N Y
Acad Sci. 966:131–142. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
134
|
Ganesan K, Selvam R, Abhirami R, Raju KV,
Manohar BM and Puvanakrishnan R: Gender differences and protective
effects of testosterone in collagen induced arthritis in rats.
Rheumatol Int. 28:345–353. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
135
|
Ganesan K, Balachandran C, Manohar BM and
Puvanakrishnan R: Effects of testosterone, estrogen and
progesterone on TNF-α mediated cellular damage in rat arthritic
synovial fibroblasts. Rheumatol Int. 32:3181–3188. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
136
|
Martin CS, Crastin A, Sagmeister MS,
Turner JD, MacDonald L, Kurowska-Stolarska M, Scheel-Toellner D,
Taylor AE, Gilligan LC, Storbeck K, et al: Inflammation dynamically
regulates steroid hormone metabolism and action within macrophages
in rheumatoid arthritis. J Autoimmun. 147:1032632024. View Article : Google Scholar : PubMed/NCBI
|
|
137
|
Weidler C, Struharova S, Schmidt M, Ugele
B, Schölmerich J and Straub RH: Tumor necrosis factor inhibits
conversion of dehydroepiandrosterone sulfate (DHEAS) to DHEA in
rheumatoid arthritis synovial cells: A prerequisite for local
androgen deficiency. Arthritis Rheum. 52:1721–1729. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
138
|
Straub RH, Harle P, Yamana S, Matsuda T,
Takasugi K, Kishimoto T and Nishimoto N: Anti-interleukin-6
receptor antibody therapy favors adrenal androgen secretion in
patients with rheumatoid arthritis: A randomized, double-blind,
placebo-controlled study. Arthritis Rheum. 54:1778–1785. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
139
|
Jurcovicova J, Svik K, Scsukova S,
Bauerova K, Rovensky J and Stancikova M: Methotrexate treatment
ameliorated testicular suppression and anorexia related leptin
reduction in rats with adjuvant arthritis. Rheumatol Int.
29:1187–1191. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
140
|
Stark K, Straub RH, Rovensky J, Blažičková
S, Eiselt G and Schmidt M: CYB5A polymorphism increases androgens
and reduces risk of rheumatoid arthritis in women. Arthritis Res
Ther. 17:562015. View Article : Google Scholar : PubMed/NCBI
|
|
141
|
Park JS, Choi SY, Hwang SH, Kim SM, Choi
J, Jung KA, Kwon JY, Kong YY, Cho ML and Park SH: CR6-interacting
factor 1 controls autoimmune arthritis by regulation of signal
transducer and activator of transcription 3 pathway and T helper
type 17 cells. Immunology. 156:413–421. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
142
|
Rontzsch A, Thoss K, Petrow PK, Henzgen S
and Bräuer R: Amelioration of murine antigen-induced arthritis by
dehydroepiandrosterone (DHEA). Inflamm Res. 53:189–198. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
143
|
Sandoughi M, Kaykhaei MA, Langarizadeh E
and Dashipour A: Effects of dehydroepiandrosterone on quality of
life in premenopausal women with rheumatoid arthritis: A
preliminary randomized clinical trial. Int J Rheum Dis.
23:1692–1697. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
144
|
Hellberg S, Raffetseder J, Rundquist O,
Magnusson R, Papapavlou G, Jenmalm MC, Ernerudh J and Gustafsson M:
Progesterone dampens immune responses in in vitro activated CD4(+)
T cells and affects genes associated with autoimmune diseases that
improve during pregnancy. Front Immunol. 12:6721682021. View Article : Google Scholar : PubMed/NCBI
|
|
145
|
Khalkhali-Ellis Z, Seftor EA, Nieva DR,
Handa RJ, Price RH Jr, Kirschmann DA, Baragi VM, Sharma RV, Bhalla
RC, Moore TL and Hendrix MJ: Estrogen and progesterone regulation
of human fibroblast-like synoviocyte function in vitro:
implications in rheumatoid arthritis. J Rheumatol. 27:1622–1631.
2000.PubMed/NCBI
|
|
146
|
Jahanbakhshi M, Babaloo Z,
Mortazavi-Jahromi SS, Shokri MM, Ahmadi H and Mirshafiey A:
Modification of sexual hormones in rheumatoid arthritis patients by
M2000 (β-D-mannuronic Acid) as a Novel NSAID with immunosuppressive
property. Endocr Metab Immune Disord Drug Targets. 18:530–536.
2018. View Article : Google Scholar : PubMed/NCBI
|
|
147
|
Tengstrand B, Carlstrom K and Hafstrom I:
Bioavailable testosterone in men with rheumatoid arthritis-high
frequency of hypogonadism. Rheumatology (Oxford). 41:285–289. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
148
|
Tengstrand B, Carlstrom K and Hafstrom I:
Gonadal hormones in men with rheumatoid arthritis-from onset
through 2 years. J Rheumatol. 36:887–892. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
149
|
Cevik R, Em S, Gur A, Nas K, Sarac AJ and
Colpan L: Sex and thyroid hormone status in women with rheumatoid
arthritis: Are there any effects of menopausal state and disease
activity on these hormones? Int J Clin Pract. 58:327–332. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
150
|
Takeuchi T, Tanaka Y, Higashitani C, Iwai
M, Komatsu K, Akazawa R and Lademacher C: A phase 2a, randomized,
double-blind, placebo-controlled trial of the efficacy and safety
of the oral gonadotropin-releasing hormone antagonist, ASP1707, in
postmenopausal female patients with rheumatoid arthritis taking
methotrexate. Mod Rheumatol. 31:53–60. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
151
|
Weitzmann MN and Pacifici R: Estrogen
deficiency and bone loss: An inflammatory tale. J Clin Invest.
116:1186–1194. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
152
|
Belenska-Todorova L, Zhivkova R, Markova M
and Ivanovska N: Follicle stimulating hormone and estradiol alter
immune response in osteoarthritic mice in an opposite manner. Int J
Immunopathol Pharmacol. 35:205873842110161982021. View Article : Google Scholar : PubMed/NCBI
|
|
153
|
Zhang X, Qiao P, Guo Q, Liang Z, Pan J, Wu
F, Wang X and Zhang L: High follicle-stimulating hormone level
associated with risk of rheumatoid arthritis and disease activity.
Front Endocrinol (Lausanne). 13:8628492022. View Article : Google Scholar : PubMed/NCBI
|
|
154
|
Vieira Borba V and Shoenfeld Y: Prolactin,
autoimmunity, and motherhood: when should women avoid
breastfeeding? Clin Rheumatol. 38:1263–1270. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
155
|
Ram S, Blumberg D, Newton P, Anderson NR
and Gama R: Raised serum prolactin in rheumatoid arthritis: genuine
or laboratory artefact? Rheumatology (Oxford). 43:1272–1274. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
156
|
Zoli A, Lizzio MM, Ferlisi EM, Massafra V,
Mirone L, Barini A, Scuderi F, Bartolozzi F and Magaró M: ACTH,
cortisol and prolactin in active rheumatoid arthritis. Clin
Rheumatol. 21:289–293. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
157
|
Han A, Kim JY, Kwak-Kim J and Lee SK:
Menopause is an inflection point of age-related immune changes in
women. J Reprod Immunol. 146:1033462021. View Article : Google Scholar : PubMed/NCBI
|
|
158
|
Humphreys JH, Verstappen SM, Hyrich KL,
Chipping JR, Marshall T and Symmons DP: The incidence of rheumatoid
arthritis in the UK: Comparisons using the 2010 ACR/EULAR
classification criteria and the 1987 ACR classification criteria.
Results from the Norfolk Arthritis Register. Ann Rheum Dis.
72:1315–1320. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
159
|
Mollard E, Pedro S, Chakravarty E, Clowse
M, Schumacher R and Michaud K: The impact of menopause on
functional status in women with rheumatoid arthritis. Rheumatology
(Oxford). 57:798–802. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
160
|
Beydoun HA, El-Amin R, McNeal M, Perry C
and Archer DF: Reproductive history and postmenopausal rheumatoid
arthritis among women 60 years or older: Third national health and
nutrition examination survey. Menopause. 20:930–935. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
161
|
Salliot C, Nguyen Y, Gusto G, Gelot A,
Gambaretti J, Mariette X, Boutron-Ruault MC and Seror R: Female
hormonal exposures and risk of rheumatoid arthritis in the French
E3N-EPIC cohort study. Rheumatology (Oxford). 60:4790–4800. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
162
|
Alpizar-Rodriguez D, Mueller RB, Moller B,
Dudler J, Ciurea A, Zufferey P, Kyburz D, Walker UA, von Mühlenen
I, Roux-Lombard P, et al: Female hormonal factors and the
development of anti-citrullinated protein antibodies in women at
risk of rheumatoid arthritis. Rheumatology (Oxford). 56:1579–1585.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
163
|
Harlow SD, Gass M, Hall JE, Lobo R, Maki
P, Rebar RW, Sherman S, Sluss PM and de Villiers TJ; STRAW + 10
Collaborative Group, : Executive summary of the Stages of
Reproductive Aging Workshop + 10: Addressing the unfinished agenda
of staging reproductive aging. J Clin Endocrinol Metab.
97:1159–1168. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
164
|
Engdahl C, Bondt A, Harre U, Raufer J,
Pfeifle R, Camponeschi A, Wuhrer M, Seeling M, Mårtensson IL,
Nimmerjahn F, et al: Estrogen induces St6gal1 expression and
increases IgG sialylation in mice and patients with rheumatoid
arthritis: A potential explanation for the increased risk of
rheumatoid arthritis in postmenopausal women. Arthritis Res Ther.
20:842018. View Article : Google Scholar : PubMed/NCBI
|
|
165
|
Guthrie KA, Dugowson CE, Voigt LF,
Koepsell TD and Nelson JL: Does pregnancy provide vaccine-like
protection against rheumatoid arthritis? Arthritis Rheum.
62:1842–1848. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
166
|
Straub RH: The complex role of estrogens
in inflammation. Endocr Rev. 28:521–574. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
167
|
Hodis HN, Mack WJ, Henderson VW, Shoupe D,
Budoff MJ, Hwang-Levine J, Li Y, Feng M, Dustin L, Kono N, et al:
Vascular effects of early versus late postmenopausal treatment with
estradiol. N Engl J Med. 374:1221–1231. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
168
|
Orellana C, Wedren S, Kallberg H,
Holmqvist M, Karlson EW, Alfredsson L and Bengtsson C; EIRA Study
Group, : Parity and the risk of developing rheumatoid arthritis:
Results from the Swedish Epidemiological Investigation of
Rheumatoid Arthritis study. Ann Rheum Dis. 73:752–755. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
169
|
Bondt A, Hafkenscheid L, Falck D, Kuijper
TM, Rombouts Y, Hazes JMW, Wuhrer M and Dolhain RJEM: ACPA IgG
galactosylation associates with disease activity in pregnant
patients with rheumatoid arthritis. Ann Rheum Dis. 77:1130–1136.
2018.PubMed/NCBI
|
|
170
|
Forger F, Marcoli N, Gadola S, Möller B,
Villiger PM and Østensen M: Pregnancy induces numerical and
functional changes of CD4+CD25 high regulatory T cells in patients
with rheumatoid arthritis. Ann Rheum Dis. 67:984–990. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
171
|
Munoz-Suano A, Kallikourdis M, Sarris M
and Betz AG: Regulatory T cells protect from autoimmune arthritis
during pregnancy. J Autoimmun. 38:J103–J108. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
172
|
Clowse ME, Chakravarty E, Costenbader KH,
Chambers C and Michaud K: Effects of infertility, pregnancy loss,
and patient concerns on family size of women with rheumatoid
arthritis and systemic lupus erythematosus. Arthritis Care Res
(Hoboken). 64:668–674. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
173
|
Littlejohn EA: Pregnancy and rheumatoid
arthritis. Best Pract Res Clin Obstet Gynaecol. 64:52–58. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
174
|
Lopez-Corbeto M, Martinez-Mateu S, Pluma
A, Ferrer R, López-Lasanta M, De Agustín JJ, Barceló M, Julià A and
Marsal S: The ovarian reserve as measured by the anti-Mullerian
hormone is not diminished in patients with rheumatoid arthritis
compared to the healthy population. Clin Exp Rheumatol. 39:337–343.
2021. View Article : Google Scholar : PubMed/NCBI
|
|
175
|
Brouwer J, Laven JS, Hazes JM, Schipper I
and Dolhain RJ: Levels of serum anti-Mullerian hormone, a marker
for ovarian reserve, in women with rheumatoid arthritis. Arthritis
Care Res (Hoboken). 65:1534–1538. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
176
|
Hampl JS and Papa DJ:
Breastfeeding-related onset, flare, and relapse of rheumatoid
arthritis. Nutr Rev. 59((8 Pt 1)): 264–268. 2001.PubMed/NCBI
|
|
177
|
Karlson EW, Mandl LA, Hankinson SE and
Grodstein F: Do breast-feeding and other reproductive factors
influence future risk of rheumatoid arthritis? Results from the
Nurses' Health Study. Arthritis Rheum. 50:3458–3467. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
178
|
Adab P, Jiang C Q, Rankin E, Tsang YW, Lam
TH, Barlow J, Thomas GN, Zhang WS and Cheng KK: Breastfeeding
practice, oral contraceptive use and risk of rheumatoid arthritis
among Chinese women: The guangzhou biobank cohort study.
Rheumatology (Oxford). 53:860–866. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
179
|
Chen H, Wang J, Zhou W, Yin H and Wang M:
Breastfeeding and risk of rheumatoid arthritis: A systematic review
and metaanalysis. J Rheumatol. 42:1563–1569. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
180
|
Orellana C, Saevarsdottir S, Klareskog L,
Karlson EW, Alfredsson L and Bengtsson C: Postmenopausal hormone
therapy and the risk of rheumatoid arthritis: Results from the
Swedish EIRA population-based case-control study. Eur J Epidemiol.
30:449–457. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
181
|
Doran MF, Crowson CS, O'fallon WM and
Gabriel SE: The effect of oral contraceptives and estrogen
replacement therapy on the risk of rheumatoid arthritis: A
population based study. J Rheumatol. 31:207–213. 2004.PubMed/NCBI
|
|
182
|
Pedersen M, Jacobsen S, Garred P, Madsen
HO, Klarlund M, Svejgaard A, Pedersen BV, Wohlfahrt J and Frisch M:
Strong combined gene-environment effects in anti-cyclic
citrullinated peptide-positive rheumatoid arthritis: A nationwide
case-control study in Denmark. Arthritis Rheum. 56:1446–1453. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
183
|
Qi S, Xin R, Guo W and Liu Y:
Meta-analysis of oral contraceptives and rheumatoid arthritis risk
in women. Ther Clin Risk Manag. 10:915–923. 2014.PubMed/NCBI
|
|
184
|
Walitt B, Pettinger M, Weinstein A, Katz
J, Torner J, Wasko MC and Howard BV; Women's Health Initiative
Investigators, : Effects of postmenopausal hormone therapy on
rheumatoid arthritis: The women's health initiative randomized
controlled trials. Arthritis Rheum. 59:302–310. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
185
|
Yuk JS, Seo YS, Im YH and Kim JH:
Menopausal hormone therapy and risk of seropositive rheumatoid
arthritis: A nationwide cohort study in Korea. Semin Arthritis
Rheum. 63:1522802023. View Article : Google Scholar : PubMed/NCBI
|
|
186
|
D'elia HF and Carlsten H: The impact of
hormone replacement therapy on humoral and cell-mediated immune
responses in vivo in post-menopausal women with rheumatoid
arthritis. Scand J Immunol. 68:661–667. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
187
|
Cutolo M, Balleari E, Giusti M, Intra E
and Accardo S: Androgen replacement therapy in male patients with
rheumatoid arthritis. Arthritis Rheum. 34:1–5. 1991. View Article : Google Scholar : PubMed/NCBI
|
|
188
|
Booji A, Biewenga-Booji CM, Huber-Bruning
O, Cornelis C, Jacobs JW and Bijlsma JW: Androgens as adjuvant
treatment in postmenopausal female patients with rheumatoid
arthritis. Ann Rheum Dis. 55:811–815. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
189
|
Hall GM, Larbre JP, Spector TD, Perry LA
and Da Silva JA: A randomized trial of testosterone therapy in
males with rheumatoid arthritis. Br J Rheumatol. 35:568–573. 1996.
View Article : Google Scholar : PubMed/NCBI
|
|
190
|
Hall GM, Daniels M, Huskisson EC and
Spector TD: A randomised controlled trial of the effect of hormone
replacement therapy on disease activity in postmenopausal
rheumatoid arthritis. Ann Rheum Dis. 53:112–116. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
191
|
Hall GM, Daniels M, Doyle DV and Spector
TD: Effect of hormone replacement therapy on bone mass in
rheumatoid arthritis patients treated with and without steroids.
Arthritis Rheum. 37:1499–505. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
192
|
Forsblad-D'elia H and Carlsten H: Hormone
replacement therapy in postmenopausal women with rheumatoid
arthritis stabilises bone mineral density by digital x-ray
radiogrammetry in a randomised controlled trial. Ann Rheum Dis.
70:1167–1168. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
193
|
Pullerits R, D'elia HF, Tarkowski A and
Carlsten H: The decrease of soluble RAGE levels in rheumatoid
arthritis patients following hormone replacement therapy is
associated with increased bone mineral density and diminished
bone/cartilage turnover: A randomized controlled trial.
Rheumatology (Oxford). 48:785–790. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
194
|
Kass A, Hollan I, Fagerland MW, Gulseth
HC, Torjesen PA and Førre ØT: Rapid anti-inflammatory effects of
gonadotropin-releasing hormone antagonism in rheumatoid arthritis
patients with high gonadotropin levels in the AGRA Trial. PLoS One.
10:e01394392015. View Article : Google Scholar : PubMed/NCBI
|
|
195
|
Kass AS, Forre OT, Fagerland MW, Gulseth
HC, Torjesen PA and Hollan I: Short-term treatment with a
gonadotropin-releasing hormone antagonist, cetrorelix, in
rheumatoid arthritis (AGRA): A randomized, double-blind,
placebo-controlled study. Scand J Rheumatol. 43:22–27. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
196
|
Brown MA and Su MA: An inconvenient
variable: Sex hormones and their impact on T cell responses. J
Immunol. 202:1927–1933. 2019. View Article : Google Scholar : PubMed/NCBI
|
